{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:41:35Z","timestamp":1792676495227,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["20121106120031"],"award-info":[{"award-number":["20121106120031"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["47144226"],"award-info":[{"award-number":["47144226"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["81202526"],"award-info":[{"award-number":["81202526"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302769"],"award-info":[{"award-number":["81302769"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ejphar.2018.07.004","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T13:55:58Z","timestamp":1530798958000},"page":"441-450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE-\/- mice"],"prefix":"10.1016","volume":"833","author":[{"given":"Jing","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-zhang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.07.004_bib1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1182\/blood-2004-12-4839","article-title":"Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo","volume":"106","author":"Bot","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2018.07.004_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbrc.2015.03.171","article-title":"Molecular imaging of inflammation in the ApoE-\/- mouse model of atherosclerosis with IodoDPA","volume":"461","author":"Catherine","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2018.07.004_bib3","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1089\/ars.2006.8.691","article-title":"NADPH oxidases in cardiovascular health and disease","volume":"8","author":"Cave","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ejphar.2018.07.004_bib4","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1161\/CIRCULATIONAHA.113.003045","article-title":"Blinding the monocytes to protect the heart","volume":"127","author":"Charo","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.07.004_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3748\/wjg.14.29","article-title":"Effect of notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion","volume":"14","author":"Chen","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.immuni.2013.11.019","article-title":"Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation","volume":"40","author":"Epelman","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2018.07.004_bib7","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1161\/CIRCULATIONAHA.106.646091","article-title":"Critical role of monocyte chemoattractant protein-1\/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy","volume":"115","author":"Frangogiannis","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.07.004_bib8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/cvr\/cvn292","article-title":"Post-infarct remodelling: contribution of wound healing and inflammation","volume":"81","author":"Frantz","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2018.07.004_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.immunol.021908.132620","article-title":"Immune and inflammatory mechanisms of atherosclerosis (*)","volume":"27","author":"Galkina","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Littman, D.R.Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2018.07.004_bib11","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.amjcard.2010.11.005","article-title":"Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region","volume":"107","author":"Gilbert","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib12","doi-asserted-by":"crossref","first-page":"17C","DOI":"10.1016\/j.amjcard.2005.03.008","article-title":"Review of trials in chronic heart failure showing broad-spectrum anti-inflammatory approaches","volume":"95","author":"Gullestad","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib13","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1582-4934.2011.01307.x","article-title":"IGF-1 deficiency resists cardiac hypertrophy and myocardial contractile dysfunction: role of microRNA-1 and microRNA-133a","volume":"16","author":"Hua","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejphar.2018.07.004_bib15","doi-asserted-by":"crossref","first-page":"e99849","DOI":"10.1371\/journal.pone.0099849","article-title":"Notoginsenoside R1 attenuates atherosclerotic lesions in ApoE deficient mouse model","volume":"9","author":"Jia","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.ejphar.2018.07.004_bib16","first-page":"2982","article-title":"CCR2 overexpression promotes the efficient recruitment of retinal microglia in vitro","volume":"18","author":"Jiang","year":"2012","journal-title":"Mol. Vis."},{"key":"10.1016\/j.ejphar.2018.07.004_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1161\/CIRCRESAHA.117.305349","article-title":"Cardiac nonmyocytes in the hub of cardiac hypertrophy","volume":"117","author":"Kamo","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.07.004_bib18","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/01.RES.0000178789.16929.cf","article-title":"Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice","volume":"97","author":"Kassiri","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.07.004_bib19","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nm1555","article-title":"Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease","volume":"13","author":"Khoury","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2018.07.004_bib20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.atherosclerosis.2009.09.007","article-title":"Combination therapy for treatment or prevention of atherosclerosis: focus on the lipid-RAAS interaction","volume":"209","author":"Koh","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2018.07.004_bib21","first-page":"13","article-title":"Inflammation and wound healing: the role of the macrophage","volume":"11","author":"Koh","year":"2013","journal-title":"Expert. Rev. Mol. Med."},{"key":"10.1016\/j.ejphar.2018.07.004_bib22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1253\/jcj.65.353","article-title":"Molecular mechanism of cardiac hypertrophy and development","volume":"65","author":"Komuro","year":"2001","journal-title":"Jpn. Circ. J."},{"key":"10.1016\/j.ejphar.2018.07.004_bib23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1142\/S0192415X86000235","article-title":"Cardiovascular pharmacology of Panax notoginseng (Burk) F.H. Chen and Salvia miltiorrhiza","volume":"14","author":"Lei","year":"1989","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.ejphar.2018.07.004_bib24","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nbt.1989","article-title":"Therapeutic siRNA silencing in inflammatory monocytes in mice","volume":"29","author":"Leuschner","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"Libby","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2018.07.004_bib26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/SHK.0b013e3181ceede4","article-title":"Notoginsenoside R1 attenuates renal ischemia-reperfusion injury in rats","volume":"34","author":"Liu","year":"2010","journal-title":"Shock"},{"key":"10.1016\/j.ejphar.2018.07.004_bib27","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/CIRCULATIONAHA.112.000116","article-title":"Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice","volume":"127","author":"Majmudar","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.07.004_bib28","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1161\/CIRCRESAHA.113.300890","article-title":"Monocyte and macrophage heterogeneity in the heart","volume":"112","author":"Nahrendorf","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2018.07.004_bib29","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1161\/CIRCULATIONAHA.109.916346","article-title":"Monocytes: protagonists of infarct inflammation and repair after myocardial infarction","volume":"121","author":"Nahrendorf","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.07.004_bib30","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1161\/01.CIR.74.6.1399","article-title":"Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging","volume":"74","author":"Pignoli","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.07.004_bib31","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1038\/ncomms3019","article-title":"Fibroblast growth factor 21 protects against cardiac hypertrophy in mice","volume":"4","author":"Planavila","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2018.07.004_bib32","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1538-7836.2009.03404.x","article-title":"Testing the inflammatory hypothesis of atherothrombosis: scientific rationale for the cardiovascular inflammation reduction trial (CIRT)","volume":"7","author":"Ridker","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.ejphar.2018.07.004_bib33","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM199704033361401","article-title":"Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men","volume":"336","author":"Ridker","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2018.07.004_bib34","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2018.07.004_bib35","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ahj.2011.06.012","article-title":"Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)","volume":"162","author":"Ridker","year":"2011","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ejphar.2018.07.004_bib36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yjmcc.2014.02.002","article-title":"Redox regulation of cardiac hypertrophy","volume":"73","author":"Sag","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib38","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/bph.12063","article-title":"Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K\/Akt signaling","volume":"168","author":"Sun","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib39","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.lfs.2007.06.008","article-title":"Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery","volume":"81","author":"Sun","year":"2007","journal-title":"Life. Sci."},{"key":"10.1016\/j.ejphar.2018.07.004_bib40","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.4049\/jimmunol.172.7.4410","article-title":"Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response","volume":"172","author":"Sunderkotter","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib41","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI29919","article-title":"Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites","volume":"117","author":"Tsou","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2018.07.004_bib42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s004240050739","article-title":"Reneman.Transcriptional regulation of metabolic processes: implications for cardiac metabolism","volume":"437","author":"van, Bilsen","year":"1998","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.ejphar.2018.07.004_bib43","first-page":"19","article-title":"Meyrelles SS. Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse","volume":"13","author":"Vasquez","year":"2012","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejphar.2018.07.004_bib44","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/CIRCULATIONAHA.112.112185","article-title":"Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-kappaB","volume":"126","author":"Verma","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.07.004_bib45","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.5551\/jat1994.1.Supplemment1_S10","article-title":"Local expression of inflammatory cytokines in human atherosclerotic plaques","volume":"1","author":"Wilcox","year":"1994","journal-title":"J. Atheroscler. Thromb. Suppl."},{"key":"10.1016\/j.ejphar.2018.07.004_bib46","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1161\/hq0302.105287","article-title":"Aortic constriction exacerbates atherosclerosis and induces cardiac dysfunction in mice lacking apolipoprotein E","volume":"22","author":"Wu","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib47","first-page":"740","article-title":"Protective effect of notoginsenoside R1 in a rat model of myocardial ischemia reperfusion injury by regulation of Vitamin D3 upregulated protein 1\/NF-kappaB pathway","volume":"70","author":"Xia","year":"2015","journal-title":"Pharmazie"},{"key":"10.1016\/j.ejphar.2018.07.004_bib48","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.vph.2005.12.002","article-title":"Notoginsenoside R1 from Panax notoginseng inhibits TNF-alpha-induced PAI-1 production in human aortic smooth muscle cells","volume":"44","author":"Zhang","year":"2006","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib49","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/01.ATV.17.3.465","article-title":"Notoginsenoside R1 counteracts endotoxin-induced activation of endothelial cells in vitro and endotoxin-induced lethality in mice in vivo","volume":"17","author":"Zhang","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2018.07.004_bib50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3892\/mmr.2015.3394","article-title":"Estrogen receptor alpha mediates the effects of notoginsenoside R1 on endotoxin-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes","volume":"12","author":"Zhong","year":"2015","journal-title":"Mol. Med. Rep."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918303704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918303704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:24:30Z","timestamp":1757975070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299918303704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":50,"alternative-id":["S0014299918303704"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.07.004","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE-\/- mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}