{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:52:21Z","timestamp":1785739941376,"version":"3.56.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007375","name":"Pr\u00f3-Reitoria de Pesquisa, Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.ejphar.2018.02.014","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T07:22:25Z","timestamp":1518247345000},"page":"108-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Nicorandil inhibits mechanical allodynia induced by paclitaxel by activating opioidergic and serotonergic mechanisms"],"prefix":"10.1016","volume":"824","author":[{"given":"Marcela I.","family":"Morais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe F.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah O.A.M.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciele A.","family":"Goulart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio C.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo S.F.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo S.A.","family":"Augusto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela M.G.B.","family":"Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngelo","family":"de F\u00e1tima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio M.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renes R.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.02.014_bib1","doi-asserted-by":"crossref","first-page":"12A","DOI":"10.1016\/0002-9149(85)91200-7","article-title":"Pharmacology of nitroglycerin and long-acting nitrates","volume":"56","author":"Abrams","year":"1985","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-2999(02)01412-7","article-title":"Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by dipyrone","volume":"444","author":"Alves","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1468","article-title":"Drug repositioning: identifying and developing new uses for existing drugs","volume":"3","author":"Ashburn","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2018.02.014_bib4","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1161\/01.HYP.0000185191.86908.a7","article-title":"Nicorandil \u2013 the drug that keeps on giving","volume":"46","author":"Barbato","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2018.02.014_bib5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","article-title":"Neuropathic pain: diagnosis, pathophysiological mechanisms and treatment","volume":"9","author":"Baron","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib6","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00702-005-0300-x","article-title":"Evidence-based pharmacological treatment of neuropathic pain syndromes","volume":"112","author":"Beniczky","year":"2005","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2018.02.014_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2018.02.014_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2217\/pmt.15.19","article-title":"Mechanisms involved in the development of chemotherapy-induced neuropathy","volume":"5","author":"Boyette-Davis","year":"2015","journal-title":"Pain Manag."},{"key":"10.1016\/j.ejphar.2018.02.014_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejphar.2017.10.026","article-title":"Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-\u03b1 and CXCL-1","volume":"818","author":"Brito","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2006.09.021","article-title":"Mechanisms of neuropathic pain","volume":"52","author":"Campbell","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2018.02.014_bib11","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/j.bmc.2014.03.011","article-title":"Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers","volume":"22","author":"C\u00e9sar","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejphar.2018.02.014_bib12","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0306-4522(00)00415-2","article-title":"Intrathecal S-nitroso-N-acetylpenicillamine and L-cysteine attenuate nerve injury-induced allodynia through noradrenergic activation in rats","volume":"101","author":"Chen","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2018.02.014_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.051508.135531","article-title":"Neuropathic pain: a maladaptive response of the nervous system to damage","volume":"32","author":"Costigan","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2018.02.014_bib14","first-page":"273","article-title":"Review of naltrexone, a long-acting opiate antagonist","volume":"3","author":"Crabtree","year":"1984","journal-title":"Clin. Pharm."},{"key":"10.1016\/j.ejphar.2018.02.014_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0014-2999(90)90446-D","article-title":"Peripheral analgesia and activation of the nitric oxide\u2013cyclic GMP pathway","volume":"186","author":"Duarte","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pbb.2013.03.004","article-title":"Activity of nicorandil, a nicotinamide derivative with a nitrate group, in the experimental model of pain induced by formaldehyde in mice","volume":"106","author":"Dutra","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2018.02.014_bib17","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejphar.2015.10.047","article-title":"Opioid pathways activation mediates the activity of nicorandil in experimental models of nociceptive and inflammatory pain","volume":"768","author":"Dutra","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0165-6147(90)90149-3","article-title":"Structure\u2013activity relationships of K+ channel openers","volume":"11","author":"Edwards","year":"1990","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2018.02.014_bib19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s12010-008-8384-z","article-title":"Gastroprotective effect of nicorandil in indomethacin and alcohol-induced acute ulcers","volume":"152","author":"El-Moselby","year":"2009","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0014-2999(92)90871-Z","article-title":"Blockade of hyperalgesia and neurogenic edema by topical application of nitroglycerin","volume":"217","author":"Ferreira","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2165\/00003495-199244040-00008","article-title":"Nicorandil: a review of its pharmacology and therapeutic efficacy in angina pectoris","volume":"44","author":"Frampton","year":"1992","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2018.02.014_bib22","doi-asserted-by":"crossref","first-page":"25J","DOI":"10.1016\/0002-9149(89)90201-4","article-title":"Pharmacokinetics of nicorandil","volume":"63","author":"Frydman","year":"1989","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib23","doi-asserted-by":"crossref","first-page":"9C","DOI":"10.1016\/0002-9149(93)90249-C","article-title":"Clinical pharmacology of organic nitrates","volume":"72","author":"Fung","year":"1993","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib24","doi-asserted-by":"crossref","first-page":"PL113","DOI":"10.1016\/0024-3205(95)02039-L","article-title":"Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice","volume":"57","author":"Gantenbein","year":"1995","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2018.02.014_bib25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.mayocp.2015.01.018","article-title":"Neuropathic pain: principles of diagnosis and treatment","volume":"90","author":"Gilron","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ejphar.2018.02.014_bib26","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.pbb.2011.07.003","article-title":"Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models","volume":"99","author":"Godin","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2018.02.014_bib27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.pbb.2012.02.012","article-title":"Nicotinic acid induces antinociceptive and anti-inflammatory effects in different experimental models","volume":"101","author":"Godin","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2018.02.014_bib28","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0022-3565(25)20323-8","article-title":"Comparison of nicorandil-induced relaxation, elevations of cyclic guanosine monophosphate and stimulation of guanylate cyclase with organic nitrate esters","volume":"258","author":"Greenberg","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2018.02.014_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1124\/jpet.111.187401","article-title":"Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia","volume":"342","author":"Ito","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2018.02.014_bib30","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/j.pain.2011.06.017","article-title":"A new definition of neuropathic pain","volume":"152","author":"Jensen","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2018.02.014_bib31","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1254\/jphs.08214FP","article-title":"K(+)- channel openers suppress epileptiform activities induced by 4-aminopyridine in cultured rat hippocampal neurons","volume":"108","author":"Kobayashi","year":"2008","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2018.02.014_bib32","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00005344-199206203-00002","article-title":"Molecular mechanism of action of nicorandil","volume":"20","author":"Kukovetz","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1017\/S1740925X0700035X","article-title":"The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain","volume":"2","author":"Ledeboer","year":"2006","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2174\/157015909790031201","article-title":"Serotonin-norepinephrine reuptake inhibitors for pain control: premise and promise","volume":"7","author":"Marks","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2005.11.029","article-title":"Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats","volume":"530","author":"Naik","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.euroneuro.2011.05.005","article-title":"Mechanisms of neuropathic pain","volume":"22","author":"Nickel","year":"2012","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib37","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pbb.2010.02.009","article-title":"Antinociceptive effect of three common analgesic drugs on peripheral neuropathy induced by paclitaxel in rats","volume":"95","author":"Pascual","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2018.02.014_bib38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0304-3959(01)00363-3","article-title":"A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel","volume":"94","author":"Polomano","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2018.02.014_bib39","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1073\/pnas.0308382101","article-title":"Peripheral analgesic blockade of hypernociception: activation of arginine\/NO\/cGMP\/protein kinase G\/ATP-sensitive K+ channel pathway","volume":"101","author":"Sachs","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2018.02.014_bib40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pbb.2014.03.025","article-title":"Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice","volume":"122","author":"Salat","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2018.02.014_bib41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2174\/157015906776359568","article-title":"Peripheral neuropathy induced by paclitaxel: recent insights and future perspectives","volume":"4","author":"Scripture","year":"2006","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib42","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1016\/j.lfs.2004.01.002","article-title":"Paclitaxel-induced neuropathic hypersensitivity in mice: responses in 10 inbred mouse strains","volume":"74","author":"Smith","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2018.02.014_bib43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-2999(00)00355-1","article-title":"Activation of ATP-sensitive K(+) channels: mechanism of peripheral antinociceptive action of the nitric oxide donor, sodium nitroprusside","volume":"400","author":"Soares","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11916-006-0020-4","article-title":"Is serotonin hyperalgesic or analgesic?","volume":"10","author":"Sommer","year":"2006","journal-title":"Curr. Pain. Headache Rep."},{"key":"10.1016\/j.ejphar.2018.02.014_bib45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0006-8993(01)01995-3","article-title":"The dual effect of a nitric oxide donor in nociception","volume":"897","author":"Sousa","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2018.02.014_bib46","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1124\/jpet.106.109702","article-title":"Nicotinamide reverses neurological and neurovascular deficits in streptozotocin diabetic rats","volume":"320","author":"Stevens","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2018.02.014_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005344-198706108-00002","article-title":"Similarity and dissimilarity in the mode and mechanism of action between nicorandil and classical nitrates: an overview","volume":"10","author":"Taira","year":"1987","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib48","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/iwj.12147","article-title":"Role of nicotinic acid and nicotinamide in nicorandil-induced ulcerations: from hypothesis to demonstration","volume":"12","author":"Trechot","year":"2015","journal-title":"Int. Wound J."},{"key":"10.1016\/j.ejphar.2018.02.014_bib49","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejphar.2013.01.074","article-title":"Multiple roles of serotonin in pain control mechanisms-implications of 5-HT7 and other 5-HT receptor types","volume":"716","author":"Viguier","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.02.014_bib50","doi-asserted-by":"crossref","first-page":"441","DOI":"10.7326\/0003-4819-140-8-200404200-00010","article-title":"Pain: moving from symptom control toward mechanism-specific pharmacologic treatment","volume":"140","author":"Woolf","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejphar.2018.02.014_bib51","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1253\/jcj.65.526","article-title":"Nicorandil, a hybrid between nitrate and ATP-sensitive potassium channel opener, preconditions human heart to ischemia during percutaneos transluminal coronary angioplasty","volume":"65","author":"Yasuda","year":"2001","journal-title":"Jpn. Circ. J."},{"key":"10.1016\/j.ejphar.2018.02.014_bib52","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991830089X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991830089X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T17:52:21Z","timestamp":1751392341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429991830089X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":52,"alternative-id":["S001429991830089X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.02.014","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicorandil inhibits mechanical allodynia induced by paclitaxel by activating opioidergic and serotonergic mechanisms","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}