{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:29:24Z","timestamp":1782840564681,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660679"],"award-info":[{"award-number":["81660679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ejphar.2017.11.035","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T07:01:41Z","timestamp":1511334101000},"page":"68-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["IcarisideII improves left ventricular remodeling in spontaneously hypertensive rats by inhibiting the ASK1-JNK\/p38 signaling pathway"],"prefix":"10.1016","volume":"819","author":[{"given":"Yuting","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2017.11.035_bib1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijcard.2005.07.061","article-title":"Myocardial expression of surviving, an apoptosis inhibitor, in aging and heart failure.\u00a0An experimental study in the spontaneously hypertensive rats","volume":"111","author":"Abbate","year":"2006","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2017.11.035_bib2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1161\/01.RES.0000012702.90501.8D","article-title":"Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection","volume":"90","author":"Baines","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2017.11.035_bib3","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1006\/jmcc.1994.1115","article-title":"Hypothesis: apoptosis may be a mechanism for the transition to heart failure with chronic pressure overload","volume":"26","author":"Bing","year":"1994","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2017.11.035_bib4","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1092734","article-title":"Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis","volume":"303","author":"Chipuk","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2017.11.035_bib5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10162-013-0404-1","article-title":"Bax, Bcl2, and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line","volume":"14","author":"Coffin","year":"2013","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.ejphar.2017.11.035_bib6","first-page":"13007","article-title":"Short interfering RNA directed against the GOLPH3 gene enhances the effect of chemotherapy against oral squamous cell carcinoma by regulating Caspase3: Bcl2 and cytochrome-c expression","volume":"8","author":"Cui","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.ejphar.2017.11.035_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fphar.2017.00039","article-title":"Icariside II, a broad-spectrum anti-cancer agent, reverses beta-amyloid-induced cognitive impairment through reducing inflammation and apoptosis in rats","volume":"8","author":"Deng","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.11.035_bib8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/01.HYP.0000103629.01745.59","article-title":"Prewitt RL Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity","volume":"43","author":"Dobrian","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2017.11.035_bib9","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(15)01225-8","article-title":"Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis","volume":"387","author":"Ettehad","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2017.11.035_bib10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00395-011-0184-x","article-title":"Distinct mechanisms for diastolic dysfunction in diabetes mellitus and chronic pressure-overload","volume":"106","author":"Falc\u00e3o-Pires","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2017.11.035_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly","volume":"65","author":"Frey","year":"2003","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2017.11.035_bib12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/jcmm.12971","article-title":"Icariside II, a novel phosphodiesterase 5 inhibitor, protects against H2O2-induced PC12 cells death by inhibiting mitochondria-mediated autophagy","volume":"21","author":"Gao","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejphar.2017.11.035_bib13","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1054\/jcaf.2002.129280","article-title":"Cardiac myocyte remodeling in hypertrophy and progression to failure","volume":"8","author":"Gerdes","year":"2002","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ejphar.2017.11.035_bib14","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1172\/JCI200524408","article-title":"Oxygen, oxidative stress, hypoxia, and heart failure","volume":"115","author":"Giordano","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2017.11.035_bib15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.cellsig.2005.05.023","article-title":"p38 MAPK regulates phosphorylation of bad via PP2A-dependent suppression of the MEK1\/2-ERK1\/2 survival pathway in TNF-alpha induced endothelial apoptosis","volume":"18","author":"Grethe","year":"2006","journal-title":"Cell Signal."},{"key":"10.1016\/j.ejphar.2017.11.035_bib16","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1161\/CIRCULATIONAHA.109.890962","article-title":"Smooth muscle-specific deletion of nitric oxide-sensitive guanylyl cyclase is sufficient to induce hypertension in mice","volume":"121","author":"Groneberg","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2017.11.035_bib17","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/fsn3.92","article-title":"Protective effect of resveratrol against pressure overload-induced heart failure","volume":"2","author":"Gupta","year":"2014","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.ejphar.2017.11.035_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/cvr\/cvn335","article-title":"Oxidative stress and left ventricular remodelling after myocardial infarction","volume":"81","author":"Hori","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2017.11.035_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/377239a0","article-title":"Hypertension in mice lacking the gene for endothelial nitric oxide synthase","volume":"377","author":"Huang","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2017.11.035_bib20","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/01.RES.0000100665.67510.F5","article-title":"Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling","volume":"93","author":"Izumiya","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2017.11.035_bib21","doi-asserted-by":"crossref","first-page":"15524","DOI":"10.1074\/jbc.M313717200","article-title":"Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo","volume":"279","author":"Kaiser","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2017.11.035_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1009884820941","article-title":"Incidence and epidemiology of heart failure","volume":"5","author":"Kannel","year":"2000","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ejphar.2017.11.035_bib23","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.7150\/ijbs.11595","article-title":"Targeting apoptosis and multiple signaling pathways with Icariside II in cancer cells","volume":"11","author":"Khan","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejphar.2017.11.035_bib24","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cell.2009.08.021","article-title":"Caspases and kinases in a death grip","volume":"138","author":"Kurokawa","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2017.11.035_bib25","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/ncb1123","article-title":"Mitochondrial p53 activates Bak and causes disruption of a Bak 2 Mcl1 complex","volume":"6","author":"Leu","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejphar.2017.11.035_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/cvr\/cvq043","article-title":"Oxidative stress contributes to methamphetamine-induced left ventricular dysfunction","volume":"87","author":"Lord","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2017.11.035_bib27","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1524-6175.2005.04806.x","article-title":"Expanding the definition and classification of hypertension","volume":"7","author":"Materson","year":"2005","journal-title":"J. Clin. Hypertens."},{"key":"10.1016\/j.ejphar.2017.11.035_bib28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/15376516.2012.666650","article-title":"Oxidative stress and cardiac hypertrophy: a review","volume":"22","author":"Maulik","year":"2012","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.ejphar.2017.11.035_bib29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cardiores.2006.03.016","article-title":"NADPH oxidasedependent redox signalling in cardiac hypertrophy, remodelling and failure","volume":"71","author":"Murdoch","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2017.11.035_bib30","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.yjmcc.2005.01.012","article-title":"Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction","volume":"38","author":"Ren","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2017.11.035_bib31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/jmcc.2002.1526","article-title":"Role of oxidative stress in myocardial hypertrophy and failure","volume":"34","author":"Sawyer","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2017.11.035_bib32","doi-asserted-by":"crossref","first-page":"7861","DOI":"10.3390\/molecules15117861","article-title":"Herba Epimedii: anti-oxidative properties and its medical implications","volume":"15","author":"Sze","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2017.11.035_bib33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.5604\/01.3001.0009.2116","article-title":"The participation of p53 and bcl-2 proteins in gastric carcinomas associated with helicobacterpylori and\/or Epstein-Barr virus (EBV)","volume":"64","author":"Szkaradkiewicz","year":"2015","journal-title":"Pol. J. Microbiol."},{"key":"10.1016\/j.ejphar.2017.11.035_bib34","first-page":"5147","article-title":"Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats","volume":"9","author":"Tian","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejphar.2017.11.035_bib35","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/jcmm.12480","article-title":"Antioxidant icariside II combined with insulin restores erectile function in streptozotocin-induced type 1 diabetic rats","author":"Wang","year":"2015","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2017.11.035_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0735-1097(00)00705-1","article-title":"Sildenafil citrate potentiates the hypotensive effects of nitric oxide donor drugs in male patients with stable angina","volume":"36","author":"Webb","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2017.11.035_bib37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuroscience.2016.04.022","article-title":"Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats","volume":"328","author":"Yin","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2017.11.035_bib38","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/jcmm.12273","article-title":"Aliskiren-attenuated myocardium apoptosis via regulation of autophagy and connexin-43 in aged spontaneously hypertensive rats","volume":"18","author":"Zhang","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejphar.2017.11.035_bib39","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.3892\/etm.2014.1598","article-title":"Icariin attenuates angiotensin II-induced hypertrophy and apoptosis in H9c2 cardiomyocytes by inhibiting reactive oxygen species-dependent JNK and p38 pathways","volume":"7","author":"Zhou","year":"2014","journal-title":"Exp. Ther. Med."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917307689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917307689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T18:31:44Z","timestamp":1535221904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299917307689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":39,"alternative-id":["S0014299917307689"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.11.035","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IcarisideII improves left ventricular remodeling in spontaneously hypertensive rats by inhibiting the ASK1-JNK\/p38 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.11.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}