{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:09:00Z","timestamp":1773220140166,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81573049"],"award-info":[{"award-number":["81573049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81773329"],"award-info":[{"award-number":["81773329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81430075"],"award-info":[{"award-number":["81430075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.ejphar.2018.01.048","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T15:18:56Z","timestamp":1517411936000},"page":"57-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Topical Sunitinib ointment alleviates Psoriasis-like inflammation by inhibiting the proliferation and apoptosis of keratinocytes"],"prefix":"10.1016","volume":"824","author":[{"given":"Ye-Hong","family":"Kuang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Ke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Qiu","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Chen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun-Shi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Kun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Sha","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.01.048_bib1","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1158\/1535-7163.MCT-10-1124","article-title":"New insights into molecular mechanisms of sunitinib-associated side effects","volume":"10","author":"Aparicio-Gallego","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ejphar.2018.01.048_bib2","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/sj.jid.5700276","article-title":"Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar","volume":"126","author":"Arbiser","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0002-9343(97)00178-2","article-title":"Human papillomavirus and human disease","volume":"102","author":"Beutner","year":"1997","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejphar.2018.01.048_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0625.2010.01198.x","article-title":"Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases","volume":"20","author":"von Bonin","year":"2011","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib5","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1128\/MCB.16.4.1595","article-title":"Activation and association of Stat3 with Src in v-Src-transformed cell lines","volume":"16","author":"Cao","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib6","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1158\/0008-5472.CAN-03-3197","article-title":"Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis","volume":"64","author":"Chan","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2018.01.048_bib7","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.4161\/cbt.7.12.6967","article-title":"Activated STAT3 is a mediator and biomarker of VEGF endothelial activation","volume":"7","author":"Chen","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.ejphar.2018.01.048_bib8","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1084\/jem.180.3.1141","article-title":"Overexpression of vascular permeability factor\/vascular endothelial growth factor and its receptors in psoriasis","volume":"180","author":"Detmar","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2018.01.048_bib9","first-page":"1507","article-title":"Fibroblast function in psoriatic arthritis. II. Increased expression of beta platelet derived growth factor receptors and increased production of growth factor and cytokines","volume":"21","author":"Espinoza","year":"1994","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib10","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s13238-013-2084-3","article-title":"NF-kappaB and STAT3 signaling pathways collaboratively link inflammation to cancer","volume":"4","author":"Fan","year":"2013","journal-title":"Protein Cell."},{"key":"10.1016\/j.ejphar.2018.01.048_bib11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1468-3083.2011.04053.x","article-title":"Effect of psoriasis therapy on VEGF and its soluble receptors serum concentrations","volume":"26","author":"Flisiak","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib12","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1067\/mjd.2002.126215","article-title":"Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: a double-blind, randomized, vehicle-controlled study","volume":"47","author":"Geisse","year":"2002","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib13","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1158\/1078-0432.CCR-06-2328","article-title":"Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma","volume":"13","author":"Goodman","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2018.01.048_bib14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1006\/bbrc.1999.0684","article-title":"EGF-induced activation of Stat1, Stat3, and Stat5b is unrelated to the stimulation of DNA synthesis in cultured hepatocytes","volume":"258","author":"Guren","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2018.01.048_bib15","first-page":"207","article-title":"[Influence of histatin 1 on the proliferation and migration of HaCaT cells]","volume":"28","author":"Jiang","year":"2012","journal-title":"Zhonghua. Shao. Shang. Za. Zhi."},{"key":"10.1016\/j.ejphar.2018.01.048_bib16","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/1346-8138.12289","article-title":"Dramatic effect of sunitinib with rapid but transient improvement for psoriasis in a patient with metastatic renal carcinoma","volume":"40","author":"Kato","year":"2013","journal-title":"J. Dermatol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.trsl.2007.01.003","article-title":"SU-011248, a vascular endothelial growth factor receptor-tyrosine kinase inhibitor, controls chronic psoriasis","volume":"149","author":"Keshtgarpour","year":"2007","journal-title":"Transl. Res."},{"key":"10.1016\/j.ejphar.2018.01.048_bib18","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/1523-1747.ep12476485","article-title":"Increased dermal expression of platelet-derived growth factor receptors in growth-activated skin wounds and psoriasis","volume":"96","author":"Krane","year":"1991","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib19","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1182\/blood-2003-08-2964","article-title":"Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia","volume":"104","author":"Kunstfeld","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2018.01.048_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1076\/ceyr.23.1.69.5421","article-title":"Differential expression analysis by gene array of cell cycle modulators in human corneal epithelial cells stimulated with epidermal growth factor (EGF), hepatocyte growth factor (HGF), or keratinocyte growth factor (KGF)","volume":"23","author":"Lee","year":"2001","journal-title":"Curr. Eye. Res."},{"key":"10.1016\/j.ejphar.2018.01.048_bib21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1158\/1940-6207.CAPR-10-0249","article-title":"Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma","volume":"4","author":"Leeman-Neill","year":"2011","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.ejphar.2018.01.048_bib22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1582-4934.2007.00112.x","article-title":"Overexpression of vascular endothelial growth factor (VEGF) receptors on keratinocytes in psoriasis: regulated by calcium independent of VEGF","volume":"12","author":"Man","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejphar.2018.01.048_bib23","first-page":"327","article-title":"In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic\/pharmacodynamic relationship","volume":"9","author":"Mendel","year":"2003","journal-title":"Clin. Cance. Res."},{"key":"10.1016\/j.ejphar.2018.01.048_bib24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/jid.2010.255","article-title":"Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor","volume":"131","author":"Miyoshi","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2174\/1568010043343958","article-title":"Epidemiology of psoriasis","volume":"3","author":"Naldi","year":"2004","journal-title":"Curr. Drug. Targets Inflamm. Allergy"},{"key":"10.1016\/j.ejphar.2018.01.048_bib26","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/MAJ.0b013e3181dd1aa5","article-title":"Improvement of psoriasis during sunitinib therapy for renal cell carcinoma","volume":"339","author":"Narayanan","year":"2010","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.ejphar.2018.01.048_bib27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis","volume":"361","author":"Nestle","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2018.01.048_bib28","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1210\/me.2005-0515","article-title":"Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations by growth factors and TSH of human thyrocytes in primary culture","volume":"20","author":"Paternot","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib29","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1089\/dna.2013.2252","article-title":"Four polymorphisms of VEGF (+405C>G, \u2212460T>C, \u22122578C>A, and \u22121154G>A) in susceptibility to psoriasis: a meta-analysis","volume":"33","author":"Qi","year":"2014","journal-title":"Dna. Cell. Biol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib30","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1017\/S146239940900129X","article-title":"Molecular pathophysiology of psoriasis and molecular targets of antipsoriatic therapy","volume":"11","author":"Racz","year":"2009","journal-title":"Expert. Rev. Mol. Med."},{"key":"10.1016\/j.ejphar.2018.01.048_bib31","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1158\/0008-5472.195.65.1","article-title":"Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth","volume":"65","author":"Rivat","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2018.01.048_bib32","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1038\/sj.onc.1202694","article-title":"STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation","author":"Sachsenmaier","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2018.01.048_bib33","doi-asserted-by":"crossref","first-page":"E615","DOI":"10.1152\/ajpendo.00035.2011","article-title":"Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2\/Akt\/mTOR\/S6K1 pathways through modulation of Bcl-2 and BAD","volume":"302","author":"Saito","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2018.01.048_bib34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nm1162","article-title":"Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model","volume":"11","author":"Sano","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2018.01.048_bib35","first-page":"978","article-title":"Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of sum-102PT human breast cancer cells","volume":"57","author":"Sartor","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2018.01.048_bib36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10911-008-9083-7","article-title":"ERBB3\/HER3 and ERBB2\/HER2 duet in mammary development and breast cancer","volume":"13","author":"Stern","year":"2008","journal-title":"J. Mammary Gland. Biol. Neoplasia"},{"key":"10.1016\/j.ejphar.2018.01.048_bib37","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.canlet.2008.07.034","article-title":"A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis","volume":"273","author":"Su","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejphar.2018.01.048_bib38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jaad.2004.02.022","article-title":"Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology","volume":"51","author":"Szeimies","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib39","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4049\/jimmunol.1102224","article-title":"IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice","volume":"188","author":"Van Belle","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib40","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","volume":"182","author":"van der Fits","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib41","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1128\/MCB.16.4.1759","article-title":"Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins","volume":"16","author":"Vignais","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ejphar.2018.01.048_bib42","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1016\/j.ejca.2010.07.008","article-title":"STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling","volume":"46","author":"Wang","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejphar.2018.01.048_bib43","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1158\/0008-5472.CAN-08-4323","article-title":"Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells","volume":"69","author":"Xin","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2018.01.048_bib44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1158\/1541-7786.MCR-09-0220","article-title":"Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways","volume":"8","author":"Yang","year":"2010","journal-title":"Mol. Cancer Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918300645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918300645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T17:13:33Z","timestamp":1660410813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299918300645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":44,"alternative-id":["S0014299918300645"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.01.048","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical Sunitinib ointment alleviates Psoriasis-like inflammation by inhibiting the proliferation and apoptosis of keratinocytes","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.01.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}