{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:19:46Z","timestamp":1780384786082,"version":"3.54.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.ejphar.2019.172671","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T11:07:05Z","timestamp":1568891225000},"page":"172671","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Inhibition of naltrexone on relapse in methamphetamine self-administration and conditioned place preference in rats"],"prefix":"10.1016","volume":"865","author":[{"given":"Liang-kun","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-ming","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-ming","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2019.172671_bib1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.brainres.2004.06.051","article-title":"Naltrexone attenuates cue- but not drug-induced methamphetamine seeking: a possible mechanism for the dissociation of primary and secondary reward","volume":"1021","author":"Anggadiredja","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2019.172671_bib2","doi-asserted-by":"crossref","first-page":"692","DOI":"10.2174\/1871527314666150529132503","article-title":"Targeting the toll of drug abuse: the translational potential of toll-like receptor 4","volume":"14","author":"Bachtell","year":"2015","journal-title":"CNS Neurol. Disord. - Drug Targets"},{"key":"10.1016\/j.ejphar.2019.172671_bib3","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1523\/JNEUROSCI.0387-04.2004","article-title":"Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism","volume":"24","author":"Baucum","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ejphar.2019.172671_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejphar.2010.04.010","article-title":"The glial cell modulator and phosphodiesterase inhibitor, AV411 (ibudilast), attenuates prime- and stress-induced methamphetamine relapse","volume":"637","author":"Beardsley","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172671_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0006-8993(93)90309-B","article-title":"Naltrexone reverses ethanol-induced dopamine release in the nucleus accumbens in awake, freely moving rats","volume":"621","author":"Benjamin","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2019.172671_bib6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0006-8993(97)01281-X","article-title":"Methamphetamine-induced alterations in dopamine transporter function","volume":"782","author":"Bennett","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2019.172671_bib7","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/syn.20528","article-title":"Neuronal dopamine transporter activity, density and methamphetamine inhibition are differentially altered in the nucleus accumbens and striatum with no changes in glycosylation in rats behaviorally sensitized to methamphetamine","volume":"62","author":"Bjorklund","year":"2008","journal-title":"Synapse"},{"key":"10.1016\/j.ejphar.2019.172671_bib8","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1046\/j.1471-4159.2000.0742221.x","article-title":"Methamphetamine rapidly decreases vesicular dopamine uptake","volume":"74","author":"Brown","year":"2000","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.ejphar.2019.172671_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.addbeh.2014.08.007","article-title":"Depression and executive dysfunction contribute to a metamemory deficit among individuals with methamphetamine use disorders","volume":"40","author":"Casaletto","year":"2015","journal-title":"Addict. Behav."},{"key":"10.1016\/j.ejphar.2019.172671_bib10","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s11373-006-9102-x","article-title":"Methamphetamine-induced behavioral sensitization in mice: alterations in mu-opioid receptor","volume":"13","author":"Chiu","year":"2006","journal-title":"J.\u00a0Biomed. Sci."},{"key":"10.1016\/j.ejphar.2019.172671_bib11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejphar.2008.05.028","article-title":"Differential regional effects of methamphetamine on dopamine transport","volume":"590","author":"Chu","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172671_bib12","doi-asserted-by":"crossref","DOI":"10.1097\/FBP.0000000000000485","article-title":"Optogenetic inhibition of the medial prefrontal cortex reduces methamphetamine-primed reinstatement in male and female rats","author":"Cordie","year":"2019","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172671_bib13","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbr.2011.09.022","article-title":"Acetylcholine from the mesopontine tegmental nuclei differentially affects methamphetamine induced locomotor activity and neurotransmitter levels in the mesolimbic pathway","volume":"226","author":"Dobbs","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2019.172671_bib14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3389\/fnmol.2017.00409","article-title":"Toll-like receptor 4 mediates methamphetamine-induced neuroinflammation through caspase-11 signaling pathway in astrocytes","volume":"10","author":"Du","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2019.172671_bib15","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/gbb.12100","article-title":"Morphine intake and the effects of naltrexone and buprenorphine on the acquisition of methamphetamine intake","volume":"13","author":"Eastwood","year":"2014","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.ejphar.2019.172671_bib16","series-title":"European Drug Report: Trends and Developments 2013","author":"European Monitoring Centre for Drugs and Drug Addiction","year":"2013"},{"key":"10.1016\/j.ejphar.2019.172671_bib17","article-title":"Inhibitory effects of Shati\/Nat8l overexpression in the medial prefrontal cortex on methamphetamine-induced conditioned place preference in mice","author":"Haddar","year":"2019","journal-title":"Addict. Biol."},{"key":"10.1016\/j.ejphar.2019.172671_bib18","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1046\/j.1471-4159.1999.0720661.x","article-title":"Differential regional effects of methamphetamine on the activities of tryptophan and tyrosine hydroxylase","volume":"72","author":"Haughey","year":"1999","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.ejphar.2019.172671_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1124\/jpet.113.207522","article-title":"Stimulants as specific inducers of dopamine-independent \u03c3 agonist self-administration in rats","volume":"347","author":"Hiranita","year":"2013","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2019.172671_bib20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1176\/jnp.2009.21.3.254","article-title":"Quantitative EEG abnormalities are associated with memory impairment in recently abstinent methamphetamine-dependent individuals","volume":"21","author":"Kalechstein","year":"2009","journal-title":"J.\u00a0Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.ejphar.2019.172671_bib21","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.drugalcdep.2018.07.045","article-title":"A\u00a0preliminary randomized clinical trial of naltrexone reduces striatal resting state functional connectivity in people with methamphetamine use disorder","volume":"192","author":"Kohno","year":"2018","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.ejphar.2019.172671_bib22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0014-2999(98)00741-9","article-title":"Nature of methamphetamine-induced rapid and reversible changes in dopamine transporters","volume":"361","author":"Kokoshka","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172671_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.drugalcdep.2018.06.038","article-title":"Pharmacotherapy for amphetamine dependence: a systematic review","volume":"191","author":"Lee","year":"2018","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.ejphar.2019.172671_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2018.12.010","article-title":"\u03b14\u03b22 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats","volume":"845","author":"Levin","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2019.172671_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042365","article-title":"Identification of rat ventral tegmental area GABAergic neurons","volume":"7","author":"Margolis","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2019.172671_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/JCP.0000000000000488","article-title":"Separate and combined effects of naltrexone and extended-release alprazolam on the reinforcing, subject-rated, and cardiovascular effects of methamphetamine","volume":"36","author":"Marks","year":"2016","journal-title":"J.\u00a0Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2019.172671_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/01.yco.0000165592.52811.84","article-title":"Emerging research on methamphetamine","volume":"18","author":"Maxwell","year":"2005","journal-title":"Curr. Opin. Psychiatr."},{"key":"10.1016\/j.ejphar.2019.172671_bib28","first-page":"15","article-title":"Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration","volume":"45","author":"Meyer","year":"1984","journal-title":"J.\u00a0Clin. Psychiatry"},{"key":"10.1016\/j.ejphar.2019.172671_bib29","first-page":"159","article-title":"Dynamic regulation of the dopamine transporter","volume":"479","author":"Mortensen","year":"2003","journal-title":"Eur. J. Pharmacol., Transporters as targets for drugs and endogenous compounds"},{"key":"10.1016\/j.ejphar.2019.172671_bib30","series-title":"Annual Report on Drug Control in China (Report (Annual\/Periodic))","author":"Office of China National Narcotics Control Commission","year":"2017"},{"key":"10.1016\/j.ejphar.2019.172671_bib31","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1017\/S146114570800936X","article-title":"Dose-dependent reduction of hazardous alcohol use in a placebo-controlled trial of naltrexone for smoking cessation","volume":"12","author":"O'Malley","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2019.172671_bib32","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/npp.2013.231","article-title":"Dysregulation of dopamine and glutamate release in the prefrontal cortex and nucleus accumbens following methamphetamine self-administration and during reinstatement in rats","volume":"39","author":"Parsegian","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2019.172671_bib33","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1038\/npp.2015.83","article-title":"The effects of naltrexone on subjective response to methamphetamine in a clinical sample: a double-blind, placebo-controlled laboratory study","volume":"40","author":"Ray","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2019.172671_bib34","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0090-9556(25)08823-3","article-title":"Disposition and pharmacokinetics of naltrexone after intravenous and oral administration in rhesus monkeys","volume":"17","author":"Reuning","year":"1989","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2019.172671_bib35","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1111\/j.1471-4159.2009.05910.x","article-title":"Rapid substrate-induced down-regulation in function and surface localization of dopamine transporters: rat dorsal striatum versus nucleus accumbens","volume":"108","author":"Richards","year":"2009","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.ejphar.2019.172671_bib36","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s00213-017-4607-8","article-title":"Naltrexone moderates the relationship between cue-induced craving and subjective response to methamphetamine in individuals with methamphetamine use disorder","volume":"234","author":"Roche","year":"2017","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2019.172671_bib37","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1749-6632.2009.05148.x","article-title":"Regulation of the dopamine transporter","volume":"1187","author":"Schmitt","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2019.172671_bib38","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00213-006-0316-4","article-title":"Effect of methamphetamine self-administration on tyrosine hydroxylase and dopamine transporter levels in mesolimbic and nigrostriatal dopamine pathways of the rat","volume":"185","author":"Shepard","year":"2006","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2019.172671_bib39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pbb.2014.11.018","article-title":"Naltrexone and bupropion, alone or combined, do not alter the reinforcing effects of intranasal methamphetamine","volume":"129","author":"Stoops","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2019.172671_bib40","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1523\/JNEUROSCI.17-07-02585.1997","article-title":"\u03bc-Opioid receptors are localized to extrasynaptic plasma membranes of GABAergic neurons and their targets in the rat nucleus accumbens","volume":"17","author":"Svingos","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ejphar.2019.172671_bib41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0006-8993(97)01124-4","article-title":"Opioid receptor modulation of feeding-evoked dopamine release in the rat nucleus accumbens","volume":"785","author":"Taber","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2019.172671_bib42","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbr.2016.12.010","article-title":"Effects of chronic methamphetamine on psychomotor and cognitive functions and dopamine signaling in the brain","volume":"320","author":"Thanos","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2019.172671_bib43","unstructured":"United Nations Office on Drugs and Crime, n.d. reportWorld Drug Report 2018: Opioid Crisis, Prescription Drug Abuse Expands; Cocaine and Opium Hit Record Highs (Report (Annual\/Periodic))."},{"key":"10.1016\/j.ejphar.2019.172671_bib44","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1360-0443.2007.01772.x","article-title":"Approaches to the development of medications for the treatment of methamphetamine dependence","volume":"102","author":"Vocci","year":"2007","journal-title":"Addiction"},{"key":"10.1016\/j.ejphar.2019.172671_bib45","first-page":"4","article-title":"Alcohol abuse and alcoholism: an overview","volume":"62","author":"Volpicelli","year":"2001","journal-title":"J.\u00a0Clin. Psychiatry"},{"key":"10.1016\/j.ejphar.2019.172671_bib46","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41386-018-0097-6","article-title":"Chemogenetic activation of ventral tegmental area GABA neurons, but not mesoaccumbal GABA terminals, disrupts responding to reward-predictive cues","volume":"44","author":"Wakabayashi","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2019.172671_bib47","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.9b00225","article-title":"Methamphetamine activates Toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell","author":"Wang","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejphar.2019.172671_bib48","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1523\/JNEUROSCI.5282-03.2004","article-title":"The ventral tegmental area is required for the behavioral and nucleus accumbens neuronal firing responses to incentive cues","volume":"24","author":"Yun","year":"2004","journal-title":"J.\u00a0Neurosci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919306235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299919306235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:33:51Z","timestamp":1757975631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299919306235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":48,"alternative-id":["S0014299919306235"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172671","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of naltrexone on relapse in methamphetamine self-administration and conditioned place preference in rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2019.172671","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"172671"}}