{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T21:48:25Z","timestamp":1785534505593,"version":"3.56.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["81570408"],"award-info":[{"award-number":["81570408"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["81773736"],"award-info":[{"award-number":["81773736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of South China Innovation Foundation for Postgraduate","award":["2017XCX03"],"award-info":[{"award-number":["2017XCX03"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ejphar.2018.11.009","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T16:29:49Z","timestamp":1542040189000},"page":"177-189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Coiled-coil domain-containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1\/2 phosphorylation and TET2 expression"],"prefix":"10.1016","volume":"843","author":[{"given":"Duo","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Long","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-dong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-ke","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2018.11.009_bib1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.gene.2013.05.044","article-title":"Aza-induced cardiomyocyte differentiation of P19 EC-cells by epigenetic co-regulation and ERK signaling","volume":"526","author":"Abbey","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.ejphar.2018.11.009_bib2","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1006\/bbrc.2002.6337","article-title":"Cloning, expression, and mapping of a gene that is upregulated in adipose tissue of mice deficient in bombesin receptor subtype-3","volume":"290","author":"Aoki","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2018.11.009_bib3","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1074\/jbc.M412593200","article-title":"DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells","volume":"280","author":"Bommer","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.11.009_bib4","doi-asserted-by":"crossref","first-page":"18325","DOI":"10.4238\/2015.December.23.20","article-title":"Application of the ERK signaling pathway inhibitor PD98059 in long-term in vivo experiments","volume":"14","author":"Chen","year":"2015","journal-title":"Genet. Mol. Res.: GMR"},{"key":"10.1016\/j.ejphar.2018.11.009_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cmet.2010.04.016","article-title":"GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries","volume":"12","author":"Davies","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejphar.2018.11.009_bib6","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1038\/nutd.2015.19","article-title":"Regional distribution of body fat in relation to DNA methylation within the LPL, ADIPOQ and PPARgamma promoters in subcutaneous adipose tissue","volume":"5","author":"Drogan","year":"2015","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.ejphar.2018.11.009_bib7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11883-017-0667-9","article-title":"Genetics of triglycerides and the risk of atherosclerosis","volume":"19","author":"Dron","year":"2017","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.ejphar.2018.11.009_bib8","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1016\/j.febslet.2011.08.025","article-title":"Transcriptional repression of the tumor suppressor DRO1 by AIB1","volume":"585","author":"Ferragud","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2018.11.009_bib9","doi-asserted-by":"crossref","first-page":"18502","DOI":"10.1038\/srep18502","article-title":"A lipasin\/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase","volume":"5","author":"Fu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2018.11.009_bib10","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.aag1381","article-title":"Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice","volume":"355","author":"Fuster JJ","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2018.11.009_bib11","first-page":"1","article-title":"Placental lipoprotein lipase DNA methylation alterations are associated with gestational diabetes and body composition at 5 years of age","author":"Gagne-Ouellet","year":"2017","journal-title":"Epigenetics"},{"key":"10.1016\/j.ejphar.2018.11.009_bib12","first-page":"2","article-title":"Increased binding of apolipoproteins A-I and E4 to triglyceride-rich lipoproteins is linked to induction of hypertriglyceridemia","author":"Gorshkova","year":"2017","journal-title":"JSM Atheroscler."},{"key":"10.1016\/j.ejphar.2018.11.009_bib13","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.cmet.2014.01.017","article-title":"The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries","volume":"19","author":"Goulbourne","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejphar.2018.11.009_bib14","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1158\/1541-7786.MCR-14-0205-T","article-title":"DRO1 inactivation drives colorectal carcinogenesis in ApcMin\/+ mice","volume":"12","author":"Grill","year":"2014","journal-title":"Mol. Cancer Res.: MCR"},{"key":"10.1016\/j.ejphar.2018.11.009_bib15","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature10443","article-title":"The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes","volume":"477","author":"Gu","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2018.11.009_bib16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.cca.2018.02.006","article-title":"Lipoprotein lipase: biosynthesis, regulatory factors, and its role in atherosclerosis and other diseases","volume":"480","author":"He","year":"2018","journal-title":"Clin. Chim. Acta: Int. J. Clin. Chem."},{"key":"10.1016\/j.ejphar.2018.11.009_bib17","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1159\/000453135","article-title":"Roles of 1,25(OH)2D3 and vitamin D receptor in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus by regulating the activation of CD4+ T cells and the PKCdelta\/ERK signaling pathway","volume":"40","author":"He","year":"2016","journal-title":"Cell. Physiol. Biochem.: Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2018.11.009_bib18","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.1210597","article-title":"Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine","volume":"333","author":"Ito","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2018.11.009_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/B978-0-12-387685-0.00002-0","article-title":"Natural history of eukaryotic DNA methylation systems","volume":"101","author":"Iyer","year":"2011","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.ejphar.2018.11.009_bib20","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bbalip.2014.03.013","article-title":"Physiological regulation of lipoprotein lipase","volume":"1841","author":"Kersten","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2018.11.009_bib21","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1210\/en.2005-0476","article-title":"Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism","volume":"146","author":"Koster","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2018.11.009_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11883-017-0661-2","article-title":"The role of emerging risk factors in cardiovascular outcomes","volume":"19","author":"Lacey","year":"2017","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.ejphar.2018.11.009_bib23","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1194\/jlr.M078220","article-title":"Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL","volume":"58","author":"Larsson","year":"2017","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ejphar.2018.11.009_bib24","doi-asserted-by":"crossref","first-page":"15903","DOI":"10.1038\/ncomms15903","article-title":"Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis","volume":"8","author":"Li","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2018.11.009_bib25","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1161\/CIRCULATIONAHA.113.002887","article-title":"Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity","volume":"128","author":"Liu","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.11.009_bib26","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bbagrm.2014.06.004","article-title":"Epigenetic regulation of smooth muscle cell plasticity","volume":"1849","author":"Liu","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2018.11.009_bib27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbrc.2004.07.161","article-title":"URB expression in human bone marrow stromal cells and during mouse development","volume":"322","author":"Liu","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2018.11.009_bib28","doi-asserted-by":"crossref","first-page":"12249","DOI":"10.1074\/jbc.M608525200","article-title":"Inhibition of the extracellular signal-regulated kinase\/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells","volume":"282","author":"Lu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.11.009_bib29","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1172\/JCI11774","article-title":"Heparin-binding defective lipoprotein lipase is unstable and causes abnormalities in lipid delivery to tissues","volume":"107","author":"Lutz","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2018.11.009_bib30","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1210\/endo.142.6.8154","article-title":"Cloning and characterization of a novel gene that is regulated by estrogen and is associated with mammary gland carcinogenesis","volume":"142","author":"Marcantonio","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2018.11.009_bib31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fcell.2018.00022","article-title":"Tet enzymes, variants, and differential effects on function","volume":"6","author":"Melamed","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2018.11.009_bib32","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1161\/CIR.0b013e3182160726","article-title":"Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association","volume":"123","author":"Miller","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2018.11.009_bib33","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.bbadis.2018.02.006","article-title":"Nutraceuticals as therapeutic agents for atherosclerosis","volume":"1864","author":"Moss","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2018.11.009_bib34","first-page":"e2089","article-title":"Dyslipidemia and associated cardiovascular risk factors among young Nepalese university students","volume":"10","author":"Nepal","year":"2018","journal-title":"Cureus"},{"key":"10.1016\/j.ejphar.2018.11.009_bib35","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1210\/me.2011-1275","article-title":"Identification of steroid-sensitive gene-1\/Ccdc80 as a JAK2-binding protein","volume":"27","author":"O'Leary","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ejphar.2018.11.009_bib36","first-page":"23","article-title":"Adipose tissue and serum CCDC80 in obesity and its association with related metabolic disease","author":"Osorio-Conles","year":"2017","journal-title":"Mol. Med."},{"key":"10.1016\/j.ejphar.2018.11.009_bib37","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.biochi.2015.10.020","article-title":"Betulinic acid downregulates expression of oxidative stress-induced lipoprotein lipase via the PKC\/ERK\/c-Fos pathway in RAW264.7 macrophages","volume":"119","author":"Peng","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.ejphar.2018.11.009_bib38","first-page":"2723","article-title":"Histone deacetylase inhibitors reverse CpG methylation by regulating DNMT1 through ERK signaling","volume":"31","author":"Sarkar","year":"2011","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejphar.2018.11.009_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2017.01.024","article-title":"Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants","volume":"258","author":"Shahid","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2018.11.009_bib40","first-page":"149","article-title":"DNA methylation in states of cell physiology and pathology","volume":"45","author":"Sulewska","year":"2007","journal-title":"Folia Histochem. Cytobiol."},{"key":"10.1016\/j.ejphar.2018.11.009_bib41","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2018.11.009_bib42","doi-asserted-by":"crossref","first-page":"8136","DOI":"10.1074\/jbc.M809535200","article-title":"Bidirectional modulation of adipogenesis by the secreted protein Ccdc80\/DRO1\/URB","volume":"284","author":"Tremblay","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.11.009_bib43","doi-asserted-by":"crossref","first-page":"24972","DOI":"10.1074\/jbc.M113.456244","article-title":"Steroid-sensitive gene 1 is a novel cyclic GMP-dependent protein kinase I substrate in vascular smooth muscle cells","volume":"288","author":"Wang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2018.11.009_bib44","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1172\/JCI16751","article-title":"Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy","volume":"111","author":"Yagyu","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2018.11.009_bib45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1472-6882-12-22","article-title":"Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK\/ERK pathways","volume":"12","author":"Yang","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.ejphar.2018.11.009_bib46","doi-asserted-by":"crossref","first-page":"150272","DOI":"10.1098\/rsob.150272","article-title":"The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking","volume":"6","author":"Zhang","year":"2016","journal-title":"Open Biol."},{"key":"10.1016\/j.ejphar.2018.11.009_bib47","doi-asserted-by":"crossref","first-page":"34543","DOI":"10.1038\/srep34543","article-title":"ERK\/c-jun recruits Tet1 to induce zta expression and epstein-barr virus reactivation through DNA demethylation","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2018.11.009_bib48","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/hmg\/ddt461","article-title":"Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes","volume":"23","author":"Zhang","year":"2014","journal-title":"Hum. Mol. Genet."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918306599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299918306599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:05:39Z","timestamp":1762142739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299918306599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":48,"alternative-id":["S0014299918306599"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.11.009","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coiled-coil domain-containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1\/2 phosphorylation and TET2 expression","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2018.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}