{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:41:22Z","timestamp":1792035682472,"version":"4.4.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21402166"],"award-info":[{"award-number":["21402166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of Zhejiang Province","award":["LQ15H310003"],"award-info":[{"award-number":["LQ15H310003"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ejphar.2018.08.015","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T08:05:00Z","timestamp":1534233900000},"page":"83-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1\/NRF2 pathway in rats"],"prefix":"10.1016","volume":"836","author":[{"given":"Zhiping","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifu","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.08.015_bib1","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.jnutbio.2011.10.012","article-title":"Inhibition of NF-\u03baB nuclear translocation via HO-1 activation underlies \u03b1-tocopheryl succinate toxicity","volume":"23","author":"Bellezza","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ejphar.2018.08.015_bib2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1152\/physrev.00023.2002","article-title":"Unique structural features that influence neutrophil emigration into the lung","volume":"83","author":"Burns","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2018.08.015_bib3","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1016\/j.bmc.2005.12.021","article-title":"Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines","volume":"14","author":"Cardenas","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejphar.2018.08.015_bib4","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1182\/blood.V84.7.2068.2068","article-title":"Leukocyte-endothelial adhesion molecules","volume":"84","author":"Carlos","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2018.08.015_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1043-6618(03)00248-2","article-title":"Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives","volume":"49","author":"Cho","year":"2004","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2018.08.015_bib6","doi-asserted-by":"crossref","first-page":"974713","DOI":"10.1155\/2012\/974713","article-title":"Protective effect of the fruit hull of Gleditsia sinensis on LPS-induced acute lung injury is associated with Nrf2 activation","volume":"2012","author":"Choi","year":"2012","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.ejphar.2018.08.015_bib7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bcp.2014.03.016","article-title":"Chrysin attenuates inflammation by regulating M1\/M2 status via activating PPAR\u03b3","volume":"89","author":"Feng","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.08.015_bib8","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1096\/fj.201601349R","article-title":"Inhibition of inflammasome activation improves lung acute injury induced by carrageenan in a mouse model of pleurisy","volume":"31","author":"Fusco","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2018.08.015_bib9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","article-title":"NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses","volume":"16","author":"Ghosh","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2018.08.015_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2010.08.064","article-title":"Chrysin suppresses LPS-stimulated proinflammatory responses by blocking NF-\u03baB and JNK activations in microglia cells","volume":"485","author":"Ha","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2018.08.015_bib11","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.freeradbiomed.2013.07.029","article-title":"Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-\u03b21 by activating the Nrf2\/ARE pathway in glomerular mesangial cells","volume":"65","author":"Huang","year":"2013","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2018.08.015_bib12","first-page":"178","article-title":"Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist ages-induced upregulation of fbronetin and transforming growth factor-\u03b21 in rat glomerular mesangial cells","volume":"399","author":"Huang","year":"2015","journal-title":"Mol. Cell."},{"key":"10.1016\/j.ejphar.2018.08.015_bib13","first-page":"504","article-title":"Desoxyrhapontigenin up-regulates Nrf2-mediated heme oxygenase-1 expression in macrophages and inflammatory lung injury","volume":"18","author":"Joo","year":"2014","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.ejphar.2018.08.015_bib14","first-page":"18","article-title":"Chrysin attenuates VCAM-1 expression and monocyte adhesion in lipopolysaccharide-stimulated brain endothelial cells by preventing NF-\u03baB signaling","volume":"3","author":"Lee","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2018.08.015_bib15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2353\/ajpath.2009.090016","article-title":"Overexpression of HO-1 protects against TNF-alpha-mediated airway inflammation by down-regulation of TNFR1-dependent oxidative stress","volume":"175","author":"Lee","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2018.08.015_bib16","first-page":"678","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat. Rev."},{"key":"10.1016\/j.ejphar.2018.08.015_bib17","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","article-title":"Activation of Nrf2-antioxidant signaling attenuates NF-\u03baB-inflammatory response and elicits apoptosis","volume":"76","author":"Li","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.08.015_bib18","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.molmed.2004.09.003","article-title":"Nrf2-Keap1 defnes a physiologically important stress response mechanism","volume":"10","author":"Motohashi","year":"2004","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejphar.2018.08.015_bib19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1748-1716.2012.02425.x","article-title":"Aged red garlic extract reduces lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages and acute pulmonary inflammation through heme oxygenase-1 induction","volume":"205","author":"Park","year":"2012","journal-title":"Acta Physiol."},{"key":"10.1016\/j.ejphar.2018.08.015_bib20","first-page":"803","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev."},{"key":"10.1016\/j.ejphar.2018.08.015_bib21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.fitote.2015.03.019","article-title":"Suppression of inflammatory response by chrysin, a flavone isolated from Potentilla evestita Th. Wolf. In silico predictive study on its mechanistic effect","volume":"103","author":"Rauf","year":"2015","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejphar.2018.08.015_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1155\/2014\/105120","article-title":"Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice","volume":"2014","author":"Ribeiro","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2018.08.015_bib23","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0196-9781(99)00086-8","article-title":"Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan","volume":"20","author":"Saleh","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2018.08.015_bib24","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.bbrc.2006.10.102","article-title":"Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide","volume":"351","author":"Thimmulappa","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2018.08.015_bib25","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.4049\/jimmunol.147.6.1803","article-title":"Sequential appearance of IL-1 and IL-6 activities in rat carrageenan-induced pleurisy","volume":"147","author":"Utsunomiya","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.08.015_bib26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1248\/bpb.b16-00756","article-title":"Protective effects of tyrosol against LPS-induced acute lung injury via inhibiting NF-\u03baB and AP-1 activation and activating the HO-1\/Nrf2 pathways","volume":"40","author":"Wang","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2018.08.015_bib27","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1006\/bbrc.2001.6067","article-title":"NF-kappaB activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells","volume":"289","author":"Xia","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918304643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918304643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T10:06:53Z","timestamp":1693822013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299918304643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":27,"alternative-id":["S0014299918304643"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.08.015","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1\/NRF2 pathway in rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.08.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}