{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:51:35Z","timestamp":1793407895473,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["305058\/2018-5"],"award-info":[{"award-number":["305058\/2018-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Araucaria Foundation, Brazil","award":["37556.413.40855.12042013"],"award-info":[{"award-number":["37556.413.40855.12042013"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ejphar.2019.172460","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T03:44:59Z","timestamp":1561002299000},"page":"172460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Role of TRPA1 receptors in skin inflammation induced by volatile chemical irritants in mice"],"prefix":"10.1016","volume":"858","author":[{"given":"Ma\u00edra Macedo","family":"Nor\u00f5es","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Gonzaga","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Cristina","family":"Gavioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"de Paula Soares Rachetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Fleith","family":"Otuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"de Almeida Cabrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"da Silveira Prudente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janiana Ra\u00edza Jentsch Matias","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muryel","family":"de Carvalho Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Preti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"De Logu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Nassini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Andr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2019.172460_bib1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI34886","article-title":"Cigarette smoke-induced neurogenic inflammation is mediated by \u03b1,\u03b2-unsaturated aldehydes and the TRPA1 receptor in rodents","author":"Andr\u00e9","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2019.172460_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/jid.2009.58","article-title":"Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin","author":"Atoyan","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.ejphar.2019.172460_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2019.172460_bib4","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1215555110","article-title":"UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes","author":"Bellono","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejphar.2019.172460_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/jid.2009.179","article-title":"An ice-Cold TR(i)P to skin biology: the role of TRPA1 in human epidermal keratinocytes","author":"B\u00edr\u00f3","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.ejphar.2019.172460_bib6","article-title":"Chemical activation of sensory TRP channels","author":"Boonen","year":"2017","journal-title":"Top. Med. Chem."},{"key":"10.1016\/j.ejphar.2019.172460_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2013.03.003","article-title":"Targeting TRP channels for pain relief","author":"Brederson","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172460_bib8","series-title":"ACP Medicine. Section 2. Dermatology","article-title":"Contact dermatitis and related disorders","author":"Cao","year":"2008"},{"key":"10.1016\/j.ejphar.2019.172460_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ph9040077","article-title":"TRP channels in skin biology and pathophysiology","author":"Caterina","year":"2016","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejphar.2019.172460_bib10","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-015-1088-3","article-title":"TRPA1 as a drug target - promise and challenges","author":"Chen","year":"2015","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172460_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-4-48","article-title":"HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity","author":"Eid","year":"2008","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2019.172460_bib11","doi-asserted-by":"crossref","DOI":"10.1152\/japplphysiol.00043.2015","article-title":"Role of calcium ions in the positive interaction between TRPA1 and TRPV1 channels in bronchopulmonary sensory neurons","author":"Hsu","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2019.172460_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/nri3150","article-title":"Early immune events in the induction of allergic contact dermatitis","author":"Kaplan","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2019.172460_bib13","series-title":"Improving Bioscience Research Reporting: the Arrive Guidelines for Reporting Animal Research","author":"Kilkenny","year":"2013"},{"key":"10.1016\/j.ejphar.2019.172460_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0705924104","article-title":"TRPA1 mediates formalin-induced pain","author":"McNamara","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejphar.2019.172460_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2009.12.008","article-title":"Dermatotoxicology: historical perspective and advances","author":"Ngo","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172460_bib16","doi-asserted-by":"crossref","DOI":"10.1007\/s00424-012-1158-z","article-title":"The transient receptor potential channel TRPA1: from gene to pathophysiology","author":"Nilius","year":"2012","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"10.1016\/j.ejphar.2019.172460_bib17","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1300300","article-title":"TRPA1-Dependent pruritus in IL-13-induced chronic atopic dermatitis","author":"Oh","year":"2013","journal-title":"J. Immunol."},{"issue":"26","key":"10.1016\/j.ejphar.2019.172460_bib18","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/S0024-3205(00)00585-3","article-title":"In vivo activity of pseudoguaianolide sesquiterpene lactones in acute and chronic inflammation","volume":"66","author":"Recio","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2019.172460_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2009.01.016","article-title":"Involvement of capsaicin-sensitive afferents and the Transient Receptor Potential Vanilloid 1 Receptor in xylene-induced nocifensive behaviour and inflammation in the mouse","author":"S\u00e1ndor","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2019.172460_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/1710-1492-4-2-59","article-title":"Occupational contact dermatitis","author":"Sasseville","year":"2008","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"10.1016\/j.ejphar.2019.172460_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2011.03.017","article-title":"The involvement of TRPA1 channel activation in the inflammatory response evoked by topical application of cinnamaldehyde to mice","author":"Silva","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2019.172460_bib22","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M110.106153","article-title":"Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel","author":"Staruschenko","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.172460_bib23","doi-asserted-by":"crossref","DOI":"10.1165\/rcmb.2008-0292OC","article-title":"Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation","author":"Taylor-Clark","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"5","key":"10.1016\/j.ejphar.2019.172460_bib24","first-page":"404","article-title":"Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde","volume":"61","author":"Tian","year":"2009","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.ejphar.2019.172460_bib25","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.5318-12.2013","article-title":"The ion channel TRPA1 is required for chronic itch","author":"Wilson","year":"2013","journal-title":"J. Neurosci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919304121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919304121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T22:44:33Z","timestamp":1569105873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299919304121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":26,"alternative-id":["S0014299919304121"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172460","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of TRPA1 receptors in skin inflammation induced by volatile chemical irritants in mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172460","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"172460"}}