{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:45:49Z","timestamp":1781743549843,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503327"],"award-info":[{"award-number":["81503327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZYMS008"],"award-info":[{"award-number":["ZYMS008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ejphar.2020.173167","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T19:30:55Z","timestamp":1590867055000},"page":"173167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Glycyrrhetinic acid attenuates disturbed vitamin a metabolism in non-alcoholic fatty liver disease through AKR1B10"],"prefix":"10.1016","volume":"883","author":[{"given":"Lei","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173167_bib1","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.biocel.2012.07.026","article-title":"Induction of carnitine palmitoyl transferase 1 and fatty acid oxidation by retinoic acid in HepG2 cells","volume":"44","author":"Amengual","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejphar.2020.173167_bib2","first-page":"221","article-title":"Molecular pathways in non-alcoholic fatty liver disease","volume":"7","author":"Berlanga","year":"2014","journal-title":"Clin. Exp. Gastroenterol."},{"key":"10.1016\/j.ejphar.2020.173167_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.pharmthera.2019.01.006","article-title":"Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders","volume":"197","author":"Blaner","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2020.173167_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-94-024-0945-1_4","article-title":"Vitamin A absorption, storage and mobilization","volume":"81","author":"Blaner","year":"2016","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.ejphar.2020.173167_bib5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1387\/ijdb.170227ms","article-title":"CYP26 function is required for the tissue-specific modulation of retinoic acid signaling during amphioxus development","volume":"61","author":"Carvalho","year":"2017","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ejphar.2020.173167_bib6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2020.173167_bib7","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2174\/1389450116666150325231015","article-title":"The link between hepatic vitamin A metabolism and nonalcoholic fatty liver disease","volume":"16","author":"Chen","year":"2015","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejphar.2020.173167_bib8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/bcp.12899","article-title":"The role of nutraceuticals for the treatment of non-alcoholic fatty liver disease","volume":"83","author":"Del Ben","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173167_bib9","first-page":"1015","article-title":"Determination of glycolaldehyde and glyceraldehyde in plasma by SPE-HPLC\/MS","volume":"7","author":"Dong","year":"2006","journal-title":"Chin. J. Analy Chem."},{"key":"10.1016\/j.ejphar.2020.173167_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-94-024-0945-1_5","article-title":"Retinoic acid synthesis and degradation","volume":"81","author":"Kedishvili","year":"2016","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.ejphar.2020.173167_bib11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nbt1284","article-title":"Relating protein pharmacology by ligand chemistry","volume":"25","author":"Keiser","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejphar.2020.173167_bib12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-60327-325-1_15","article-title":"Reverse-phase high-performance liquid chromatography (HPLC) analysis of retinol and retinyl esters in mouse serum and tissues","volume":"652","author":"Kim","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2020.173167_bib13","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1002\/hep.26699","article-title":"All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade","volume":"59","author":"Kim","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2020.173167_bib14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbalip.2011.04.004","article-title":"Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models","volume":"1821","author":"Kumar","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"Suppl. 2","key":"10.1016\/j.ejphar.2020.173167_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1440-1746.2011.07007.x","article-title":"Retinoic acids and hepatic stellate cells in liver disease","volume":"27","author":"Lee","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2020.173167_bib16","article-title":"Glycyrrhizic acid in the treatment of liver diseases: literature review","volume":"2014","author":"Li","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.ejphar.2020.173167_bib18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3945\/ajcn.114.105155","article-title":"Association of serum retinoic acid with hepatic steatosis and liver injury in nonalcoholic fatty liver disease","volume":"102","author":"Liu","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ejphar.2020.173167_bib19","volume":"vol. 145","author":"Metzler","year":"2018"},{"key":"10.1016\/j.ejphar.2020.173167_bib20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1017\/S0029665117001069","article-title":"Alterations in vitamin A\/retinoic acid homeostasis in diet-induced obesity and insulin resistance","volume":"76","author":"Mody","year":"2017","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.ejphar.2020.173167_bib21","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1248\/yakushi.17-00204","article-title":"Scientific evaluation of crude drugs and kampo medicines using the eastern blotting method and its application to biological metabolic studies","volume":"138","author":"Morinaga","year":"2018","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.ejphar.2020.173167_bib22","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/ptr.6178","article-title":"Liquorice (Glycyrrhiza glabra): a phytochemical and pharmacological review","volume":"32","author":"Pastorino","year":"2018","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejphar.2020.173167_bib23","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2020.173167_bib24","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/TP.0000000000002480","article-title":"Nonalcoholic fatty liver disease: basic pathogenetic mechanisms in the progression from NAFLD to NASH","volume":"103","author":"Pierantonelli","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.ejphar.2020.173167_bib25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.reprotox.2017.05.014","article-title":"Retinoic acid in developmental toxicology: teratogen, morphogen and biomarker","volume":"72","author":"Piersma","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ejphar.2020.173167_bib26","doi-asserted-by":"crossref","first-page":"E29","DOI":"10.3390\/nu10010029","article-title":"Disturbed vitamin A metabolism in non-alcoholic fatty liver disease (NAFLD)","volume":"10","author":"Saeed","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2020.173167_bib27","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1101\/gad.1533407","article-title":"RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development","volume":"21","author":"Sandell","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejphar.2020.173167_bib29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1124\/dmd.117.075341","article-title":"Inhibition of the all-trans retinoic acid (atRA) hydroxylases CYP26A1 and CYP26B1 results in dynamic, tissue-specific changes in endogenous atRA signaling","volume":"45","author":"Stevison","year":"2017","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2020.173167_bib30","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.biopha.2017.08.123","article-title":"Glycyrrhizic acid: a promising carrier material for anticancer therapy","volume":"95","author":"Su","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2020.173167_bib32","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1039\/C6FO00773B","article-title":"Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice","volume":"7","author":"Wang","year":"2016","journal-title":"Food Funct"},{"key":"10.1016\/j.ejphar.2020.173167_bib33","doi-asserted-by":"crossref","first-page":"E190","DOI":"10.3390\/nu9030190","article-title":"Vitamin A supplementation programs and country-level evidence of vitamin A deficiency","volume":"9","author":"Wirth","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2020.173167_bib34","series-title":"Study on the Preparation and Purification of Glycyrrhetinic Acid and Acetylglycyrrhetinic Acid [D]","author":"Xu","year":"2011"},{"key":"10.1016\/j.ejphar.2020.173167_bib35","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1124\/dmd.118.082008","article-title":"Glycyrrhizin alleviates nonalcoholic steatohepatitis via modulating bile acids and meta-inflammation","volume":"46","author":"Yan","year":"2018","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2020.173167_bib37","doi-asserted-by":"crossref","first-page":"11166","DOI":"10.1074\/jbc.RA119.009023","article-title":"The retinoic acid hydroxylase Cyp26a1 has minor effects on postnatal vitamin A homeostasis, but is required for exogenous atRA clearance","volume":"294","author":"Zhong","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173167_bib38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1124\/jpet.119.258517","article-title":"Characterization of vitamin A metabolome in human livers with and without nonalcoholic fatty liver disease","volume":"370","author":"Zhong","year":"2019","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2020.173167_bib39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ab.2019.04.022","article-title":"CYP26A1 gene promoter is a useful tool for reporting RAR-mediated retinoid activity","volume":"15","author":"Zolfaghari","year":"2019","journal-title":"Anal. Biochem."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920302594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920302594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:07:57Z","timestamp":1762142877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920302594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":35,"alternative-id":["S0014299920302594"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173167","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycyrrhetinic acid attenuates disturbed vitamin a metabolism in non-alcoholic fatty liver disease through AKR1B10","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173167","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"173167"}}