{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:35:19Z","timestamp":1790789719892,"version":"4.1.0"},"reference-count":212,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31471208"],"award-info":[{"award-number":["31471208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671195"],"award-info":[{"award-number":["31671195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603013"],"award-info":[{"award-number":["81603013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"crossref","award":["2014CFA021"],"award-info":[{"award-number":["2014CFA021"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"crossref","award":["2015CFB639"],"award-info":[{"award-number":["2015CFB639"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003172","name":"HUST","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003172","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tongji Medical College"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ejphar.2017.11.051","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T06:06:37Z","timestamp":1512540397000},"page":"169-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"special_numbering":"C","title":["Caenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseases"],"prefix":"10.1016","volume":"819","author":[{"given":"Liang","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anlin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2017.11.051_bib1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.phymed.2010.03.008","article-title":"Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2\/insulin-like signaling pathway","volume":"17","author":"Abbas","year":"2010","journal-title":"Phytomed.: Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.ejphar.2017.11.051_bib2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuron.2009.12.016","article-title":"The transcellular spread of cytosolic amyloids, prions, and prionoids","volume":"64","author":"Aguzzi","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2017.11.051_bib3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature09873","article-title":"Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan","volume":"472","author":"Alavez","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2017.11.051_bib4","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.2174\/138161211795703753","article-title":"Caenorhabditis elegans-based model systems for antifungal drug discovery","volume":"17","author":"Anastassopoulou","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2017.11.051_bib5","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1093\/hmg\/ddq230","article-title":"Neurotoxic effects of TDP-43 overexpression in C. elegans","volume":"19","author":"Ash","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib6","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1093\/hmg\/ddq230","article-title":"Neurotoxic effects of TDP-43 overexpression in C. elegans","volume":"19","author":"Ash","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib7","first-page":"879","article-title":"Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies","volume":"152","author":"Baba","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib8","doi-asserted-by":"crossref","first-page":"e42441","DOI":"10.1371\/journal.pone.0042441","article-title":"An in vivo C. elegans model system for screening EGFR-inhibiting anti-cancer drugs","volume":"7","author":"Bae","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2148-4-6","article-title":"Evolutionary and functional relationships within the DJ1 superfamily","volume":"4","author":"Bandyopadhyay","year":"2004","journal-title":"BMC Evolut. Biol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.conb.2009.10.010","article-title":"Microfluidics for the analysis of behavior, nerve regeneration, and neural cell biology in C. elegans","volume":"19","author":"Ben-Yakar","year":"2009","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib11","doi-asserted-by":"crossref","DOI":"10.3791\/833","article-title":"Generation of stable transgenic C. elegans using microinjection","author":"Berkowitz","year":"2008","journal-title":"J. Vis. Exp.: JoVE"},{"key":"10.1016\/j.ejphar.2017.11.051_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1756-6606-3-35","article-title":"Nigrostriatal neuronal death following chronic dichlorvos exposure: crosstalk between mitochondrial impairments, alpha synuclein aggregation, oxidative damage and behavioral changes","volume":"3","author":"Binukumar","year":"2010","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ejphar.2017.11.051_bib13","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1523\/JNEUROSCI.5831-09.2010","article-title":"Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans","volume":"30","author":"Bizat","year":"2010","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib14","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2174\/1871527311211080005","article-title":"Effects of alpha-synuclein overexpression in transgenic Caenorhabditis elegans strains","volume":"11","author":"Bodhicharla","year":"2012","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.ejphar.2017.11.051_bib15","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1093\/hmg\/ddu373","article-title":"Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model","volume":"23","author":"Bonanomi","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.nbd.2017.04.010","article-title":"Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases","volume":"105","author":"Brady","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2017.11.051_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neurobiolaging.2007.05.011","article-title":"A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau","volume":"30","author":"Brandt","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2017.11.051_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.ejphar.2017.11.051_bib19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1534\/genetics.109.104976","article-title":"In the beginning was the worm","volume":"182","author":"Brenner","year":"2009","journal-title":"Genetics"},{"key":"10.1016\/j.ejphar.2017.11.051_bib20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrn3887","article-title":"Spreading of pathology in neurodegenerative diseases: a focus on human studies","volume":"16","author":"Brettschneider","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib21","doi-asserted-by":"crossref","first-page":"7597","DOI":"10.1523\/JNEUROSCI.0990-06.2006","article-title":"Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model","volume":"26","author":"Brignull","year":"2006","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib22","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.pbb.2006.10.017","article-title":"Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans","volume":"85","author":"Brown","year":"2006","journal-title":"Pharmacol., Biochem., Behav."},{"key":"10.1016\/j.ejphar.2017.11.051_bib23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrm2873","article-title":"Prion-like transmission of protein aggregates in neurodegenerative diseases","volume":"11","author":"Brundin","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib24","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.4161\/15384101.2014.973309","article-title":"Spermidine protects against alpha-synuclein neurotoxicity","volume":"13","author":"Buttner","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ejphar.2017.11.051_bib25","doi-asserted-by":"crossref","first-page":"e28835","DOI":"10.1371\/journal.pone.0028835","article-title":"Icariin and its derivative icariside II extend healthspan via insulin\/IGF-1 pathway in C. elegans","volume":"6","author":"Cai","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s11030-013-9452-z","article-title":"Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer's disease","volume":"17","author":"Cao","year":"2013","journal-title":"Mol. Divers"},{"key":"10.1016\/j.ejphar.2017.11.051_bib27","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.2174\/1568026617666170131114401","article-title":"C. elegans as model for drug discovery","volume":"17","author":"Carretero","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejphar.2017.11.051_bib28","doi-asserted-by":"crossref","first-page":"23103","DOI":"10.3390\/ijms141123103","article-title":"Oxidative stress mechanisms underlying Parkinson's disease-associated neurodegeneration in C. elegans","volume":"14","author":"Chakraborty","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/1028415X.2017.1299437","article-title":"Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: a model for anti-Parkinson testing","author":"Chalorak","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neulet.2015.10.009","article-title":"Lycopene attenuates Abeta1-42 secretion and its toxicity in human cell and Caenorhabditis elegans models of Alzheimer disease","volume":"608","author":"Chen","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2017.11.051_bib31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13065-015-0143-y","article-title":"Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases","volume":"9","author":"Chen","year":"2015","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.ejphar.2017.11.051_bib32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13024-015-0046-3","article-title":"Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16\/FOXO target gene expression","volume":"10","author":"Chen","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejphar.2017.11.051_bib33","doi-asserted-by":"crossref","first-page":"4860","DOI":"10.1016\/j.bbagen.2013.06.029","article-title":"Inhibiting toxic aggregation of amyloidogenic proteins: a therapeutic strategy for protein misfolding diseases","volume":"1830","author":"Cheng","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2017.11.051_bib34","doi-asserted-by":"crossref","first-page":"13147","DOI":"10.1021\/jf201702h","article-title":"Coffee components inhibit amyloid formation of human islet amyloid polypeptide in vitro: possible link between coffee consumption and diabetes mellitus","volume":"59","author":"Cheng","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2017.11.051_bib35","first-page":"9","article-title":"Trends in high-throughput and functional neuroimaging in Caenorhabditis elegans","author":"Cho","year":"2017","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"10.1016\/j.ejphar.2017.11.051_bib36","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1126\/science.1124646","article-title":"Opposing activities protect against age-onset proteotoxicity","volume":"313","author":"Cohen","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2017.11.051_bib37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/9780470559277.ch130160","article-title":"High-throughput screening for novel anti-infectives using a C. elegans pathogenesis model","volume":"6","author":"Conery","year":"2014","journal-title":"Curr. Protoc. Chem. Biol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib38","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1126\/science.282.5396.2012","article-title":"Genome sequence of the nematode C. elegans: a platform for investigating biology","volume":"282","author":"Consortium","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2017.11.051_bib39","doi-asserted-by":"crossref","DOI":"10.1039\/C7LC00509A","article-title":"Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans","author":"Cornaglia","year":"2017","journal-title":"Lab Chip"},{"key":"10.1016\/j.ejphar.2017.11.051_bib40","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/hmg\/9.6.869","article-title":"A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes","volume":"9","author":"Culetto","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ncl.2014.09.003","article-title":"Huntington disease: pathogenesis and treatment","volume":"33","author":"Dayalu","year":"2015","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.ejphar.2017.11.051_bib42","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/mds.23546","article-title":"New animal models of Parkinson's disease","volume":"26","author":"Dehay","year":"2011","journal-title":"Mov. Disord.: Off. J. Mov. Disord. Soc."},{"key":"10.1016\/j.ejphar.2017.11.051_bib43","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2017.11.051_bib44","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.nbd.2010.07.002","article-title":"Tetracycline and its analogues protect Caenorhabditis elegans from beta amyloid-induced toxicity by targeting oligomers","volume":"40","author":"Diomede","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2017.11.051_bib45","doi-asserted-by":"crossref","first-page":"e58893","DOI":"10.1371\/journal.pone.0058893","article-title":"Oleuropein aglycone protects transgenic C. elegans strains expressing Abeta42 by reducing plaque load and motor deficit","volume":"8","author":"Diomede","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib46","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990\u20132015: a systematic analysis for the Global burden of disease study 2015","volume":"388","author":"Disease","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2017.11.051_bib47","doi-asserted-by":"crossref","DOI":"10.3791\/2252","article-title":"Assaying beta-amyloid toxicity using a transgenic C. elegans model","author":"Dostal","year":"2010","journal-title":"J. Vis. Exp.: JoVE"},{"key":"10.1016\/j.ejphar.2017.11.051_bib48","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1534\/genetics.110.120436","article-title":"Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of beta-amyloid peptide toxicity","volume":"186","author":"Dostal","year":"2010","journal-title":"Genetics"},{"key":"10.1016\/j.ejphar.2017.11.051_bib49","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0197-4580(02)00225-7","article-title":"Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model","volume":"24","author":"Drake","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2017.11.051_bib50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/jmbi.2001.4743","article-title":"Non-fibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils","volume":"310","author":"El-Agnaf","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/acel.12171","article-title":"A novel inhibitor of the insulin\/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity","volume":"13","author":"El-Ami","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.ejphar.2017.11.051_bib52","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1073\/pnas.96.1.179","article-title":"Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron","volume":"96","author":"Faber","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib53","doi-asserted-by":"crossref","first-page":"17131","DOI":"10.1073\/pnas.262544899","article-title":"Glutamine\/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity","volume":"99","author":"Faber","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib54","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1046\/j.1471-4159.1998.71041616.x","article-title":"In vivo aggregation of beta-amyloid peptide variants","volume":"71","author":"Fay","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2017.11.051_bib55","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-1-62703-110-3_8","article-title":"Improved vectors for selection of transgenic Caenorhabditis elegans","volume":"940","author":"Ferguson","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib56","doi-asserted-by":"crossref","first-page":"569","DOI":"10.4161\/auto.4776","article-title":"Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans","volume":"3","author":"Florez-McClure","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.ejphar.2017.11.051_bib57","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nrneurol.2013.223","article-title":"Alzheimer disease therapy--moving from amyloid-beta to tau","volume":"9","author":"Giacobini","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib58","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1476-5381.2010.00725.x","article-title":"High-throughput screening and small animal models, where are we?","volume":"160","author":"Giacomotto","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib59","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1471-4159.2003.02134.x","article-title":"Oligomerization and neurotoxicity of the amyloid ADan peptide implicated in familial Danish dementia","volume":"88","author":"Gibson","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2017.11.051_bib60","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.1124514","article-title":"Progressive disruption of cellular protein folding in models of polyglutamine diseases","volume":"311","author":"Gidalevitz","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2017.11.051_bib61","doi-asserted-by":"crossref","first-page":"e1000399","DOI":"10.1371\/journal.pgen.1000399","article-title":"Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity","volume":"5","author":"Gidalevitz","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib62","doi-asserted-by":"crossref","first-page":"D472","DOI":"10.1093\/nar\/gkl894","article-title":"WormBook: the online review of Caenorhabditis elegans biology","volume":"35","author":"Girard","year":"2007","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.ejphar.2017.11.051_bib63","first-page":"357","article-title":"The amyloid deposits in Alzheimer's disease: their nature and pathogenesis","volume":"2","author":"Glenner","year":"1984","journal-title":"Appl. Pathol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib64","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/40767","article-title":"Familial Parkinson's disease. The awakening of alpha-synuclein","volume":"388","author":"Goedert","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2017.11.051_bib65","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/acel.12327","article-title":"Rifampicin reduces advanced glycation end products and activates DAF-16 to increase lifespan in Caenorhabditis elegans","volume":"14","author":"Golegaonkar","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.ejphar.2017.11.051_bib66","doi-asserted-by":"crossref","first-page":"e15460","DOI":"10.1371\/journal.pone.0015460","article-title":"Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin alpha1-antitrypsin Z","volume":"5","author":"Gosai","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib67","doi-asserted-by":"crossref","first-page":"13556","DOI":"10.1038\/srep13556","article-title":"Inhibitory effects of magnolol and honokiol on human calcitonin aggregation","volume":"5","author":"Guo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2017.11.051_bib68","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1471-2202-6-54","article-title":"Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans","volume":"6","author":"Gutierrez-Zepeda","year":"2005","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib69","doi-asserted-by":"crossref","first-page":"e1501244","DOI":"10.1126\/sciadv.1501244","article-title":"An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Abeta42 aggregates linked with Alzheimer's disease","volume":"2","author":"Habchi","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejphar.2017.11.051_bib70","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/dvdy.22231","article-title":"C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease","volume":"239","author":"Harrington","year":"2010","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ejphar.2017.11.051_bib71","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-017-2339-0","article-title":"The protection of novel 2-arylethenylquinoline derivatives against impairment of associative learning memory induced by neural Abeta in C. elegans Alzheimer's disease model","author":"He","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2017.11.051_bib72","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ntt.2008.11.005","article-title":"Utility of Caenorhabditis elegans in high throughput neurotoxicological research","volume":"32","author":"Helmcke","year":"2010","journal-title":"Neurotoxicol. Teratol."},{"issue":"448\u2013450","key":"10.1016\/j.ejphar.2017.11.051_bib73","first-page":"526","article-title":"The same prion strain causes vCJD and BSE","volume":"389","author":"Hill","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2017.11.051_bib74","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nrneurol.2016.111","article-title":"Supportive and symptomatic management of amyotrophic lateral sclerosis","volume":"12","author":"Hobson","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib75","doi-asserted-by":"crossref","DOI":"10.3791\/2090","article-title":"Generation of transgenic C. elegans by biolistic transformation","author":"Hochbaum","year":"2010","journal-title":"J. Vis. Exp.: JoVE"},{"key":"10.1016\/j.ejphar.2017.11.051_bib76","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1126\/science.270.5235.410","article-title":"The nematode Caenorhabditis elegans and its genome","volume":"270","author":"Hodgkin","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2017.11.051_bib77","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1242\/jcs.136150","article-title":"Metabolism and mis-metabolism of the neuropathological signature protein TDP-43","volume":"127","author":"Huang","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib78","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2017.11.051_bib79","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1039\/b707861g","article-title":"A microfabricated array of clamps for immobilizing and imaging C. elegans","volume":"7","author":"Hulme","year":"2007","journal-title":"Lab Chip"},{"key":"10.1016\/j.ejphar.2017.11.051_bib80","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jat.3357","article-title":"The C. elegans model in toxicity testing","volume":"37","author":"Hunt","year":"2017","journal-title":"J. Appl. Toxicol.: JAT"},{"key":"10.1016\/j.ejphar.2017.11.051_bib81","article-title":"A systematic RNAi screen of neuroprotective genes identifies novel modulators of alpha-synuclein-associated effects in transgenic Caenorhabditis elegans","author":"Jadiya","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib82","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11064-011-0580-5","article-title":"Effect of phenolic compounds against Abeta aggregation and Abeta-induced toxicity in transgenic C. elegans","volume":"37","author":"Jagota","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2017.11.051_bib83","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","article-title":"Parkinson's disease: clinical features and diagnosis","volume":"79","author":"Jankovic","year":"2008","journal-title":"J. Neurol., Neurosurg., Psychiatry"},{"key":"10.1016\/j.ejphar.2017.11.051_bib84","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1039\/C5FO00664C","article-title":"Inhibition effects of tanshinone on the aggregation of alpha-synuclein","volume":"7","author":"Ji","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.ejphar.2017.11.051_bib85","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00335-011-9339-1","article-title":"SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments","volume":"22","author":"Joyce","year":"2011","journal-title":"Mamm. Genome: Off. J. Int. Mamm. Genome. Soc."},{"key":"10.1016\/j.ejphar.2017.11.051_bib86","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd2031","article-title":"Finding function in novel targets: C. elegans as a model organism","volume":"5","author":"Kaletta","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2017.11.051_bib87","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1038\/emboj.2009.257","article-title":"Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models","volume":"28","author":"Karpinar","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2017.11.051_bib88","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/mds.25499","article-title":"The many faces of alpha-synuclein mutations","volume":"28","author":"Kasten","year":"2013","journal-title":"Mov. Disord.: Off. J. Mov. Disord. Soc."},{"key":"10.1016\/j.ejphar.2017.11.051_bib89","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/dvdy.24426","article-title":"Efficient generation of transgenic reporter strains and analysis of expression patterns in Caenorhabditis elegans using library MosSCI","volume":"245","author":"Kaymak","year":"2016","journal-title":"Dev. Dyn.: Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.ejphar.2017.11.051_bib90","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1750-1326-5-59","article-title":"Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans","volume":"5","author":"Keowkase","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejphar.2017.11.051_bib91","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuropharm.2010.04.008","article-title":"Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans","volume":"59","author":"Keowkase","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2017.11.051_bib92","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1055\/s-0041-111621","article-title":"Cratoxylum formosum extract protects against amyloid-beta toxicity in a Caenorhabditis elegans model of Alzheimer's disease","volume":"82","author":"Keowkase","year":"2016","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2017.11.051_bib93","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1038\/emm.2016.109","article-title":"Mechanisms of aging-related proteinopathies in Caenorhabditis elegans","volume":"48","author":"Kim","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ejphar.2017.11.051_bib94","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/17460441.2017.1319358","article-title":"An update on the use of C. elegans for preclinical drug discovery: screening and identifying anti-infective drugs","volume":"12","author":"Kim","year":"2017","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.ejphar.2017.11.051_bib95","doi-asserted-by":"crossref","unstructured":"Kimble, J., Crittenden, S.L., 2005. Germline proliferation and its control. In: WormBook: The Online Review of C elegans Biology, pp. 1\u201314.","DOI":"10.1895\/wormbook.1.13.1"},{"key":"10.1016\/j.ejphar.2017.11.051_bib96","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2017.11.051_bib97","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0092-8674(00)81781-X","article-title":"Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice","volume":"95","author":"Klement","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2017.11.051_bib98","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4062\/biomolther.2014.084","article-title":"Caenorhabditis elegans: a model system for anti-cancer drug discovery and therapeutic target identification","volume":"22","author":"Kobet","year":"2014","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.ejphar.2017.11.051_bib99","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.83.11.4044","article-title":"Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease","volume":"83","author":"Kosik","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib100","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/hmg\/ddl067","article-title":"Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans","volume":"15","author":"Kraemer","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib101","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.1073\/pnas.1533448100","article-title":"Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy","volume":"100","author":"Kraemer","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib102","first-page":"6","article-title":"Genetic defects in beta-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling","author":"Krieg","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.ejphar.2017.11.051_bib103","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0298-106","article-title":"Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease","volume":"18","author":"Kruger","year":"1998","journal-title":"Nat. Genet"},{"key":"10.1016\/j.ejphar.2017.11.051_bib104","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s12640-013-9440-1","article-title":"1MeTIQ provides protection against Abeta-induced reduction of surface expression of synaptic proteins and inhibits H(2)O(2)-induced oxidative stress in primary hippocampal neurons","volume":"25","author":"Kuszczyk","year":"2014","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ejphar.2017.11.051_bib105","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1074\/jbc.M504860200","article-title":"Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans","volume":"281","author":"Kuwahara","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2017.11.051_bib106","doi-asserted-by":"crossref","first-page":"e1000067","DOI":"10.1371\/journal.pgen.1000067","article-title":"A genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels","volume":"4","author":"Kwok","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib107","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature04657","article-title":"A small-molecule screen in C. elegans yields a new calcium channel antagonist","volume":"441","author":"Kwok","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2017.11.051_bib108","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1471-4159.2003.01809.x","article-title":"Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein","volume":"86","author":"Lakso","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2017.11.051_bib109","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1039\/C4LC00789A","article-title":"A multi-channel device for high-density target-selective stimulation and long-term monitoring of cells and subcellular features in C. elegans","volume":"14","author":"Lee","year":"2014","journal-title":"Lab Chip"},{"key":"10.1016\/j.ejphar.2017.11.051_bib110","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1093\/hmg\/dds155","article-title":"Human DJ-1 and its homologs are novel glyoxalases","volume":"21","author":"Lee","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib111","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/nprot.2006.245","article-title":"RNAi screens in Caenorhabditis elegans in a 96-well liquid format and their application to the systematic identification of genetic interactions","volume":"1","author":"Lehner","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejphar.2017.11.051_bib112","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-genet-120213-092244","article-title":"Neural regulatory pathways of feeding and fat in Caenorhabditis elegans","volume":"49","author":"Lemieux","year":"2015","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib113","doi-asserted-by":"crossref","first-page":"e62166","DOI":"10.1371\/journal.pone.0062166","article-title":"An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans","volume":"8","author":"Leung","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib114","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/aps.2012.190","article-title":"Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis","volume":"34","author":"Li","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2017.11.051_bib115","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1073\/pnas.93.10.4839","article-title":"Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase","volume":"93","author":"Li","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib116","doi-asserted-by":"crossref","first-page":"16208","DOI":"10.1523\/JNEUROSCI.2911-10.2010","article-title":"Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy","volume":"30","author":"Liachko","year":"2010","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib117","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00401-016-1600-y","article-title":"The phosphatase calcineurin regulates pathological TDP-43 phosphorylation","volume":"132","author":"Liachko","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib118","doi-asserted-by":"crossref","first-page":"86640","DOI":"10.1039\/C6RA17770K","article-title":"Isoliquiritigenin and liquiritin from Glycyrrhiza uralensis inhibit alpha-synuclein amyloid formation","volume":"6","author":"Liao","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejphar.2017.11.051_bib119","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jalz.2013.12.013","article-title":"International Alzheimer's Disease Research Portfolio (IADRP) aims to capture global Alzheimer's disease research funding","volume":"10","author":"Liggins","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.ejphar.2017.11.051_bib120","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1073\/pnas.92.20.9368","article-title":"Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans","volume":"92","author":"Link","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib121","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.exger.2006.06.059","article-title":"C-elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease","volume":"41","author":"Link","year":"2006","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib122","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.exger.2006.06.059","article-title":"C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease","volume":"41","author":"Link","year":"2006","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib123","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0197-4580(00)00237-2","article-title":"Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34","volume":"22","author":"Link","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2017.11.051_bib124","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0197-4580(02)00224-5","article-title":"Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model","volume":"24","author":"Link","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2017.11.051_bib125","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1093\/hmg\/ddr312","article-title":"Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models","volume":"20","author":"Liu","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","author":"Livingston","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2017.11.051_bib127","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neulet.2008.05.003","article-title":"Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease","volume":"439","author":"Locke","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2017.11.051_bib128","doi-asserted-by":"crossref","first-page":"e27762","DOI":"10.1371\/journal.pone.0027762","article-title":"FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity","volume":"6","author":"Lublin","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib129","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1016\/j.ddtec.2012.02.002","article-title":"Alzheimer's disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for beta-amyloid peptide-induced toxicity","volume":"10","author":"Lublin","year":"2013","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib130","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nrd3368","article-title":"Impact of high-throughput screening in biomedical research","volume":"10","author":"Macarron","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2017.11.051_bib131","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/jmg.30.12.982","article-title":"Gametic but not somatic instability of CAG repeat length in Huntington's disease","volume":"30","author":"MacDonald","year":"1993","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib132","first-page":"e50773","article-title":"A rapid protocol for integrating extrachromosomal arrays with high transmission rate into the C. elegans genome","author":"Mariol","year":"2013","journal-title":"J. Vis. Exp.: JoVE"},{"key":"10.1016\/j.ejphar.2017.11.051_bib133","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/biot.201000183","article-title":"Modeling human diseases in Caenorhabditis elegans","volume":"5","author":"Markaki","year":"2010","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.ejphar.2017.11.051_bib134","doi-asserted-by":"crossref","first-page":"e63283","DOI":"10.1371\/journal.pone.0063283","article-title":"A cocoa peptide protects Caenorhabditis elegans from oxidative stress and beta-amyloid peptide toxicity","volume":"8","author":"Martorell","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib135","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1385\/JMN\/31:02:127","article-title":"Identification of neuroprotective compounds of caenorhabditis elegans dopaminergic neurons against 6-OHDA","volume":"31","author":"Marvanova","year":"2007","journal-title":"J. Mol. Neurosci.: MN"},{"key":"10.1016\/j.ejphar.2017.11.051_bib136","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib137","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1073\/pnas.1402228111","article-title":"Clioquinol promotes the degradation of metal-dependent amyloid-beta (Abeta) oligomers to restore endocytosis and ameliorate Abeta toxicity","volume":"111","author":"Matlack","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib138","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1750-1326-7-57","article-title":"Utility of an improved model of amyloid-beta (Abeta(1)(-)(4)(2)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease","volume":"7","author":"McColl","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejphar.2017.11.051_bib139","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mito.2015.02.005","article-title":"Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans","volume":"22","author":"McCormack","year":"2015","journal-title":"Mitochondrion"},{"key":"10.1016\/j.ejphar.2017.11.051_bib140","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.biopsych.2012.08.027","article-title":"Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity","volume":"73","author":"McCormick","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2017.11.051_bib141","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.nbd.2005.03.017","article-title":"Progressive neurodegeneration in C. elegans model of tauopathy","volume":"20","author":"Miyasaka","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2017.11.051_bib142","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neurobiolaging.2015.11.004","article-title":"Curcumin improves tau-induced neuronal dysfunction of nematodes","volume":"39","author":"Miyasaka","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2017.11.051_bib143","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/wrna.110","article-title":"RNAi screening: new approaches, understandings, and organisms","volume":"3","author":"Mohr","year":"2012","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib144","doi-asserted-by":"crossref","first-page":"13023","DOI":"10.1038\/ncomms13023","article-title":"Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model","volume":"7","author":"Mondal","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2017.11.051_bib145","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","article-title":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Mortality","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2017.11.051_bib146","doi-asserted-by":"crossref","first-page":"10414","DOI":"10.1073\/pnas.0604055103","article-title":"Identification of novel antimicrobials using a live-animal infection model","volume":"103","author":"Moy","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib147","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1749-6632.1999.tb07826.x","article-title":"Polyglutamine domain proteins with expanded repeats bind neurofilament, altering the neurofilament network","volume":"893","author":"Nagai","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib148","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.2174\/1871527314666150821110538","article-title":"A fluorescence resonance energy transfer assay For monitoring alpha- Synclein aggregation in a Caenorhabditis elegans model For Parkinson's disease","volume":"14","author":"Nagarajan","year":"2015","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.ejphar.2017.11.051_bib149","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2017.11.051_bib150","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.addr.2013.12.001","article-title":"C. elegans in high-throughput drug discovery","volume":"69\u201370","author":"O'Reilly","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejphar.2017.11.051_bib151","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1093\/hmg\/10.19.2013","article-title":"Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans","volume":"10","author":"Oeda","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib152","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1091\/mbc.E15-09-0648","article-title":"Two distinct myosin II populations coordinate ovulatory contraction of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad","volume":"27","author":"Ono","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejphar.2017.11.051_bib153","first-page":"740162","article-title":"Carqueja (Baccharis trimera) protects against oxidative stress and beta-amyloid-induced toxicity in Caenorhabditis elegans","volume":"2015","author":"Paiva","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ejphar.2017.11.051_bib154","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/humu.21527","article-title":"Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism","volume":"32","author":"Park","year":"2011","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ejphar.2017.11.051_bib155","doi-asserted-by":"crossref","first-page":"13318","DOI":"10.1073\/pnas.231476398","article-title":"Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death","volume":"98","author":"Parker","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib156","doi-asserted-by":"crossref","DOI":"10.1038\/nrn.2017.92","article-title":"Polyglutamine spinocerebellar ataxias - from genes to potential treatments","author":"Paulson","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib157","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.gde.2017.03.011","article-title":"Prion-like transmission of pathogenic protein aggregates in genetic models of neurodegenerative disease","volume":"44","author":"Pearce","year":"2017","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ejphar.2017.11.051_bib158","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0968-0004(98)01350-4","article-title":"Glutamine repeats and neurodegenerative diseases: molecular aspects","volume":"24","author":"Perutz","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib159","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature05991","article-title":"An antidepressant that extends lifespan in adult Caenorhabditis elegans","volume":"450","author":"Petrascheck","year":"2007","journal-title":"Nature"},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2017.11.051_bib160","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.parkreldis.2015.08.015","article-title":"Phenotypic spectrum of alpha-synuclein mutations: new insights from patients and cellular models","volume":"22","author":"Petrucci","year":"2016","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.ejphar.2017.11.051_bib161","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.ejphar.2017.11.051_bib162","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/hmg\/ddi071","article-title":"A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure","volume":"14","author":"Poirier","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib163","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/ng1884","article-title":"Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase","volume":"38","author":"Ramirez","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib164","doi-asserted-by":"crossref","first-page":"10149","DOI":"10.1523\/JNEUROSCI.0336-11.2011","article-title":"Copper reduces Abeta oligomeric species and ameliorates neuromuscular synaptic defects in a C. elegans model of inclusion body myositis","volume":"31","author":"Rebolledo","year":"2011","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"issue":"Suppl","key":"10.1016\/j.ejphar.2017.11.051_bib166","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2017.11.051_bib167","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1523\/JNEUROSCI.2912-14.2015","article-title":"Stabilization of nontoxic Abeta-oligomers: insights into the mechanism of action of hydroxyquinolines in Alzheimer's disease","volume":"35","author":"Ryan","year":"2015","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib168","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1093\/brain\/awt097","article-title":"Is SOD1 loss of function involved in amyotrophic lateral sclerosis?","volume":"136","author":"Saccon","year":"2013","journal-title":"Brain: J. Neurol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib169","doi-asserted-by":"crossref","first-page":"9210","DOI":"10.1523\/JNEUROSCI.2281-09.2009","article-title":"LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans","volume":"29","author":"Saha","year":"2009","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib170","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cub.2007.01.074","article-title":"LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins","volume":"17","author":"Sakaguchi-Nakashima","year":"2007","journal-title":"Curr. Biol.: CB"},{"key":"10.1016\/j.ejphar.2017.11.051_bib171","doi-asserted-by":"crossref","first-page":"16482","DOI":"10.1074\/jbc.M808255200","article-title":"Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth","volume":"284","author":"Samann","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2017.11.051_bib172","doi-asserted-by":"crossref","first-page":"e43990","DOI":"10.1371\/journal.pone.0043990","article-title":"Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against beta-amyloid toxicity in transgenic Caenorhabditis elegans","volume":"7","author":"Sangha","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exppara.2013.05.011","article-title":"Caenorhabditis elegans as a model for the screening of anthelminthic compounds: ultrastructural study of the effects of albendazole","volume":"135","author":"Sant'anna","year":"2013","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib174","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1074\/jbc.M114.588798","article-title":"Insights into the role of the unusual disulfide bond in copper-zinc superoxide dismutase","volume":"290","author":"Sea","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2017.11.051_bib175","doi-asserted-by":"crossref","first-page":"e20085","DOI":"10.1371\/journal.pone.0020085","article-title":"OrthoList: a compendium of C. elegans genes with human orthologs","volume":"6","author":"Shaye","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib176","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1212\/01.WNL.0000142992.81995.F0","article-title":"A clinical trial of creatine in ALS","volume":"63","author":"Shefner","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2017.11.051_bib177","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00005072-199604000-00011","article-title":"Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement","volume":"55","author":"Shibata","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib178","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2174\/1871527311211080007","article-title":"Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces alpha synuclein aggregation in Caenorhabditis elegans","volume":"11","author":"Shukla","year":"2012","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.ejphar.2017.11.051_bib179","doi-asserted-by":"crossref","first-page":"11049","DOI":"10.1073\/pnas.96.20.11049","article-title":"Cellular mechanisms of beta-amyloid production and secretion","volume":"96","author":"Sinha","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.11.051_bib180","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.3390\/molecules20034492","article-title":"Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound","volume":"20","author":"Sola","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2017.11.051_bib181","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1093\/hmg\/ddi371","article-title":"A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress","volume":"14","author":"Springer","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib182","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2174\/138945011795677854","article-title":"C. elegans: an all in one model for antimicrobial drug discovery","volume":"12","author":"Squiban","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejphar.2017.11.051_bib183","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2017.11.051_bib184","doi-asserted-by":"crossref","first-page":"24713","DOI":"10.1074\/jbc.M103501200","article-title":"Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95","volume":"276","author":"Sun","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2017.11.051_bib185","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2046-2395-1-9","article-title":"Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans","volume":"1","author":"Sutphin","year":"2012","journal-title":"Longev Health."},{"key":"10.1016\/j.ejphar.2017.11.051_bib186","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nrneurol.2016.36","article-title":"Clearance systems in the brain--implications for Alzheimer disease","volume":"12","author":"Tarasoff-Conway","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib187","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1750-1326-4-38","article-title":"What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?","volume":"4","author":"Teschendorf","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejphar.2017.11.051_bib188","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-1-61779-328-8_9","article-title":"Modeling dopamine neuron degeneration in Caenorhabditis elegans","volume":"793","author":"Tucci","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib189","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0006-291X(90)92011-N","article-title":"Two novel variants of transthyretin identified in Japanese cases with familial amyloidotic polyneuropathy: transthyretin (Glu42 to Gly) and transthyretin (Ser50 to Arg)","volume":"169","author":"Ueno","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2017.11.051_bib190","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.nbd.2013.03.015","article-title":"Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo","volume":"55","author":"Vaccaro","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2017.11.051_bib191","doi-asserted-by":"crossref","first-page":"e42117","DOI":"10.1371\/journal.pone.0042117","article-title":"Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio","volume":"7","author":"Vaccaro","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib192","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.1096284","article-title":"Hereditary early-onset Parkinson's disease caused by mutations in PINK1","volume":"304","author":"Valente","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2017.11.051_bib193","doi-asserted-by":"crossref","first-page":"42655","DOI":"10.1074\/jbc.M505910200","article-title":"Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans","volume":"280","author":"Ved","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2017.11.051_bib194","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1038\/ncomms8319","article-title":"Neurodegeneration in C. elegans models of ALS requires TIR-1\/Sarm1 immune pathway activation in neurons","volume":"6","author":"Veriepe","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2017.11.051_bib195","doi-asserted-by":"crossref","first-page":"e504","DOI":"10.1371\/journal.pone.0000504","article-title":"Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans","volume":"2","author":"Voisine","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib196","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib197","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/hmg\/ddl017","article-title":"Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin","volume":"15","author":"Wang","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib198","doi-asserted-by":"crossref","first-page":"e1000350","DOI":"10.1371\/journal.pgen.1000350","article-title":"An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans","volume":"5","author":"Wang","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib199","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nmeth.1556","article-title":"RNAi screening for fat regulatory genes with SRS microscopy","volume":"8","author":"Wang","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ejphar.2017.11.051_bib200","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0012-1606(79)90069-1","article-title":"Fertilization and sperm competition in the nematode Caenorhabditis elegans","volume":"73","author":"Ward","year":"1979","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejphar.2017.11.051_bib201","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/hmg\/9.4.503","article-title":"Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice","volume":"9","author":"Wheeler","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib202","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/17482960802146106","article-title":"ALSOD: the amyotrophic lateral sclerosis online database","volume":"9","author":"Wroe","year":"2008","journal-title":"Amyotroph. Lateral Scler.: Off. Publ. World Fed. Neurol. Res. Group Mot. Neuron Dis."},{"key":"10.1016\/j.ejphar.2017.11.051_bib203","doi-asserted-by":"crossref","first-page":"13102","DOI":"10.1523\/JNEUROSCI.3448-06.2006","article-title":"Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans","volume":"26","author":"Wu","year":"2006","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib204","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fnmol.2016.00158","article-title":"The role of the carboxyl-terminal sequence of Tau and MAP2 in the pathogenesis of dementia","volume":"9","author":"Xie","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib205","doi-asserted-by":"crossref","first-page":"e63874","DOI":"10.1371\/journal.pone.0063874","article-title":"Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176","volume":"8","author":"Xin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.11.051_bib206","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/gerona\/glp020","article-title":"SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation","volume":"64","author":"Yanase","year":"2009","journal-title":"J. Gerontol. Ser. A, Biol. Sci. Med. Sci."},{"key":"10.1016\/j.ejphar.2017.11.051_bib207","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3109\/17482968.2011.622405","article-title":"Widespread neuronal and glial hyperphosphorylated tau deposition in ALS with cognitive impairment","volume":"13","author":"Yang","year":"2012","journal-title":"Amyotroph. Lateral Scler.: Off. Publ. World Fed. Neurol. Res. Group Mot. Neuron Dis."},{"key":"10.1016\/j.ejphar.2017.11.051_bib208","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/hmg\/dds431","article-title":"Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity","volume":"22","author":"Yao","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib209","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neuroscience.2014.07.068","article-title":"Diphenyl-diselenide suppresses amyloid-beta peptide in Caenorhabditis elegans model of Alzheimer's disease","volume":"278","author":"Zamberlan","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2017.11.051_bib210","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/hmg\/ddu493","article-title":"Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration","volume":"24","author":"Zhan","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib211","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1093\/hmg\/ddr076","article-title":"TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin\/IGF-1 signaling","volume":"20","author":"Zhang","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.11.051_bib212","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","article-title":"Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology","volume":"44","author":"Zimprich","year":"2004","journal-title":"Neuron"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917307847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917307847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T04:44:43Z","timestamp":1751085883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299917307847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":212,"alternative-id":["S0014299917307847"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.11.051","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Caenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.11.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}