{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:16:47Z","timestamp":1781090207099,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/09858-3"],"award-info":[{"award-number":["2015\/09858-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/02012-4"],"award-info":[{"award-number":["2016\/02012-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308144\/2014-7"],"award-info":[{"award-number":["308144\/2014-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ejphar.2018.05.046","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T19:04:24Z","timestamp":1527793464000},"page":"124-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Treatment with galectin-1 eye drops regulates mast cell degranulation and attenuates the severity of conjunctivitis"],"prefix":"10.1016","volume":"833","author":[{"given":"Claudia","family":"Mello-Bosnic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Dantas","family":"Gimenes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Maria","family":"Oliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Damas","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.05.046_bib1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/2040622315612745","article-title":"Ocular itch associated with allergic conjunctivitis: latest evidence and clinical management","volume":"7","author":"Ackerman","year":"2016","journal-title":"Ther. Adv. Chronic Dis."},{"key":"10.1016\/j.ejphar.2018.05.046_bib2","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.4049\/jimmunol.162.3.1685","article-title":"Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10","volume":"162","author":"Ajuebor","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib3","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri3495","article-title":"Mitogen-activated protein kinases in innate immunity","volume":"13","author":"Arthur","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib4","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2311::AID-IMMU2311>3.0.CO;2-G","article-title":"Beta-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells","volume":"28","author":"Blaser","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/jop.1993.9.321","article-title":"Effects of Mipragoside on ocular allergic inflammation in the rabbit","volume":"9","author":"Bucolo","year":"1993","journal-title":"J. Ocul. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.exer.2007.07.005","article-title":"IL-10 confers protection from mast cell degranulation in a mouse model of allergic conjunctivitis","volume":"85","author":"Bundoc","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2018.05.046_bib7","first-page":"1310","article-title":"Mast cells modulate the inflammatory process in endotoxin-induced uveitis","volume":"17","author":"Da Silva","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.ejphar.2018.05.046_bib8","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.jaci.2015.09.059","article-title":"IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3","volume":"137","author":"Desai","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib9","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/all.13334","article-title":"Clinical implications of mast cell involvement in allergic conjunctivitis","volume":"73","author":"Elieh Ali Komi","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.ejphar.2018.05.046_bib10","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jaci.2009.06.012","article-title":"Critical role of IgE-dependent mast cell activation in a murine model of allergic conjunctivitis","volume":"124","author":"Fukuda","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib11","doi-asserted-by":"crossref","first-page":"E4837","DOI":"10.1073\/pnas.1601958113","article-title":"Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1","volume":"113","author":"Ge","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2018.05.046_bib12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ejphar.2003.08.080","article-title":"Nadroparine inhibits the hypersensitivity response in the conjunctiva","volume":"481","author":"Giannoulaki","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00011-005-0059-4","article-title":"Inflammation-induced modulation of cellular galectin-1 and-3 expression in a model of rat peritonitis","volume":"55","author":"Gil","year":"2006","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.ejphar.2018.05.046_bib14","first-page":"74","article-title":"Effect of exogenous galectin-1 on leukocyte migration: modulation of cytokine levels and adhesion molecules","volume":"4","author":"Gil","year":"2011","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib15","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.cellbi.2005.12.010","article-title":"Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3","volume":"30","author":"Gil","year":"2006","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ejphar.2018.05.046_bib16","doi-asserted-by":"crossref","first-page":"17946","DOI":"10.1038\/srep17946","article-title":"Aflibercept traps galectin-1, an angiogenic factor associated with diabetic retinopathy","volume":"5","author":"Kanda","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2018.05.046_bib17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/00003226-200001000-00017","article-title":"The role of nitric oxide in experimental allergic conjunctivitis","volume":"19","author":"Ko","year":"2000","journal-title":"Cornea"},{"key":"10.1016\/j.ejphar.2018.05.046_bib18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/cbf.2973","article-title":"Cyclical mechanical stretch enhances degranulation and IL-4 secretion in RBL-2H3 mast cells","volume":"32","author":"Komiyama","year":"2014","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.ejphar.2018.05.046_bib19","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0002-9440(10)63507-9","article-title":"A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation","volume":"163","author":"La","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib20","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1023\/B:GLYC.0000014072.34840.04","article-title":"Introduction to galectins","volume":"19","author":"Leffler","year":"2002","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.ejphar.2018.05.046_bib21","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1365-2222.2006.02499.x","article-title":"Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures","volume":"36","author":"Leonardi","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2018.05.046_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/clin.1997.4507","article-title":"A novel murine model of allergic conjunctivitis","volume":"87","author":"Magone","year":"1998","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib23","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1167\/iovs.14-15100","article-title":"Immunomodulatory effects of galectin-1 on an IgE-mediated allergic conjunctivitis model","volume":"56","author":"Mello","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2018.05.046_bib24","first-page":"1525","article-title":"Conjunctival mast cell as a mediator of eosinophilic response in ocular allergy","volume":"14","author":"Miyazaki","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.ejphar.2018.05.046_bib25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1677\/JOE-08-0512","article-title":"Endogenous galectins and the control of the host inflammatory response","volume":"201","author":"Norling","year":"2009","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib26","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1096\/fj.07-9268com","article-title":"Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking","volume":"22","author":"Norling","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2018.05.046_bib27","first-page":"451","article-title":"Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness","volume":"54","author":"Owen","year":"2004","journal-title":"Br. J. Gen. Pract."},{"key":"10.1016\/j.ejphar.2018.05.046_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/jop.2010.0147","article-title":"Effect of aminoguanidine on the conjunctival histamine and nitrite levels in experimental conjunctivitis","volume":"27","author":"Papathanassiou","year":"2011","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2018.05.046_bib29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1084\/jem.190.3.385","article-title":"Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis","volume":"190","author":"Rabinovich","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2018.05.046_bib30","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.4049\/jimmunol.160.10.4831","article-title":"Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization","volume":"160","author":"Rabinovich","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib31","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.4049\/jimmunol.1103063","article-title":"Galectin-1 reduces the severity of herpes simplex virus-induced ocular immunopathological lesions","volume":"188","author":"Rajasagi","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib32","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1167\/iovs.05-1234","article-title":"Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis","volume":"47","author":"Romero","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2018.05.046_bib33","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0016-5085(03)00267-1","article-title":"Galectin-1 suppresses experimental colitis in mice","volume":"124","author":"Santucci","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2018.05.046_bib34","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.4049\/jimmunol.1701172","article-title":"Galectin-1: a jack-of-all-trades in the resolution of acute and chronic inflammation","volume":"199","author":"Sundblad","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib35","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.4049\/jimmunol.1203501","article-title":"Galectin-1-mediated suppression of Pseudomonas aeruginosa-induced corneal immunopathology","volume":"190","author":"Suryawanshi","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib36","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1006\/phrs.1999.0637","article-title":"Changes in histamine content following pharmacologically-induced mast cell degranulation in the rat conjunctiva","volume":"41","author":"Tiligada","year":"2000","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2018.05.046_bib37","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.4049\/jimmunol.176.10.6323","article-title":"Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses","volume":"176","author":"Toscano","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib38","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0002-9394(81)90178-1","article-title":"Animal and human ocular surface response to a topical nonimmune mast-cell degranulating agent (compound 48\/80)","volume":"91","author":"Udell","year":"1981","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2172-15-9","article-title":"Exogenous interleukin-10 alleviates allergic inflammation but inhibits local interleukin-10 expression in a mouse allergic rhinitis model","volume":"15","author":"Wang","year":"2014","journal-title":"BMC Immunol."},{"key":"10.1016\/j.ejphar.2018.05.046_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2017.02.015","article-title":"Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy","volume":"159","author":"Yang","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2018.05.046_bib41","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1172\/JCI43598","article-title":"Identification of an IFN-\u03b3\/mast cell axis in a mouse model of chronic asthma","volume":"121","author":"Yu","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2018.05.046_bib42","first-page":"1036","article-title":"Protective effects of the galectin-1 protein on in vivo and in vitro models of ocular inflammation","volume":"21","author":"Zanon","year":"2015","journal-title":"Mol. Vis."},{"key":"10.1016\/j.ejphar.2018.05.046_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1189\/jlb.70.1.73","article-title":"Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis","volume":"70","author":"Zu\u00f1iga","year":"2001","journal-title":"J. Leukoc. Biol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918303169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918303169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T22:46:12Z","timestamp":1693694772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299918303169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":43,"alternative-id":["S0014299918303169"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.05.046","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment with galectin-1 eye drops regulates mast cell degranulation and attenuates the severity of conjunctivitis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.05.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}