{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:33:47Z","timestamp":1778999627190,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Projects of Medical and Health Technology Development Program in Shandong, China","award":["2013WSB01025"],"award-info":[{"award-number":["2013WSB01025"]}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2016HB09"],"award-info":[{"award-number":["ZR2016HB09"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601421"],"award-info":[{"award-number":["81601421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ejphar.2018.06.003","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T08:40:04Z","timestamp":1528274404000},"page":"210-220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Thymol alleviates lipopolysaccharide-stimulated inflammatory response via downregulation of RhoA-mediated NF-\u03baB signalling pathway in human peritoneal mesothelial cells"],"prefix":"10.1016","volume":"833","author":[{"given":"Qinglian","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fajuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.06.003_bib1","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1681\/ASN.2006111292","article-title":"Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions","volume":"18","author":"Aroeira","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2018.06.003_bib2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cardiores.2003.12.004","article-title":"Inhibition of Rho-kinase protects the heart against ischemia\/reperfusion injury","volume":"61","author":"Bao","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.06.003_bib3","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.4049\/jimmunol.157.6.2577","article-title":"In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes","volume":"157","author":"Bellingan","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.06.003_bib4","first-page":"28","article-title":"Changes in peritoneal membrane after continuous ambulatory peritoneal dialysis--a histopathological study","volume":"15","author":"Bertoli","year":"1999","journal-title":"Adv. Perit. Dial."},{"key":"10.1016\/j.ejphar.2018.06.003_bib5","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/ndt\/gfu313","article-title":"Prevention of peritoneal dialysis-related infections","volume":"30","author":"Campbell","year":"2015","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.ejphar.2018.06.003_bib6","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3109\/10715762.2015.1087643","article-title":"Effects of esculetin on lipopolysaccharide (LPS)-induced acute lung injury via regulation of RhoA\/Rho Kinase\/NF-small ka, CyrillicB pathways in vivo and in vitro","volume":"49","author":"Chen","year":"2015","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.ejphar.2018.06.003_bib7","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1681\/ASN.2009070694","article-title":"The pathophysiology of the peritoneal membrane","volume":"21","author":"Devuyst","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2018.06.003_bib8","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","article-title":"Rho GTPases in cell biology","volume":"420","author":"Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2018.06.003_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/1547691X.2015.1029145","article-title":"Modulatory effects of thymol and carvacrol on inflammatory transcription factors in lipopolysaccharide-treated macrophages","volume":"13","author":"Gholijani","year":"2016","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.ejphar.2018.06.003_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.0105-2896.2006.00375.x","article-title":"Circuitry of nuclear factor kappaB signaling","volume":"210","author":"Hoffmann","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ejphar.2018.06.003_bib11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ejphar.2017.01.021","article-title":"Rho-kinase inhibitor prevents acute injury against transient focal cerebral ischemia by enhancing the expression and function of GABA receptors in rats","volume":"797","author":"Huang","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.06.003_bib12","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1074-7613(01)00151-0","article-title":"Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation","volume":"14","author":"Hurst","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2018.06.003_bib13","first-page":"1289","article-title":"Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4","volume":"15","author":"Kato","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2018.06.003_bib14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejphar.2018.06.003_bib15","doi-asserted-by":"crossref","first-page":"e0159459","DOI":"10.1371\/journal.pone.0159459","article-title":"Chitin-induced airway epithelial cell innate immune responses are inhibited by carvacrol\/thymol","volume":"11","author":"Khosravi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2018.06.003_bib16","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1074\/jbc.M113.520130","article-title":"IkappaB kinase gamma\/nuclear factor-kappaB-essential modulator (IKKgamma\/NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated KINASE (ROCK) to phosphorylate IKKbeta in response to transforming growth factor (TGF)-beta1","volume":"289","author":"Kim","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.06.003_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1523-1755.1999.00264.x","article-title":"The peritoneal membrane in chronic peritoneal dialysis","volume":"55","author":"Krediet","year":"1999","journal-title":"Kidney Int."},{"issue":"Suppl 4","key":"10.1016\/j.ejphar.2018.06.003_bib18","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1177\/089686080002004S03","article-title":"Pathophysiology of peritoneal membrane failure","volume":"20","author":"Krediet","year":"2000","journal-title":"Perit. Dial. Int."},{"key":"10.1016\/j.ejphar.2018.06.003_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/lt.24020","article-title":"Rho-kinase inhibitor targeting the liver prevents ischemia\/reperfusion injury in the steatotic liver without major systemic adversity in rats","volume":"21","author":"Kuroda","year":"2015","journal-title":"Liver Transpl."},{"key":"10.1016\/j.ejphar.2018.06.003_bib20","article-title":"TLR4 signaling pathway modulators as potential therapeutics in inflammation and sepsis","volume":"5","author":"Kuzmich","year":"2017","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.ejphar.2018.06.003_bib21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cyto.2007.04.006","article-title":"Differential cytokine and chemokine responses of bovine mammary epithelial cells to Staphylococcus aureus and Escherichia coli","volume":"38","author":"Lahouassa","year":"2007","journal-title":"Cytokine"},{"key":"10.1016\/j.ejphar.2018.06.003_bib22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s10753-013-9732-x","article-title":"Thymol inhibits LPS-stimulated inflammatory response via down-regulation of NF-kappaB and MAPK signaling pathways in mouse mammary epithelial cells","volume":"37","author":"Liang","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2018.06.003_bib23","doi-asserted-by":"crossref","first-page":"F1088","DOI":"10.1152\/ajprenal.90746.2008","article-title":"Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling","volume":"296","author":"Meyer-Schwesinger","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ejphar.2018.06.003_bib24","doi-asserted-by":"crossref","first-page":"12779","DOI":"10.1074\/jbc.273.21.12779","article-title":"Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases","volume":"273","author":"Montaner","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.06.003_bib25","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3389\/fphar.2017.00380","article-title":"Pharmacological properties and molecular mechanisms of thymol: prospects for its therapeutic potential and pharmaceutical development","volume":"8","author":"Nagoor Meeran","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.06.003_bib26","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.athoracsur.2016.07.067","article-title":"Protective effect of inhaled rho-kinase inhibitor on lung ischemia-reperfusion injury","volume":"103","author":"Ohata","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.ejphar.2018.06.003_bib27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of toll-like receptors \u2013 redefining innate immunity","volume":"13","author":"O'Neill","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2018.06.003_bib28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1101\/gad.11.4.463","article-title":"Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins","volume":"11","author":"Perona","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejphar.2018.06.003_bib29","doi-asserted-by":"crossref","first-page":"932340","DOI":"10.1155\/2014\/932340","article-title":"p120 modulates LPS-induced NF-kappaB activation partially through RhoA in bronchial epithelial cells","volume":"2014","author":"Qin","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ejphar.2018.06.003_bib30","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/S0016-5085(03)00283-X","article-title":"Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis","volume":"124","author":"Segain","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2018.06.003_bib31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/01.TP.0000128618.41619.E7","article-title":"Involvement of Rho-kinase in cold ischemia-reperfusion injury after liver transplantation in rats","volume":"78","author":"Shiotani","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.ejphar.2018.06.003_bib32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.exer.2008.03.012","article-title":"Focus on molecules: nuclear factor-kappaB","volume":"88","author":"Srivastava","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2018.06.003_bib33","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ki.1993.36","article-title":"Human peritoneal mesothelial cells synthesize interleukin-6: induction by IL-1 beta and TNF alpha","volume":"43","author":"Topley","year":"1993","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2018.06.003_bib34","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1177\/1479164116687935","article-title":"Inhibition of Rho kinase protects from ischaemia-reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes","volume":"14","author":"Tratsiakovich","year":"2017","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"10.1016\/j.ejphar.2018.06.003_bib35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10753-017-0676-4","article-title":"Preventive and therapeutic effects of thymol in a lipopolysaccharide-induced acute lung injury mice model","volume":"41","author":"Wan","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2018.06.003_bib36","article-title":"Rho kinase inhibitor, fasudil, attenuates contrast-induced acute kidney injury","author":"Wang","year":"2017","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2018.06.003_bib37","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00109-002-0370-2","article-title":"Rho\/Rho-kinase mediated signaling in physiology and pathophysiology","volume":"80","author":"Wettschureck","year":"2002","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.ejphar.2018.06.003_bib38","doi-asserted-by":"crossref","first-page":"20042","DOI":"10.18632\/oncotarget.15373","article-title":"Thymol mitigates lipopolysaccharide-induced endometritis by regulating the TLR4- and ROS-mediated NF-kappaB signaling pathways","volume":"8","author":"Wu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2018.06.003_bib39","doi-asserted-by":"crossref","first-page":"27583","DOI":"10.1038\/srep27583","article-title":"Abrogating ClC-3 inhibits LPS-induced inflammation via blocking the TLR4\/NF-kappaB pathway","volume":"6","author":"Xiang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2018.06.003_bib40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.micpath.2017.12.065","article-title":"Protective effects of thymol on LPS-induced acute lung injury in mice","volume":"116","author":"Yao","year":"2017","journal-title":"Microb. Pathog."},{"issue":"Suppl 2","key":"10.1016\/j.ejphar.2018.06.003_bib41","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1177\/089686080902902S03","article-title":"Intrinsic cells: mesothelial cells \u2013 central players in regulating inflammation and resolution","volume":"29","author":"Yung","year":"2009","journal-title":"Perit. Dial. Int."},{"key":"10.1016\/j.ejphar.2018.06.003_bib42","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/089686080602600207","article-title":"Peritoneal mesothelial cell culture and biology","volume":"26","author":"Yung","year":"2006","journal-title":"Perit. Dial. Int."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918303224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918303224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T00:58:10Z","timestamp":1693702690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299918303224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":42,"alternative-id":["S0014299918303224"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.06.003","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thymol alleviates lipopolysaccharide-stimulated inflammatory response via downregulation of RhoA-mediated NF-\u03baB signalling pathway in human peritoneal mesothelial cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}