{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:34:34Z","timestamp":1773516874819,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.ejphar.2020.173096","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T10:16:27Z","timestamp":1585995387000},"page":"173096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Effects of vibegron, a novel \u03b23-adrenoceptor agonist, and its combination with imidafenacin or silodosin in a rat with partial bladder outlet obstruction."],"prefix":"10.1016","volume":"878","author":[{"given":"Itaru","family":"Maruyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumi","family":"Tsuchioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanobu","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173096_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/nau.10052","article-title":"The standardization of terminology of lower urinary tract function: report from the Standardization Sub-committee of the International Continence Society","volume":"21","author":"Abrams","year":"2002","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.ejphar.2020.173096_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.urology.2003.09.050","article-title":"Describing bladder storage function: overactive bladder syndrome and detrusor overactivity","volume":"62","author":"Abrams","year":"2003","journal-title":"Urology"},{"key":"10.1016\/j.ejphar.2020.173096_bib3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.eururo.2014.02.012","article-title":"Combination treatment with mirabegron and solifenacin in patients with overactive bladder: efficacy and safety results from a randomized, double-blind, dose-ranging, phase 2 study (Symphony)","volume":"67","author":"Abrams","year":"2015","journal-title":"Eur. Urol."},{"key":"10.1016\/j.ejphar.2020.173096_bib4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/nau.20826","article-title":"Effects of CL316,243, a \u03b23-adrenoceptor agonist, and intravesical prostaglandin E2 on the primary bladder afferent activity of the rat","volume":"29","author":"Aizawa","year":"2010","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.ejphar.2020.173096_bib5","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.eururo.2010.10.035","article-title":"Effects of nitric oxide on the primary bladder afferent activities of the rat with and without intravesical acrolein treatment","volume":"59","author":"Aizawa","year":"2011","journal-title":"Eur. Urol."},{"key":"10.1016\/j.ejphar.2020.173096_bib6","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.juro.2014.09.005","article-title":"Selective inhibitory effect of imidafenacin and 5-hydroxymethyl tolterodine on capsaicin sensitive C fibers of the primary bladder mechanosensitive afferent nerves in the rat","volume":"193","author":"Aizawa","year":"2015","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2020.173096_bib7","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/nau.23547","article-title":"Inhibitory effects of silodosin on the bladder mechanosensitive afferent activities and their relation with bladder myogenic contractions in male rats with bladder outlet obstruction","volume":"37","author":"Aizawa","year":"2018","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.ejphar.2020.173096_bib8","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1124\/pr.56.4.4","article-title":"Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence","volume":"56","author":"Andersson","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2020.173096_bib9","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/nau.21108","article-title":"Rodent models for urodynamic investigation","volume":"30","author":"Andersson","year":"2011","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.ejphar.2020.173096_bib10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11934-013-0335-8","article-title":"\u03b23-receptor agonists for overactive bladder--new frontier or more of the same?","volume":"14","author":"Andersson","year":"2013","journal-title":"Curr. Urol. Rep."},{"key":"10.1016\/j.ejphar.2020.173096_bib11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/1756287218781255","article-title":"The efficacy of mirabegron in the treatment of urgency and the potential utility of combination therapy","volume":"10","author":"Andersson","year":"2018","journal-title":"Ther. Adv. Urol."},{"key":"10.1016\/j.ejphar.2020.173096_bib12","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1097\/01.ju.0000067541.73285.eb","article-title":"Combination treatment with an alpha-blocker plus an anticholinergic for bladder outlet obstruction: a prospective, randomized, controlled study","volume":"169","author":"Athanasopoulos","year":"2003","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2020.173096_bib13","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1523\/JNEUROSCI.22-18-08063.2002","article-title":"\u03b2-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells","volume":"22","author":"Birder","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2020.173096_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/nau.23224","article-title":"Beta-3 adrenergic receptor is expressed in acetylcholine-containing nerve fibers of the human urinary bladder: an immunohistochemical study","volume":"36","author":"Coelho","year":"2017","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.ejphar.2020.173096_bib15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2015.03.074","article-title":"Involvement of \u03b23-adrenoceptors in the inhibitory control of cholinergic activity in human bladder: direct evidence by [(3)H]-acetylcholine release experiments in the isolated detrusor","volume":"758","author":"D' Agostino","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173096_bib16","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1124\/jpet.116.237313","article-title":"Pharma-cological characterization of a novel beta 3 adrenergic agonist, vibegron: evaluation of antimuscarinic receptor selectivity for combination therapy for overactive bladder","volume":"360","author":"Di Salvo","year":"2016","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2020.173096_bib17","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1464-410X.2006.06258.x","article-title":"Antimuscarinic drugs in detrusor overactivity and the overactive bladder syndrome: motor or sensory actions?","volume":"98","author":"Finney","year":"2006","journal-title":"BJU Int."},{"key":"10.1016\/j.ejphar.2020.173096_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00210-012-0814-3","article-title":"Effect of mirabegron, a novel \u03b23-adrenoceptor agonist, on bladder function during storage phase in rats","volume":"386","author":"Hatanaka","year":"2013","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173096_bib19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1742-1241.2010.02611.x","article-title":"Antimuscarinics for treatment of storage lower urinary tract symptoms in men: a systematic review","volume":"65","author":"Kaplan","year":"2011","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.ejphar.2020.173096_bib20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/iju.13471","article-title":"Benefits and limitations of animal models in partial bladder outlet obstruction for translational research","volume":"25","author":"Kitta","year":"2018","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.ejphar.2020.173096_bib21","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1464-410X.2004.05039.x","article-title":"Comparison of doxazosin with or without tolterodine in men with symptomatic bladder outlet obstruction and an overactive bladder","volume":"94","author":"Lee","year":"2004","journal-title":"BJU Int."},{"key":"10.1016\/j.ejphar.2020.173096_bib22","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1152\/ajpregu.00499.2001","article-title":"Age-related changes in urethrovesical coordination in male rats: relationship with bladder instability?","volume":"284","author":"Lluel","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ejphar.2020.173096_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1248\/yakushi.126.237","article-title":"Pharmacokinetics and disposition of silodosin (KMD-3213)","volume":"126","author":"Matsubara","year":"2006","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.ejphar.2020.173096_bib24","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0022-5347(17)44485-5","article-title":"Cystometrical evaluation of bladder instability in rats with infravesical outflow obstruction","volume":"137","author":"Malmgren","year":"1987","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2020.173096_bib25","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1038\/sj.bjp.0706619","article-title":"Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate","volume":"147","author":"Michel","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173096_bib26","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.eururo.2018.10.006","article-title":"Vibegron (RVT-901\/MK-4618\/KRP-114V) administered once daily as monotherapy or concomitantly with tolterodine in patients with an overactive bladder: a multicenter, phase IIb, randomized, double-blind, controlled trial","volume":"75","author":"Mitcheson","year":"2019","journal-title":"Eur. Urol."},{"key":"10.1016\/j.ejphar.2020.173096_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2125.2007.02999.x","article-title":"Absolute bioavailability of imidafenacin after oral administration to healthy subjects","volume":"65","author":"Ohno","year":"2008","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173096_bib28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejphar.2006.06.054","article-title":"Effect of tamsulosin on spontaneous bladder contraction in conscious rats with bladder outlet obstruction: comparison with effect on intraurethral pressure","volume":"545","author":"Ohtake","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173096_bib29","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00210-008-0274-y","article-title":"Expression and functional role of \u03b2-adrenoceptors in the human urinary bladder urothelium","volume":"377","author":"Otsuka","year":"2008","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173096_bib30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1464-410X.2003.04309.x","article-title":"Safety and efficacy of alfuzosin 10 mg once-daily in the treatment of lower urinary tract symptoms and clinical benign prostatic hyperplasia: a pooled analysis of three double-blind, placebo-controlled studies","volume":"92","author":"Roehrborn","year":"2003","journal-title":"BJU Int."},{"key":"10.1016\/j.ejphar.2020.173096_bib31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.phrs.2013.12.006","article-title":"Modulation of nerve-evoked contractions by \u03b23-adrenoceptor agonism in human and rat isolated urinary bladder","volume":"80","author":"Rouget","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2020.173096_bib32","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/nau.10004","article-title":"Similarities and differences in female and male rat voiding","volume":"21","author":"Streng","year":"2002","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.ejphar.2020.173096_bib33","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/luts.12109","article-title":"Synergic suppressive effect of silodosin and imidafenacin on non-voiding bladder contractions in male rats with subacute bladder outlet obstruction","volume":"9","author":"Sugiyama","year":"2017","journal-title":"Low. Urin. Tract. Symptoms"},{"key":"10.1016\/j.ejphar.2020.173096_bib34","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1590\/S1677-55382009000100012","article-title":"Investigations into the presence of functional \u03b21, \u03b22 and \u03b23-adrenoceptors in urothelium and detrusor of human bladder","volume":"35","author":"Tyagi","year":"2009","journal-title":"Int. Braz J. Urol."},{"key":"10.1016\/j.ejphar.2020.173096_bib35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/luts.12091","article-title":"Urodynamic efficacy and safety of mirabegron add-on treatment with tamsulosin for Japanese male patients with overactive bladder","volume":"8","author":"Wada","year":"2016","journal-title":"Low. Urin. Tract. Symptoms"},{"key":"10.1016\/j.ejphar.2020.173096_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0090-4295(01)01635-1","article-title":"\u03b23-adrenoceptors in human detrusor muscle","volume":"59","author":"Yamaguchi","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.ejphar.2020.173096_bib37","doi-asserted-by":"crossref","first-page":"172727","DOI":"10.1016\/j.ejphar.2019.172727","article-title":"Effects of the combination of vibegron and imidafenacin on bladder function in urethane-anesthetized rats","volume":"864","author":"Yamazaki","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173096_bib38","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/nau.20984","article-title":"Alpha1-adrenoceptor antagonists improve bladder storage function through reduction of afferent activity in rats with bladder outlet obstruction","volume":"30","author":"Yazaki","year":"2011","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.ejphar.2020.173096_bib39","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00345-009-0481-2","article-title":"Selective \u03b11A-blocker improves bladder storage function in rats via suppression of C-fiber afferent activity","volume":"28","author":"Yokoyama","year":"2010","journal-title":"World J. Urol."},{"key":"10.1016\/j.ejphar.2020.173096_bib40","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/00365590902836740","article-title":"Naftopidil and propiverine hydrochloride for treatment of male lower urinary tract symptoms suggestive of benign prostatic hyperplasia and concomitant overactive bladder: a prospective randomized controlled study","volume":"43","author":"Yokoyama","year":"2009","journal-title":"Scand. J. Urol. Nephrol."},{"key":"10.1016\/j.ejphar.2020.173096_bib41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.urology.2003.11.003","article-title":"Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging","volume":"63","author":"Yoshida","year":"2004","journal-title":"Urology"},{"key":"10.1016\/j.ejphar.2020.173096_bib42","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.eururo.2017.12.022","article-title":"Vibegron, a novel potent and selective \u03b23-adrenoreceptor agonist, for the treatment of patients with overactive bladder: a randomized, double-blind, placebo-controlled phase 3 study","volume":"73","author":"Yoshida","year":"2018","journal-title":"Eur. Urol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920301886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920301886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:36:00Z","timestamp":1757975760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920301886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":42,"alternative-id":["S0014299920301886"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173096","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of vibegron, a novel \u03b23-adrenoceptor agonist, and its combination with imidafenacin or silodosin in a rat with partial bladder outlet obstruction.","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173096"}}