{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:06:44Z","timestamp":1772140004795,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001588","name":"Enterprise Ireland","doi-asserted-by":"publisher","award":["ARE20080001"],"award-info":[{"award-number":["ARE20080001"]}],"id":[{"id":"10.13039\/501100001588","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministerio de Econom\u00eda et al. Competitividad","award":["BFU2012-32105"],"award-info":[{"award-number":["BFU2012-32105"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.ejphar.2017.08.020","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T17:30:44Z","timestamp":1502904644000},"page":"216-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Involvement of cyclic nucleotide-gated channels in spontaneous activity generated in isolated interstitial cells of Cajal from the rabbit urethra"],"prefix":"10.1016","volume":"814","author":[{"given":"Maria","family":"Sancho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eamonn","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeles","family":"Garcia-Pascual","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domingo","family":"Triguero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith D.","family":"Thornbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Hollywood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard P.","family":"Sergeant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2017.08.020_bib1","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1074\/jbc.R800075200","article-title":"Cyclic nucleotide-regulated cation channels","volume":"284","author":"Biel","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2017.08.020_bib2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1113\/jphysiol.2006.110932","article-title":"Contribution of reverse Na+-Ca2+ exchange to spontaneous activity in interstitial cells of Cajal in the rabbit urethra","volume":"574","author":"Bradley","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2017.08.020_bib3","first-page":"56","article-title":"Ultrasensitivity, speed, and resolution: optimizing low-light microscopy with the back-illuminated electron-multiplying CCD","author":"Coates","year":"2003","journal-title":"Eur. Conf. Biomed. Opt."},{"key":"10.1016\/j.ejphar.2017.08.020_bib4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.physiol.68.040104.134728","article-title":"CNG and HCN channels: two peas, one pod","volume":"68","author":"Craven","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2017.08.020_bib5","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1113\/JP270883","article-title":"The role of Ca2+ influx in spontaneous Ca2+ wave propagation in interstitial cells of Cajal from the rabbit urethra","volume":"593","author":"Drumm","year":"2015","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2017.08.020_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ceca.2014.07.002","article-title":"The role of cAMP dependent protein kinase in modulating spontaneous intracellular Ca2+ waves in interstitial cells of Cajal from the rabbit urethra","volume":"56","author":"Drumm","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2017.08.020_bib7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1124\/pr.57.4.8","article-title":"International Union of Pharmacology LI. Nomenclature and structure-function relationships of cyclic nucleotide regulated channels","volume":"57","author":"Hofmann","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2017.08.020_bib8","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1113\/jphysiol.2004.078097","article-title":"Calcium oscillations in interstitial cells of the rabbit urethra","volume":"565","author":"Johnston","year":"2005","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.ejphar.2017.08.020_bib9","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1152\/physrev.00008.2002","article-title":"Cyclic nucleotide-gated ion channels","volume":"82","author":"Kaupp","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2017.08.020_bib10","doi-asserted-by":"crossref","first-page":"6788","DOI":"10.1016\/S0021-9258(18)88849-4","article-title":"Cyclic GMP directly regulates a cation conductance in membranes of bovide rods by a cooperative mechanism","volume":"260","author":"Koch","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2017.08.020_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jtbi.2011.12.007","article-title":"Structure of cell networks critically determines oscillation regularity","volume":"297","author":"Kori","year":"2012","journal-title":"J. Theor. Biol."},{"issue":"4953","key":"10.1016\/j.ejphar.2017.08.020_bib12","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1126\/science.2158146","article-title":"Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum","volume":"248","author":"Leblanc","year":"1990","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ejphar.2017.08.020_bib13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbrc.2006.10.160","article-title":"Na+ entry via TRPC6 causes Ca2+ entry via NCX reversal in ATP stimulated smooth muscle cells","volume":"352","author":"Lemos","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.ejphar.2017.08.020_bib14","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1161\/CIRCRESAHA.107.155531","article-title":"Transient receptor potential channel 6-mediated, localized cytosolic [Na+] transients drive Na+\/Ca2+ exchanger-mediated Ca2+ entry in purinergically stimulated aorta smooth muscle cells","volume":"101","author":"Poburko","year":"2007","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2017.08.020_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0165-0270(91)90017-T","article-title":"Low access resistance perforated patch recordings using amphotericin B","volume":"37","author":"Rae","year":"1991","journal-title":"J. Neurosci. Methods"},{"issue":"Pt 1","key":"10.1016\/j.ejphar.2017.08.020_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1113\/jphysiol.2005.090951","article-title":"Electrophysiological and molecular identification of voltage-gated sodium channels in murine vascular myocytes","volume":"568","author":"Saleh","year":"2005","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.ejphar.2017.08.020_bib17","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1152\/physrev.00037.2013","article-title":"Interstitial cells: regulators of smooth muscle function","volume":"94","author":"Sanders","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2017.08.020_bib18","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1469-7793.2000.t01-2-00359.x","article-title":"Specialized pacemaking cells in the rabbit urethra","volume":"526","author":"Sergeant","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2017.08.020_bib19","doi-asserted-by":"crossref","first-page":"C1349","DOI":"10.1152\/ajpcell.2001.280.5.C1349","article-title":"Role of IP3 in modulation of spontaneous activity in pacemaker cells of rabbit urethra","volume":"280","author":"Sergeant","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2017.08.020_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1113\/jphysiol.2006.108621","article-title":"Activation of the cGMP\/PKG pathway inhibits electrical activity in rabbit urethral interstitial cells of Cajal by reducing the spatial spread of Ca2+ waves","volume":"574","author":"Sergeant","year":"2006","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.ejphar.2017.08.020_bib21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.yjmcc.2008.06.005","article-title":"Epinephrine-induced Ca2+ influx in vascular endothelial cells is mediated by CNGA2 channels","volume":"45","author":"Shen","year":"2008","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.ejphar.2017.08.020_bib22","doi-asserted-by":"crossref","first-page":"e106152","DOI":"10.1371\/journal.pone.0106152","article-title":"A model for the fast synchronous oscillations of firing rate in rat suprachiasmatic nucleus neurons cultured in a multielectrode array dish","volume":"9","author":"Stepanyuk","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.08.020_bib23","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1073\/pnas.83.4.1163","article-title":"Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium and L-cis-Diltiazem","volume":"83","author":"Stern","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.08.020_bib24","doi-asserted-by":"crossref","first-page":"F1353","DOI":"10.1152\/ajprenal.00403.2009","article-title":"Presence of cyclic nucleotide-gated channels in the rat urethra and their involvement in nerve-mediated nitrergic relaxation","volume":"297","author":"Triguero","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ejphar.2017.08.020_bib25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.ne.19.030196.001315","article-title":"Structure and function of cyclic nucleotide-gated channels","volume":"19","author":"Zagotta","year":"1996","journal-title":"Annu. Rev. Neurosci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917305344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917305344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T07:46:22Z","timestamp":1659339982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299917305344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":25,"alternative-id":["S0014299917305344"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.08.020","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of cyclic nucleotide-gated channels in spontaneous activity generated in isolated interstitial cells of Cajal from the rabbit urethra","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.08.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}