{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:22:28Z","timestamp":1793276548416,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.ejphar.2020.172939","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T02:19:09Z","timestamp":1579573149000},"page":"172939","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Nobiletin suppresses IL-21\/IL-21 receptor-mediated inflammatory response in MH7A fibroblast-like synoviocytes (FLS): An implication in rheumatoid arthritis"],"prefix":"10.1016","volume":"875","author":[{"given":"Zhongbing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qirong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ejphar.2020.172939_bib1","doi-asserted-by":"crossref","first-page":"E905","DOI":"10.3390\/ijms18050905","article-title":"Matrix metalloproteinase gene activation resulting from disordered epigenetic mechanisms in rheumatoid arthritis","volume":"18","author":"Araki","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ejphar.2020.172939_bib2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.canlet.2007.06.001","article-title":"High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma","volume":"256","author":"Akamatsu","year":"2007","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.ejphar.2020.172939_bib3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.imbio.2016.10.001","article-title":"STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis","volume":"222","author":"Ahmad","year":"2017","journal-title":"Immunobiology"},{"key":"10.1016\/j.ejphar.2020.172939_bib4","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3389\/fimmu.2017.01341","article-title":"RANTES\/CCL5 induces collagen degradation by activating MMP-1 and MMP-13 expression in human rheumatoid arthritis synovial fibroblasts","volume":"8","author":"Agere","year":"2017","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.ejphar.2020.172939_bib5","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1136\/annrheumdis-2014-206028","article-title":"The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis","volume":"74","author":"Boyle","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2020.172939_bib6","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.3389\/fimmu.2018.01226","article-title":"STAT3 hyperactivation associates with follicular helper T cell differentiation and disease activity in rheumatoid arthritis","volume":"9","author":"Deng","year":"2018","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.ejphar.2020.172939_bib7","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1002\/jcp.26158","article-title":"Multifaceted role of IL-21 in rheumatoid arthritis: current understanding and future perspectives","volume":"233","author":"Dinesh","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.ejphar.2020.172939_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s12276-019-0245-z","article-title":"Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1\/FOXO3a-mediated autophagy and mitochondrial biogenesis","volume":"51","author":"Dusabimana","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ejphar.2020.172939_bib9","series-title":"Type II Collagen. InBiochemistry of Collagens, Laminins and Elastin","first-page":"13","volume":"vol. 1","author":"Gudmann","year":"2016"},{"issue":"3","key":"10.1016\/j.ejphar.2020.172939_bib10","first-page":"277","article-title":"Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues","volume":"22","author":"Ghasemi","year":"2009","journal-title":"Pak. J. Pharm. Sci."},{"issue":"8","key":"10.1016\/j.ejphar.2020.172939_bib11","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/ddr.21230","article-title":"Nobiletin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration and attenuates neointimal hyperplasia in a rat carotid artery injury model","volume":"75","author":"Guan","year":"2014","journal-title":"Drug Dev. Res."},{"issue":"17","key":"10.1016\/j.ejphar.2020.172939_bib12","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1080\/10408398.2016.1246413","article-title":"The therapeutic potential of plant flavonoids on rheumatoid arthritis","volume":"57","author":"Hughes","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr. 2017"},{"key":"10.1016\/j.ejphar.2020.172939_bib13","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/art.39547","article-title":"Brief report: JNK-2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis","volume":"68","author":"Ismail","year":"2016","journal-title":"Arthritis Rheumatol."},{"issue":"6","key":"10.1016\/j.ejphar.2020.172939_bib14","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3390\/molecules22060967","article-title":"Anti-inflammatory and neuroprotective constituents from the peels of Citrus grandis","volume":"22","author":"Kuo","year":"2017","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.ejphar.2020.172939_bib15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1189\/jlb.5A0516-217RR","article-title":"Synovial IL-21\/TNF producing CD4+ T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes","volume":"101","author":"Lebre","year":"2017","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.ejphar.2020.172939_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4196\/kjpp.2018.22.3.311","article-title":"Nobiletin attenuates neurotoxic mitochondrial calcium overload through K+ influx and \u0394\u03a8m across mitochondrial inner membrane","volume":"22","author":"Lee","year":"2018","journal-title":"Korean J. Physiol. Pharmacol."},{"issue":"12","key":"10.1016\/j.ejphar.2020.172939_bib17","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/S0006-2952(03)00203-X","article-title":"Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages","volume":"65","author":"Lin","year":"2003","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2020.172939_bib18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/jvh.12152","article-title":"Enhanced high-mobility group box 1 (HMGB 1) modulates regulatory T cells (T reg)\/T helper 17 (T h17) balance via toll-like receptor (TLR)-4 & interleukin (IL)-6 pathway in patients with chronic hepatitis B","volume":"21","author":"Li","year":"2014","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.ejphar.2020.172939_bib19","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.biopha.2016.03.051","article-title":"Nobiletin protects against murine l-arginine-induced acute pancreatitis in association with downregulating p38MAPK and AKT","volume":"81","author":"Liu","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"7\u20138","key":"10.1016\/j.ejphar.2020.172939_bib20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.etp.2015.04.008","article-title":"Nobiletin ameliorates cisplatin-induced acute kidney injury due to its anti-oxidant, anti-inflammatory and anti-apoptotic effects","volume":"67","author":"Malik","year":"2015","journal-title":"Exp. Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.ejphar.2020.172939_bib21","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s13075-015-0660-z","article-title":"Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus","volume":"17","author":"Rasmussen","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejphar.2020.172939_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/295081","article-title":"Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis","volume":"2012","author":"Shi","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.ejphar.2020.172939_bib22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.fct.2018.01.047","article-title":"Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes","volume":"113","author":"Surichan","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.ejphar.2020.172939_bib23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/BF02249017","article-title":"Detection of stromelysin in synovial fluid and serum from patients with rheumatoid arthritis and osteoarthritis","volume":"13","author":"Sasaki","year":"1994","journal-title":"Clin. Rheumatol."},{"issue":"5","key":"10.1016\/j.ejphar.2020.172939_bib25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jbspin.2015.09.002","article-title":"JAK1-STAT3 blockade by JAK inhibitor SHR0302 attenuates inflammatory responses of adjuvant-induced arthritis rats and decreases Th17 and total B cells","volume":"83","author":"Wu","year":"2016","journal-title":"Jt. Bone Spine"},{"issue":"2","key":"10.1016\/j.ejphar.2020.172939_bib26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/cei.12751","article-title":"Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis","volume":"184","author":"Xing","year":"2016","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.ejphar.2020.172939_bib27","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.clim.2015.08.012","article-title":"Role of HMGB1 in regulation of STAT3 expression in CD4+ T cells from patients with aGVHD after allogeneic hematopoietic stem cell transplantation","volume":"161","author":"Xu","year":"2015","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.ejphar.2020.172939_bib28","doi-asserted-by":"crossref","first-page":"7420265","DOI":"10.1155\/2018\/7420265","article-title":"Nobiletin inhibits hepatic lipogenesis via activation of AMP-activated protein kinase","volume":"2018","author":"Yuk","year":"2018","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.ejphar.2020.172939_bib29","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06376","article-title":"Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function","volume":"4","author":"Yang","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.ejphar.2020.172939_bib30","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.foodchem.2015.09.072","article-title":"Antioxidant activity of Citrus fruits","volume":"196","author":"Zou","year":"2016","journal-title":"Food Chem."},{"issue":"5","key":"10.1016\/j.ejphar.2020.172939_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10787-017-0385-5","article-title":"Protective effects of paeonol on inflammatory response in IL-1\u03b2-induced human fibroblast-like synoviocytes and rheumatoid arthritis progression via modulating NF-\u03baB pathway","volume":"25","author":"Zhai","year":"2017","journal-title":"Inflammopharmacology"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920300315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920300315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:34:45Z","timestamp":1757975685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920300315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":31,"alternative-id":["S0014299920300315"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.172939","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nobiletin suppresses IL-21\/IL-21 receptor-mediated inflammatory response in MH7A fibroblast-like synoviocytes (FLS): An implication in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.172939","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"172939"}}