{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:15:28Z","timestamp":1791645328514,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51537004"],"award-info":[{"award-number":["51537004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation for Young Scientists of China","award":["51707075"],"award-info":[{"award-number":["51707075"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ejphar.2019.172445","type":"journal-article","created":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T02:47:43Z","timestamp":1560566863000},"page":"172445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Liquiritigenin inhibits IL-1\u03b2-induced inflammation and cartilage matrix degradation in rat chondrocytes"],"prefix":"10.1016","volume":"858","author":[{"given":"Chang","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhuang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2019.172445_bib1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.joca.2017.10.008","article-title":"Osteoarthritis year in review 2017: biology","volume":"26","author":"Appleton","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ejphar.2019.172445_bib2","series-title":"Intraarticular Corticosteroid for Treatment of Osteoarthritis of the Knee","author":"Bellamy","year":"2006"},{"key":"10.1016\/j.ejphar.2019.172445_bib3","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.joca.2008.03.009","article-title":"Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes","volume":"16","author":"Chabane","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ejphar.2019.172445_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122146","article-title":"Insights on molecular mechanisms of chondrocytes death in osteoarthritis","volume":"17","author":"Charlier","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2019.172445_bib5","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1016\/j.biomaterials.2013.12.076","article-title":"The amelioration of cartilage degeneration by ADAMTS-5 inhibitor delivered in a hyaluronic acid hydrogel","volume":"35","author":"Chen","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2019.172445_bib6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.joca.2010.10.019","article-title":"Selenomethionine inhibits IL-1beta inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes","volume":"19","author":"Cheng","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ejphar.2019.172445_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/nu9010070","article-title":"Phytomedicine in joint disorders","volume":"9","author":"Dragos","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2019.172445_bib8","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1136\/annrheumdis-2016-210478","article-title":"Knee and hip intra-articular adipose tissues (IAATs) compared with autologous subcutaneous adipose tissue: a specific phenotype for a central player in osteoarthritis","volume":"76","author":"Eymard","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2019.172445_bib9","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1021\/jf404731z","article-title":"Development of a monoclonal antibody-based immunochemical assay for liquiritin and its application to the quality control of licorice products","volume":"62","author":"Fujii","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2019.172445_bib10","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2019.172445_bib11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0083-6729(06)74016-X","article-title":"The role of IL-1 and IL-1Ra in joint inflammation and cartilage degradation","volume":"74","author":"Jacques","year":"2006","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.ejphar.2019.172445_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12906-016-0997-0","article-title":"Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease","volume":"16","author":"Jung","year":"2016","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.ejphar.2019.172445_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.2042-7158.2010.01175.x","article-title":"Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of liquiritigenin and its two glucuronides, M1 and M2, in rats","volume":"63","author":"Kang","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172445_bib14","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1021\/jf404939f","article-title":"Bioactivity and potential health benefits of licorice","volume":"62","author":"Kao","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2019.172445_bib15","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.joca.2015.03.036","article-title":"Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use","volume":"23","author":"Kraus","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ejphar.2019.172445_bib16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.gene.2013.05.069","article-title":"A current review of molecular mechanisms regarding osteoarthritis and pain","volume":"527","author":"Lee","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.ejphar.2019.172445_bib17","doi-asserted-by":"crossref","first-page":"9642","DOI":"10.4238\/2014.November.14.9","article-title":"Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages","volume":"13","author":"Li","year":"2014","journal-title":"Genet. Mol. Res. : GMR"},{"key":"10.1016\/j.ejphar.2019.172445_bib18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/BOR.0000000000000162","article-title":"Biologic basis of osteoarthritis: state of the evidence","volume":"27","author":"Malemud","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.ejphar.2019.172445_bib19","series-title":"Osteoarthritis Year in Review 2018: Clinical. Osteoarthritis and Cartilage","author":"Mandl","year":"2018"},{"key":"10.1016\/j.ejphar.2019.172445_bib20","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/138945010791011938","article-title":"NF-kappaB signaling: multiple angles to target OA","volume":"11","author":"Marcu","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejphar.2019.172445_bib21","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.drudis.2018.05.023","article-title":"Recent advances in intra-articular drug delivery systems for osteoarthritis therapy","volume":"23","author":"Maudens","year":"2018","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejphar.2019.172445_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3727\/096504018X15185747911701","article-title":"Liquiritigenin inhibits colorectal cancer proliferation, invasion, and epithelial-to-mesenchymal transition by decreasing expression of runt-related transcription factor 2","volume":"27","author":"Meng","year":"2019","journal-title":"Oncology research"},{"key":"10.1016\/j.ejphar.2019.172445_bib23","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/jgh.12812","article-title":"Amelioration of trinitrobenzene sulfonic acid-induced colitis in mice by liquiritigenin","volume":"30","author":"Min","year":"2015","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2019.172445_bib24","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harbor perspectives in biology"},{"key":"10.1016\/j.ejphar.2019.172445_bib25","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.bbrc.2016.06.126","article-title":"Biochanin-A antagonizes the interleukin-1beta-induced catabolic inflammation through the modulation of NFkappaB cellular signaling in primary rat chondrocytes","volume":"477","author":"Oh","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2019.172445_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.csm.2004.08.007","article-title":"Basic science of articular cartilage and osteoarthritis","volume":"24","author":"Pearle","year":"2005","journal-title":"Clin. Sports Med."},{"key":"10.1016\/j.ejphar.2019.172445_bib27","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F","article-title":"Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets","volume":"44","author":"Pelletier","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ejphar.2019.172445_bib28","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3389\/fnagi.2018.00348","article-title":"Phytochemical and pharmacological role of liquiritigenin and isoliquiritigenin from Radix Glycyrrhizae in human health and disease models","volume":"10","author":"Ramalingam","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ejphar.2019.172445_bib29","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nrrheum.2016.136","article-title":"Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis","volume":"12","author":"Robinson","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ejphar.2019.172445_bib30","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joca.2006.04.008","article-title":"NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis","volume":"14","author":"Roman-Blas","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ejphar.2019.172445_bib31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.joca.2009.11.005","article-title":"MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation","volume":"18","author":"Sondergaard","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ejphar.2019.172445_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/NOR.0b013e31827d96da","article-title":"Osteoarthritis: detection, pathophysiology, and current\/future treatment strategies","volume":"32","author":"Sovani","year":"2013","journal-title":"Orthopedic nursing"},{"key":"10.1016\/j.ejphar.2019.172445_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bbapap.2011.06.020","article-title":"Proteases involved in cartilage matrix degradation in osteoarthritis","volume":"1824","author":"Troeberg","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2019.172445_bib34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fphar.2019.00041","article-title":"Schisandrin a inhibits the IL-1beta-induced inflammation and cartilage degradation via suppression of MAPK and NF-kappaB signal pathways in rat chondrocytes","volume":"10","author":"Tu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172445_bib35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s13287-018-0955-5","article-title":"The legacy effects of electromagnetic fields on bone marrow mesenchymal stem cell self-renewal and multiple differentiation potential","volume":"9","author":"Tu","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2019.172445_bib36","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.joms.2013.06.201","article-title":"Alteration of cartilage degeneration and inflammation markers in temporomandibular joint osteoarthritis occurs proportionally","volume":"71","author":"Vos","year":"2013","journal-title":"J. Oral Maxillofac. Surg. : official journal of the American Association of Oral and Maxillofacial Surgeons"},{"key":"10.1016\/j.ejphar.2019.172445_bib37","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.arthro.2009.12.018","article-title":"The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders","volume":"26","author":"Wassilew","year":"2010","journal-title":"Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association"},{"key":"10.1016\/j.ejphar.2019.172445_bib38","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.molimm.2018.08.026","article-title":"Interleukin-33 deficiency exacerbated experimental autoimmune encephalomyelitis with an influence on immune cells and glia cells","volume":"101","author":"Xiao","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ejphar.2019.172445_bib39","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.biopha.2016.12.066","article-title":"Liquiritigenin attenuates cardiac injury induced by high fructose-feeding through fibrosis and inflammation suppression","volume":"86","author":"Xie","year":"2017","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.ejphar.2019.172445_bib40","doi-asserted-by":"crossref","first-page":"13041","DOI":"10.3390\/molecules200713041","article-title":"Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver","volume":"20","author":"Yu","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2019.172445_bib41","first-page":"649568","article-title":"Liquiritigenin protects rats from carbon tetrachloride induced hepatic injury through PGC-1alpha pathway","volume":"2015","author":"Zhang","year":"2015","journal-title":"eCAM"},{"key":"10.1016\/j.ejphar.2019.172445_bib42","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.biopha.2018.07.045","article-title":"Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-kappaB and NLRP3 inflammasome pathways","volume":"106","author":"Zhu","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919303978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919303978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T02:43:48Z","timestamp":1568947428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299919303978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":42,"alternative-id":["S0014299919303978"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172445","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquiritigenin inhibits IL-1\u03b2-induced inflammation and cartilage matrix degradation in rat chondrocytes","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172445","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"172445"}}