{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:45:58Z","timestamp":1791431158317,"version":"4.3.3"},"reference-count":144,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012522","name":"Central Mechanical Engineering Research Institute, Council of Scientific and Industrial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012522","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.ejphar.2019.172553","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T02:12:44Z","timestamp":1563329564000},"page":"172553","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"special_numbering":"C","title":["Endoplasmic reticulum stress: A master regulator of metabolic syndrome"],"prefix":"10.1016","volume":"860","author":[{"given":"Sreelekshmi","family":"Mohan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preetha Rani M.","family":"R","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathapan","family":"Ayyappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghu K.","family":"G","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2019.172553_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-20499-7","article-title":"Kaempferol mitigates endoplasmic reticulum stress induced cell death by targeting caspase 3\/7","volume":"8","author":"Abdullah","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2019.172553_bib2","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1210\/en.2011-1881","article-title":"Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistance","volume":"153","author":"Achard","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2019.172553_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1242\/jcs.005777","article-title":"Shaping the endoplasmic reticulum into the nuclear envelope","volume":"121","author":"Anderson","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2019.172553_bib4","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1161\/CIRCRESAHA.109.211920","article-title":"TRB3 function in cardiac endoplasmic reticulum stress","volume":"106","author":"Avery","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2019.172553_bib5","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1021\/jm300713s","volume":"55","author":"Axten","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2019.172553_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2009.06.002","article-title":"Translation attenuation through eIF2\u03b1 phosphorylation prevents oxidative stress and maintains the differentiated state in \u03b2 cells","volume":"10","author":"Back","year":"2009","journal-title":"Cell Metabol."},{"key":"10.1016\/j.ejphar.2019.172553_bib7","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrendo.2016.124","article-title":"Endoplasmic reticulum proteostasis in hepatic steatosis","volume":"12","author":"Baiceanu","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ejphar.2019.172553_bib8","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2019.172553_bib9","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1111\/j.1742-1241.2008.01848.x","article-title":"Adiposopathy Working Group. Is adiposopathy (sick fat) an endocrine disease?","volume":"62","author":"Bays","year":"2008","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.ejphar.2019.172553_bib10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12192-013-0443-x","article-title":"Astaxanthin reduces hepatic endoplasmic reticulum stress and nuclear factor-\u03baB-mediated inflammation in high fructose and high fat diet-fed mice","volume":"19","author":"Bhuvaneswari","year":"2014","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.ejphar.2019.172553_bib11","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.2337\/diabetes.51.7.2301","article-title":"Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene","volume":"51","author":"Biason-Lauber","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2019.172553_bib12","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2337\/db08-1746","article-title":"Endoplasmic reticulum stress: another link between obesity and insulin resistance\/inflammation?","volume":"58","author":"Boden","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2019.172553_bib13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/B978-0-12-385116-1.00004-2","article-title":"Measurement of the increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals","volume":"489","author":"Boden","year":"2011","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ejphar.2019.172553_bib14","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1242\/jcs.045625","article-title":"ATF6\u03b1 induces XBP1-independent expansion of the endoplasmic reticulum","volume":"122","author":"Bommiasamy","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2019.172553_bib15","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1096\/fj.11-182931","article-title":"Peptides derived from the bifunctional kinase\/RNase enzyme IRE1\u03b1 modulate IRE1\u03b1 activity and protect cells from endoplasmic reticulum stress","volume":"25","author":"Bouchecareilh","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2019.172553_bib16","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1126\/science.1101902","article-title":"A selective inhibitor of eIF2\u03b1 dephosphorylation protects cells from ER stress","volume":"307","author":"Boyce","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2019.172553_bib17","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0143-4160(03)00127-1","article-title":"Calcium dynamics and endoplasmic reticular function in the regulation of protein synthesis: implications for cell growth and adaptability","volume":"34","author":"Brostrom","year":"2003","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2019.172553_bib18","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1517\/14728222.2013.756471","article-title":"Targeting endoplasmic reticulum stress in metabolic disease","volume":"17","author":"Cao","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejphar.2019.172553_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.phrs.2018.04.013","article-title":"Natural products targeting ER stress pathway for the treatment of cardiovascular diseases","volume":"132","author":"Choy","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2019.172553_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.molmed.2011.07.010","article-title":"Endoplasmic reticulum stress, obesity and diabetes","volume":"18","author":"Cnop","year":"2012","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejphar.2019.172553_bib21","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.molmet.2017.06.001","article-title":"Endoplasmic reticulum stress and eIF2\u03b1 phosphorylation: the Achilles heel of pancreatic \u03b2 cells","volume":"6","author":"Cnop","year":"2017","journal-title":"Mol. Metab."},{"key":"10.1016\/j.ejphar.2019.172553_bib22","doi-asserted-by":"crossref","first-page":"E869","DOI":"10.1073\/pnas.1115623109","article-title":"The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule","volume":"109","author":"Cross","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2019.172553_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2019.00382","article-title":"Nrf2 as a potential mediator of cardiovascular risk in metabolic diseases","volume":"10","author":"da Costa","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172553_bib24","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1042\/BJ20091827","article-title":"Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site","volume":"429","author":"Damiano","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2019.172553_bib25","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/glia.20793","article-title":"Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation","volume":"57","author":"Danilov","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2019.172553_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2018.01457","article-title":"Emerging roles for mesencephalic astrocyte-derived neurotrophic factor (MANF) in pancreatic beta cells and diabetes","volume":"9","author":"Danilova","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2019.172553_bib27","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/hep.24279","article-title":"The contribution of endoplasmic reticulum stress to liver diseases","volume":"53","author":"Dara","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2019.172553_bib28","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/78085","article-title":"EIF2AK3, encoding translation initiation factor 2-\u03b1 kinase 3, is mutated in patients with Wolcott-Rallison syndrome","volume":"25","author":"Delepine","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ejphar.2019.172553_bib29","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/j.celrep.2017.05.020","article-title":"ER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis","volume":"19","author":"DeZwaan-McCabe","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2019.172553_bib30","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2165\/11317750-000000000-00000","article-title":"The effect of physical exercise on endothelial function","volume":"39","author":"Di Francescomarino","year":"2009","journal-title":"Sport. Med."},{"key":"10.1016\/j.ejphar.2019.172553_bib31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1210\/er.2007-0015","article-title":"The role for endoplasmic reticulum stress in diabetes mellitus","volume":"29","author":"Eizirik","year":"2007","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2019.172553_bib32","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nm.2067","article-title":"Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis","volume":"15","author":"Erbay","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2019.172553_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/408927","article-title":"Mitochondria-targeted protective compounds in Parkinson's and Alzheimer's diseases","author":"Fern\u00e1ndez-Moriano","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ejphar.2019.172553_bib34","first-page":"266","article-title":"Endoplasmic reticulum stress and pancreatic \u03b2-cell death","volume":"22","author":"Fonseca","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2019.172553_bib35","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1172\/JCI39678","article-title":"Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells","volume":"120","author":"Fonseca","year":"2010","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2019.172553_bib36","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature09968","article-title":"Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity","volume":"473","author":"Fu","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2019.172553_bib37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/biof.135","article-title":"Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease","volume":"37","author":"Gentile","year":"2011","journal-title":"Biofactors"},{"key":"10.1016\/j.ejphar.2019.172553_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells7060063","article-title":"Endoplasmic reticulum stress in metabolic disorders","volume":"7","author":"Ghemrawi","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2019.172553_bib39","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bcp.2018.02.022","article-title":"Lipid bilayer stress in obesity-linked inflammatory and metabolic disorders","volume":"153","author":"Gianfrancesco","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172553_bib40","first-page":"1","article-title":"Endoplasmic reticulum stress-related inflammation and cardiovascular diseases","author":"Gotoh","year":"2011","journal-title":"Int. J. Inflamm."},{"key":"10.1016\/j.ejphar.2019.172553_bib41","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/CIRCRESAHA.110.227033","article-title":"Biology of endoplasmic reticulum stress in the heart","volume":"107","author":"Groenendyk","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2019.172553_bib42","doi-asserted-by":"crossref","first-page":"20755","DOI":"10.1074\/jbc.M112.340919","article-title":"Lecithin: cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice","volume":"287","author":"Hager","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.172553_bib43","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cell.2009.07.017","article-title":"IRE1\u03b1 kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates","volume":"138","author":"Han","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2019.172553_bib44","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1194\/jlr.R067595","article-title":"The role of ER stress in lipid metabolism and lipotoxicity","volume":"57","author":"Han","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ejphar.2019.172553_bib45","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ncb2738","article-title":"ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death","volume":"15","author":"Han","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib46","doi-asserted-by":"crossref","first-page":"44338","DOI":"10.1074\/jbc.M112.428987","article-title":"Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK","volume":"287","author":"Harding","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.172553_bib47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib48","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature01137","article-title":"A central role for JNK in obesity and insulin resistance","volume":"420","author":"Hirosumi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2019.172553_bib49","first-page":"1","article-title":"The role of endoplasmic reticulum stress in cardiovascular disease and exercise","author":"Hong","year":"2017","journal-title":"Int. J. Vasc. Med."},{"key":"10.1016\/j.ejphar.2019.172553_bib50","first-page":"1","article-title":"Nrf2 and cardiovascular defense","author":"Howden","year":"2013","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ejphar.2019.172553_bib51","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1128\/MCB.26.8.3071-3084.2006","article-title":"Autocrinetumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1\u03b1-mediated NF-\u03baB activation and down-regulation of TRAF2 expression","volume":"26","author":"Hu","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib52","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1167\/iovs.08-2123","article-title":"Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death","volume":"50","author":"Inokuchi","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2019.172553_bib53","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0006-291X(03)01318-4","article-title":"Small molecule inhibitors of the RNA-dependent protein kinase","volume":"308","author":"Jammi","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2019.172553_bib54","doi-asserted-by":"crossref","first-page":"E454","DOI":"10.1152\/ajpendo.00203.2004","article-title":"Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance","volume":"288","author":"Kabir","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2019.172553_bib55","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1248\/bpb.b17-00342","article-title":"ER stress and disease: toward prevention and treatment","volume":"40","author":"Kaneko","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2019.172553_bib56","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra043898","article-title":"Primary biliary cirrhosis","volume":"353","author":"Kaplan","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2019.172553_bib57","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.2337\/db10-0308","article-title":"Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women","volume":"59","author":"Kars","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2019.172553_bib58","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1074\/jbc.M807308200","article-title":"Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1","volume":"284","author":"Kim","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.172553_bib59","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000440905","article-title":"Mechanism of ER stress and inflammation for hepatic insulin resistance in obesity","volume":"67","author":"Kim","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.ejphar.2019.172553_bib60","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/sj.cdd.4402276","article-title":"A molecular chaperone inducer protects neurons from ER stress","volume":"15","author":"Kudo","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2019.172553_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2168-9431.1000140","article-title":"Role of ER stress in inflammasome activation and non-alcoholic fatty liver disease progression","volume":"5","author":"Lebeaupin","year":"2016","journal-title":"Single Cell Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib62","doi-asserted-by":"crossref","first-page":"8885","DOI":"10.1073\/pnas.1105564108","article-title":"Dual and opposing roles of the unfolded protein response regulated by IRE1\u03b1 and XBP1 in proinsulin processing and insulin secretion","volume":"108","author":"Lee","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2019.172553_bib63","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1074\/jbc.R113.534743","article-title":"Unfolded protein response signaling and metabolic diseases","volume":"289","author":"Lee","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.172553_bib64","first-page":"291","article-title":"Focus: infectious diseases: BiP: master regulator of the unfolded protein response and crucial factor in flavivirus biology","volume":"90","author":"Lewy","year":"2017","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.ejphar.2019.172553_bib65","doi-asserted-by":"crossref","first-page":"37030","DOI":"10.1074\/jbc.M405195200","volume":"279","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.172553_bib66","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1159\/000335802","article-title":"Mitochondria-targeted antioxidants protect pancreatic \u03b2-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity","volume":"28","author":"Lim","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2019.172553_bib67","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1159\/000447788","article-title":"Inhibition of cardiomyocytes hypertrophy by resveratrol is associated with amelioration of endoplasmic reticulum stress","volume":"39","author":"Lin","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2019.172553_bib68","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/aps.2015.145","article-title":"Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases","volume":"37","author":"Liu","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2019.172553_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms20071658","article-title":"Endoplasmic Reticulum Stress: a critical molecular driver of endothelial dysfunction and cardiovascular disturbances associated with diabetes","volume":"20","author":"Maamoun","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2019.172553_bib70","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","article-title":"Endoplasmic reticulum stress in liver disease","volume":"54","author":"Malhi","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2019.172553_bib71","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1101\/gad.1250704","article-title":"CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum","volume":"18","author":"Marciniak","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejphar.2019.172553_bib72","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1152\/physrev.00015.2006","article-title":"Endoplasmic reticulum stress signaling in disease","volume":"86","author":"Marciniak","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2019.172553_bib73","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1182\/blood-2011-07-366633","article-title":"Blockade of XBP1 splicing by inhibition of IRE1\u03b1 is a promising therapeutic option in multiple myeloma","volume":"119","author":"Mimura","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2019.172553_bib74","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.yjmcc.2009.10.026","article-title":"ER stress in cardiovascular disease","volume":"48","author":"Minamino","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2019.172553_bib75","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/CIRCRESAHA.110.227819","article-title":"Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease","volume":"107","author":"Minamino","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2019.172553_bib76","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1074\/jbc.272.7.4327","article-title":"Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins","volume":"272","author":"Morris","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.172553_bib77","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3934\/publichealth.2014.2.109","article-title":"Prevalence of obesity: a public health problem poorly understood","volume":"1","author":"Nicklas","year":"2014","journal-title":"AIMS Public Health"},{"key":"10.1016\/j.ejphar.2019.172553_bib78","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.3109\/10715762.2014.959514","article-title":"(-)-Hydroxycitric acid attenuates endoplasmic reticulum stress-mediated alterations in 3T3-L1 adipocytes by protecting mitochondria and downregulating inflammatory markers","volume":"48","author":"Nisha","year":"2014","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.ejphar.2019.172553_bib79","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.surg.2008.08.038","article-title":"Inflammation in obesity-related diseases","volume":"145","author":"O'Rourke","year":"2009","journal-title":"Surgery"},{"key":"10.1016\/j.ejphar.2019.172553_bib80","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neulet.2010.08.015","article-title":"Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice","volume":"484","author":"Oida","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2019.172553_bib81","doi-asserted-by":"crossref","first-page":"30142","DOI":"10.1074\/jbc.M115.676239","article-title":"Hepatic Xbp1 gene deletion promotes endoplasmic reticulum stress-induced liver injury and apoptosis","volume":"290","author":"Olivares","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.172553_bib82","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ceb.2010.11.002","article-title":"Chemical and\/or biological therapeutic strategies to ameliorate protein misfolding diseases","volume":"23","author":"Ong","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib83","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nchembio.368","article-title":"Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis","volume":"6","author":"Ong","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2018.01308","article-title":"The role of natural products in targeting cardiovascular diseases via Nrf2 Pathway: novel molecular mechanisms and therapeutic approaches","volume":"9","author":"Ooi","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172553_bib85","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev-nutr-071811-150644","article-title":"Endoplasmic reticulum stress in nonalcoholic fatty liver disease","volume":"32","author":"Pagliassotti","year":"2012","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.ejphar.2019.172553_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a007666","article-title":"Endoplasmic reticulum stress, pancreatic \u03b2-cell degeneration, and diabetes","volume":"2","author":"Papa","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ejphar.2019.172553_bib87","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1182\/blood-2010-08-303099","article-title":"Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma","volume":"117","author":"Papandreou","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2019.172553_bib88","doi-asserted-by":"crossref","first-page":"19320","DOI":"10.1073\/pnas.1012044107","article-title":"Sarco (endo) plasmic reticulum Ca2+ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity","volume":"107","author":"Park","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2019.172553_bib89","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1210\/jc.2011-3408","article-title":"Crosstalk between advanced glycation and endoplasmic reticulum stress: emerging therapeutic targeting for metabolic diseases","volume":"97","author":"Piperi","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2019.172553_bib90","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/cdd.2016.138","article-title":"SIRT1 protects the heart from ER stress-induced cell death through eIF2\u03b1 deacetylation","volume":"24","author":"Prola","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2019.172553_bib91","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1038\/emboj.2013.183","article-title":"Toll\u2010like receptor\u2010mediated IRE1\u03b1 activation as a therapeutic target for inflammatory arthritis","volume":"32","author":"Qiu","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2019.172553_bib92","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib93","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nature05483","article-title":"Adipocytes as regulators of energy balance and glucose homeostasis","volume":"444","author":"Rosen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2019.172553_bib94","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/febs.14389","article-title":"Liver function and dysfunction\u2013a unique window into the physiological reach of ER stress and the unfolded protein response","volume":"286","author":"Rutkowski","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2019.172553_bib95","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.phrs.2017.02.018","article-title":"Unraveling the role of ER stress inhibitors in the context of metabolic diseases","volume":"119","author":"Sarvani","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2019.172553_bib96","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","article-title":"The mammalian unfolded protein response","volume":"74","author":"Schroder","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejphar.2019.172553_bib97","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejphar.2019.172553_bib98","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.1074\/jbc.M113.545699","article-title":"Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP)","volume":"289","author":"Shao","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.172553_bib99","article-title":"Baicalin protects the cardiomyocytes from ER stress-induced apoptosis: inhibition of CHOP through induction of endothelial nitric oxide synthase","volume":"9","author":"Shen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2019.172553_bib100","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0163-7827(01)00010-8","article-title":"Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes","volume":"40","author":"Shimano","year":"2001","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.ejphar.2019.172553_bib101","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neulet.2006.09.074","article-title":"Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress","volume":"409","author":"Shimazawa","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2019.172553_bib102","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00109-007-0279-x","article-title":"Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia","volume":"85","author":"Shohet","year":"2007","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.ejphar.2019.172553_bib103","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1749-6632.2010.05627.x","article-title":"Animal and human studies with the mitochondria-targeted antioxidant MitoQ","volume":"1201","author":"Smith","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2019.172553_bib104","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cmet.2012.09.004","article-title":"Silencing of lipid metabolism genes through IRE1\u03b1-mediated mRNA decay lowers plasma lipids in mice","volume":"16","author":"So","year":"2012","journal-title":"Cell Metabol."},{"key":"10.1016\/j.ejphar.2019.172553_bib105","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.200406136","article-title":"XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum","volume":"167","author":"Sriburi","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib106","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cpr.12102","article-title":"Quercetin ameliorates tunicamycin-induced endoplasmic reticulum stress in endothelial cells","volume":"47","author":"Suganya","year":"2014","journal-title":"Cell Prolif"},{"key":"10.1016\/j.ejphar.2019.172553_bib107","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2217\/17460875.3.5.545","article-title":"Macrophage infiltration into adipose tissue: initiation, propagation and remodeling","volume":"3","author":"Surmi","year":"2008","journal-title":"Future Lipidol."},{"key":"10.1016\/j.ejphar.2019.172553_bib108","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.bbrc.2006.09.009","article-title":"ER stress contributes to ischemia-induced cardiomyocyte apoptosis","volume":"349","author":"Szegezdi","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2019.172553_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/1851420","article-title":"Role of mitochondria-associated endoplasmic reticulum membrane in inflammation-mediated metabolic diseases","author":"Thoudam","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2019.172553_bib110","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1161\/01.RES.0000233317.70421.03","article-title":"Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes","volume":"99","author":"Thuerauf","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2019.172553_bib111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2012.00240","article-title":"Obesity and endoplasmic reticulum (ER) stresses","volume":"3","author":"Tripathi","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2019.172553_bib112","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.1201396","article-title":"Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis","volume":"332","author":"Tsaytler","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2019.172553_bib113","doi-asserted-by":"crossref","first-page":"637","DOI":"10.14336\/AD.2018.0513","article-title":"The anti-inflammatory and anti-oxidant mechanisms of the Keap1\/Nrf2\/ARE signaling pathway in chronic diseases","volume":"10","author":"Tu","year":"2019","journal-title":"Aging Dis."},{"key":"10.1016\/j.ejphar.2019.172553_bib114","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"Van Meer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib115","first-page":"1","article-title":"Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease","author":"Verdile","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2019.172553_bib116","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mam.2018.11.001","article-title":"Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity","volume":"66","author":"Villalobos-Labra","year":"2018","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.ejphar.2019.172553_bib117","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1096\/fj.02-0644fje","article-title":"Overexpression of the stress protein Grp94 reduces cardiomyocyte necrosis due to calcium overload and simulated ischemia","volume":"17","author":"Vitadello","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2019.172553_bib118","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/embo-reports\/kvf202","article-title":"Structural organization of the endoplasmic reticulum","volume":"3","author":"Voeltz","year":"2002","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ejphar.2019.172553_bib119","doi-asserted-by":"crossref","first-page":"12743","DOI":"10.1074\/jbc.M110.199737","article-title":"Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease","volume":"286","author":"Volkmann","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2019.172553_bib121","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1747-0285.2010.01048.x","article-title":"Structural determinants of PERK inhibitor potency and selectivity","volume":"76","author":"Wang","year":"2010","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejphar.2019.172553_bib122","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s10495-014-1039-3","article-title":"Elatoside C protects against hypoxia\/reoxygenation-induced apoptosis in H9c2 cardiomyocytes through the reduction of endoplasmic reticulum stress partially depending on STAT3 activation","volume":"19","author":"Wang","year":"2014","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejphar.2019.172553_bib123","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.201110131","article-title":"The impact of the unfolded protein response on human disease","volume":"197","author":"Wang","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib124","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cmet.2012.09.003","article-title":"IRE1\u03b1-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis","volume":"6","author":"Wang","year":"2012","journal-title":"Cell Metabol."},{"key":"10.1016\/j.ejphar.2019.172553_bib125","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature08111","article-title":"The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis","volume":"460","author":"Wang","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2019.172553_bib126","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1379\/1466-1268(1996)001<0109:IOMACC>2.3.CO;2","article-title":"Influence of molecular and chemical chaperones on protein folding","volume":"1","author":"Welch","year":"1996","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.ejphar.2019.172553_bib127","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009135","article-title":"Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells","volume":"5","author":"Wiley","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2019.172553_bib128","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1080\/17474124.2016.1179575","article-title":"Targeting endoplasmic reticulum stress in liver disease","volume":"10","author":"Wu","year":"2016","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2019.172553_bib129","doi-asserted-by":"crossref","first-page":"918","DOI":"10.2337\/db10-1433","article-title":"Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and \u03b2-cell dysfunction in humans","volume":"60","author":"Xiao","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2019.172553_bib130","doi-asserted-by":"crossref","first-page":"848","DOI":"10.2337\/db11-0955","article-title":"Preventing \u03b2-cell loss and diabetes with calcium channel blockers","volume":"61","author":"Xu","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2019.172553_bib131","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1091\/mbc.e09-02-0133","article-title":"Induction of liver steatosis and lipid droplet formation in ATF6\u03b1-knockout mice burdened with pharmacological endoplasmic reticulum stress","volume":"21","author":"Yamamoto","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejphar.2019.172553_bib132","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(01)00611-0","article-title":"XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor","volume":"107","author":"Yoshida","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2019.172553_bib133","doi-asserted-by":"crossref","first-page":"6755","DOI":"10.1128\/MCB.20.18.6755-6767.2000","article-title":"ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response","volume":"20","author":"Yoshida","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib134","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1128\/MCB.21.4.1239-1248.2001","article-title":"Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6\u03b1 and 6\u03b2 that activates the mammalian unfolded protein response","volume":"21","author":"Yoshida","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ejphar.2019.172553_bib135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037782","article-title":"A BAX\/BAK and cyclophilin D-independent intrinsic apoptosis pathway","volume":"7","author":"Zamorano","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2019.172553_bib136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/312943","article-title":"ER stress and lipid metabolism in adipocytes","author":"Zha","year":"2012","journal-title":"Biochem. Res. Int."},{"key":"10.1016\/j.ejphar.2019.172553_bib137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcvm.2017.00029","article-title":"Role of endoplasmic reticulum stress, autophagy, and inflammation in cardiovascular disease","volume":"4","author":"Zhang","year":"2017","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2019.172553_bib138","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/sj.cdd.4402072","article-title":"Bax and the mitochondrial permeability transition cooperate in the release of cytochrome c during endoplasmic reticulum-stress-induced apoptosis","volume":"14","author":"Zhang","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2019.172553_bib139","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.toxlet.2019.03.007","article-title":"PERK regulates Nrf2\/ARE antioxidant pathway against dibutyl phthalate-induced mitochondrial damage and apoptosis dependent of reactive oxygen species in mouse spermatocyte-derived cells","volume":"308","author":"Zhang","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejphar.2019.172553_bib140","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1159\/000478960","article-title":"Nobiletin, a polymethoxy flavonoid, protects against cardiac hypertrophy induced by pressure-overload via inhibition of NAPDH oxidases and endoplasmic reticulum stress","volume":"42","author":"Zhang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2019.172553_bib141","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2006.11.002","article-title":"PERK EIF2AK3 control of pancreatic \u03b2 cell differentiation and proliferation is required for postnatal glucose homeostasis","volume":"4","author":"Zhang","year":"2006","journal-title":"Cell Metabol."},{"key":"10.1016\/j.ejphar.2019.172553_bib142","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neulet.2011.09.003","article-title":"Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia\u2013reperfusion injury","volume":"504","author":"Zhang","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2019.172553_bib143","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/aps.2015.136","article-title":"Berberine protects rat heart from ischemia\/reperfusion injury via activating JAK2\/STAT3 signaling and attenuating endoplasmic reticulum stress","volume":"37","author":"Zhao","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2019.172553_bib144","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nm.2293","article-title":"Regulation of glucose homeostasis through a XBP-1\u2013FoxO1 interaction","volume":"17","author":"Zhou","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2019.172553_bib145","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.cell.2011.11.029","article-title":"Suppression of PKR promotes network excitability and enhanced cognition by interferon-\u03b3-mediated disinhibition","volume":"147","author":"Zhu","year":"2011","journal-title":"Cell"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919305059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919305059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:30:00Z","timestamp":1757975400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299919305059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":144,"alternative-id":["S0014299919305059"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172553","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endoplasmic reticulum stress: A master regulator of metabolic syndrome","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172553","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"172553"}}