{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:39:26Z","timestamp":1791830366756,"version":"4.3.4"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Anonymous Trust"},{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","award":["94\/S18744"],"award-info":[{"award-number":["94\/S18744"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","award":["BBS\/Q\/Q2004\/05599"],"award-info":[{"award-number":["BBS\/Q\/Q2004\/05599"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/15\/28\/31384"],"award-info":[{"award-number":["PG\/15\/28\/31384"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/11\/106\/29235"],"award-info":[{"award-number":["PG\/11\/106\/29235"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG08\/106\/26155"],"award-info":[{"award-number":["PG08\/106\/26155"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/07\/062\/23278"],"award-info":[{"award-number":["PG\/07\/062\/23278"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/04\/096\/17627"],"award-info":[{"award-number":["PG\/04\/096\/17627"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"MRC","doi-asserted-by":"publisher","award":["G0400608"],"award-info":[{"award-number":["G0400608"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["059528"],"award-info":[{"award-number":["059528"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ejphar.2018.06.029","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T01:36:12Z","timestamp":1529544972000},"page":"314-319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Cardioprotective signalling: Past, present and future"],"prefix":"10.1016","volume":"833","author":[{"given":"Aleksandar","family":"Jovanovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.06.029_bib1","doi-asserted-by":"crossref","first-page":"H470","DOI":"10.1152\/ajpheart.00800.2009","article-title":"Obestatin affords cardioprotection to the ischemic-reperfused isolated rat heart and inhibits apoptosis in cultures of similarly stressed cardiomyocytes","volume":"299","author":"Alloatti","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.biocel.2012.10.005","article-title":"Testosterone protects female embryonic heart H9C2 cells against severe metabolic stress by activating estrogen receptors and up-regulating IES SUR2B","volume":"45","author":"Ballantyne","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-3-319-55330-6_12","article-title":"Connexin 43 and mitochondria in cardiovascular health and disease","volume":"982","author":"Boengler","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib4","doi-asserted-by":"crossref","first-page":"H1764","DOI":"10.1152\/ajpheart.01071.2006","article-title":"Loss of ischemic preconditioning's cardioprotection in aged mouse hearts is associated with reduced gap junctional and mitochondrial levels of connexin 43","volume":"292","author":"Boengler","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/cvr\/cvq154","article-title":"Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury","volume":"88","author":"Budas","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib6","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1096\/fj.04-1602fje","article-title":"Hypoxia-induced preconditioning in adult stimulated cardiomyocytes is mediated by the opening and trafficking of sarcolemmal KATP channels","volume":"18","author":"Budas","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2018.06.029_bib7","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1096\/fj.06-6252fje","article-title":"3'phosphoinositide-dependent kinase-1 (PDK1) is essential for ischaemic preconditioning of the myocardium","volume":"20","author":"Budas","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2018.06.029_bib8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/cvr\/cvq082","article-title":"Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia\/reperfusion injury via anti-apoptosis through its target PDCD4","volume":"87","author":"Cheng","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib9","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1111\/bph.12903","article-title":"Signalling pathways and mechanisms of protection in pre- and postconditioning: historical perspective and lessons for the future","volume":"172","author":"Cohen","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib10","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s00395-008-0737-9","article-title":"Acidosis, oxygen, and interference with mitochondrial permeability transition pore formation in the early minutes of reperfusion are critical to postconditioning's success","volume":"103","author":"Cohen","year":"2008","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/hh1501.094266","article-title":"Acetylcholine, bradykinin, opioids, and phenylephrine, but not adenosine, trigger preconditioning by generating free radicals and opening mitochondrial KATP channels","volume":"89","author":"Cohen","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib12","doi-asserted-by":"crossref","first-page":"31444","DOI":"10.1074\/jbc.M303051200","article-title":"Chronic mild hypoxia protects heart-derived H9c2 cells against acute hypoxia\/reoxygenation by regulating expression of the SUR2A subunit of the ATP-sensitive K+ channels","volume":"278","author":"Crawford","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.06.029_bib13","doi-asserted-by":"crossref","first-page":"H1592","DOI":"10.1152\/ajpheart.00902.2002","article-title":"B-type natriuretic peptide limits infarct size in rat isolated hearts via KATP channel opening","volume":"284","author":"D'Souza","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/cvr\/cvq084","article-title":"Direct evidence of chloride ion efflux in ischaemic and pharmacological preconditioning of cultured cardiomyocytes","volume":"87","author":"Diaz","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbamcr.2010.01.018","article-title":"Infection with AV-SUR2A protects H9C2 cells against metabolic stress: a mechanism of SUR2A-mediated cytoprotection independent from the KATP channels activity","volume":"1803","author":"Du","year":"2010","journal-title":"Biochim. Biophys. Acta-Mol. Cell Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib16","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1006\/jmcc.2001.1418","article-title":"AlphaB crystallin translocation and phosphorylation: signal transduction pathways and preconditioning in the isolated rat heart","volume":"33","author":"Eaton","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib17","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/0006-291X(92)90698-K","article-title":"Tumor necrosis factor-alpha pretreatment is protective in a rat model of myocardial ischemia-reperfusion injury","volume":"184","author":"Eddy","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2018.06.029_bib18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ejphar.2016.08.001","article-title":"Ranolazine triggers pharmacological preconditioning and postconditioning in anesthetized rabbits through activation of RISK pathway","volume":"789","author":"Efentakis","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1152\/physrev.00003.2015","article-title":"KATP channels in the cardiovascular system","volume":"96","author":"Foster","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2018.06.029_bib20","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.yjmcc.2008.11.019","article-title":"Cardioprotective signaling to mitochondria","volume":"46","author":"Garlid","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib21","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/01.RES.81.6.1072","article-title":"Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection","volume":"81","author":"Garlid","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib22","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1161\/01.CIR.94.9.2193","article-title":"Myocardial protection by brief ischemia in noncardiac tissue","volume":"94","author":"Gho","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.06.029_bib23","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2147\/DDDT.S127916","article-title":"Cardioprotection with halogenated gases: how does it occur?","volume":"11","author":"Guerrero-Orriach","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejphar.2018.06.029_bib24","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1007\/s11033-013-2495-5","article-title":"Hexokinase cellular trafficking in ischemia-reperfusion and ischemic preconditioning is altered in type I diabetic heart","volume":"40","author":"Gurel","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ejphar.2018.06.029_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00395-018-0670-5","article-title":"The SAFE pathway for cardioprotection: is this a promising target?","volume":"113","author":"Hadebe","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib26","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1111\/bph.12899","article-title":"The role of hexokinase in cardioprotection - mechanism and potential for translation","volume":"172","author":"Halestrap","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib27","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCRESAHA.116.305348","article-title":"Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning","volume":"116","author":"Heusch","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib28","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/CIRCRESAHA.116.308736","article-title":"Time to give up on cardioprotection? A critical appraisal of clinical studies on ischemic pre-, post-, and remote conditioning","volume":"119","author":"Heusch","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib29","doi-asserted-by":"crossref","first-page":"H1567","DOI":"10.1152\/ajpheart.1998.275.5.H1567","article-title":"Mitochondrial ATP-sensitive K+ channels modulate cardiac mitochondrial function","volume":"275","author":"Holmuhamedov","year":"1998","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00395-015-0516-3","article-title":"Activation of mitochondrial STAT-3 and reduced mitochondria damage during hypothermia treatment for post-cardiac arrest myocardial dysfunction","volume":"110","author":"Huang","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cardiores.2004.06.001","article-title":"Ischemic preconditioning attenuates calpain-mediated degradation of structural proteins through a protein kinase A-dependent mechanism","volume":"64","author":"Inserte","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/00003246-199102000-00021","article-title":"Cardioprotective effects of authentic nitric oxide in myocardial ischemia with reperfusion","volume":"19","author":"Johnson","year":"1991","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ejphar.2018.06.029_bib33","first-page":"639","article-title":"Pinacidil prevents membrane depolarisation and intracellular Ca2+ loading in single cardiomyocytes exposed to severe metabolic stress","volume":"7","author":"Jovanovi\u0107","year":"2001","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2018.06.029_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biocel.2015.10.029","article-title":"Phenylephrine preconditioning in embryonic heart H9c2 cells is mediated by up-regulation of SUR2B\/Kir6.2: a first evidence for functional role of SUR2B in sarcolemmal KATP channels and cardioprotection","volume":"70","author":"Jovanovi\u0107","year":"2016","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib35","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1096\/fasebj.13.8.923","article-title":"Gene delivery of Kir6.2\/SUR2A in conjunction with pinacidil handles intracellular Ca2+ homeostasis under metabolic stress","volume":"13","author":"Jovanovi\u0107","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2018.06.029_bib36","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1016\/j.biocel.2009.05.012","article-title":"M-LDH physically associated with sarcolemmal KATP channels mediates cytoprotection in heart embryonic H9C2 cells","volume":"41","author":"Jovanovi\u0107","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib37","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.bbamcr.2009.04.007","article-title":"Dual mechanism of cytoprotection afforded by M-LDH in embryonic heart H9C2 cells","volume":"1793","author":"Jovanovi\u0107","year":"2009","journal-title":"Biochim. Biophys. Acta-Mol. Cell Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib38","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1006\/abbi.1999.1337","article-title":"Cell-permeable superoxide dismutase and glutathione peroxidase mimetics afford superior protection against doxorubicin-induced cardiotoxicity: the role of reactive oxygen and nitrogen intermediates","volume":"15","author":"Konorev","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2018.06.029_bib39","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jtcvs.2013.01.005","article-title":"Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ischemic preconditioning during coronary artery bypass grafting","volume":"147","author":"Kottenberg","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.ejphar.2018.06.029_bib40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/cvr\/cvp274","article-title":"Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway","volume":"84","author":"Lacerda","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib41","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1161\/CIRCULATIONAHA.105.581058","article-title":"Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase)","volume":"112","author":"Lecour","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.06.029_bib42","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.3892\/mmr.2014.3042","article-title":"Protein kinase C signaling pathway involvement in cardioprotection during isoflurane pretreatment","volume":"11","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2018.06.029_bib43","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00395-014-0423-z","article-title":"MicroRNA-144 is a circulating effector of remote ischemic preconditioning","volume":"109","author":"Li","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yexcr.2017.03.037","article-title":"MicroRNA-133 mediates cardiac diseases: mechanisms and clinical implications","volume":"354","author":"Liu","year":"2017","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib45","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0022-2828(95)90038-1","article-title":"Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts","volume":"27","author":"Liu","year":"1995","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib46","doi-asserted-by":"crossref","first-page":"e12978","DOI":"10.1111\/apha.12978","article-title":"Molecular pathways of oestrogen receptors and \u03b2-adrenergic receptors in cardiac cells: recognition of their similarities, interactions and therapeutic value","volume":"222","author":"Machuki","year":"2018","journal-title":"Acta Physiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib47","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1111\/bph.12901","article-title":"p38 MAPK in cardioprotection - are we there yet?","volume":"172","author":"Martin","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib48","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0008-6363(96)00078-8","article-title":"Norepinephrine induces cardiac heat shock protein 70 and delayed cardioprotection in the rat through alpha 1 adrenoceptors","volume":"32","author":"Meng","year":"1996","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib49","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/jcp.24565","article-title":"Cardioprotective role of P38 MAPK during myocardial infarction via parallel activation of \u03b1-crystallin B and Nrf2","volume":"229","author":"Mitra","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib50","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1016\/j.bbamcr.2014.07.007","article-title":"Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen","volume":"1843","author":"Mohammed Abdul","year":"2014","journal-title":"Biochim. Biophys. Acta-Mol. Cell. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib51","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bbadis.2015.01.001","article-title":"Mild hypoxia in vivo regulates cardioprotective SUR2A: a role for Akt and LDH","volume":"1852","author":"Mohammed Abdul","year":"2015","journal-title":"Biochim. Biophys. Acta-Mol. Basis Dis."},{"key":"10.1016\/j.ejphar.2018.06.029_bib52","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijcard.2015.04.069","article-title":"A link between ATP and SUR2A: a novel mechanism explaining cardioprotection at high altitude","volume":"189","author":"Mohammed Abdul","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib53","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/jcmm.13064","article-title":"Exposure to 15% oxygen in vivo up-regulates cardioprotective SUR2A without affecting ERK1\/2 and Akt: a crucial role for AMPK","volume":"21","author":"Mohammed Abdul","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejphar.2018.06.029_bib54","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2121-14-40","article-title":"Respiratory uncoupling by increased H(+) or K(+) flux is beneficial for heart mitochondrial turnover of reactive oxygen species but not for permeability transition","volume":"14","author":"Morota","year":"2013","journal-title":"BMC Cell. Biol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib55","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.06.029_bib56","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1161\/01.RES.79.1.137","article-title":"Calcium preconditioning elicits strong protection against ischemic injury via protein kinase C signaling pathway","volume":"79","author":"Miyawaki","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib57","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1042\/CS20160036","article-title":"Protein kinase C mechanisms that contribute to cardiac remodelling","volume":"130","author":"Newton","year":"2016","journal-title":"Clin. Sci."},{"key":"10.1016\/j.ejphar.2018.06.029_bib58","first-page":"398","article-title":"Infarct size limitation by adrenomedullin: protein kinase A but not PI3-kinase is linked to mitochondrial KCa channels","volume":"77","author":"Nishida","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib59","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1161\/CIRCRESAHA.107.169953","article-title":"Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse","volume":"103","author":"Nishino","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib60","doi-asserted-by":"crossref","first-page":"H537","DOI":"10.1152\/ajpheart.00071.2006","article-title":"Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury","volume":"291","author":"Nithipatikom","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib61","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/1440-1681.12816","article-title":"Angiotensin II-preconditioning is associated with increased PKC\u03b5\/PKC\u03b4 ratio and prosurvival kinases in mitochondria","volume":"44","author":"Nu\u00f1ez","year":"2017","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"32","key":"10.1016\/j.ejphar.2018.06.029_bib62","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0143-4179(98)90033-6","article-title":"Expression and protective effects of urocortin in cardiac myocytes","volume":"1998","author":"Okosi","year":"1998","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2018.06.029_bib63","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/14728222.2018.1439015","article-title":"Non-coding RNAs as therapeutic targets for preventing myocardial ischemia-reperfusion injury","volume":"22","author":"Ong","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejphar.2018.06.029_bib64","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yjmcc.2014.11.005","article-title":"The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury","volume":"78","author":"Ong","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF01816946","article-title":"Basic fibroblast growth factor is cardioprotective in ischemia-reperfusion injury","volume":"143","author":"Padua","year":"1995","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2018.06.029_bib66","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1213\/ane.0b013e318193e934","article-title":"Transient metabolic alkalosis during early reperfusion abolishes helium preconditioning against myocardial infarction: restoration of cardioprotection by cyclosporin A in rabbits","volume":"108","author":"Pagel","year":"2009","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2018.06.029_bib67","doi-asserted-by":"crossref","first-page":"67227","DOI":"10.18632\/oncotarget.18438","article-title":"Intrinsic remote conditioning of the myocardium as a comprehensive cardiac response to ischemia and reperfusion","volume":"8","author":"Pavo","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2018.06.029_bib68","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4331\/wjbc.v5.i2.231","article-title":"Regulation and function of signal transducer and activator of transcription 3","volume":"5","author":"Qi","year":"2014","journal-title":"World J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.06.029_bib69","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/01.RES.0000230315.56904.de","article-title":"Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection","volume":"99","author":"Rodriguez-Sinovas","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib70","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00395-017-0662-x","article-title":"The RISK pathway and beyond","volume":"113","author":"Rossello","year":"2017","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib71","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/01.CIR.0000133390.12306.C7","article-title":"Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C","volume":"110","author":"Sanada","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.06.029_bib72","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/CIRCRESAHA.107.148791","article-title":"Enhancing repair of the mammalian heart","volume":"100","author":"Santini","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib73","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1161\/01.CIR.101.20.2418","article-title":"Selective pharmacological agents implicate mitochondrial but not sarcolemmal K(ATP) channels in ischemic cardioprotection","volume":"101","author":"Sato","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.06.029_bib74","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.pharmthera.2015.06.005","article-title":"Connexin 43 is an emerging therapeutic target in ischemia\/reperfusion injury, cardioprotection and neuroprotection","volume":"153","author":"Schulz","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2018.06.029_bib75","first-page":"1263","article-title":"Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim. Biophys","volume":"1813","author":"Semenza","year":"2011","journal-title":"Acta-Mol. Cell. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib76","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/1074248413494814","article-title":"Role of protein kinase C in ischemic \"conditioning\": from first evidence to current perspectives","volume":"18","author":"Simkhovich","year":"2013","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2018.06.029_bib77","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCRESAHA.117.306878","article-title":"Across-species transfer of protection by remote ischemic preconditioning with species-specific myocardial signal transduction by reperfusion injury salvage kinase and survival activating factor enhancement pathways","volume":"117","author":"Skyschally","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib78","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jtcvs.2008.08.074","article-title":"Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia\/reperfusion injury","volume":"138","author":"Sodha","year":"2009","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.ejphar.2018.06.029_bib79","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.phrs.2010.01.008","article-title":"Nicotinamide-rich diet protects the heart against ischaemia-reperfusion in mice: a crucial role for cardiac SUR2A","volume":"61","author":"Sukhodub","year":"2010","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib80","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1111\/j.1582-4934.2010.01156.x","article-title":"Nicotinamide-rich diet improves physical endurance by upregulating SUR2A in the heart","volume":"15","author":"Sukhodub","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejphar.2018.06.029_bib81","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/jcp.20862","article-title":"AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K+ channels","volume":"210","author":"Sukhodub","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib82","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/cvr\/cvn067","article-title":"Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning","volume":"79","author":"Suleman","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib83","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/cvr\/cvr315","article-title":"Myocardial protection with mild hypothermia","volume":"94","author":"Tissier","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib84","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/01.CIR.86.3.986","article-title":"Myocardial protective effects of adenosine. infarct size reduction with pretreatment and continued receptor stimulation during ischemia","volume":"86","author":"Toombs","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.06.029_bib85","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-3-319-55330-6_18","article-title":"Nitrite-nitric oxide signaling and cardioprotection","volume":"982","author":"Totzeck","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib86","doi-asserted-by":"crossref","first-page":"e75872","DOI":"10.1371\/journal.pone.0075872","article-title":"Ischemic postconditioning-mediated miRNA-21 protects against cardiac ischemia\/reperfusion injury via PTEN\/Akt pathway","volume":"8","author":"Tu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2018.06.029_bib87","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1006\/jmcc.1996.0054","article-title":"Pretreatment with endothelin-1 mimics ischemic preconditioning against infarction in isolated rabbit heart","volume":"28","author":"Wang","year":"1996","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib88","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/cvr\/cvs096","article-title":"Loss of the miR-144\/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1","volume":"94","author":"Wang","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib89","doi-asserted-by":"crossref","first-page":"703","DOI":"10.17219\/acem\/62693","article-title":"Stat proteins as intracellular regulators of resistance to myocardial injury in the context of cardiac remodeling and targeting for therapy","volume":"26","author":"Wincewicz","year":"2017","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.ejphar.2018.06.029_bib90","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.yjmcc.2013.10.016","article-title":"Zinc plays a critical role in the cardioprotective effect of postconditioning by enhancing the activation of the RISK pathway in rat hearts","volume":"66","author":"Xu","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib91","doi-asserted-by":"crossref","first-page":"H2484","DOI":"10.1152\/ajpheart.00590.2005","article-title":"Protein kinase C and preconditioning: role of the sarcoplasmic reticulum","volume":"289","author":"Yamamura","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib92","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1161\/01.CIR.98.14.1414","article-title":"Whole-body hyperthermia provides biphasic cardioprotection against ischemia\/reperfusion injury in the rat","volume":"98","author":"Yamashita","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.06.029_bib93","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/14728222.2017.1275566","article-title":"Tackling myocardial ischemic injury: the signal transducer and activator of transcription 3 (STAT3) at a good site","volume":"21","author":"Yang","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejphar.2018.06.029_bib94","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1161\/01.RES.73.6.1193","article-title":"Role of nitric oxide, muscarinic receptors, and the ATP-sensitive K+ channel in mediating the effects of acetylcholine to mimic preconditioning in dogs","volume":"73","author":"Yao","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.06.029_bib95","doi-asserted-by":"crossref","first-page":"H579","DOI":"10.1152\/ajpheart.01064.2002","article-title":"Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning","volume":"285","author":"Zhao","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2018.06.029_bib96","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejphar.2017.08.019","article-title":"Tetrandrine cardioprotection in ischemia-reperfusion (I\/R) injury via JAK3\/STAT3\/Hexokinase II","volume":"813","author":"Zhang","year":"2017","journal-title":"Eur. J. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918303649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918303649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T07:06:24Z","timestamp":1751699184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299918303649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":96,"alternative-id":["S0014299918303649"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.06.029","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardioprotective signalling: Past, present and future","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.06.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}