{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:05:10Z","timestamp":1788289510592,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.ejphar.2018.04.019","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T05:39:27Z","timestamp":1524116367000},"page":"121-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["Treatment with D-\u03b2-hydroxybutyrate protects heart from ischemia\/reperfusion injury in mice"],"prefix":"10.1016","volume":"829","author":[{"given":"Yongsheng","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishuai","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.04.019_bib1","doi-asserted-by":"crossref","first-page":"66444","DOI":"10.18632\/oncotarget.12119","article-title":"\u03b2-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation","volume":"7","author":"Bae","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2018.04.019_bib2","first-page":"H2240","article-title":"Generation of superoxide in cardiomyocytes during ischemia before reperfusion","volume":"277","author":"Becker","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2840001","article-title":"Control of respiration and ATP synthesis in mammalian mitochondria and cells","volume":"284","author":"Brown","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2018.04.019_bib4","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s11064-015-1700-4","article-title":"The ketone body, \u03b2-hydroxybutyrate stimulates the autophagic flux and prevents neuronal death induced by glucose deprivation in cortical cultured neurons","volume":"41","author":"Camberos-Luna","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2018.04.019_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/1479164113516134","article-title":"Dipeptidyl peptidase-4 inhibitor reduces infarct size and preserves cardiac function via mitochondrial protection in ischaemia-reperfusion rat heart","volume":"11","author":"Chinda","year":"2014","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"10.1016\/j.ejphar.2018.04.019_bib6","doi-asserted-by":"crossref","first-page":"H1060","DOI":"10.1152\/ajpheart.00646.2012","article-title":"Ketone body metabolism and cardiovascular disease","volume":"304","author":"Cotter","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib7","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1124\/pr.113.008300","article-title":"Interaction of risk factors, comorbidities, and comedications with ischemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning","volume":"66","author":"Ferdinandy","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2018.04.019_bib8","doi-asserted-by":"crossref","first-page":"25864","DOI":"10.1074\/jbc.M502456200","article-title":"Ketone bodies stimulate chaperone-mediated autophagy","volume":"280","author":"Finn","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.04.019_bib9","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/eurheartj\/eht090","article-title":"Myocardial reperfusion injury: looking beyond primary PCI","volume":"34","author":"Fr\u00f6hlich","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejphar.2018.04.019_bib10","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1080\/15548627.2015.1063768","article-title":"Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury","volume":"11","author":"Godar","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.ejphar.2018.04.019_bib11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pneurobio.2016.06.006","article-title":"Mitochondrial function in hypoxic ischemic injury and influence of aging","volume":"157","author":"Ham","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2018.04.019_bib13","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"NC3Rs Reporting Guidelines Working Group","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib14","doi-asserted-by":"crossref","first-page":"e24620","DOI":"10.1371\/journal.pone.0024620","article-title":"D-\u03b2-hydroxybutyrate is protective in mouse models of Huntington's disease","volume":"6","author":"Lim","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2018.04.019_bib15","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.4103\/1673-5374.169615","article-title":"Attenuation of endoplasmic reticulum stress as a treatment strategy against ischemia\/reperfusion injury","volume":"10","author":"Lin","year":"2015","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ejphar.2018.04.019_bib16","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0735-1097(96)00214-8","article-title":"Blood ketone bodies in congestive heart failure","volume":"28","author":"Lommi","year":"1996","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib17","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.4161\/auto.21036","article-title":"Autophagy is impaired in cardiac ischemia-reperfusion injury","volume":"8","author":"Ma","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.ejphar.2018.04.019_bib18","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s10495-016-1277-7","article-title":"Inhibition of autophagy by chloroquine induces apoptosis in primary effusion lymphoma in vitro and in vivo through induction of endoplasmic reticulum stress","volume":"21","author":"Masud Alam","year":"2016","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejphar.2018.04.019_bib19","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","article-title":"Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy","volume":"100","author":"Matsui","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.04.019_bib20","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1111\/bph.12955","article-title":"Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP","volume":"172","author":"McGrath","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib21","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2018.04.019_bib22","doi-asserted-by":"crossref","first-page":"19687","DOI":"10.1074\/jbc.M116.740597","article-title":"Cardiac myocyte-specific knockout of iPLA2\u03b3 decreases oxidized fatty acids during ischemia\/reperfusion and reduces infarct size","volume":"291","author":"Moon","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.04.019_bib23","doi-asserted-by":"crossref","first-page":"H867","DOI":"10.1152\/ajpheart.00875.2014","article-title":"Cardioprotective HIF-1a-frataxin signaling against ischemia-reperfusion injury","volume":"309","author":"Nanayakkara","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib24","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1111\/bph.13788","article-title":"D-\u03b2-hydroxybutyrate promotes functional recovery and relieves pain hypersensitivity in mice with spinal cord injury","volume":"174","author":"Qian","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib25","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1038\/ncomms4944","article-title":"The \u03b2-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages","volume":"5","author":"Rahman","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2018.04.019_bib26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.biocel.2016.08.020","article-title":"Mechanisms of communication between mitochondria and lysosomes","volume":"79","author":"Raimundo","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib27","doi-asserted-by":"crossref","first-page":"150","DOI":"10.14336\/AD.2015.0820","article-title":"The role of autophagy, mitophagy and lysosomal functions in modulating bioenergetics and survival in the context of redox and proteotoxic damage: implications for neurodegenerative diseases","volume":"7","author":"Redmann","year":"2016","journal-title":"Aging Dis."},{"key":"10.1016\/j.ejphar.2018.04.019_bib28","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.cellsig.2016.04.005","article-title":"\u03b2-Hydroxybutyrate: a signaling metabolite in starvation response?","volume":"28","author":"Rojas-Morales","year":"2016","journal-title":"Cell Signal."},{"key":"10.1016\/j.ejphar.2018.04.019_bib29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00246-010-9855-x","article-title":"Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart?","volume":"32","author":"Sciarretta","year":"2011","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib30","doi-asserted-by":"crossref","first-page":"310","DOI":"10.4161\/auto.18673","article-title":"Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning","volume":"8","author":"Sheng","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.ejphar.2018.04.019_bib31","doi-asserted-by":"crossref","first-page":"567","DOI":"10.33549\/physiolres.932338","article-title":"Short-term fasting reduces the extent of myocardial infarction and incidence of reperfusion arrhythmias in rats","volume":"61","author":"Snorek","year":"2012","journal-title":"Physiol. Res."},{"key":"10.1016\/j.ejphar.2018.04.019_bib32","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1002\/jcp.26137","article-title":"Crosstalk of ER stress-mediated autophagy and ER-phagy: involvement of UPR and the core autophagy machinery","volume":"233","author":"Song","year":"2018","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1254\/jjp.87.143","article-title":"Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats","volume":"87","author":"Suzuki","year":"2001","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib34","first-page":"H1290","article-title":"Nitric oxide donors protect the murine myocardium against infarction via modulation of mitochondrial permeability transition","volume":"288","author":"Wang","year":"2005","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib35","doi-asserted-by":"crossref","first-page":"e70956","DOI":"10.1371\/journal.pone.0070956","article-title":"Ginsenoside Rd attenuates myocardial ischemia\/reperfusion injury via Akt\/GSK-3\u03b2 signaling and inhibition of the mitochondria-dependent apoptotic pathway","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2018.04.019_bib36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijcard.2016.01.119","article-title":"Endoplasmic reticulum stress-induced apoptosis: a possible role in myocardial ischemia-reperfusion injury","volume":"208","author":"Wu","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2018.04.019_bib37","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/CIRCULATIONAHA.113.002416","article-title":"Histone deacetylase inhibition blunts ischemia\/reperfusion injury by inducing cardiomyocyte autophagy","volume":"129","author":"Xie","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.04.019_bib38","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2018.04.019_bib39","doi-asserted-by":"crossref","first-page":"30299","DOI":"10.1074\/jbc.M607007200","article-title":"Endoplasmic reticulum stress triggers autophagy","volume":"281","author":"Yorimitsu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.04.019_bib40","doi-asserted-by":"crossref","first-page":"H1968","DOI":"10.1152\/ajpheart.00250.2002","article-title":"dl-3-Hydroxybutyrate administration prevents myocardial damage after coronary occlusion in rat hearts","volume":"283","author":"Zou","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991830236X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991830236X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T23:47:56Z","timestamp":1604188076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429991830236X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":40,"alternative-id":["S001429991830236X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.04.019","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment with D-\u03b2-hydroxybutyrate protects heart from ischemia\/reperfusion injury in mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}