{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:50:12Z","timestamp":1790884212615,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012663","name":"Henan Province University Innovation Talents Support Program","doi-asserted-by":"publisher","award":["154200510010"],"award-info":[{"award-number":["154200510010"]}],"id":[{"id":"10.13039\/501100012663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010012","name":"National Aerospace Science Foundation of China","doi-asserted-by":"publisher","award":["81573151"],"award-info":[{"award-number":["81573151"]}],"id":[{"id":"10.13039\/501100010012","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ejphar.2019.172526","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T19:16:46Z","timestamp":1562354206000},"page":"172526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"special_numbering":"C","title":["Antidiabetic effects of pterostilbene through PI3K\/Akt signal pathway in high fat diet and STZ-induced diabetic rats"],"prefix":"10.1016","volume":"859","author":[{"given":"Hualei","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao Rong","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Teng wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huina","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songcheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejphar.2019.172526_bib1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jcb.24402","article-title":"Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus","volume":"114","author":"Akash","year":"2013","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.ejphar.2019.172526_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/dom.12400","article-title":"Novel therapeutics for type 2 diabetes: insulin resistance","volume":"17","author":"Altaf","year":"2015","journal-title":"Diabetes Obes. Metab."},{"issue":"11","key":"10.1016\/j.ejphar.2019.172526_bib3","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1211\/jpp.58.11.0009","article-title":"The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats","volume":"58","author":"Amarnath Satheesh","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"issue":"9","key":"10.1016\/j.ejphar.2019.172526_bib4","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.2337\/dc16-er09","article-title":"Erratum. Classification and diagnosis of diabetes. Sec. 2. In standards of medical Care in diabetes-2016. Diabetes Care 2016;39(suppl. 1):S13-S22","volume":"39","author":"American Diabetes","year":"2016","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.ejphar.2019.172526_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/nu10111702","article-title":"Physical exercise improves glycemic and inflammatory profile and attenuates progression of periodontitis in diabetic rats (HFD\/STZ)","volume":"10","author":"Andrade","year":"2018","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.ejphar.2019.172526_bib6","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1463-1326.2010.01225.x","article-title":"Rosiglitazone and pioglitazone increase fracture risk in women and men with type 2 diabetes","volume":"12","author":"Aubert","year":"2010","journal-title":"Diabetes Obes. Metab."},{"issue":"17","key":"10.1016\/j.ejphar.2019.172526_bib7","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1089\/ars.2015.6437","article-title":"Pterostilbene decreases the antioxidant defenses of aggressive cancer cells in vivo: a physiological glucocorticoids- and nrf2-dependent mechanism","volume":"24","author":"Benlloch","year":"2016","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2019.172526_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2016.02.054","article-title":"Anti-hyperlipidemic and anti-peroxidative role of pterostilbene via Nrf2 signaling in experimental diabetes","volume":"777","author":"Bhakkiyalakshmi","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2019.172526_bib9","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.2337\/dc10-2235","article-title":"Type 2 diabetes: uses of thiazolidinediones and insulin","volume":"34","author":"Bloomgarden","year":"2011","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.ejphar.2019.172526_bib10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrm782","article-title":"Regulated transport of the glucose transporter GLUT4","volume":"3","author":"Bryant","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5522","key":"10.1016\/j.ejphar.2019.172526_bib11","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1126\/science.292.5522.1728","article-title":"Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt 2 (PKB beta)","volume":"292","author":"Cho","year":"2001","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ejphar.2019.172526_bib12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.it.2003.10.013","article-title":"Inflammation: the link between insulin resistance, obesity and diabetes","volume":"25","author":"Dandona","year":"2004","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2019.172526_bib13","first-page":"148","article-title":"Association of oxidative stress and obesity with insulin resistance in type 2 diabetes mellitus","volume":"25","author":"Das","year":"2016","journal-title":"Mymensingh Med. J. : MMJ"},{"issue":"4","key":"10.1016\/j.ejphar.2019.172526_bib14","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s12291-015-0516-y","article-title":"Endothelial dysfunction in type 2 diabetes mellitus","volume":"31","author":"Dhananjayan","year":"2016","journal-title":"Indian J. Clin. Biochem.: Indian J. Clin. Biochem."},{"issue":"2","key":"10.1016\/j.ejphar.2019.172526_bib15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2019.172526_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/160980","article-title":"Studies on the antidiabetic activities of Cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats","volume":"2014","author":"Dong","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.ejphar.2019.172526_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Droge","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2019.172526_bib18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.phrs.2017.08.002","article-title":"Anti-inflammatory activity of natural stilbenoids: a review","volume":"124","author":"Dvorakova","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"21","key":"10.1016\/j.ejphar.2019.172526_bib19","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1001\/jama.2016.6458","article-title":"Trends in obesity among adults in the United States, 2005 to 2014","volume":"315","author":"Flegal","year":"2016","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.ejphar.2019.172526_bib20","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide dismutases: role in redox signaling, vascular function, and diseases","volume":"15","author":"Fukai","year":"2011","journal-title":"Antioxidants Redox Signal."},{"issue":"1","key":"10.1016\/j.ejphar.2019.172526_bib21","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.bbagen.2012.10.016","article-title":"Insulin sensitization via partial agonism of PPARgamma and glucose uptake through translocation and activation of GLUT4 in PI3K\/p-Akt signaling pathway by embelin in type 2 diabetic rats","volume":"1830","author":"Gandhi","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.ejphar.2019.172526_bib22","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4239\/wjd.v6.i4.598","article-title":"Type 2 diabetes mellitus: from a metabolic disorder to an inflammatory condition","volume":"6","author":"Hameed","year":"2015","journal-title":"World J. Diabetes"},{"issue":"2","key":"10.1016\/j.ejphar.2019.172526_bib23","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1006\/bbrc.1993.2111","article-title":"Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase","volume":"195","author":"Kanai","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.ejphar.2019.172526_bib24","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.2337\/diabetes.48.12.2398","article-title":"Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity","volume":"48","author":"Kaneto","year":"1999","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.ejphar.2019.172526_bib25","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00280-010-1525-4","article-title":"Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats","volume":"68","author":"Kapetanovic","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"12","key":"10.1016\/j.ejphar.2019.172526_bib26","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.metabol.2015.09.002","article-title":"Insulin resistance in type 1 diabetes mellitus","volume":"64","author":"Kaul","year":"2015","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.ejphar.2019.172526_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.20463\/jenb.2016.06.20.2.6","article-title":"The effect of exercise training combined with PPARgamma agonist on skeletal muscle glucose uptake and insulin sensitivity in induced diabetic obese Zucker rats","volume":"20","author":"Kim","year":"2016","journal-title":"J. Exerc. Nutr. Biochem."},{"key":"10.1016\/j.ejphar.2019.172526_bib28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12933-016-0383-8","article-title":"Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway","volume":"15","author":"Korkmaz-Icoz","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"issue":"3","key":"10.1016\/j.ejphar.2019.172526_bib29","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.sjbs.2016.11.007","article-title":"Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: an in vivo approach","volume":"25","author":"Li","year":"2018","journal-title":"Saudi J. Biol. Sci."},{"issue":"7","key":"10.1016\/j.ejphar.2019.172526_bib30","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2019.172526_bib31","first-page":"696372","article-title":"The effects of probiotic soymilk fortified with omega-3 on blood glucose, lipid profile, haematological and oxidative stress, and inflammatory parameters in streptozotocin nicotinamide-induced diabetic rats","author":"Mohammadi Sartang","year":"2015","journal-title":"J. Diabetes Res."},{"issue":"5","key":"10.1016\/j.ejphar.2019.172526_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/met.2015.0133","article-title":"The best obesity indices to discriminate type 2 diabetes mellitus","volume":"14","author":"Motamed","year":"2016","journal-title":"Metab. Syndrome Relat. Disord."},{"issue":"1","key":"10.1016\/j.ejphar.2019.172526_bib33","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2337\/diacare.27.1.256","article-title":"Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association","volume":"27","author":"Nesto","year":"2004","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.ejphar.2019.172526_bib34","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.lfs.2006.02.036","article-title":"Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats","volume":"79","author":"Pari","year":"2006","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.ejphar.2019.172526_bib35","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/carcin\/bgq004","article-title":"Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin\/p65 downstream signaling pathway and colon carcinogenesis in rats","volume":"31","author":"Paul","year":"2010","journal-title":"Carcinogenesis"},{"issue":"6","key":"10.1016\/j.ejphar.2019.172526_bib36","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jdiacomp.2015.04.012","article-title":"PPARgamma-PI3K\/AKT-NO signal pathway is involved in cardiomyocyte hypertrophy induced by high glucose and insulin","volume":"29","author":"Peng","year":"2015","journal-title":"J. Diabet. Complicat."},{"issue":"4","key":"10.1016\/j.ejphar.2019.172526_bib37","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80211-7","article-title":"PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro","volume":"4","author":"Rosen","year":"1999","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.ejphar.2019.172526_bib38","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.diabres.2005.05.009","article-title":"The effect of dual PPAR alpha\/gamma stimulation with combination of rosiglitazone and fenofibrate on metabolic parameters in type 2 diabetic patients","volume":"71","author":"Seber","year":"2006","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.ejphar.2019.172526_bib39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12967-015-0412-5","article-title":"Caulerpa lentillifera extract ameliorates insulin resistance and regulates glucose metabolism in C57BL\/KsJ-db\/db mice via PI3K\/AKT signaling pathway in myocytes","volume":"13","author":"Sharma","year":"2015","journal-title":"J. Transl. Med."},{"issue":"4","key":"10.1016\/j.ejphar.2019.172526_bib40","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cmet.2014.08.005","article-title":"Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes","volume":"20","author":"Soccio","year":"2014","journal-title":"Cell Metabol."},{"issue":"2","key":"10.1016\/j.ejphar.2019.172526_bib41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cmet.2005.08.001","article-title":"Fluid retention mediated by renal PPARgamma","volume":"2","author":"Staels","year":"2005","journal-title":"Cell Metabol."},{"issue":"10","key":"10.1016\/j.ejphar.2019.172526_bib42","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/nm1001-1133","article-title":"Regulation of pancreatic beta-cell growth and survival by the serine\/threonine protein kinase Akt 1\/PKBalpha","volume":"7","author":"Tuttle","year":"2001","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.ejphar.2019.172526_bib43","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.diabres.2011.10.029","article-title":"IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030","volume":"94","author":"Whiting","year":"2011","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.ejphar.2019.172526_bib44","article-title":"One functional variant in the 3'-untranslated region of TLR4 is associated with the elevated risk of ventilator-associated pneumonia in the patients with chronic obstructive pulmonary disease","author":"Zhao","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.ejphar.2019.172526_bib45","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1159\/000445565","article-title":"Regulation of insulin resistance by multiple MiRNAs via targeting the GLUT4 signalling pathway","volume":"38","author":"Zhou","year":"2016","journal-title":"Cell. Physiol. Biochem. : Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejphar.2019.172526_bib46","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00125-008-1255-x","article-title":"Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis","volume":"52","author":"Zraika","year":"2009","journal-title":"Diabetologia"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919304789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919304789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:30:12Z","timestamp":1757975412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299919304789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":46,"alternative-id":["S0014299919304789"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172526","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antidiabetic effects of pterostilbene through PI3K\/Akt signal pathway in high fat diet and STZ-induced diabetic rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"172526"}}