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Lett."},{"key":"10.1016\/j.ejphar.2018.01.005_bib74","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1124\/jpet.115.225540","article-title":"Control of macrophage dynamics as a potential therapeutic approach for clinical disorders involving chronic inflammation","volume":"354","author":"Ohashi","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2018.01.005_bib75","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2015.03.064","article-title":"SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo","volume":"757","author":"Oon","year":"2015","journal-title":"Eur. J. 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Neurol."},{"key":"10.1016\/j.ejphar.2018.01.005_bib83","doi-asserted-by":"crossref","first-page":"e0151901","DOI":"10.1371\/journal.pone.0151901","article-title":"Association between SIRT1 gene polymorphisms and breast cancer in Egyptians","volume":"11","author":"Rizk","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2018.01.005_bib84","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12974-015-0470-x","article-title":"Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology","volume":"13","author":"Rosenberger","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ejphar.2018.01.005_bib85","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neuroscience.2015.05.064","article-title":"Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress","volume":"301","author":"Ryou","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2018.01.005_bib86","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fnmol.2016.00157","article-title":"Role of chaperone-mediated autophagy dysfunctions in the pathogenesis of Parkinson's disease","volume":"9","author":"Sala","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2018.01.005_bib87","doi-asserted-by":"crossref","first-page":"1238303","DOI":"10.1126\/science.1238303","article-title":"Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state","volume":"341","author":"Santagata","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2018.01.005_bib88","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.neuroscience.2004.03.023","article-title":"Enlarged ventricles, astrogliosis and neurodegeneration in heat shock factor 1 null mouse brain, Enlarged ventricles, astrogliosis and neurodegeneration in heat shock factor 1 null mouse brain","volume":"126","author":"Santos","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2018.01.005_bib89","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ccr.2011.05.025","article-title":"Proinvasion metastasis drivers in early-stage melanoma are oncogenes","volume":"20","author":"Scott","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ejphar.2018.01.005_bib90","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/asj.12687","article-title":"Fbxw7\u03b2, E3 ubiquitin ligase, negative regulation of primary myoblast differentiation, proliferation and migration","volume":"88","author":"Shin","year":"2017","journal-title":"Anim. Sci. J."},{"key":"10.1016\/j.ejphar.2018.01.005_bib91","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1074\/jbc.M108154200","article-title":"A high affinity HSF-1 binding site in the 5\u2032-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressor","volume":"277","author":"Singh","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.01.005_bib92","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.semcdb.2015.03.003","article-title":"Molecular chaperones and neuronal proteostasis, Molecular chaperones and neuronal proteostasis","volume":"40","author":"Smith","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2018.01.005_bib93","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00259-009-1103-3","article-title":"Riluzole protects Huntington disease patients from brain glucose hypometabolism and grey matter volume loss and increases production of neurotrophins","volume":"36","author":"Squitieri","year":"2009","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.ejphar.2018.01.005_bib94","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1016\/j.cub.2015.06.045","article-title":"Age-dependent TDP-43-mediated motor neuron degeneration requires GSK3, hat-trick, and xmas-2","volume":"25","author":"Sreedharan","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ejphar.2018.01.005_bib95","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/jac\/dku326","article-title":"Methylene blue inhibits the asexual development of vivax malaria parasites from a region of increasing chloroquine resistance","volume":"70","author":"Suwanarusk","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejphar.2018.01.005_bib96","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1158\/0008-5472.CAN-05-3410","article-title":"Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death","volume":"66","author":"Swift","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2018.01.005_bib97","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.expneurol.2016.08.013","article-title":"Preservation of neuromuscular function in symptomatic SOD1-G93A mice by peripheral infusion of methylene blue","volume":"285","author":"Talbot","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2018.01.005_bib98","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3892\/ijmm.2015.2414","article-title":"The interactive association between heat shock factor 1 and heat shockproteins in primary myocardial cells subjected to heat stress","volume":"37","author":"Tang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2018.01.005_bib99","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003799","article-title":"PGC-1\u03b1 rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function","volume":"4","author":"Tsunemi","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejphar.2018.01.005_bib100","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1073\/pnas.1016424108","article-title":"Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1, Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1","volume":"108","author":"Uchida","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2018.01.005_bib101","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1523\/JNEUROSCI.3039-13.2014","article-title":"HSF1 protects neurons through a novel trimerization- and HSP-independent mechanism, HSF1 protects neurons through a novel trimerization- and HSP-independent mechanism","volume":"34","author":"Verma","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2018.01.005_bib102","doi-asserted-by":"crossref","first-page":"19716","DOI":"10.1021\/acsami.6b01776","article-title":"Enhancement in the neuroprotective power of riluzole against cerebral ischemia using a brain targeted drug delivery vehicle","volume":"8","author":"Verma","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejphar.2018.01.005_bib103","doi-asserted-by":"crossref","first-page":"15714","DOI":"10.1074\/jbc.M109.098806","article-title":"Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation","volume":"285","author":"Wang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.01.005_bib104","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.1523\/JNEUROSCI.4936-13.2014","volume":"34","author":"Wang","year":"2014","journal-title":"J. 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