{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:25:17Z","timestamp":1773678317218,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20180157"],"award-info":[{"award-number":["BK20180157"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602788"],"award-info":[{"award-number":["81602788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.ejphar.2019.03.004","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T01:55:32Z","timestamp":1551491732000},"page":"174-185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Adapalene suppressed the proliferation of melanoma cells by S-phase arrest and subsequent apoptosis via induction of DNA damage"],"prefix":"10.1016","volume":"851","author":[{"given":"Hongyang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Bu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2019.03.004_bib1","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1101\/gad.914401","article-title":"Cell cycle checkpoint signaling through the ATM and ATR kinases","volume":"15","author":"Abraham","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejphar.2019.03.004_bib2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev-pathol-012513-104658","article-title":"The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia","volume":"9","author":"Bastian","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.ejphar.2019.03.004_bib3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrm3629","article-title":"Control of cell cycle transcription during G1 and S phases","volume":"14","author":"Bertoli","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2019.03.004_bib4","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.3389\/fimmu.2018.01474","article-title":"Biomarkers for clinical benefit of immune checkpoint inhibitor treatment-a review from the melanoma perspective and beyond","volume":"9","author":"Buder-Bakhaya","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2019.03.004_bib5","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.addr.2010.07.003","article-title":"Retinoid pathway and cancer therapeutics","volume":"62","author":"Bushue","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejphar.2019.03.004_bib6","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/s41467-018-03877-7","article-title":"Inhibition of cancer stem cell like cells by a synthetic retinoid","volume":"9","author":"Chen","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2019.03.004_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/ITT.S134842","article-title":"Melanoma treatment in review","volume":"7","author":"Domingues","year":"2018","journal-title":"ImmunoTargets Ther."},{"key":"10.1016\/j.ejphar.2019.03.004_bib8","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/jid.2015.14","article-title":"Targeted therapies in melanoma: translational research at its finest","volume":"135","author":"Ho","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.ejphar.2019.03.004_bib9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1523-1747.2000.00868.x","article-title":"The role of specific retinoid receptors in sebocyte growth and differentiation in culture","volume":"114","author":"Kim","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.ejphar.2019.03.004_bib10","doi-asserted-by":"crossref","first-page":"734","DOI":"10.5604\/17322693.966832","article-title":"Dacarbazine, a chemotherapeutic against metastatic melanoma and a reference drug for new treatment modalities","volume":"65","author":"Koprowska","year":"2011","journal-title":"Post. Hig. Med. doswiadczalnej"},{"key":"10.1016\/j.ejphar.2019.03.004_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12943-016-0578-3","article-title":"Therapeutic implications of cellular and molecular biology of cancer stem cells in melanoma","volume":"16","author":"Kumar","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ejphar.2019.03.004_bib12","doi-asserted-by":"crossref","first-page":"18984","DOI":"10.1074\/jbc.273.30.18984","article-title":"Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis","volume":"273","author":"Ling","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.03.004_bib13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1126\/science.1253735","article-title":"The melanoma revolution: from UV carcinogenesis to a new era in therapeutics","volume":"346","author":"Lo","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2019.03.004_bib14","doi-asserted-by":"crossref","first-page":"e0158760","DOI":"10.1371\/journal.pone.0158760","article-title":"All-trans retinoic acid plus arsenic trioxide versus all-trans retinoic acid plus chemotherapy for newly diagnosed acute promyelocytic leukemia: a meta-analysis","volume":"11","author":"Ma","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2019.03.004_bib15","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.clinthera.2015.02.018","article-title":"The next immune-checkpoint inhibitors: PD-1\/PD-L1 blockade in melanoma","volume":"37","author":"Mahoney","year":"2015","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ejphar.2019.03.004_bib16","doi-asserted-by":"crossref","first-page":"e002","DOI":"10.1621\/nrs.07002","article-title":"Function of retinoic acid receptors during embryonic development","volume":"7","author":"Mark","year":"2009","journal-title":"Nucl. Recept. Signal."},{"key":"10.1016\/j.ejphar.2019.03.004_bib17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1046\/j.1365-4362.2000.00050.x","article-title":"Adapalene: an update on newer comparative studies between the various retinoids","volume":"39","author":"Millikan","year":"2000","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.ejphar.2019.03.004_bib18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.cellbio.13.1.261","article-title":"Cyclin-dependent kinases: engines, clocks, and microprocessors","volume":"13","author":"Morgan","year":"1997","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2019.03.004_bib19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrm2163","article-title":"The spindle-assembly checkpoint in space and time","volume":"8","author":"Musacchio","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2019.03.004_bib20","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature09626","article-title":"Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation","volume":"468","author":"Nazarian","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2019.03.004_bib21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ijc.11410","article-title":"The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro","volume":"107","author":"Ocker","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejphar.2019.03.004_bib22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.canlet.2003.12.026","article-title":"Potentiated anticancer effects on hepatoma cells by the retinoid adapalene","volume":"208","author":"Ocker","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejphar.2019.03.004_bib23","first-page":"367","article-title":"The utility of bexarotene in mycosis fungoides and Sezary syndrome","volume":"8","author":"Panchal","year":"2015","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.ejphar.2019.03.004_bib24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jep.2018.04.015","article-title":"Total saponins of Albiziae Cortex show anti-hepatoma carcinoma effects by inducing S phase arrest and mitochondrial apoptosis pathway activation","volume":"221","author":"Qian","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2019.03.004_bib25","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"Rogakou","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.03.004_bib26","doi-asserted-by":"crossref","first-page":"665","DOI":"10.4161\/cbt.28555","article-title":"Melanoma immunotherapy","volume":"15","author":"Sanlorenzo","year":"2014","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.ejphar.2019.03.004_bib27","doi-asserted-by":"crossref","first-page":"15003","DOI":"10.1038\/nrdp.2015.3","article-title":"Melanoma","volume":"1","author":"Schadendorf","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.ejphar.2019.03.004_bib28","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.3892\/mmr.2015.4310","article-title":"Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma","volume":"12","author":"Shi","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2019.03.004_bib29","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ceb.2013.07.003","article-title":"Mitosis and apoptosis: how is the balance set?","volume":"25","author":"Topham","year":"2013","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ejphar.2019.03.004_bib30","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1158\/1078-0432.CCR-16-0698","article-title":"Dynamic changes in PD-L1 expression and immune infiltrates early during treatment predict response to PD-1 blockade in melanoma","volume":"23","author":"Vilain","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2019.03.004_bib31","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.3892\/ijo.2017.3894","article-title":"3-Hydroxyterphenyllin, a natural fungal metabolite, induces apoptosis and S phase arrest in human ovarian carcinoma cells","volume":"50","author":"Wang","year":"2017","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejphar.2019.03.004_bib32","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.2165\/00003495-200464130-00005","article-title":"Adapalene: a review of its use in the treatment of acne vulgaris","volume":"64","author":"Waugh","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2019.03.004_bib33","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1016\/j.febslet.2010.05.021","article-title":"Focus on histone variant H2AX: to be or not to be","volume":"584","author":"Yuan","year":"2010","journal-title":"FEBS Lett."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919301530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919301530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T10:41:41Z","timestamp":1565174501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299919301530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":33,"alternative-id":["S0014299919301530"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.03.004","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adapalene suppressed the proliferation of melanoma cells by S-phase arrest and subsequent apoptosis via induction of DNA damage","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}