{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:32:23Z","timestamp":1777458743017,"version":"3.51.4"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2012-2396"],"award-info":[{"award-number":["PICT 2012-2396"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2016-2289"],"award-info":[{"award-number":["PICT 2016-2289"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"publisher","award":["PIP0750"],"award-info":[{"award-number":["PIP0750"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.ejphar.2019.01.070","type":"journal-article","created":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T15:26:04Z","timestamp":1549121164000},"page":"96-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["p38 mitogen activated protein kinase mediates cardiac Na+\/H+ exchanger inhibition induced by Sildenafil"],"prefix":"10.1016","volume":"849","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0599-510X","authenticated-orcid":false,"given":"Romina G.","family":"D\u00edaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiana S.","family":"Escudero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda S.","family":"Brea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricio E.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e9stor G.","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejphar.2019.01.070_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cardiores.2005.01.007","article-title":"Mechanism of cGMP-mediated protection in a cellular model of myocardial reperfusion injury","volume":"66","author":"Abdallah","year":"2005","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.ejphar.2019.01.070_bib2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cardiores.2003.09.031","article-title":"Protein kinase activation and myocardial ischemia\/reperfusion injury","volume":"61","author":"Armstrong","year":"2004","journal-title":"Cardiovasc. Res."},{"issue":"9","key":"10.1016\/j.ejphar.2019.01.070_bib3","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.21037\/jtd.2016.08.53","article-title":"Losmapimod does not reduce cardiovascular events in patients with acute myocardial infarction","volume":"8","author":"Aronow","year":"2016","journal-title":"J. Thorac. Dis."},{"issue":"3","key":"10.1016\/j.ejphar.2019.01.070_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cardfail.2007.11.006","article-title":"Effects of 5\u2032-phosphodiesterase four-week long inhibition with sildenafil in patients with chronic heart failure: a double-blind, placebo-controlled clinical trial","volume":"14","author":"Behling","year":"2008","journal-title":"J. Card. Fail."},{"issue":"12B","key":"10.1016\/j.ejphar.2019.01.070_bib5","doi-asserted-by":"crossref","first-page":"29M","DOI":"10.1016\/j.amjcard.2005.07.008","article-title":"Phosphodiesterase 5 mechanisms and therapeutic applications","volume":"96","author":"Burnett","year":"2005","journal-title":"Am. J. Cardiol."},{"issue":"2","key":"10.1016\/j.ejphar.2019.01.070_bib6","doi-asserted-by":"crossref","first-page":"H846","DOI":"10.1152\/ajpheart.01231.2008","article-title":"Phenylephrine and sustained acidosis activate the neonatal rat cardiomyocyte Na+\/H+ exchanger through phosphorylation of amino acids Ser770 and Ser771","volume":"297","author":"Coccaro","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2019.01.070_bib7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.bi.58.070189.002321","article-title":"The structure and regulation of protein phosphatases","volume":"58","author":"Cohen","year":"1989","journal-title":"Annu. Rev. Biochem."},{"issue":"4\u20135","key":"10.1016\/j.ejphar.2019.01.070_bib8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1159\/000322321","article-title":"Phosphodiesterase 5A inhibition decreases NHE-1 activity without altering steady state pH(i): role of phosphatases","volume":"26","author":"Diaz","year":"2010","journal-title":"Cell. Physiol. Biochem."},{"issue":"9","key":"10.1016\/j.ejphar.2019.01.070_bib9","doi-asserted-by":"crossref","first-page":"6885","DOI":"10.1074\/jbc.M206320200","article-title":"Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite","volume":"278","author":"Duyndam","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ejphar.2019.01.070_bib10","first-page":"1","article-title":"Protein phosphatase 2A regulatory subunits and cancer","volume":"1795","author":"Eichhorn","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"43","key":"10.1016\/j.ejphar.2019.01.070_bib11","doi-asserted-by":"crossref","first-page":"32831","DOI":"10.1074\/jbc.M603416200","article-title":"cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes","volume":"281","author":"Fiedler","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"17","key":"10.1016\/j.ejphar.2019.01.070_bib12","doi-asserted-by":"crossref","first-page":"11363","DOI":"10.1073\/pnas.162100799","article-title":"Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes","volume":"99","author":"Fiedler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.ejphar.2019.01.070_bib13","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1160\/TH08-11-0764","article-title":"Myocardial protection against reperfusion injury: the cGMP pathway","volume":"101","author":"Garcia-Dorado","year":"2009","journal-title":"Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.ejphar.2019.01.070_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000325201","article-title":"Myocardial reperfusion injury: reactive oxygen species vs. NHE-1 reactivation","volume":"27","author":"Garciarena","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"issue":"5558","key":"10.1016\/j.ejphar.2019.01.070_bib15","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1126\/science.1067289","article-title":"MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha","volume":"295","author":"Ge","year":"2002","journal-title":"Science"},{"issue":"9337","key":"10.1016\/j.ejphar.2019.01.070_bib16","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(02)11024-5","article-title":"Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial","volume":"360","author":"Ghofrani","year":"2002","journal-title":"Lancet"},{"issue":"34","key":"10.1016\/j.ejphar.2019.01.070_bib17","doi-asserted-by":"crossref","first-page":"31676","DOI":"10.1074\/jbc.M304400200","article-title":"Stimulation of the plasma membrane Na+\/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway","volume":"278","author":"Haworth","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.ejphar.2019.01.070_bib18","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1016\/j.yexcr.2011.09.011","article-title":"A novel cardioprotective p38-MAPK\/mTOR pathway","volume":"317","author":"Hernandez","year":"2011","journal-title":"Exp. Cell Res."},{"issue":"3 Suppl.","key":"10.1016\/j.ejphar.2019.01.070_bib19","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.urology.2006.05.047","article-title":"Cardiovascular safety of sildenafil citrate (Viagra): an updated perspective","volume":"68","author":"Jackson","year":"2006","journal-title":"Urology"},{"issue":"Pt 3","key":"10.1016\/j.ejphar.2019.01.070_bib20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/bj3530417","article-title":"Protein phosphatase 2A: a highly regulated family of serine\/threonine phosphatases implicated in cell growth and signalling","volume":"353","author":"Janssens","year":"2001","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.ejphar.2019.01.070_bib21","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pharmthera.2014.05.013","article-title":"Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives","volume":"144","author":"Javadov","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2019.01.070_bib22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yjmcc.2013.02.006","article-title":"NHE-1: still a viable therapeutic target","volume":"61","author":"Karmazyn","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"9","key":"10.1016\/j.ejphar.2019.01.070_bib23","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1161\/01.RES.85.9.777","article-title":"The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease","volume":"85","author":"Karmazyn","year":"1999","journal-title":"Circ. Res."},{"issue":"22","key":"10.1016\/j.ejphar.2019.01.070_bib24","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1128\/MCB.21.22.7545-7557.2001","article-title":"Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization","volume":"21","author":"Khaled","year":"2001","journal-title":"Mol. Cell. Biol."},{"issue":"20","key":"10.1016\/j.ejphar.2019.01.070_bib25","doi-asserted-by":"crossref","first-page":"12825","DOI":"10.1073\/pnas.202474099","article-title":"Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3","volume":"99","author":"Kubasiak","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.ejphar.2019.01.070_bib26","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1161\/01.RES.83.8.824","article-title":"p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+\/H+ exchange and ERK1\/2","volume":"83","author":"Kusuhara","year":"1998","journal-title":"Circ. Res."},{"issue":"Pt 1","key":"10.1016\/j.ejphar.2019.01.070_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1469-7793.1999.0159z.x","article-title":"Characterization of intracellular pH regulation in the guinea-pig ventricular myocyte","volume":"517","author":"Leem","year":"1999","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.ejphar.2019.01.070_bib28","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1182\/blood-2005-03-1308","article-title":"Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3","volume":"107","author":"Li","year":"2006","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.ejphar.2019.01.070_bib29","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1021\/ac035231d","article-title":"Open tubular immobilized metal ion affinity chromatography combined with MALDI MS and MS\/MS for identification of protein phosphorylation sites","volume":"76","author":"Liu","year":"2004","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.ejphar.2019.01.070_bib30","doi-asserted-by":"crossref","first-page":"H97","DOI":"10.1152\/ajpheart.00956.2002","article-title":"Modulation of protein phosphatase 2a by adenosine A1 receptors in cardiomyocytes: role for p38 MAPK","volume":"285","author":"Liu","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.ejphar.2019.01.070_bib31","doi-asserted-by":"crossref","first-page":"H2204","DOI":"10.1152\/ajpheart.01050.2003","article-title":"Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes","volume":"286","author":"Liu","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"13","key":"10.1016\/j.ejphar.2019.01.070_bib32","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1161\/01.CIR.99.13.1685","article-title":"Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion","volume":"99","author":"Ma","year":"1999","journal-title":"Circulation"},{"issue":"21","key":"10.1016\/j.ejphar.2019.01.070_bib33","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1161\/CIRCULATIONAHA.105.563486","article-title":"Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury","volume":"113","author":"Maekawa","year":"2006","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.ejphar.2019.01.070_bib34","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cell.2006.10.035","article-title":"Role for the PP2A\/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis","volume":"127","author":"Margolis","year":"2006","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.ejphar.2019.01.070_bib35","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.athoracsur.2007.10.054","article-title":"Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study","volume":"85","author":"Mentzer","year":"2008","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"10.1016\/j.ejphar.2019.01.070_bib36","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1006\/bbrc.2000.2522","article-title":"Activation of Akt during simulated ischemia\/reperfusion in cardiac myocytes","volume":"270","author":"Mockridge","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.ejphar.2019.01.070_bib37","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/CIRCRESAHA.108.175141","article-title":"Activation of Na+\/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure","volume":"103","author":"Nakamura","year":"2008","journal-title":"Circ. Res."},{"issue":"15","key":"10.1016\/j.ejphar.2019.01.070_bib38","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1001\/jama.2016.3609","article-title":"Effect of losmapimod on cardiovascular outcomes in patients hospitalized with acute myocardial infarction: a randomized clinical trial","volume":"315","author":"O'Donoghue","year":"2016","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.ejphar.2019.01.070_bib39","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/iub.1323","article-title":"The Na(+)\/H(+) exchanger and pH regulation in the heart","volume":"66","author":"Odunewu-Aderibigbe","year":"2014","journal-title":"IUBMB Life"},{"issue":"16","key":"10.1016\/j.ejphar.2019.01.070_bib40","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0960-9822(03)00535-9","article-title":"Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites","volume":"13","author":"Ory","year":"2003","journal-title":"Curr. Biol."},{"issue":"5","key":"10.1016\/j.ejphar.2019.01.070_bib41","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1161\/HYPERTENSIONAHA.107.087759","article-title":"Phosphodiesterase 5A inhibition induces Na+\/H+ exchanger blockade and protection against myocardial infarction","volume":"49","author":"Perez","year":"2007","journal-title":"Hypertension"},{"issue":"11","key":"10.1016\/j.ejphar.2019.01.070_bib42","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1161\/ATVBAHA.110.209205","article-title":"Inhibition of p38 mitogen-activated protein kinase reduces inflammation after coronary vascular injury in humans","volume":"30","author":"Sarov-Blat","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.ejphar.2019.01.070_bib43","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1124\/jpet.301.2.501","article-title":"On the role of phosphatase in regulation of cardiac L-type calcium current by cyclic GMP","volume":"301","author":"Shen","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"8","key":"10.1016\/j.ejphar.2019.01.070_bib44","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1161\/CIRCRESAHA.108.175877","article-title":"Protein kinase B\/Akt phosphorylates and inhibits the cardiac Na+\/H+ exchanger NHE1","volume":"103","author":"Snabaitis","year":"2008","journal-title":"Circ. Res."},{"issue":"29","key":"10.1016\/j.ejphar.2019.01.070_bib45","doi-asserted-by":"crossref","first-page":"20252","DOI":"10.1074\/jbc.M600268200","article-title":"A novel role for protein phosphatase 2A in receptor-mediated regulation of the cardiac sarcolemmal Na+\/H+ exchanger NHE1","volume":"281","author":"Snabaitis","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.ejphar.2019.01.070_bib46","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nm1175","article-title":"Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy","volume":"11","author":"Takimoto","year":"2005","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.ejphar.2019.01.070_bib47","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1161\/01.RES.0000083490.43943.85","article-title":"Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia","volume":"93","author":"Tanno","year":"2003","journal-title":"Circ. Res."},{"issue":"25","key":"10.1016\/j.ejphar.2019.01.070_bib48","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1161\/01.CIR.102.25.3032","article-title":"Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators","volume":"102","author":"Theroux","year":"2000","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ejphar.2019.01.070_bib49","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/toxsci\/kfh132","article-title":"Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42\/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes","volume":"79","author":"Trouba","year":"2004","journal-title":"Toxicol. Sci."},{"issue":"8","key":"10.1016\/j.ejphar.2019.01.070_bib50","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1111\/j.1440-1681.2009.05193.x","article-title":"p38 mitogen-activated protein kinase (MAPK) is activated by noradrenaline and serves a cardioprotective role, whereas adrenaline induces p38 MAPK dephosphorylation","volume":"36","author":"Tsang","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"18","key":"10.1016\/j.ejphar.2019.01.070_bib51","doi-asserted-by":"crossref","first-page":"13710","DOI":"10.1016\/S0021-9258(17)36888-6","article-title":"Mutation of calmodulin-binding site renders the Na+\/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective","volume":"269","author":"Wakabayashi","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.ejphar.2019.01.070_bib52","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1073\/pnas.89.6.2424","article-title":"The Na+\/H+ antiporter cytoplasmic domain mediates growth factor signals and controls \"H(+)-sensing\"","volume":"89","author":"Wakabayashi","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.ejphar.2019.01.070_bib53","doi-asserted-by":"crossref","first-page":"C1542","DOI":"10.1152\/ajpcell.2001.281.5.C1542","article-title":"Differential MAP kinase activation and Na(+)\/H(+) exchanger phosphorylation by H(2)O(2) in rat cardiac myocytes","volume":"281","author":"Wei","year":"2001","journal-title":"Am. J. Physiol. Cell. Physiol."},{"issue":"7","key":"10.1016\/j.ejphar.2019.01.070_bib54","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1128\/MCB.21.7.2373-2383.2001","article-title":"p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression","volume":"21","author":"Westermarck","year":"2001","journal-title":"Mol. Cell. Biol."},{"issue":"Pt 2","key":"10.1016\/j.ejphar.2019.01.070_bib55","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1113\/jphysiol.1994.sp020251","article-title":"Effect of metabolic inhibitors and second messengers upon Na(+)-H+ exchange in the sheep cardiac Purkinje fibre","volume":"478","author":"Wu","year":"1994","journal-title":"J. Physiol."},{"issue":"8","key":"10.1016\/j.ejphar.2019.01.070_bib56","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.biocel.2013.04.027","article-title":"Dual role of cyclic GMP in cardiac cell survival","volume":"45","author":"Xu","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"20","key":"10.1016\/j.ejphar.2019.01.070_bib57","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1523\/JNEUROSCI.4107-06.2007","article-title":"Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons","volume":"27","author":"Zhang","year":"2007","journal-title":"J. Neurosci."},{"issue":"16","key":"10.1016\/j.ejphar.2019.01.070_bib58","doi-asserted-by":"crossref","first-page":"15649","DOI":"10.1074\/jbc.M410858200","article-title":"p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process","volume":"280","author":"Zhu","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ejphar.2019.01.070_bib59","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cellsig.2006.05.032","article-title":"Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1","volume":"19","author":"Zuluaga","year":"2007","journal-title":"Cell Signal."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919300536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919300536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T09:25:47Z","timestamp":1662888347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299919300536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":59,"alternative-id":["S0014299919300536"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.01.070","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p38 mitogen activated protein kinase mediates cardiac Na+\/H+ exchanger inhibition induced by Sildenafil","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.01.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}