{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:23:04Z","timestamp":1783714984747,"version":"3.55.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"am","delay-in-days":311,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"R\u00e9gion Poitou-Charentes"},{"DOI":"10.13039\/501100004099","name":"La Ligue Contre le Cancer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.ejphar.2019.04.039","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T11:04:37Z","timestamp":1556103877000},"page":"30-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The vitamin K-dependent factor, protein S, regulates brain neural stem cell migration and phagocytic activities towards glioma cells"],"prefix":"10.1016","volume":"855","author":[{"given":"Aur\u00e9lie","family":"Ginisty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Arnault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Vallette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Benzakour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Coronas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2019.04.039_bib1","doi-asserted-by":"crossref","first-page":"13986","DOI":"10.18632\/oncotarget.14753","article-title":"Protein S drives oral squamous cell carcinoma tumorigenicity through regulation of AXL","volume":"8","author":"Abboud-Jarrous","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2019.04.039_bib2","doi-asserted-by":"crossref","first-page":"12846","DOI":"10.1073\/pnas.97.23.12846","article-title":"Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas","volume":"97","author":"Aboody","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejphar.2019.04.039_bib3","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/mt.2011.100","article-title":"Neural stem cell-based cell carriers enhance therapeutic efficacy of an oncolytic adenovirus in an orthotopic mouse model of human glioblastoma","volume":"19","author":"Ahmed","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejphar.2019.04.039_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ni871","article-title":"Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells","volume":"4","author":"Anderson","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib5","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1172\/JCI39325","article-title":"Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis","volume":"119","author":"Burstyn-Cohen","year":"2009","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2019.04.039_bib6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1215\/15228517-2-3-174","article-title":"Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells","volume":"2","author":"Chang","year":"2000","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib7","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.3892\/ijo.2016.3755","article-title":"Silencing of PROS1 induces apoptosis and inhibits migration and invasion of glioblastoma multiforme cells","volume":"49","author":"Che Mat","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nature11287","article-title":"A restricted cell population propagates glioblastoma growth after chemotherapy","volume":"488","author":"Chen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2019.04.039_bib9","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1038\/onc.2016.120","article-title":"Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer","volume":"35","author":"Chien","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2019.04.039_bib10","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1093\/brain\/awq128","article-title":"Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells","volume":"133","author":"Chirasani","year":"2010","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1593\/neo.03427","article-title":"Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4","volume":"6","author":"Ehtesham","year":"2004","journal-title":"Neoplasia"},{"key":"10.1016\/j.ejphar.2019.04.039_bib12","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1182\/blood-2012-05-429183","article-title":"The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner","volume":"120","author":"Fraineau","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2019.04.039_bib13","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/stem.1045","article-title":"An endogenous vitamin K-dependent mechanism regulates cell proliferation in the brain subventricular stem cell niche","volume":"30","author":"Gely-Pernot","year":"2012","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2019.04.039_bib14","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/stem.1862","article-title":"Evidence for a subventricular zone neural stem cell phagocytic activity stimulated by the vitamin K-dependent factor protein S","volume":"33","author":"Ginisty","year":"2015","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2019.04.039_bib15","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1523\/JNEUROSCI.5118-04.2005","article-title":"Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival","volume":"25","author":"Glass","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2019.04.039_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1750-1326-6-13","article-title":"Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator\/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway","volume":"6","author":"Guo","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejphar.2019.04.039_bib17","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1111\/j.1742-4658.2006.05529.x","article-title":"Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily","volume":"273","author":"Hafizi","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2019.04.039_bib18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1006\/exer.2002.2030","article-title":"Gas6 binding to photoreceptor outer segments requires gamma-carboxyglutamic acid (Gla) and Ca(2+) and is required for OS phagocytosis by RPE cells in vitro","volume":"75","author":"Hall","year":"2002","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2019.04.039_bib19","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1215\/S1152851704000754","article-title":"Neural stem cell migration toward gliomas in vitro","volume":"7","author":"Heese","year":"2005","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/boc.201500090","article-title":"Efferocytosis of apoptotic human papillomavirus-positive cervical cancer cells by human primary fibroblasts","volume":"108","author":"Hermetet","year":"2016","journal-title":"Biol. Cell"},{"key":"10.1016\/j.ejphar.2019.04.039_bib21","first-page":"1121","article-title":"Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity","volume":"37","author":"Inoue","year":"2010","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/neuonc\/nos268","article-title":"Relationship of glioblastoma multiforme to the subventricular zone is associated with survival","volume":"15","author":"Jafri","year":"2013","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib23","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1200\/JCO.1992.10.7.1074","article-title":"Carboplatin and etoposide chemotherapy regimen for recurrent malignant glioma: a phase II study","volume":"10","author":"Jeremic","year":"1992","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib24","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJMra061808","article-title":"Cancer stem cells","volume":"355","author":"Jordan","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2019.04.039_bib25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/hep.29478","article-title":"A microRNA-7\/growth arrest specific 6\/TYRO3 axis regulates the growth and invasiveness of sorafenib-resistant cells in human hepatocellular carcinoma","volume":"67","author":"Kabir","year":"2018","journal-title":"Hepatol. Baltim. Md"},{"key":"10.1016\/j.ejphar.2019.04.039_bib26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-1-4615-4221-6_13","article-title":"Cellular effects and signalling pathways activated by the anti-coagulant factor, protein S, in vascular cells protein S cellular effects","volume":"476","author":"Kanthou","year":"2000","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib27","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1158\/1535-7163.MCT-09-0707","article-title":"Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity","volume":"9","author":"Keating","year":"2010","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.ejphar.2019.04.039_bib28","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1634\/stemcells.2007-0887","article-title":"Neural stem cell targeting of glioma is dependent on phosphoinositide 3-kinase signaling","volume":"26","author":"Kendall","year":"2008","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2019.04.039_bib29","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1038\/mt.2013.179","article-title":"N-acetylcysteine amide augments the therapeutic effect of neural stem cell-based antiglioma oncolytic virotherapy","volume":"21","author":"Kim","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejphar.2019.04.039_bib30","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.18632\/oncotarget.1793","article-title":"MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme","volume":"5","author":"Knubel","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2019.04.039_bib31","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/ijc.25709","article-title":"Human glioblastoma-initiating cells invade specifically the subventricular zones and olfactory bulbs of mice after striatal injection","volume":"129","author":"Kroonen","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejphar.2019.04.039_bib32","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1182\/blood.V95.2.633","article-title":"Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway","volume":"95","author":"Lan","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2019.04.039_bib33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41586-018-0389-3","article-title":"Human glioblastoma arises from subventricular zone cells with low-level driver mutations","volume":"560","author":"Lee","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2019.04.039_bib34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1182\/blood-2008-05-158048","article-title":"Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages","volume":"113","author":"Liao","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2019.04.039_bib35","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1517\/14728222.2010.515980","article-title":"Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors","volume":"14","author":"Linger","year":"2010","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejphar.2019.04.039_bib36","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/ncb2299","article-title":"Phagocytic activity of neuronal progenitors regulates adult neurogenesis","volume":"13","author":"Lu","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib37","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/stem.1581","article-title":"Generation of neuronal progenitor cells in response to tumors in the human brain","volume":"32","author":"Macas","year":"2014","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2019.04.039_bib38","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.4049\/jimmunol.0803503","article-title":"Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages","volume":"183","author":"McColl","year":"2009","journal-title":"J. Immunol. Baltim."},{"key":"10.1016\/j.ejphar.2019.04.039_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082108","article-title":"Identification of novel genetic alterations in samples of malignant glioma patients","volume":"8","author":"Milinkovic","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2019.04.039_bib40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11060-016-2278-7","article-title":"Influence of glioblastoma contact with the lateral ventricle on survival: a meta-analysis","volume":"131","author":"Mistry","year":"2017","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11060-016-2221-y","article-title":"Migrating glioma cells express stem cell markers and give rise to new tumors upon xenografting","volume":"130","author":"Munthe","year":"2016","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib42","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1634\/stemcells.2008-0226","article-title":"Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal","volume":"27","author":"Nicoleau","year":"2009","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2019.04.039_bib43","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1530\/ERC-16-0126","article-title":"Role of protein S in castration-resistant prostate cancer-like cells","volume":"23","author":"Ning","year":"2016","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.ejphar.2019.04.039_bib44","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1432-1033.1997.t01-2-00147.x","article-title":"Stimulation of Sky tyrosine phosphorylation by bovine protein S--domains involved in the receptor-ligand interaction","volume":"246","author":"Nyberg","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejphar.2019.04.039_bib45","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1158\/1078-0432.CCR-16-3102","article-title":"Efficient mitochondrial glutamine targeting prevails over glioblastoma metabolic plasticity","volume":"23","author":"Oizel","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2019.04.039_bib46","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4161\/auto.4731","article-title":"Phagocytosis of cells dying through autophagy evokes a pro-inflammatory response in macrophages","volume":"3","author":"Petrovski","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.ejphar.2019.04.039_bib47","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1471-4159.1993.tb03574.x","article-title":"Protein S, an antithrombotic factor, is synthesized and released by neural tumor cells","volume":"61","author":"Phillips","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2019.04.039_bib48","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1210\/me.2008-0169","article-title":"Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration","volume":"22","author":"Pierce","year":"2008","journal-title":"Mol. Endocrinol. Baltim. Md"},{"key":"10.1016\/j.ejphar.2019.04.039_bib49","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1158\/1078-0432.CCR-16-1518","article-title":"Neural stem cell-based anticancer gene therapy: a first-in-human study in recurrent high-grade glioma patients","volume":"23","author":"Portnow","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2019.04.039_bib50","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mcn.2006.06.011","article-title":"TAM receptor function in the retinal pigment epithelium","volume":"33","author":"Prasad","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2019.04.039_bib51","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neuroscience.2007.09.047","article-title":"Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons","volume":"150","author":"Prieto","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2019.04.039_bib52","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.cell.2017.07.016","article-title":"Neural precursor-derived pleiotrophin mediates subventricular zone invasion by glioma","volume":"170","author":"Qin","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2019.04.039_bib53","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1038\/onc.2011.588","article-title":"Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology","volume":"31","author":"Rogers","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2019.04.039_bib54","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/stem.1349","article-title":"Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue","volume":"31","author":"Ruiz-Onta\u00f1on","year":"2013","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2019.04.039_bib55","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1158\/0008-5472.CAN-17-2433","article-title":"Activation of the receptor tyrosine kinase AXL regulates the immune microenvironment in glioblastoma","volume":"78","author":"Sadahiro","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2019.04.039_bib56","doi-asserted-by":"crossref","first-page":"34019","DOI":"10.1074\/jbc.M112.384438","article-title":"Proteomic profiling of androgen-independent prostate cancer cell lines reveals a role for protein S during the development of high grade and castration-resistant prostate cancer","volume":"287","author":"Saraon","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.04.039_bib57","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1593\/neo.04781","article-title":"Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor","volume":"7","author":"Schmidt","year":"2005","journal-title":"Neoplasia"},{"key":"10.1016\/j.ejphar.2019.04.039_bib58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ajpath.2017.08.029","article-title":"Space invaders: brain tumor exploitation of the stem cell niche","volume":"188","author":"Sinnaeve","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib59","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1158\/0008-5472.CAN-03-1246","article-title":"Neural progenitor cell lines inhibit rat tumor growth in vivo","volume":"64","author":"Staflin","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2019.04.039_bib60","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1002\/jnr.21344","article-title":"Instructive cross-talk between neural progenitor cells and gliomas","volume":"85","author":"Staflin","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2019.04.039_bib61","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0092-8674(95)90520-0","article-title":"The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3\/Axl family of receptor tyrosine kinases","volume":"80","author":"Stitt","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2019.04.039_bib62","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/nm.2827","article-title":"Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1","volume":"18","author":"Stock","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2019.04.039_bib63","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"Stupp","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib64","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1084\/jem.20170681","article-title":"Resolvins suppress tumor growth and enhance cancer therapy","volume":"215","author":"Sulciner","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2019.04.039_bib65","doi-asserted-by":"crossref","first-page":"25750","DOI":"10.1074\/jbc.M114.569020","article-title":"Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation","volume":"289","author":"Tsou","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.04.039_bib66","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1073\/pnas.0510923103","article-title":"Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival","volume":"103","author":"Vajkoczy","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejphar.2019.04.039_bib67","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fnene.2010.00131","article-title":"Microglia in close vicinity of glioma cells: correlation between phenotype and metabolic alterations","volume":"2","author":"Voisin","year":"2010","journal-title":"Front. Neuroenergetics"},{"key":"10.1016\/j.ejphar.2019.04.039_bib68","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1242\/jcs.078907","article-title":"Phagocytosis of dying tumor cells by human peritoneal mesothelial cells","volume":"124","author":"Wagner","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2019.04.039_bib69","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1634\/stemcells.2008-0307","article-title":"The antitumorigenic response of neural precursors depends on subventricular proliferation and age","volume":"26","author":"Walzlein","year":"2008","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2019.04.039_bib70","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00281-018-0698-5","article-title":"Efferocytosis in the tumor microenvironment","volume":"40","author":"Werfel","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib71","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1158\/0008-5472.CAN-18-1106","article-title":"Treatment-induced tumor cell apoptosis and secondary necrosis drive tumor progression in the residual tumor microenvironment through MerTK and Ido1","volume":"79","author":"Werfel","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2019.04.039_bib72","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tcb.2006.02.003","article-title":"Phosphatidylserine recognition by phagocytes: a view to a kill","volume":"16","author":"Wu","year":"2006","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib73","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jocn.2009.05.006","article-title":"The role of microglia in central nervous system immunity and glioma immunology","volume":"17","author":"Yang","year":"2010","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.ejphar.2019.04.039_bib74","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4161\/auto.23839","article-title":"A chimerical phagocytosis model reveals the recruitment by Sertoli cells of autophagy for the degradation of ingested illegitimate substrates","volume":"9","author":"Yefimova","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.ejphar.2019.04.039_bib75","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1095\/biolreprod.107.063107","article-title":"Dimeric transferrin inhibits phagocytosis of residual bodies by testicular rat Sertoli cells","volume":"78","author":"Yefimova","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ejphar.2019.04.039_bib76","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11060-010-0477-1","article-title":"Longitudinal MRI evidence for decreased survival among periventricular glioblastoma","volume":"104","author":"Young","year":"2011","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.ejphar.2019.04.039_bib77","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/stem.2522","article-title":"Protein S regulates neural stem cell quiescence and neurogenesis","volume":"35","author":"Zelentsova","year":"2017","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2019.04.039_bib78","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1158\/1541-7786.MCR-08-0146","article-title":"Neural stem cell tropism to glioma: critical role of tumor hypoxia","volume":"6","author":"Zhao","year":"2008","journal-title":"Mol. Canc. Res."},{"key":"10.1016\/j.ejphar.2019.04.039_bib79","doi-asserted-by":"crossref","first-page":"15521","DOI":"10.1523\/JNEUROSCI.4437-10.2010","article-title":"Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region","volume":"30","author":"Zhong","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2019.04.039_bib80","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1182\/blood-2010-01-262386","article-title":"Protein S controls hypoxic\/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor","volume":"115","author":"Zhu","year":"2010","journal-title":"Blood"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919302730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919302730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:26:33Z","timestamp":1757975193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299919302730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":80,"alternative-id":["S0014299919302730"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.04.039","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The vitamin K-dependent factor, protein S, regulates brain neural stem cell migration and phagocytic activities towards glioma cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.04.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}