{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:37:54Z","timestamp":1764603474734,"version":"3.41.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Science Centre, Krak\u00f3w, Poland","award":["2013\/09\/B\/NZ7\/04010"],"award-info":[{"award-number":["2013\/09\/B\/NZ7\/04010"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ejphar.2017.11.037","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T18:31:06Z","timestamp":1511807466000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Interactions of aliskiren, a direct renin inhibitor, with antiepileptic drugs in the test of maximal electroshock in mice"],"prefix":"10.1016","volume":"819","author":[{"given":"Krzysztof","family":"\u0141ukawski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Raszewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanis\u0142aw J.","family":"Czuczwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2017.11.037_bib1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0306-4522(00)00209-8","article-title":"The lesional and epileptogenic consequences of lithium-pilocarpine-induced status epilepticus are affected by previous exposure to isolated seizures: effects of amygdala kindling and maximal electroshocks","volume":"99","author":"Andr\u00e9","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2017.11.037_bib2","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/ana.24147","article-title":"Losartan prevents acquired epilepsy via TGF-\u03b2 signaling suppression","volume":"75","author":"Bar-Klein","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejphar.2005.01.040","article-title":"Influence of aminoglutethimide and spironolactone on the efficacy of carbamazepine and diphenylhydantoin against amygdala-kindled seizures in rats","volume":"516","author":"Borowicz","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib4","first-page":"623","article-title":"Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor","volume":"60","author":"Buczko","year":"2008","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejphar.2017.11.037_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2165\/00023210-200115050-00001","article-title":"The new generation of GABA enhancers","volume":"15","author":"Czuczwar","year":"2001","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejphar.2017.11.037_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0920-1211(97)00033-8","article-title":"Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1","volume":"28","author":"Dalby","year":"1997","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2017.11.037_bib7","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0306-3623(95)02147-7","article-title":"1,4-Benzodiazepine derivatives as anticonvulsant agents in DBA\/2 mice","volume":"27","author":"De Sarro","year":"1996","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/HYPERTENSIONAHA.111.173534","article-title":"Attenuation of brain damage and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion","volume":"58","author":"Dong","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2017.11.037_bib9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neuroscience.2003.08.015","article-title":"Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats","volume":"123","author":"Ealls","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2017.11.037_bib10","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1007\/s00424-014-1596-x","article-title":"Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS","volume":"467","author":"Gao","year":"2015","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.ejphar.2017.11.037_bib11","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0306-4522(91)90073-W","article-title":"Autoradiographic localization of subtypes of angiotensin II antagonist binding in the rat brain","volume":"44","author":"Gehlert","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2017.11.037_bib12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.taap.2013.12.019","article-title":"Aliskiren toxicity in juvenile rats is determined by ontogenic regulation of intestinal P-glycoprotein expression","volume":"275","author":"Hoffmann","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00019052-199804000-00008","article-title":"Mechanisms and experimental models of seizure generation","volume":"11","author":"Jefferys","year":"1998","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2116\/analsci.1.385","article-title":"Direct method for determination of valproic acid in serum by high performance liquid chromatography","volume":"1","author":"Kondo","year":"1985","journal-title":"Anal. Sci."},{"key":"10.1016\/j.ejphar.2017.11.037_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","article-title":"A simplified method of evaluating dose-effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2017.11.037_bib16","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.seizure.2011.01.003","article-title":"Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs","volume":"20","author":"L\u00f6scher","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.ejphar.2017.11.037_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0920-1211(91)90075-Q","article-title":"The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II.\u00a0Maximal electroshock seizure models","volume":"8","author":"L\u00f6scher","year":"1991","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2017.11.037_bib18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pneurobio.2005.04.006","article-title":"Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases","volume":"76","author":"L\u00f6scher","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.euroneuro.2005.03.005","article-title":"Levetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the rotarod test in mice","volume":"15","author":"Luszczki","year":"2005","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1046\/j.1528-1157.2003.32702.x","article-title":"Interactions between oxcarbazepine and conventional antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis","volume":"44","author":"Luszczki","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2017.11.037_bib21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejphar.2010.04.053","article-title":"Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock","volume":"640","author":"\u0141ukawski","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib22","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00702-010-0455-y","article-title":"Captopril potentiates the anticonvulsant activity of carbamazepine and lamotrigine in the mouse maximal electroshock seizure model","volume":"117","author":"\u0141ukawski","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2017.11.037_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/FBP.0b013e3283512c85","article-title":"The role of \u03b11 and \u03b15 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats","volume":"23","author":"Mili\u0107","year":"2012","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1472-8206.1987.tb00547.x","article-title":"Effect of peptidyl-dipeptidase inhibitors in experimental convulsions in mice","volume":"1","author":"Minano","year":"1987","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuro.2009.10.002","article-title":"Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman","volume":"31","author":"Myhrer","year":"2010","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ejphar.2017.11.037_bib26","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.neures.2007.12.002","article-title":"Cardiovascular responses and neurotransmitter changes during blockade of angiotensin II receptors within the ventrolateral medulla","volume":"60","author":"Patel","year":"2008","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejphar.2017.11.037_bib27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejphar.2013.03.036","article-title":"Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models","volume":"708","author":"Patel","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1528-1157.2002.13001.x","article-title":"The importance of drug interactions in epilepsy therapy","volume":"43","author":"Patsalos","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2017.11.037_bib29","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1474-4422(03)00409-5","article-title":"Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs","volume":"2","author":"Patsalos","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1042\/CS20100053","article-title":"Inhibition of the renin-angiotensin system prevents seizures in a rat model of epilepsy","volume":"119","author":"Pereira","year":"2010","journal-title":"Clin. Sci."},{"key":"10.1016\/j.ejphar.2017.11.037_bib31","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1523\/JNEUROSCI.07-06-01866.1987","article-title":"Resolving GABAA\/benzodiazepine receptors: cellular and subcellular localization in the CNS with monoclonal antibodies","volume":"7","author":"Richards","year":"1987","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.037_bib32","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.lfs.2004.10.012","article-title":"Angiotensin peptides modulatory system: how is it implicated in the control of seizure susceptibility?","volume":"76","author":"Tchekalarova","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2017.11.037_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pbb.2014.10.005","article-title":"Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy","volume":"127","author":"Tchekalarova","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2017.11.037_bib34","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1113\/expphysiol.2005.029959","article-title":"H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine","volume":"92","author":"Thwaites","year":"2007","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0378-5173(01)00916-4","article-title":"Carbapenem antibiotics inhibit valproic acid transport in Caco-2 cell monolayers","volume":"233","author":"Torii","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejphar.2017.11.037_bib36","doi-asserted-by":"crossref","first-page":"474870","DOI":"10.1155\/2012\/474870","article-title":"Renin-Angiotensin system and sympathetic neurotransmitter release in the central nervous system of hypertension","volume":"2012","author":"Tsuda","year":"2012","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.ejphar.2017.11.037_bib37","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1177\/0091270008323258","article-title":"Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren","volume":"48","author":"Vaidyanathan","year":"2008","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib38","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2165\/00003088-200847080-00002","article-title":"Clinical pharmacokinetics and pharmacodynamics of aliskiren","volume":"47","author":"Vaidyanathan","year":"2008","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejphar.2017.11.037_bib39","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/321864a0","article-title":"Benzodiazepine impairs and \u03b2-carboline enhances performance in learning and memory tasks","volume":"321","author":"Venault","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2017.11.037_bib40","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.0306-5251.2001.01474.x","article-title":"In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9)","volume":"52","author":"Wen","year":"2001","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.11.037_bib41","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0006-291X(03)01451-7","article-title":"Structure-based design of aliskiren, a novel orally effective renin inhibitor","volume":"308","author":"Wood","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917307707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917307707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T15:33:31Z","timestamp":1751038411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299917307707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":41,"alternative-id":["S0014299917307707"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.11.037","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interactions of aliskiren, a direct renin inhibitor, with antiepileptic drugs in the test of maximal electroshock in mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.11.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}