{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:15:22Z","timestamp":1774365322364,"version":"3.50.1"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.ejphar.2018.04.030","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T08:32:23Z","timestamp":1525077143000},"page":"87-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Local administration of mangiferin prevents experimental inflammatory mechanical hyperalgesia through CINC-1\/epinephrine\/PKA pathway and TNF-\u03b1 inhibition"],"prefix":"10.1016","volume":"830","author":[{"given":"Lilian W\u00fcnsch","family":"Rocha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan Jos\u00e9 Magayewski","family":"Bonet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Herrera","family":"Tambeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7875-0691","authenticated-orcid":false,"given":"Felipe Meira","family":"de-Faria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Amilcar","family":"Parada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.04.030_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neulet.2007.03.025","article-title":"Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells","volume":"418","author":"Amazzal","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2018.04.030_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.abb.2008.06.017","article-title":"Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells","volume":"477","author":"Bhatia","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2018.04.030_bib3","doi-asserted-by":"crossref","first-page":"39511","DOI":"10.1074\/jbc.M110.159681","article-title":"Tumor necrosis factor alpha-induced inflammation is increased but apoptosis is inhibited by common food additive carrageenan","volume":"285","author":"Bhattacharyya","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.04.030_bib4","doi-asserted-by":"crossref","first-page":"10764","DOI":"10.1074\/jbc.M114.630053","article-title":"Carrageenan Inhibits Insulin Signaling through GRB10-mediated decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1","volume":"290","author":"Bhattacharyya","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.04.030_bib5","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jnutbio.2009.07.002","article-title":"Carrageenan-induced innate immune response is modified by enzymes that hydrolyze distinct galactosidic bonds","volume":"21","author":"Bhattacharyya","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ejphar.2018.04.030_bib6","doi-asserted-by":"crossref","first-page":"G829","DOI":"10.1152\/ajpgi.00380.2006","article-title":"Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells","volume":"292","author":"Borthakur","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2018.04.030_bib8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib9","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/j.1532-2149.2012.00240.x","article-title":"Neutrophils recruited by CXCR1\/2 signalling mediate post-incisional pain","volume":"17","author":"Carreira","year":"2013","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ejphar.2018.04.030_bib10","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1172\/JCI28075","article-title":"MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals","volume":"116","author":"Chen","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2018.04.030_bib11","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1476-5381.1991.tb12502.x","article-title":"Interleukin-8 as a mediator of sympathetic pain","volume":"104","author":"Cunha","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib12","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1189\/jlb.0907654","article-title":"Crucial role of neutrophils in the development of mechanical inflammatory hypernociception","volume":"83","author":"Cunha","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib13","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1073\/pnas.0409225102","article-title":"A cascade of cytokines mediates mechanical inflammatory hypernociception in mice","volume":"102","author":"Cunha","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2018.04.030_bib14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejphar.2010.09.037","article-title":"P2X3 and P2X2\/3 receptors mediate mechanical hyperalgesia induced by bradykinin, but not by pro-inflammatory cytokines, PGE(2) or dopamine","volume":"649","author":"de Oliveira Fusaro","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib15","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1523\/JNEUROSCI.5085-14.2015","article-title":"Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming","volume":"35","author":"Ferrari","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2018.04.030_bib16","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1111\/j.1476-5381.1993.tb13946.x","article-title":"Bradykinin initiates cytokine-mediated inflammatory hyperalgesia","volume":"110","author":"Ferreira","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib17","doi-asserted-by":"crossref","first-page":"19038","DOI":"10.1073\/pnas.0807922105","article-title":"Teleantagonism: a pharmacodynamic property of the primary nociceptive neuron","volume":"105","author":"Funez","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2018.04.030_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.phrs.2003.12.020","article-title":"Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production on macrophages and microglia by a standard aqueous extract of Mangifera indica L. (VIMANG). Role of mangiferin isolated from the extract","volume":"50","author":"Garrido","year":"2004","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2018.04.030_bib19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.phrs.2003.12.003","article-title":"In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG)","volume":"50","author":"Garrido","year":"2004","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2018.04.030_bib20","first-page":"4627","article-title":"Control of COX-2 gene expression through peroxisome proliferator-activated receptor gamma in human cervical cancer cells","volume":"9","author":"Han","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2018.04.030_bib21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ejphar.2013.08.004","article-title":"Mechanisms underlying the antinociceptive effect of mangiferin in the formalin test","volume":"718","author":"Izquierdo","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/0975-7406.94820","article-title":"Analgesic and cytotoxic activity of Acorus calamus L., Kigelia pinnata L., Mangifera indica L. and Tabernaemontana divaricata L","volume":"4","author":"Khan","year":"2012","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.ejphar.2018.04.030_bib23","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.intimp.2004.03.002","article-title":"Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin","volume":"4","author":"Leiro","year":"2004","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.archoralbio.2016.08.003","article-title":"Mangiferin inhibits lipopolysaccharide-induced production of interleukin-6 in human oral epithelial cells by suppressing toll-like receptor signaling","volume":"71","author":"Li","year":"2016","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib25","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.jpba.2011.03.012","article-title":"Structure elucidation of in vivo and in vitro metabolites of mangiferin","volume":"55","author":"Liu","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejphar.2018.04.030_bib26","first-page":"456","article-title":"Cytokine-induced neutrophil chemoattractant 1 (CINC-1) mediates the sympathetic component of inflammatory mechanical hypersensitivitiy in rats","volume":"13","author":"Lorenzetti","year":"2002","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.ejphar.2018.04.030_bib27","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.3748\/wjg.v16.i39.4922","article-title":"Anti-inflammatory effects of Mangifera indica L. extract in a model of colitis","volume":"16","author":"Marquez","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/1099-1573(200009)14:6<424::AID-PTR643>3.0.CO;2-8","article-title":"Evaluation of the in vitro antioxidant activity of Mangifera indica L. extract (Vimang)","volume":"14","author":"Martinez","year":"2000","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2018.04.030_bib29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.tox.2005.06.008","article-title":"Immunotherapeutic effects of mangiferin mediated by the inhibition of oxidative stress to activated lymphocytes, neutrophils and macrophages","volume":"215","author":"Muruganandan","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2018.04.030_bib30","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/biof.1299","article-title":"The potential role of mangiferin in cancer treatment through its immunomodulatory, anti-angiogenic, apoptopic, and gene regulatory effects","volume":"42","author":"Nunez Selles","year":"2016","journal-title":"Biofactors"},{"key":"10.1016\/j.ejphar.2018.04.030_bib31","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1021\/jf011064b","article-title":"Isolation and quantitative analysis of phenolic antioxidants, free sugars, and polyols from mango (Mangifera indica L.) stem bark aqueous decoction used in Cuba as a nutritional supplement","volume":"50","author":"Nunez Selles","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2018.04.030_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pain.2008.10.024","article-title":"Peripheral mechanisms underlying the essential role of P2X3,2\/3 receptors in the development of inflammatory hyperalgesia","volume":"141","author":"Oliveira","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2018.04.030_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ejphar.2015.12.006","article-title":"Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation","volume":"770","author":"Pan","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib34","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.4049\/jimmunol.170.2.1043","article-title":"Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors","volume":"170","author":"Pang","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib35","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/ptr.1813","article-title":"Mangifera indica L. extract (Vimang) inhibits 2-deoxyribose damage induced by Fe (III) plus ascorbate","volume":"20","author":"Pardo-Andreu","year":"2006","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2018.04.030_bib36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/1715163513481569","article-title":"Cardiovascular risk: are all NSAIDs alike?","volume":"146","author":"Pawlosky","year":"2013","journal-title":"Can. Pharm. J. (Ott.)"},{"key":"10.1016\/j.ejphar.2018.04.030_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.56499\/jppres14.050_3.1.13","article-title":"Acute and 28-day subchronic toxicity studies of mangiferin, a glucosyl xanthone isolated from Mangifera indica L. stem bark","volume":"3","author":"Prado","year":"2015","journal-title":"J. Pharm. Pharmacogn. Res."},{"key":"10.1016\/j.ejphar.2018.04.030_bib38","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s10753-016-0451-y","article-title":"Mangiferin inhibits IL-1beta-induced inflammatory response by activating PPAR-gamma in human osteoarthritis chondrocytes","volume":"40","author":"Qu","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2018.04.030_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainresrev.2008.12.020","article-title":"Role of interleukin-1beta during pain and inflammation","volume":"60","author":"Ren","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ejphar.2018.04.030_bib40","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1211\/jpp.58.3.0014","article-title":"Anti-allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin","volume":"58","author":"Rivera","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib41","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ab.2010.02.036","article-title":"Reversible Ponceau staining as a loading control alternative to actin in Western blots","volume":"401","author":"Romero-Calvo","year":"2010","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2018.04.030_bib42","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1476-5381.2008.00093.x","article-title":"The role of PKA and PKCepsilon pathways in prostaglandin E2-mediated hypernociception","volume":"156","author":"Sachs","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib43","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1476-5381.1995.tb15035.x","article-title":"Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia","volume":"115","author":"Safieh-Garabedian","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0006-8993(00)02596-8","article-title":"Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway","volume":"876","author":"Sammons","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2018.04.030_bib45","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1523\/JNEUROSCI.0233-08.2008","article-title":"Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons","volume":"28","author":"Schnizler","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2018.04.030_bib46","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.3892\/mmr.2016.4947","article-title":"Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells","volume":"13","author":"Shi","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2018.04.030_bib47","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/ar2143","article-title":"A pilot study of IL-1 inhibition by anakinra in acute gout","volume":"9","author":"So","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejphar.2018.04.030_bib48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejphar.2016.02.055","article-title":"Mangiferin protect myocardial insults through modulation of MAPK\/TGF-beta pathways","volume":"776","author":"Suchal","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib49","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cbi.2016.03.018","article-title":"Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase","volume":"251","author":"Takeda","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ejphar.2018.04.030_bib50","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.taap.2016.07.005","article-title":"Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model","volume":"306","author":"Takeda","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib51","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ejpain.2011.06.007","article-title":"Effect of gonadal steroid hormones on formalin-induced temporomandibular joint inflammation","volume":"16","author":"Torres-Chavez","year":"2012","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ejphar.2018.04.030_bib52","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2018.04.030_bib53","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/j.1471-4159.2009.06259.x","article-title":"Ciliary neurotrophic factor infused intracerebroventricularly shows reduced catabolic effects when linked to the TAT protein transduction domain","volume":"110","author":"Vieira","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2018.04.030_bib54","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.pbb.2012.11.006","article-title":"The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice","volume":"103","author":"Villarreal","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2018.04.030_bib55","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/sj.bjp.0705181","article-title":"Opposite nociceptive effects of the arginine\/NO\/cGMP pathway stimulation in dermal and subcutaneous tissues","volume":"138","author":"Vivancos","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.04.030_bib56","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1590\/S0100-879X2004000300017","article-title":"An electronic pressure-meter nociception paw test for rats","volume":"37","author":"Vivancos","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ejphar.2018.04.030_bib57","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/138955712800493870","article-title":"Perspectives on medicinal properties of mangiferin","volume":"12","author":"Vyas","year":"2012","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejphar.2018.04.030_bib58","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/bja\/aes431","article-title":"Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review and meta-analysis","volume":"110","author":"Waldron","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.ejphar.2018.04.030_bib59","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991830253X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991830253X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T11:23:03Z","timestamp":1720264983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429991830253X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":59,"alternative-id":["S001429991830253X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.04.030","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local administration of mangiferin prevents experimental inflammatory mechanical hyperalgesia through CINC-1\/epinephrine\/PKA pathway and TNF-\u03b1 inhibition","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}