{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:33:58Z","timestamp":1790505238365,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST105-2314-B-016-035-MY3, MOST105-2628-B-038-012-MY3, MOST105-2314-B-038-026, MOST105-2314-B-281-004-MY2"],"award-info":[{"award-number":["MOST105-2314-B-016-035-MY3, MOST105-2628-B-038-012-MY3, MOST105-2314-B-038-026, MOST105-2314-B-281-004-MY2"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST105-2314-B-038-059-MY3"],"award-info":[{"award-number":["MOST105-2314-B-038-059-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taipei Medical University-Wan Fang Hospital","award":["105-swf-02, 105-wf-eva-08, 105-wf-eva-14, 106-eva-02, 106-eva-06"],"award-info":[{"award-number":["105-swf-02, 105-wf-eva-08, 105-wf-eva-14, 106-eva-02, 106-eva-06"]}]},{"name":"Taipei Medical University-Wan Fang Hospital","award":["106-swf-01"],"award-info":[{"award-number":["106-swf-01"]}]},{"DOI":"10.13039\/501100002811","name":"Cathay General Hospital","doi-asserted-by":"publisher","award":["106CGH-TMU-04"],"award-info":[{"award-number":["106CGH-TMU-04"]}],"id":[{"id":"10.13039\/501100002811","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chi-Mei Medical Center","award":["107CM-TMU-04"],"award-info":[{"award-number":["107CM-TMU-04"]}]},{"name":"Chi-Mei Medical Center","award":["CMNDMC10606"],"award-info":[{"award-number":["CMNDMC10606"]}]},{"name":"Foundation for the Development of Internal Medicine in Okinawa","award":["29-02-001"],"award-info":[{"award-number":["29-02-001"]}]},{"name":"Ministry of National Defense-Medical Affairs Bureau, Taiwan","award":["MAB-107-044"],"award-info":[{"award-number":["MAB-107-044"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ejphar.2018.07.003","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T13:35:11Z","timestamp":1530624911000},"page":"462-471","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Factor Xa inhibitors differently modulate electrical activities in pulmonary veins and the sinoatrial node"],"prefix":"10.1016","volume":"833","author":[{"given":"Chien-Jung","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Chuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Higa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Hung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ann","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.07.003_bib1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/01.CIR.98.10.946","article-title":"Impact of atrial fibrillation on the risk of death: the Framingham Heart Study","volume":"98","author":"Benjamin","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.07.003_bib2","doi-asserted-by":"crossref","first-page":"H283","DOI":"10.1152\/ajpheart.00232.2003","article-title":"Na+ current through KATP channels: consequences for Na+ and K+ fluxes during early myocardial ischemia","volume":"286","author":"Bollensdorff","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2018.07.003_bib3","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1161\/CIRCEP.112.971556","article-title":"Dabigatran and thrombin modulate electrophysiological characteristics of pulmonary vein and left atrium","volume":"5","author":"Chang","year":"2012","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.ejphar.2018.07.003_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1423-0127-20-17","article-title":"Rivaroxaban modulates electrical and mechanical characteristics of left atrium","volume":"20","author":"Chang","year":"2013","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejphar.2018.07.003_bib5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ijcard.2016.07.027","article-title":"Gap junction modifiers regulate electrical activities of the sinoatrial node and pulmonary vein: therapeutic implications in atrial arrhythmogenesis","volume":"221","author":"Chang","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2018.07.003_bib6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ijcard.2015.03.066","article-title":"Selective and non-selective non-steroidal anti-inflammatory drugs differentially regulate pulmonary vein and atrial arrhythmogenesis","volume":"184","author":"Chang","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2018.07.003_bib7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pbiomolbio.2007.07.013","article-title":"Simulation of spontaneous action potentials of cardiomyocytes in pulmonary veins of rabbits","volume":"96","author":"Chang","year":"2008","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.ejphar.2018.07.003_bib8","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1161\/01.CIR.100.18.1879","article-title":"Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation","volume":"100","author":"Chen","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.07.003_bib9","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1159\/000083815","article-title":"Atrial fibrillation and the hypercoagulable state","volume":"33","author":"Choudhury","year":"2003","journal-title":"Pathophysiol. Haemost. Thromb."},{"key":"10.1016\/j.ejphar.2018.07.003_bib10","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1056\/NEJM199809033391003","article-title":"Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins","volume":"339","author":"Haissaguerre","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2018.07.003_bib11","doi-asserted-by":"crossref","first-page":"69231","DOI":"10.18632\/oncotarget.12470","article-title":"Firbobroblast growth factor 23 dysregulates late sodium current and calcium homeostasis with enhanced arrhythmogenesis in pulmonary vein cardiomyocytes","volume":"7","author":"Huang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2018.07.003_bib12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.yjmcc.2014.09.009","article-title":"Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes","volume":"76","author":"Karpinski","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2018.07.003_bib13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1254\/jphs.FMJ04005X4","article-title":"Physiology and pathophysiology of proteinase-activated receptors (PARs): PARs in the respiratory system: cellular signaling and physiological\/pathological roles","volume":"97","author":"Kawabata","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2018.07.003_bib14","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1093\/eurheartj\/ehu181","article-title":"Edoxaban: a focused review of its clinical pharmacology","volume":"35","author":"Lip","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejphar.2018.07.003_bib15","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1365-2362.2012.02655.x","article-title":"ATX-II-induced pulmonary vein arrhythmogenesis related to atrial fibrillation and long QT syndrome","volume":"42","author":"Lu","year":"2012","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2018.07.003_bib16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1124\/mol.116.106666","article-title":"Contributions of protease-activated receptors PAR1 and PAR4 to thrombin-induced GPIIbIIIa activation in human platelets","volume":"91","author":"Matthew","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.07.003_bib17","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.yjmcc.2011.12.003","article-title":"Pathophysiology of the cardiac late Na current and its potential as a drug target","volume":"5252","author":"Moreno","year":"2012","journal-title":"J. Mol. Journal of Molecular and Cellular CardiologyCell. Cardiol."},{"key":"10.1016\/j.ejphar.2018.07.003_bib18","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"Patel","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2018.07.003_bib19","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1124\/mol.107.043182","article-title":"Protease-activated receptor-1 mediates thrombin-induced persistent sodium current in human cardiomyocytes","volume":"73","author":"Pinet","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.07.003_bib20","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/jcb.23427","article-title":"Determinants of the specificity of protease-activated receptors 1 and 2 signaling by factor Xa and thrombin","volume":"113","author":"Rana","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2018.07.003_bib21","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/cvr\/cvt343","article-title":"Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants","volume":"101","author":"Spronk","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.07.003_bib22","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1111\/j.1540-8167.2006.00401.x","article-title":"Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current","volume":"17","author":"Undrovinas","year":"2006","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.ejphar.2018.07.003_bib23","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/j.hrthm.2008.09.008","article-title":"Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine","volume":"12","author":"Wu","year":"2008","journal-title":"Heart Rhythm"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918303716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918303716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T05:02:13Z","timestamp":1571547733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299918303716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":23,"alternative-id":["S0014299918303716"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.07.003","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Factor Xa inhibitors differently modulate electrical activities in pulmonary veins and the sinoatrial node","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}