{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T23:49:23Z","timestamp":1775260163424,"version":"3.50.1"},"reference-count":190,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ejphar.2018.10.040","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T12:26:56Z","timestamp":1540902416000},"page":"208-220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["A novel therapeutic potential of cysteinyl leukotrienes and their receptors modulation in the neurological complications associated with Alzheimer's disease"],"prefix":"10.1016","volume":"842","author":[{"given":"Syed Obaidur","family":"Rahman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-2672","authenticated-orcid":false,"given":"Mohd.","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abul Kalam","family":"Najmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.10.040_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1749-8090-6-81","article-title":"Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats","volume":"6","author":"Al-Amran","year":"2011","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.ejphar.2018.10.040_bib2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/ejcts\/ezs312","article-title":"Cysteinyl leukotriene receptor antagonist montelukast ameliorates acute lung injury following haemorrhagic shock in rats","volume":"43","author":"Al-Amran","year":"2013","journal-title":"Eur. J. Cardio-thorac. Surg. : Off. J. Eur. Assoc. Cardio-thorac. Surg."},{"key":"10.1016\/j.ejphar.2018.10.040_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/039463200501800208","article-title":"P2Y1 and cysteinyl leukotriene receptors mediate purine and cysteinyl leukotriene co-release in primary cultures of rat microglia","volume":"18","author":"Ballerini","year":"2005","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3171\/jns.1996.85.1.0112","article-title":"Protective effect of the 5-lipoxygenase inhibitor AA-861 on cerebral edema after transient ischemia","volume":"85","author":"Baskaya","year":"1996","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.ejphar.2018.10.040_bib5","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0306-4522(02)00230-0","article-title":"Chronic gliosis triggers Alzheimer's disease-like processing of amyloid precursor protein","volume":"113","author":"Bates","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2018.10.040_bib6","doi-asserted-by":"crossref","first-page":"29584","DOI":"10.1074\/jbc.M204994200","volume":"277","author":"Bhat","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.10.040_bib7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.stem.2015.09.003","article-title":"Adult mammalian neural stem cells and neurogenesis: five decades later","volume":"17","author":"Bond","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejphar.2018.10.040_bib8","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1128\/MCB.19.3.1950","article-title":"Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity","volume":"19","author":"Bonizzi","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib9","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3389\/fimmu.2015.00632","article-title":"Myeloid dendritic cells are potential players in human neurodegenerative diseases","volume":"6","author":"Boss\u00f9","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib10","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/jnr.21252","article-title":"Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides","volume":"85","author":"Bourne","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib11","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3233\/JAD-143156","article-title":"Synergistic actions of microglia and astrocytes in the progression of Alzheimer's disease","author":"Bouvier","year":"2015","journal-title":"J. Alzheimer's Dis.: JAD"},{"key":"10.1016\/j.ejphar.2018.10.040_bib12","first-page":"1","article-title":"Dendritic cells as an alternate approach for treatment of neurodegenerative disorders","author":"Brezovakova","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib13","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.psyneuen.2008.02.013","article-title":"Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice","volume":"33","author":"Buchanan","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ejphar.2018.10.040_bib14","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1074\/jbc.M706579200","article-title":"NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42","volume":"283","author":"Buggia-Prevot","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.10.040_bib15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/cne.21668","article-title":"CD11c\/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain","volume":"508","author":"Bulloch","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1460-9568.2007.05652.x","article-title":"Selective ablation of bone marrow\u2010derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model","volume":"26","author":"Butovsky","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/00207454.2013.833510","article-title":"Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease","volume":"124","author":"Cai","year":"2014","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2008.05.017","article-title":"Mutant amyloid-beta-sensitized dendritic cells as Alzheimer's disease vaccine","volume":"200","author":"Cao","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2003.12.012","article-title":"Molecular and functional aspects of human cysteinyl leukotriene receptors","volume":"50","author":"Capra","year":"2004","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/med.20071","article-title":"Cysteinyl\u2010leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends","volume":"27","author":"Capra","year":"2007","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejphar.2018.10.040_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neuroscience.2014.05.047","article-title":"Increased expression of Aquaporin 4 in the rat hippocampus and cortex during trimethyltin-induced neurodegeneration","volume":"274","author":"Ceccariglia","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2018.10.040_bib22","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1128\/JVI.03149-13","article-title":"Enhancement of blood-brain barrier permeability and reduction of tight junction protein expression are modulated by chemokines\/cytokines induced by rabies virus infection","volume":"88","author":"Chai","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib23","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S1474-4422(16)00114-9","article-title":"Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation","volume":"15","author":"Chamorro","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib24","doi-asserted-by":"crossref","first-page":"7598","DOI":"10.1523\/JNEUROSCI.5172-09.2010","article-title":"Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1","volume":"30","author":"Chapman","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1017\/S1461145711000149","article-title":"Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease","volume":"15","author":"Chen","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib26","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.brainres.2015.08.007","article-title":"CysLT2 receptor mediates lipopolysaccharide-induced microglial inflammation and consequent neurotoxicity in vitro","volume":"1624","author":"Chen","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbi.2016.10.021","article-title":"Preventive effect of genetic knockdown and pharmacological blockade of CysLT1R on lipopolysaccharide (LPS)-induced memory deficit and neurotoxicity in vivo.","volume":"60","author":"Chen","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2018.10.040_bib28","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.neurobiolaging.2006.06.007","article-title":"The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old","volume":"28","author":"Chinnici","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2018.10.040_bib29","doi-asserted-by":"crossref","first-page":"174657","DOI":"10.1155\/2009\/174657","article-title":"The 5-lipoxygenase as a common pathway for pathological brain and vascular aging","volume":"2009","author":"Chu","year":"2009","journal-title":"Cardiovasc. Psychiatry Neurol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib30","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.ajpath.2010.12.032","article-title":"Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of gamma-secretase","volume":"178","author":"Chu","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1742-2094-9-127","article-title":"Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model","volume":"9","author":"Chu","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ejphar.2018.10.040_bib32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.lfs.2009.12.001","article-title":"Minocycline inhibits 5-lipoxygenase expression and accelerates functional recovery in chronic phase of focal cerebral ischemia in rats","volume":"86","author":"Chu","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib33","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1745-7254.2006.00290.x","article-title":"Pranlukast reduces neutrophil but not macrophage\/microglial accumulation in brain after focal cerebral ischemia in mice","volume":"27","author":"Chu","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2018.10.040_bib34","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1038\/sj.emboj.7601341","article-title":"The orphan receptor GPR17 identified as a new dual uracil nucleotides\/cysteinyl\u2010leukotrienes receptor","volume":"25","author":"Ciana","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2018.10.040_bib35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12974-016-0483-0","article-title":"Myeloid dendritic cells are decreased in peripheral blood of Alzheimer\u2019s disease patients in association with disease progression and severity of depressive symptoms","volume":"13","author":"Ciaramella","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ejphar.2018.10.040_bib36","doi-asserted-by":"crossref","first-page":"e65352","DOI":"10.1371\/journal.pone.0065352","article-title":"Blood dendritic cell frequency declines in idiopathic Parkinson\u2019s disease and is associated with motor symptom severity","volume":"8","author":"Ciaramella","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2018.10.040_bib37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neurobiolaging.2007.06.007","article-title":"Amyloid \u03b2 peptide promotes differentiation of pro-inflammatory human myeloid dendritic cells","volume":"30","author":"Ciaramella","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2018.10.040_bib38","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0736-5748(00)00084-8","article-title":"Involvement of astrocytes in purine-mediated reparative processes in the brain","volume":"19","author":"Ciccarelli","year":"2001","journal-title":"Int. J. Dev. Neurosci.: Off. J. Int. Soc. Dev. Neurosci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib39","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1111\/j.1460-9568.2004.03613.x","article-title":"Cysteinyl\u2010leukotrienes are released from astrocytes and increase astrocyte proliferation and glial fibrillary acidic protein via cys\u2010LT1 receptors and mitogen\u2010activated protein kinase pathway","volume":"20","author":"Ciccarelli","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib40","unstructured":"ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US), 2000 Feb 29 -. Identifier NCT03402503, Safety, and Efficacy of a New Buccal Film of Montelukast in Patients With Mild to Moderate Alzheimer\u2019s Disease (BUENA); 2018 Jan 10 [cited 2018 Jul 22]; [about 4 screens]. Available from: \u3008https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT03402503?Cond=NCT03402503&rank=1\u3009."},{"key":"10.1016\/j.ejphar.2018.10.040_bib41","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neures.2006.02.013","article-title":"Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes","volume":"55","author":"Dai","year":"2006","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib42","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1365-2567.2007.02694.x","article-title":"Increased interleukin-10 production and Th2 skewing in the absence of 5-lipoxygenase","volume":"123","author":"DiMeo","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.ejphar.2018.10.040_bib43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000283480","article-title":"Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease","volume":"7","author":"Eikelenboom","year":"2010","journal-title":"Neuro-Degener. Dis."},{"key":"10.1016\/j.ejphar.2018.10.040_bib44","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.pneurobio.2005.04.002","article-title":"Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells","volume":"75","author":"Emsley","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00401-016-1606-5","article-title":"Vascular, glial, and lymphatic immune gateways of the central nervous system","volume":"132","author":"Engelhardt","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib46","doi-asserted-by":"crossref","first-page":"e1002045","DOI":"10.1371\/journal.pbio.1002045","article-title":"Adult neurogenesis in humans-common and unique traits in mammals","volume":"13","author":"Ernst","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib47","doi-asserted-by":"crossref","first-page":"25959","DOI":"10.3390\/ijms161125939","article-title":"Energy metabolism of the brain, including the cooperation between astrocytes and neurons, especially in the context of glycogen metabolism","volume":"16","author":"Falkowska","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib48","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.neuroscience.2006.02.051","article-title":"Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats","volume":"140","author":"Fang","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2018.10.040_bib49","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neulet.2006.10.065","article-title":"Spatio-temporal expression of cysteinyl leukotriene receptor-2 mRNA in rat brain after focal cerebral ischemia","volume":"412","author":"Fang","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2018.10.040_bib50","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1096\/fj.07-9131.com","article-title":"5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease","volume":"22","author":"Firuzi","year":"2008","journal-title":"FASEB J. : Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3233\/JAD-2011-102034","article-title":"Dendritic cells regulate amyloid-\u03b2-specific T-cell entry into the brain: the role of perivascular amyloid-\u03b2","volume":"27","author":"Fisher","year":"2011","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.ejphar.2018.10.040_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1734-1140(12)70725-9","article-title":"Neuronal autophagy in cerebral ischemia--a potential target for neuroprotective strategies?","volume":"64","author":"Gabryel","year":"2012","journal-title":"Pharmacol. Rep.: PR"},{"key":"10.1016\/j.ejphar.2018.10.040_bib53","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1126\/science.287.5457.1433","article-title":"Mammalian neural stem cells","volume":"287","author":"Gage","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2018.10.040_bib54","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1038\/cddis.2011.50","article-title":"Astrocytes are important mediators of Abeta-induced neurotoxicity and tau phosphorylation in primary culture","volume":"2","author":"Garwood","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2018.10.040_bib55","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.brainresbull.2015.01.008","article-title":"High therapeutic potential of positive allosteric modulation of alpha7 nAChRs in a rat model of traumatic brain injury: proof-of-concept","volume":"112","author":"Gatson","year":"2015","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2018.10.040_bib56","doi-asserted-by":"crossref","first-page":"3454212","DOI":"10.1155\/2017\/3454212","article-title":"Cysteinyl leukotrienes as potential pharmacological targets for cerebral diseases","volume":"2017","author":"Gelosa","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2018.10.040_bib57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3233\/JAD-130497","article-title":"BDNF, TNF\u03b1, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer's disease or mild cognitive impairment","volume":"37","author":"Gezen-Ak","year":"2013","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.ejphar.2018.10.040_bib58","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/cns.12596","article-title":"Cysteinyl Leukotrienes and their receptors: emerging therapeutic targets in central nervous system disorders","volume":"22","author":"Ghosh","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ejphar.2018.10.040_bib59","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1002\/glia.22885","article-title":"Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke","volume":"63","author":"Gliem","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2018.10.040_bib60","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nm1197","article-title":"Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis","volume":"11","author":"Greter","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2018.10.040_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2010.05.026","article-title":"AGEs\/RAGE complex upregulates BACE1 via NF-kappab pathway activation","volume":"33","author":"Guglielmotto","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2018.10.040_bib62","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainres.2014.10.015","article-title":"Astrocytic phospholipase A2 contributes to neuronal glutamate toxicity","volume":"1590","author":"Ha","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib63","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/brain\/aww017","article-title":"Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging","volume":"139","author":"Hamelin","year":"2016","journal-title":"Brain: a J. Neurol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib64","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2018.10.040_bib65","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000351096","article-title":"MK886 reduces cerebral amyloid angiopathy severity in TgCRND8 mice","volume":"13","author":"Hawkes","year":"2014","journal-title":"Neuro-Degener. Dis."},{"key":"10.1016\/j.ejphar.2018.10.040_bib66","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10571-015-0261-z","article-title":"The utility of cerebral blood flow as a biomarker of preclinical Alzheimer's disease","volume":"36","author":"Hays","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib67","doi-asserted-by":"crossref","first-page":"18286","DOI":"10.1038\/srep18286","article-title":"Inflammatory eicosanoids increase amyloid precursor protein expression via activation of multiple neuronal receptors","volume":"5","author":"Herbst-Robinson","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2018.10.040_bib68","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/gps.3816","article-title":"Increased systemic inflammatory interleukin\u20101\u00df and interleukin\u20106 during agitation as predictors of Alzheimer's disease","volume":"28","author":"Honma","year":"2013","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.ejphar.2018.10.040_bib69","doi-asserted-by":"crossref","first-page":"484613","DOI":"10.1155\/2013\/484613","article-title":"Role of redox signaling in neuroinflammation and neurodegenerative diseases","volume":"2013","author":"Hsieh","year":"2013","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.ejphar.2018.10.040_bib70","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/glia.20588","article-title":"Activation of CysLT receptors induces astrocyte proliferation and death after oxygen\u2013glucose deprivation","volume":"56","author":"Huang","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2018.10.040_bib71","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1742-2094-9-145","article-title":"Transforming growth factor beta1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1","volume":"9","author":"Huang","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ejphar.2018.10.040_bib72","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1159\/000335793","article-title":"Inhibition of leukotriene receptors boosts neural progenitor proliferation","volume":"28","author":"Huber","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2018.10.040_bib73","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1002\/eji.1830181233","article-title":"Tumor necrosis factor alpha stimulates leukotriene production in vivo","volume":"18","author":"Huber","year":"1988","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib74","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10787-017-0437-x","article-title":"High-salt-and cholesterol diet-associated cognitive impairment attenuated by tannins-enriched fraction of Emblica officinalis via inhibiting NF-kB pathway","volume":"26","author":"Husain","year":"2018","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ejphar.2018.10.040_bib75","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neulet.2018.02.027","article-title":"Calcium channel blocker use reduces incident dementia risk in elderly hypertensive patients: a meta-analysis of prospective studies","volume":"671","author":"Hussain","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2018.10.040_bib76","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1369\/jhc.2008.951855","article-title":"Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease","volume":"56","author":"Ikonomovic","year":"2008","journal-title":"J. Histochem. Cytochem.: Off. J. Histochem. Soc."},{"key":"10.1016\/j.ejphar.2018.10.040_bib77","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1159\/000338818","article-title":"Montelukast inhibits leukotriene stimulation of human dendritic cells in vitro","volume":"159","author":"Ilarraza","year":"2012","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib78","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.1523\/JNEUROSCI.2723-06.2006","article-title":"Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis","volume":"26","author":"Iosif","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib79","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/00004647-199706000-00003","article-title":"Rapid alteration of tau in oligodendrocytes after focal ischemic injury in the rat: involvement of free radicals","volume":"17","author":"Irving","year":"1997","journal-title":"J. Cereb. Blood Flow Metab.: Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ejphar.2018.10.040_bib80","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1097\/00001756-199611250-00054","article-title":"Accumulation of apolipoprotein E and beta-amyloid-like protein in a trace of the hippocampal CA1 pyramidal cell layer after ischaemic delayed neuronal death","volume":"7","author":"Ishimaru","year":"1996","journal-title":"NeuroReport"},{"key":"10.1016\/j.ejphar.2018.10.040_bib81","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1038\/ncomms11934","article-title":"Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis","volume":"7","author":"Iturria-Medina","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2018.10.040_bib82","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1742-2094-3-12","article-title":"Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia","volume":"3","author":"Jatana","year":"2006","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ejphar.2018.10.040_bib83","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1365-2567.2005.02241.x","article-title":"Leukotrienes modulate cytokine release from dendritic cells","volume":"116","author":"Jozefowski","year":"2005","journal-title":"Immunology"},{"key":"10.1016\/j.ejphar.2018.10.040_bib84","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ejphar.2015.07.043","article-title":"Reducing Abeta load and tau phosphorylation: emerging perspective for treating Alzheimer's disease","volume":"764","author":"Kalra","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2016.04.002","article-title":"Modulation of LOX and COX pathways via inhibition of amyloidogenesis contributes to mitoprotection against beta-amyloid oligomer-induced toxicity in an animal model of Alzheimer's disease in rats","volume":"146\u2013147","author":"Kalra","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2018.10.040_bib86","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/j.1365-2222.2007.02743.x","article-title":"Leukotriene B(4) enhances tumour necrosis factor-alpha-induced CCL27 production in human keratinocytes","volume":"37","author":"Kanda","year":"2007","journal-title":"Clin. Exp. Allergy : J. Br. Soc. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib87","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1038\/sj.npp.1301137","article-title":"Suppression of cell proliferation by interferon-alpha through interleukin-1 production in adult rat dentate gyrus","volume":"31","author":"Kaneko","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2018.10.040_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2010.06.007","article-title":"Accumulation of resident and peripheral dendritic cells in the aging CNS","volume":"33","author":"Kaunzner","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2018.10.040_bib89","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1067\/mai.2003.1636","article-title":"Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma","volume":"112","author":"Kawano","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib90","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0197-4580(02)00021-0","article-title":"Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity","volume":"23","author":"Klegeris","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2018.10.040_bib91","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1515\/revneuro-2017-0006","article-title":"Alzheimer's disease: as it was in the beginning","volume":"28","author":"Kozlov","year":"2017","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib92","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pbb.2012.07.015","article-title":"Montelukast potentiates the protective effect of rofecoxib against kainic acid-induced cognitive dysfunction in rats","volume":"103","author":"Kumar","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2018.10.040_bib93","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pupt.2016.06.001","article-title":"Cysteinyl leukotriene receptor antagonist epigenetically modulates cytokine expression and maturation of human myeloid dendritic cells","volume":"39","author":"Kuo","year":"2016","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2018.10.040_bib94","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.neuropharm.2014.01.011","article-title":"Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Abeta1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice","volume":"79","author":"Lai","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2018.10.040_bib95","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuint.2014.05.006","article-title":"Montelukast rescues primary neurons against Abeta1-42-induced toxicity through inhibiting CysLT1R-mediated NF-kappaB signaling","volume":"75","author":"Lai","year":"2014","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2018.10.040_bib96","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1471-4159.1996.66010147.x","article-title":"Arachidonate 5\u2010lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling","volume":"66","author":"Lammers","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2018.10.040_bib97","doi-asserted-by":"crossref","first-page":"e3579","DOI":"10.1371\/journal.pone.0003579","article-title":"The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair","volume":"3","author":"Lecca","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2018.10.040_bib98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1460-9568.2011.07923.x","article-title":"How many neurons do you have? Some dogmas of quantitative neuroscience under revision","volume":"35","author":"Lent","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib99","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.lfs.2011.04.024","article-title":"Cerebral ischemia aggravates cognitive impairment in a rat model of Alzheimer's disease","volume":"89","author":"Li","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib100","doi-asserted-by":"crossref","first-page":"49523","DOI":"10.1074\/jbc.M402034200","article-title":"Tumor necrosis factor-\u03b1, interleukin-1\u03b2, and interferon-\u03b3 stimulate \u03b3-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway","volume":"279","author":"Liao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.10.040_bib101","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2018.10.040_bib102","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/1742-2094-8-175","article-title":"Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors","volume":"8","author":"Liu","year":"2011","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ejphar.2018.10.040_bib103","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.2174\/138161212802002706","article-title":"The role of pericytes in blood-brain barrier function and stroke","volume":"18","author":"Liu","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2018.10.040_bib104","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/WAD.0b013e31823b2728","article-title":"Cerebrospinal fluid cytokine dynamics differ between Alzheimer disease patients and elderly controls","volume":"26","author":"Llano","year":"2012","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.ejphar.2018.10.040_bib105","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1038\/srep07405","article-title":"p38alpha (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes","volume":"4","author":"Lo","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2018.10.040_bib106","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1517\/14728222.2014.988707","article-title":"Targeting microglia for the treatment of Alzheimer's disease","volume":"19","author":"McGeer","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejphar.2018.10.040_bib107","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00441-003-0779-0","article-title":"Macrophages and dendritic cells in the rat meninges and choroid plexus: three-dimensional localisation by environmental scanning electron microscopy and confocal microscopy","volume":"313","author":"McMenamin","year":"2003","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib108","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1750-3639.2008.00132.x","article-title":"Abeta-degrading enzymes in Alzheimer's disease","volume":"18","author":"Miners","year":"2008","journal-title":"Brain Pathol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib109","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2018.10.040_bib110","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1073\/pnas.0506209103","article-title":"A\u03b2-induced meningoencephalitis is IFN-\u03b3-dependent and is associated with T cell-dependent clearance of A\u03b2 in a mouse model of Alzheimer's disease","volume":"103","author":"Monsonego","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2018.10.040_bib111","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00401-016-1570-0","article-title":"Brain imaging of neurovascular dysfunction in Alzheimer's disease","volume":"131","author":"Montagne","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib112","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.drudis.2007.03.004","article-title":"Pharmacological modulation of the leukotriene pathway in allergic airway disease","volume":"12","author":"Montuschi","year":"2007","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejphar.2018.10.040_bib113","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/S0140-6736(05)60322-4","article-title":"Leukotrienes and the brain","volume":"352","author":"Morris","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2018.10.040_bib114","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1126\/science.6719118","article-title":"Synthesis of compounds with properties of leukotrienes C4 and D4 in gerbil brains after ischemia and reperfusion","volume":"224","author":"Moskowitz","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2018.10.040_bib115","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1750-1326-6-85","article-title":"Adult hippocampal neurogenesis and its role in Alzheimer's disease","volume":"6","author":"Mu","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejphar.2018.10.040_bib116","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s12640-013-9432-1","article-title":"SR-A regulates the inflammatory activation of astrocytes","volume":"25","author":"Murgas","year":"2014","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib117","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbrc.2016.06.026","article-title":"6-Shogaol has anti-amyloidogenic activity and ameliorates Alzheimer's disease via CysLT1R-mediated inhibition of cathepsin B","volume":"477","author":"Na","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2018.10.040_bib118","doi-asserted-by":"crossref","first-page":"e49468","DOI":"10.1371\/journal.pone.0049468","article-title":"Cell therapy: a safe and efficacious therapeutic treatment for Alzheimer\u2019s disease in APP+ PS1 mice","volume":"7","author":"Nabar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2018.10.040_bib119","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0014-5793(00)02076-7","article-title":"Regulation of APP cleavage by alpha-, beta- and gamma-secretases","volume":"483","author":"Nunan","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2018.10.040_bib120","first-page":"H1249","article-title":"Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain","volume":"268","author":"Ohtsuki","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib121","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.4049\/jimmunol.173.10.6393","article-title":"A novel role of cysteinyl leukotrienes to promote dendritic cell activation in the antigen-induced immune responses in the lung","volume":"173","author":"Okunishi","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib122","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jaci.2004.03.054","article-title":"Role for cysteinyl leukotrienes in allergen-induced change in circulating dendritic cell number in asthma","volume":"114","author":"Parameswaran","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib123","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/brain\/124.3.480","article-title":"Two subsets of dendritic cells are present in human cerebrospinal fluid","volume":"124","author":"Pashenkov","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.ejphar.2018.10.040_bib124","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","article-title":"Astrocyte reactivity and reactive astrogliosis: costs and benefits","volume":"94","author":"Pekny","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2018.10.040_bib125","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2013.12.071","article-title":"The dual role of astrocyte activation and reactive gliosis","volume":"565","author":"Pekny","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2018.10.040_bib126","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.tins.2009.05.001","article-title":"Tripartite synapses: astrocytes process and control synaptic information","volume":"32","author":"Perea","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib127","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2174\/13894501113149990203","article-title":"Astrocyte-neuron interaction at tripartite synapses","volume":"14","author":"Perez-Alvarez","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejphar.2018.10.040_bib128","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2147\/NDT.S3739","article-title":"Brain ischemia and ischemic blood-brain barrier as etiological factors in sporadic Alzheimer's disease","volume":"4","author":"Pluta","year":"2008","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.ejphar.2018.10.040_bib129","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s12035-013-8439-1","article-title":"Sporadic Alzheimer's disease begins as episodes of brain ischemia and ischemically dysregulated Alzheimer's disease genes","volume":"48","author":"Pluta","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib130","first-page":"37","article-title":"Factors in creepy delayed neuronal death in hippocampus following brain ischemia-reperfusion injury with long-term survival","volume":"Supplement 106","author":"Pluta","year":"2010","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.ejphar.2018.10.040_bib131","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0006-8993(94)91081-2","article-title":"Complete cerebral ischemia with short-term survival in rats induced by cardiac arrest. I. Extracellular accumulation of Alzheimer's beta-amyloid protein precursor in the brain","volume":"649","author":"Pluta","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib132","first-page":"11","article-title":"Consideration of the ischaemic basis and treatment of Alzheimer's disease","volume":"48","author":"Pluta","year":"2010","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib133","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0002-9440(10)63724-8","article-title":"12\/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress","volume":"164","author":"Pratico","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib134","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3233\/JAD-2007-12406","article-title":"Cerebral ischemia and Alzheimer's disease: the expression of amyloid-beta and apolipoprotein E in human hippocampus","volume":"12","author":"Qi","year":"2007","journal-title":"J. Alzheimer's Dis. : JAD"},{"key":"10.1016\/j.ejphar.2018.10.040_bib135","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1023\/A:1020916905312","article-title":"Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils","volume":"24","author":"Rao","year":"1999","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib136","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0092-8674(00)00179-3","article-title":"The leukotriene C4 transporter MRP1 regulates CCL19 (MIP-3\u03b2, ELC)\u2013dependent mobilization of dendritic cells to lymph nodes","volume":"103","author":"Robbiani","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2018.10.040_bib137","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1042\/BST20140319","article-title":"The blood-brain barrier endothelium: a target for pro-inflammatory cytokines","volume":"43","author":"Rochfort","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ejphar.2018.10.040_bib138","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11064-014-1478-9","article-title":"Montelukast, a cysteinyl leukotriene receptor-1 antagonist protects against hippocampal injury induced by transient global cerebral ischemia and reperfusion in rats","volume":"40","author":"Saad","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib139","first-page":"275","article-title":"Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons","volume":"18","author":"Saez","year":"2004","journal-title":"In Vivo"},{"key":"10.1016\/j.ejphar.2018.10.040_bib140","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-neuro-070815-014015","article-title":"Alzheimer's disease mechanisms and emerging roads to novel therapeutics","volume":"39","author":"Sala Frigerio","year":"2016","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib141","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/jnc.13932","article-title":"Hypoxia\/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease","volume":"140","author":"Salminen","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2018.10.040_bib142","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/00002093-198802020-00002","article-title":"Cellular localization of messenger RNA encoding amyloid-beta-protein in normal tissue and in Alzheimer disease","volume":"2","author":"Schmechel","year":"1988","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.ejphar.2018.10.040_bib143","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0197-0186(01)00041-9","article-title":"Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation","volume":"39","author":"Sheng","year":"2001","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2018.10.040_bib144","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbrc.2006.05.023","article-title":"Distinct roles of CysLT 1 and CysLT 2 receptors in oxygen glucose deprivation-induced PC12 cell death","volume":"346","author":"Sheng","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2018.10.040_bib145","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neuroscience.2015.02.002","article-title":"HAMI 3379, a CysLT2R antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in rats","volume":"291","author":"Shi","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2018.10.040_bib146","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainres.2012.09.020","article-title":"Intracerebroventricular injection of HAMI 3379, a selective cysteinyl leukotriene receptor 2 antagonist, protects against acute brain injury after focal cerebral ischemia in rats","volume":"1484","author":"Shi","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib147","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s10753-013-9657-4","article-title":"5-Lipoxygenase inhibitor zileuton inhibits neuronal apoptosis following focal cerebral ischemia","volume":"36","author":"Shi","year":"2013","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2018.10.040_bib148","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2174\/1567202612666151026105610","article-title":"Reversal in cognition impairments, cholinergic dysfunction, and cerebral oxidative stress through the modulation of ryanodine receptors (RyRs) and Cysteinyl leukotriene-1 (CysLT1) receptors","volume":"13","author":"Singh","year":"2016","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib149","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000312669","article-title":"Cysteinyl leukotrienes and their receptors: molecular and functional characteristics","volume":"85","author":"Singh","year":"2010","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejphar.2018.10.040_bib150","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib151","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.brainres.2018.03.006","article-title":"Edaravone, a free radical scavenger, protects neuronal cells' mitochondria from ischemia by inactivating another new critical factor of the 5-lipoxygenase pathway affecting the arachidonic acid metabolism","volume":"1690","author":"Song","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib152","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0002-9440(10)63269-5","article-title":"Modulation of nuclear factor-\u03baB activity by indomethacin influences A\u03b2 levels but not A\u03b2 precursor protein metabolism in a model of Alzheimer's disease","volume":"165","author":"Sung","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib153","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-6606-6-6","article-title":"Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses","volume":"6","author":"Tanaka","year":"2013","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ejphar.2018.10.040_bib154","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.neurobiolaging.2013.09.036","article-title":"Involvement of cysteinyl leukotriene receptor 1 in Abeta1-42-induced neurotoxicity in vitro and in vivo","volume":"35","author":"Tang","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2018.10.040_bib155","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1017\/S1461145713001314","article-title":"Protective effect of pranlukast on Abeta(1)(-)(4)(2)-induced cognitive deficits associated with downregulation of cysteinyl leukotriene receptor 1","volume":"17","author":"Tang","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib156","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neuropharm.2012.08.026","article-title":"Leukotriene D4 induces cognitive impairment through enhancement of CysLT(1) R-mediated amyloid-beta generation in mice","volume":"65","author":"Tang","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2018.10.040_bib157","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jns.2004.06.015","article-title":"Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology","volume":"225","author":"Teaktong","year":"2004","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib158","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2012.04.021","article-title":"The role of astrocytes in amyloid beta-protein toxicity and clearance","volume":"236","author":"Thal","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib159","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jaci.2005.12.1342","article-title":"Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells","volume":"117","author":"Thivierge","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib160","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1165\/rcmb.2005-0407OC","article-title":"CysLT1 receptor engagement induces activator protein-1- and NF-kappaB-dependent IL-8 expression","volume":"35","author":"Thompson","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib161","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1179\/174313209X403913","article-title":"5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9","volume":"31","author":"Tu","year":"2009","journal-title":"Neurol. Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib162","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s10753-010-9191-6","article-title":"Zileuton reduces inflammatory reaction and brain damage following permanent cerebral ischemia in rats","volume":"33","author":"Tu","year":"2010","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2018.10.040_bib163","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/B978-0-12-398314-5.00004-0","article-title":"Inflammation in Parkinson's disease","volume":"88","author":"Tufekci","year":"2012","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib164","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1046\/j.1471-4159.1999.0730693.x","article-title":"Glucocorticoids stimulate inflammatory 5\u2010lipoxygenase gene expression and protein translocation in the brain","volume":"73","author":"Uz","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2018.10.040_bib165","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1096\/fasebj.12.6.439","article-title":"Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability","volume":"12","author":"Uz","year":"1998","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2018.10.040_bib166","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11064-014-1403-2","article-title":"Why are astrocytes important?","volume":"40","author":"Verkhratsky","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib167","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3233\/JAD-140144","article-title":"The effects of impaired cerebral circulation on Alzheimer's disease pathology: evidence from animal studies","author":"Villarreal","year":"2014","journal-title":"J. Alzheimer's Dis.: JAD"},{"key":"10.1016\/j.ejphar.2018.10.040_bib168","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neurobiolaging.2014.06.029","article-title":"The combined treatment of amyloid-\u03b21-42-stimulated bone marrow\u2013derived dendritic cells plus splenocytes from young mice prevents the development of Alzheimer's disease in APPswe\/PSENldE9 mice","volume":"36","author":"Wang","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2018.10.040_bib169","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.neuint.2013.01.002","article-title":"Leukotriene D4 induces amyloid-beta generation via CysLT(1)R-mediated NF-kappaB pathways in primary neurons","volume":"62","author":"Wang","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2018.10.040_bib170","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brainres.2004.05.106","article-title":"Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein","volume":"1022","author":"Wen","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib171","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/glia.22988","article-title":"Targeting microglia for the treatment of Alzheimer's Disease","volume":"64","author":"Wes","year":"2016","journal-title":"Glia"},{"issue":"Suppl 4","key":"10.1016\/j.ejphar.2018.10.040_bib172","doi-asserted-by":"crossref","first-page":"S411","DOI":"10.3233\/JAD-141467","article-title":"Cerebral blood flow measured by arterial spin labeling MRI as a preclinical marker of Alzheimer's disease","volume":"42","author":"Wierenga","year":"2014","journal-title":"J. Alzheimer's Dis. : JAD"},{"key":"10.1016\/j.ejphar.2018.10.040_bib173","doi-asserted-by":"crossref","first-page":"a021287","DOI":"10.1101\/cshperspect.a021287","article-title":"Adult neurogenesis in neurodegenerative diseases","volume":"7","author":"Winner","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib174","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/ana.20558","article-title":"Elevation of 12\/15 lipoxygenase products in AD and mild cognitive impairment","volume":"58","author":"Yao","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib175","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000081072","article-title":"Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose-and time-dependently protects against focal cerebral ischemia in mice","volume":"73","author":"Yu","year":"2005","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejphar.2018.10.040_bib176","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2005.06.046","article-title":"Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice","volume":"1053","author":"Yu","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib177","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/aps.2013.130","article-title":"Cysteinyl leukotriene receptor 1 mediates LTD 4-induced activation of mouse microglial cells in vitro","volume":"35","author":"Yu","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2018.10.040_bib178","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.expneurol.2004.12.015","article-title":"High selective expression of alpha7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer's disease and patients carrying Swedish APP 670\/671 mutation: a possible association with neuritic plaques","volume":"192","author":"Yu","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib179","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/978-1-4939-0320-7_33","article-title":"A neurovascular blood-brain barrier in vitro model","volume":"1135","author":"Zehendner","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib180","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2147\/NDT.S75546","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"11","author":"Zhang","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.ejphar.2018.10.040_bib181","first-page":"1241","article-title":"Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on transient global cerebral ischemia in rats","volume":"24","author":"Zhang","year":"2003","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2018.10.040_bib182","first-page":"1","article-title":"Protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats","volume":"39","author":"Zhang","year":"2004","journal-title":"Yao xue xue bao = Acta Pharm. Sin."},{"key":"10.1016\/j.ejphar.2018.10.040_bib183","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.brainres.2014.05.026","article-title":"Regulation of rotenone-induced microglial activation by 5-lipoxygenase and cysteinyl leukotriene receptor 1","volume":"1572","author":"Zhang","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2018.10.040_bib184","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1124\/jpet.113.203604","article-title":"HAMI 3379, a CysLT2 receptor antagonist, attenuates ischemia-like neuronal injury by inhibiting microglial activation","volume":"346","author":"Zhang","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2018.10.040_bib185","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/j.1745-7254.2006.00458.x","article-title":"Cysteinyl leukotriene receptors CysLT1 and CysLT2 are upregulated in acute neuronal injury after focal cerebral ischemia in mice","volume":"27","author":"Zhang","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2018.10.040_bib186","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2011.05.066","article-title":"Cysteinyl leukotriene receptor 2 is spatiotemporally involved in neuron injury, astrocytosis and microgliosis after focal cerebral ischemia in rats","volume":"189","author":"Zhao","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2018.10.040_bib187","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.2042-7158.2010.01238.x","article-title":"Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats","volume":"63","author":"Zhao","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.10.040_bib188","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/j.1745-7254.2006.00406.x","article-title":"Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats","volume":"27","author":"Zhou","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2018.10.040_bib189","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.lfs.2006.05.022","article-title":"Spatio-temporal properties of 5-lipoxygenase expression and activation in the brain after focal cerebral ischemia in rats","volume":"79","author":"Zhou","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2018.10.040_bib190","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918306277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918306277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T22:31:34Z","timestamp":1775255494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299918306277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":190,"alternative-id":["S0014299918306277"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.10.040","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel therapeutic potential of cysteinyl leukotrienes and their receptors modulation in the neurological complications associated with Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.10.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}