{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:57:31Z","timestamp":1785891451305,"version":"3.56.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2019YFH0174"],"award-info":[{"award-number":["2019YFH0174"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["xtcx-2016-09"],"award-info":[{"award-number":["xtcx-2016-09"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.ejphar.2019.04.049","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T01:36:11Z","timestamp":1556674571000},"page":"365-371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Decreased vasodilatory effect of Tanshinone \u2161A Sodium Sulfonate on mesenteric artery in hypertension"],"prefix":"10.1016","volume":"854","author":[{"given":"Yuanqun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2019.04.049_bib1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/01.HYP.12.6.620","article-title":"Genetics of essential hypertension. From the unimodal-bimodal controversy to molecular technology","volume":"12","author":"Camussi","year":"1988","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2019.04.049_bib2","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1111\/j.1476-5381.1994.tb17171.x","article-title":"Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle","volume":"113","author":"Edwards","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.04.049_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1476-5381.1996.tb15163.x","article-title":"Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle","volume":"117","author":"Holland","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.04.049_bib4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/TA.0b013e3182aa2d98","article-title":"Bkca opener, NS1619 pretreatment protects against shock-induced vascular hyporeactivity through PDZ-Rho GEF-RhoA-Rho kinase pathway in rats","volume":"76","author":"Hu","year":"2014","journal-title":"The journal of trauma and acute care surgery"},{"key":"10.1016\/j.ejphar.2019.04.049_bib5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1540\/jsmr.44.65","article-title":"Physiological roles of K+ channels in vascular smooth muscle cells","volume":"44","author":"Ko","year":"2008","journal-title":"Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi"},{"key":"10.1016\/j.ejphar.2019.04.049_bib6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1159\/000369928","article-title":"Exercise training reverses alterations in Kv and BKCa channel molecular expression in thoracic aorta smooth muscle cells from spontaneously hypertensive rats","volume":"51","author":"Li","year":"2014","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.ejphar.2019.04.049_bib7","first-page":"579","article-title":"[2010 Chinese guidelines for the management of hypertension]","volume":"39","author":"Liu","year":"2011","journal-title":"Zhonghua Xinxueguanbing Zazhi"},{"key":"10.1016\/j.ejphar.2019.04.049_bib8","first-page":"254","article-title":"[Effects of sodium tanshinone II-A sulfonate on slow action potentials of dissociated single ventricular cells of adult Guinea pig heart]","volume":"42","author":"Liu","year":"1990","journal-title":"Sheng Li Xue Bao : Acta Physiol. Sin."},{"key":"10.1016\/j.ejphar.2019.04.049_bib9","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1248\/bpb.b15-00527","article-title":"Relaxation induced by atrial natriuretic peptide is impaired in carotid but not renal arteries from spontaneously hypertensive rats due to reduced BKCa channel activity","volume":"38","author":"Matsumoto","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2019.04.049_bib10","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/ajh\/hpv005","article-title":"A combination of intravenous genistein plus Mg2+ enhances antihypertensive effects in SHR by endothelial protection and BKCa channel inhibition","volume":"28","author":"Sun","year":"2015","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ejphar.2019.04.049_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejphar.2011.01.028","article-title":"Unique action of sodium tanshinone II-A sulfonate (DS-201) on the Ca(2+) dependent BK(Ca) activation in mouse cerebral arterial smooth muscle cells","volume":"656","author":"Tan","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.04.049_bib12","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/aps.2014.85","article-title":"Tanshinone II-A sodium sulfonate (DS-201) enhances human BKCa channel activity by selectively targeting the pore-forming alpha subunit","volume":"35","author":"Tan","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2019.04.049_bib13","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1021\/np800119k","article-title":"Vascular effects of different lipophilic components of \u201cdanshen\u201d, a traditional Chinese medicine, in the isolated porcine coronary artery","volume":"71","author":"Wan","year":"2008","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejphar.2019.04.049_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000382025","article-title":"Chinese hypertension guidelines","volume":"3","author":"Wang","year":"2015","journal-title":"Pulse"},{"key":"10.1016\/j.ejphar.2019.04.049_bib15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejphar.2009.06.046","article-title":"Tanshinone IIA elicited vasodilation in rat coronary arteriole: roles of nitric oxide and potassium channels","volume":"617","author":"Wu","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.04.049_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2008.09.013","article-title":"Activation of high conductance Ca(2+)-activated K(+) channels by sodium tanshinoneII-A sulfonate (DS-201) in porcine coronary artery smooth muscle cells","volume":"598","author":"Yang","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.04.049_bib17","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/HYPERTENSIONAHA.111.00211","article-title":"Function of BKCa channels is reduced in human vascular smooth muscle cells from Han Chinese patients with hypertension","volume":"61","author":"Yang","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2019.04.049_bib18","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s11434-016-1046-6","article-title":"Liposome intracellular delivery of Salvia miltiorrhiza Bge. deprivative DS-201 improves its BKCa channel-activating and vasorelaxing effects","volume":"61","author":"Yu","year":"2016","journal-title":"Sci. Bull."},{"key":"10.1016\/j.ejphar.2019.04.049_bib19","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1177\/0091270005282630","article-title":"Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use","volume":"45","author":"Zhou","year":"2005","journal-title":"J. Clin. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919302997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919302997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:07:40Z","timestamp":1762142860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299919302997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":19,"alternative-id":["S0014299919302997"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.04.049","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreased vasodilatory effect of Tanshinone \u2161A Sodium Sulfonate on mesenteric artery in hypertension","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.04.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}