{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:30Z","timestamp":1786988130893,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573424"],"award-info":[{"award-number":["81573424"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273510"],"award-info":[{"award-number":["81273510"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ejphar.2019.172455","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T02:31:20Z","timestamp":1560393080000},"page":"172455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Hydrogen sulfide inhibited L-type calcium channels (CaV1.2) via up-regulation of the channel sulfhydration in vascular smooth muscle cells"],"prefix":"10.1016","volume":"858","author":[{"given":"Li","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2019.172455_bib1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1159\/000358690","article-title":"Role of calcium channels in the protective effect of hydrogen sulfide in rat cardiomyoblasts","volume":"33","author":"Avanzato","year":"2014","journal-title":"Cell. Physiol. Biochem. : Int. J. Exp. Cel. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172455_bib2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1124\/jpet.105.092023","article-title":"Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes","volume":"316","author":"Bian","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2019.172455_bib3","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/0041-0101(90)90117-P","article-title":"Bimodal operation of the ryanodine-sensitive transducer calcium channel","volume":"28","author":"Bianchi","year":"1990","journal-title":"Toxicon : Off. J. Int. Soc. Toxinol"},{"key":"10.1016\/j.ejphar.2019.172455_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/hh1901.096702","article-title":"Mechanisms of L-type Ca(2+) current downregulation in rat atrial myocytes during heart failure","volume":"89","author":"Boixel","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2019.172455_bib5","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/CBI20090368","article-title":"Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21","volume":"34","author":"Cai","year":"2010","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ejphar.2019.172455_bib6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/01.RES.76.3.325","article-title":"Functional consequences of sulfhydryl modification in the pore-forming subunits of cardiovascular Ca2+ and Na+ channels","volume":"76","author":"Chiamvimonvat","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2019.172455_bib7","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1073\/pnas.48.5.807","article-title":"Effect of ryanodine on the calcium uptake system of skeletal muscle","volume":"48","author":"Fairhurst","year":"1962","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejphar.2019.172455_bib8","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1002\/mc.22691","article-title":"CRH promotes human colon cancer cell proliferation via IL-6\/JAK2\/STAT3 signaling pathway and VEGF-induced tumor angiogenesis","volume":"56","author":"Fang","year":"2017","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.ejphar.2019.172455_bib9","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1126\/science.164.3886.1356","article-title":"The mechanism of muscular contraction","volume":"164","author":"Huxley","year":"1969","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2019.172455_bib10","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.bbrc.2006.05.002","article-title":"Hydrogen sulfide potentiates interleukin-1beta-induced nitric oxide production via enhancement of extracellular signal-regulated kinase activation in rat vascular smooth muscle cells","volume":"345","author":"Jeong","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2019.172455_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1530\/JME-13-0270","article-title":"Corticotropin-releasing hormone receptors mediate apoptosis via cytosolic calcium-dependent phospholipase A(2) and migration in prostate cancer cell RM-1","volume":"52","author":"Jin","year":"2014","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ejphar.2019.172455_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/oxfordjournals.jbchem.a135063","article-title":"Effect of dithiothreitol on activity and protein structure of human urine urokinase","volume":"97","author":"Kobayashi","year":"1985","journal-title":"J. Biochem."},{"key":"10.1016\/j.ejphar.2019.172455_bib13","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J. : Off. Pub. Fed. American. Soc. Exp. Biol."},{"key":"10.1016\/j.ejphar.2019.172455_bib14","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.yjmcc.2008.03.011","article-title":"Oxidoreductase regulation of Kv currents in rat ventricle","volume":"44","author":"Liang","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2019.172455_bib15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.stem.2014.03.005","article-title":"Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca(2+) channel sulfhydration","volume":"15","author":"Liu","year":"2014","journal-title":"Cell stem cell"},{"key":"10.1016\/j.ejphar.2019.172455_bib16","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.3748\/wjg.v21.i16.4840","article-title":"Hydrogen sulfide-induced enhancement of gastric fundus smooth muscle tone is mediated by voltage-dependent potassium and calcium channels in mice","volume":"21","author":"Meng","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2019.172455_bib17","doi-asserted-by":"crossref","first-page":"e89525","DOI":"10.1371\/journal.pone.0089525","article-title":"Magnesium inhibits Wnt\/beta-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells","volume":"9","author":"Montes de Oca","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2019.172455_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ceca.2012.07.001","article-title":"Hydrogen sulfide as a regulator of calcium channels","volume":"53","author":"Munaron","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2019.172455_bib19","doi-asserted-by":"crossref","first-page":"C169","DOI":"10.1152\/ajpcell.00282.2007","article-title":"H2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes","volume":"294","author":"Pan","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2019.172455_bib20","doi-asserted-by":"crossref","first-page":"H666","DOI":"10.1152\/ajpheart.2000.278.2.H666","article-title":"Caffeine-induced Ca(2+) sparks in mouse ventricular myocytes","volume":"278","author":"Ritter","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2019.172455_bib21","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/cvr\/cvn140","article-title":"Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes","volume":"79","author":"Sun","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2019.172455_bib22","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1161\/01.RES.0000146029.80463.7d","article-title":"Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle","volume":"95","author":"Szentesi","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2019.172455_bib23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2174\/157016106775203144","article-title":"Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular system","volume":"4","author":"Tang","year":"2006","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172455_bib24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.phrs.2011.11.006","article-title":"NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel","volume":"65","author":"Tian","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2019.172455_bib25","first-page":"3455","article-title":"Electrophysiological effects of hydrogen sulfide on human atrial fibers","volume":"124","author":"Xu","year":"2011","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.ejphar.2019.172455_bib26","first-page":"215","article-title":"Electrophysiological effects of hydrogen sulfide on Guinea pig papillary muscles in vitro","volume":"59","author":"Xu","year":"2007","journal-title":"Sheng Li Xue Bao : Acta Physiol. Sin."},{"key":"10.1016\/j.ejphar.2019.172455_bib27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2003.11.081","article-title":"The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats","volume":"313","author":"Yan","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2019.172455_bib28","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1096\/fj.04-2279fje","article-title":"Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3","volume":"18","author":"Yang","year":"2004","journal-title":"FASEB J. : Off. Pub. Fed. American. Soc. Exp. Biol."},{"key":"10.1016\/j.ejphar.2019.172455_bib29","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/cvr\/cvp420","article-title":"Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells","volume":"86","author":"Yang","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2019.172455_bib30","doi-asserted-by":"crossref","first-page":"e37073","DOI":"10.1371\/journal.pone.0037073","article-title":"Hydrogen sulfide inhibits L-type calcium currents depending upon the protein sulfhydryl state in rat cardiomyocytes","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2019.172455_bib31","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.lfs.2018.05.051","article-title":"Exogenous hydrogen sulfide ameliorates high glucose-induced myocardial injury & inflammation via the CIRP-MAPK signaling pathway in H9c2 cardiac cells","volume":"208","author":"Zhao","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2019.172455_bib32","doi-asserted-by":"crossref","first-page":"H474","DOI":"10.1152\/ajpheart.00013.2002","article-title":"H(2)S-induced vasorelaxation and underlying cellular and molecular mechanisms","volume":"283","author":"Zhao","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2019.172455_bib33","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919304078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919304078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:42:26Z","timestamp":1777394546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299919304078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":33,"alternative-id":["S0014299919304078"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172455","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide inhibited L-type calcium channels (CaV1.2) via up-regulation of the channel sulfhydration in vascular smooth muscle cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"172455"}}