{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:10:33Z","timestamp":1789999833870,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573428"],"award-info":[{"award-number":["81573428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603144"],"award-info":[{"award-number":["81603144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.ejphar.2019.172559","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T02:04:24Z","timestamp":1563415464000},"page":"172559","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Imatinib prevents elastase-induced abdominal aortic aneurysm progression by regulating macrophage-derived MMP9"],"prefix":"10.1016","volume":"860","author":[{"given":"Fengqi","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangting","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiecheng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaojun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2019.172559_bib1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2353\/ajpath.2007.060522","article-title":"Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine collagenases","volume":"170","author":"Abdul-Hussien","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2019.172559_bib2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.clml.2018.12.004","article-title":"Cardiovascular risk and cardiovascular events in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors","volume":"19","author":"Assuncao","year":"2019","journal-title":"Clin. Lymphoma, Myeloma & Leukemia"},{"key":"10.1016\/j.ejphar.2019.172559_bib3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s10016-006-9017-z","article-title":"Localized administration of doxycycline suppresses aortic dilatation in an experimental mouse model of abdominal aortic aneurysm","volume":"20","author":"Bartoli","year":"2006","journal-title":"Ann. Vasc. Surg."},{"key":"10.1016\/j.ejphar.2019.172559_bib4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1517\/14728222.10.4.547","article-title":"Pharmacological targets in the treatment of abdominal aortic aneurysms","volume":"10","author":"Bergoeing","year":"2006","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejphar.2019.172559_bib5","doi-asserted-by":"crossref","unstructured":"Brewster, D.C., Cronenwett, J.L., Hallett, J.W., Jr, Johnston, K.W., Krupski, W.C., Matsumura, J.S., Joint council of the American association for vascular, S., society for vascular, S., 2003. Guidelines for the treatment of abdominal aortic aneurysms. Report of a subcommittee of the joint council of the American association for vascular surgery and society for vascular surgery. J. Vasc. Surg. 37, 1106-1117.","DOI":"10.1067\/mva.2003.363"},{"key":"10.1016\/j.ejphar.2019.172559_bib6","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3892\/mco.2016.800","article-title":"Cardiotoxicity associated with targeted cancer therapies","volume":"4","author":"Chen","year":"2016","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2019.172559_bib7","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1172\/JCI2182","article-title":"Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms","volume":"102","author":"Curci","year":"1998","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2019.172559_bib8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11936-017-0524-8","article-title":"Cardiovascular complications of targeted therapies for chronic myeloid leukemia","volume":"19","author":"Damrongwatanasuk","year":"2017","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2019.172559_bib9","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1161\/01.ATV.18.10.1625","article-title":"Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms","volume":"18","author":"Davis","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2019.172559_bib10","doi-asserted-by":"crossref","first-page":"36441","DOI":"10.18632\/oncotarget.5541","article-title":"Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages","volume":"6","author":"Ding","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2019.172559_bib11","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.canlet.2014.10.034","article-title":"SAHA triggered MET activation contributes to SAHA tolerance in solid cancer cells","volume":"356","author":"Ding","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejphar.2019.172559_bib12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/CIRCGENETICS.112.963082","article-title":"Matrix metalloproteinase-9 genotype as a potential genetic marker for abdominal aortic aneurysm","volume":"5","author":"Duellman","year":"2012","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.ejphar.2019.172559_bib13","first-page":"172","article-title":"Alteration of MMP-2 and -14 expression by imatinib in HPV-positive and -negative squamous cell carcinoma","volume":"28","author":"Faber","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejphar.2019.172559_bib14","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1161\/01.ATV.15.8.1145","article-title":"Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm","volume":"15","author":"Freestone","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2019.172559_bib15","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jamcollsurg.2012.06.414","article-title":"The role of extracellular signal-related kinase during abdominal aortic aneurysm formation","volume":"215","author":"Ghosh","year":"2012","journal-title":"J. Am. Coll. Surg."},{"key":"10.1016\/j.ejphar.2019.172559_bib16","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1038\/ncomms3129","article-title":"Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis","volume":"4","author":"Hosaka","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2019.172559_bib17","series-title":"Impaired Nocturnal Melatonin Secretion in Non-dipper Hypertensive Patients","first-page":"19","volume":"vol. 12","author":"Jonas","year":"2003"},{"key":"10.1016\/j.ejphar.2019.172559_bib18","doi-asserted-by":"crossref","first-page":"14283","DOI":"10.18632\/oncotarget.15093","article-title":"Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases","volume":"8","author":"Kong","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2019.172559_bib19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nrcardio.2010.187","article-title":"Epidemiology of thoracic aortic dissection","volume":"8","author":"LeMaire","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejphar.2019.172559_bib20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jss.2011.05.041","article-title":"Local and systemic alterations in signal transducers and activators of transcription (STAT) associated with human abdominal aortic aneurysms","volume":"176","author":"Liao","year":"2012","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ejphar.2019.172559_bib21","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1042\/CS20070352","article-title":"Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm","volume":"114","author":"Lindeman","year":"2008","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.ejphar.2019.172559_bib22","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1161\/CIRCULATIONAHA.108.806505","article-title":"Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells","volume":"119","author":"Lindeman","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2019.172559_bib23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1161\/CIRCRESAHA.117.305262","article-title":"Thrombospondin-1 (TSP1) contributes to the development of vascular inflammation by regulating monocytic cell motility in mouse models of abdominal aortic aneurysm","volume":"117","author":"Liu","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2019.172559_bib24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.surg.2004.12.004","article-title":"MMP-12 has a role in abdominal aortic aneurysms in mice","volume":"137","author":"Longo","year":"2005","journal-title":"Surgery"},{"key":"10.1016\/j.ejphar.2019.172559_bib25","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI0215334","article-title":"Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms","volume":"110","author":"Longo","year":"2002","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2019.172559_bib26","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1161\/CIRCRESAHA.107.148668","article-title":"Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model","volume":"101","author":"Miyake","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2019.172559_bib27","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2019.172559_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.ejphar.2019.172559_bib29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrcardio.2010.180","article-title":"Pathophysiology and epidemiology of abdominal aortic aneurysms","volume":"8","author":"Nordon","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejphar.2019.172559_bib30","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0741-5214(96)70279-3","article-title":"Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase","volume":"23","author":"Petrinec","year":"1996","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ejphar.2019.172559_bib31","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.3324\/haematol.2011.060087","article-title":"High-dose imatinib induction followed by standard-dose maintenance in pre-treated chronic phase chronic myeloid leukemia patients--final analysis of a randomized, multicenter, phase III trial","volume":"97","author":"Petzer","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.ejphar.2019.172559_bib32","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI8931","article-title":"Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms","volume":"105","author":"Pyo","year":"2000","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2019.172559_bib33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/cvr\/cvs263","article-title":"Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice","volume":"96","author":"Qin","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2019.172559_bib34","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrcardio.2017.52","article-title":"Monocytes and macrophages in abdominal aortic aneurysm","volume":"14","author":"Raffort","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejphar.2019.172559_bib35","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nm.1958","article-title":"Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms","volume":"15","author":"Satoh","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2019.172559_bib36","first-page":"1145","article-title":"Down-regulation of MMP-2 expression due to inhibition of receptor tyrosine kinases by imatinib and carboplatin in HNSCC","volume":"25","author":"Schultz","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejphar.2019.172559_bib37","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.ATV.0000214999.12921.4f","article-title":"Inflammation and cellular immune responses in abdominal aortic aneurysms","volume":"26","author":"Shimizu","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2019.172559_bib38","doi-asserted-by":"crossref","unstructured":"Sorelius, K., Wanhainen, A., Furebring, M., Bjorck, M., Gillgren, P., Mani, K., Swedish collaborator group for mycotic abdominal aortic, A., 2016. Nationwide study of the treatment of mycotic abdominal aortic aneurysms comparing open and endovascular repair. Circulation 134, 1822-1832.","DOI":"10.1161\/CIRCULATIONAHA.116.024021"},{"key":"10.1016\/j.ejphar.2019.172559_bib39","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1158\/1078-0432.CCR-15-1243","article-title":"Efficacy and biological activity of imatinib in metastatic dermatofibrosarcoma protuberans (DFSP)","volume":"22","author":"Stacchiotti","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2019.172559_bib40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1067\/msg.2002.121421","article-title":"Abdominal aortic aneurysms: basic mechanisms and clinical implications","volume":"39","author":"Thompson","year":"2002","journal-title":"Curr. Probl. Surg."},{"key":"10.1016\/j.ejphar.2019.172559_bib41","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1172\/JCI118037","article-title":"Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages","volume":"96","author":"Thompson","year":"1995","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2019.172559_bib42","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3892\/or.2014.3225","article-title":"Imatinib-associated matrix metalloproteinase suppression in p16-positive squamous cell carcinoma compared to HPV-negative HNSCC cells in vitro","volume":"32","author":"Umbreit","year":"2014","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejphar.2019.172559_bib43","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2016.04.006","article-title":"Imatinib treatment attenuates growth and inflammation of angiotensin II induced abdominal aortic aneurysm","volume":"249","author":"Vorkapic","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2019.172559_bib44","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.leukres.2010.01.004","article-title":"Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studies","volume":"34","author":"Wolf","year":"2010","journal-title":"Leuk. Res."},{"key":"10.1016\/j.ejphar.2019.172559_bib45","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1161\/ATVBAHA.111.242198","article-title":"Syndecan-1 displays a protective role in aortic aneurysm formation by modulating T cell-mediated responses","volume":"32","author":"Xiao","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2019.172559_bib46","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.phrs.2018.05.002","article-title":"Imatinib prevents lung cancer metastasis by inhibiting M2-like polarization of macrophages","volume":"133","author":"Yao","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2019.172559_bib47","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/jso.21630","article-title":"Surgical management in metastatic gastrointestinal stromal tumor (GIST) patients after imatinib mesylate treatment","volume":"102","author":"Yeh","year":"2010","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.ejphar.2019.172559_bib48","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/nm1335","article-title":"Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase","volume":"11","author":"Yoshimura","year":"2005","journal-title":"Nat. Med."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919305114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919305114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T10:18:37Z","timestamp":1569320317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299919305114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":48,"alternative-id":["S0014299919305114"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172559","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imatinib prevents elastase-induced abdominal aortic aneurysm progression by regulating macrophage-derived MMP9","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172559","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"172559"}}