{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:45:06Z","timestamp":1788295506587,"version":"build-2803163510"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["2017-SWYY-075"],"award-info":[{"award-number":["2017-SWYY-075"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["2017-YY-039"],"award-info":[{"award-number":["2017-YY-039"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["201910313010Z"],"award-info":[{"award-number":["201910313010Z"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["201910313021"],"award-info":[{"award-number":["201910313021"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ejphar.2020.173299","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T11:22:23Z","timestamp":1592911343000},"page":"173299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["6H2L, a novel synthetic derivative of bifendate, induces apoptosis in hepatoma cells via mitochondrial and MAPK pathway"],"prefix":"10.1016","volume":"882","author":[{"given":"Lirong","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyuan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173299_bib1","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jamaoncol.2017.3055","article-title":"The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level results from the global burden of disease study 2015","volume":"3","author":"Akinyemiju","year":"2017","journal-title":"Jama Oncol."},{"key":"10.1016\/j.ejphar.2020.173299_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/bj3450271","article-title":"Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria","volume":"345","author":"Antonsson","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2020.173299_bib3","doi-asserted-by":"crossref","first-page":"10244","DOI":"10.1074\/jbc.M112355200","article-title":"Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes","volume":"277","author":"Aoki","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173299_bib4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/cdd.2008.148","article-title":"Tumour cell survival signalling by the ERK1\/2 pathway","volume":"16","author":"Balmanno","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2020.173299_bib5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2147\/JHC.S61146","article-title":"Hepatocellular carcinoma: a review","volume":"3","author":"Balogh","year":"2016","journal-title":"J. Hepatocell. Carcinoma"},{"issue":"Suppl. 2","key":"10.1016\/j.ejphar.2020.173299_bib6","doi-asserted-by":"crossref","first-page":"ii15","DOI":"10.1093\/annonc\/mdt053","article-title":"Multidisciplinary approach for HCC patients: hepatology for the oncologists","volume":"24","author":"Barone","year":"2013","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ejphar.2020.173299_bib7","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1093\/carcin\/23.11.1831","article-title":"The role of MAPK pathways in the action of chemotherapeutic drugs","volume":"23","author":"Boldt","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejphar.2020.173299_bib8","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1038\/srep04698","article-title":"Cell death stages in single apoptotic and necrotic cells monitored by Raman microspectroscopy","volume":"4","author":"Brauchle","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2020.173299_bib9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0891-5849(00)00317-8","article-title":"Mitochondrial free radical generation, oxidative stress, and aging","volume":"29","author":"Cadenas","year":"2000","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.ejphar.2020.173299_bib10","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1053\/j.gastro.2018.04.020","article-title":"Germline duplication of SNORA18L5 increases risk for HBV-related hepatocellular carcinoma by altering localization of ribosomal proteins and decreasing levels of p53","volume":"155","author":"Cao","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2020.173299_bib11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.ejphar.2020.173299_bib12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/sj.cdd.4400629","article-title":"Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis","volume":"7","author":"Chen","year":"2000","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2020.173299_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000443404","article-title":"Natural products as a vital source for the discovery of cancer chemotherapeutic and chemopreventive agents","volume":"25","author":"Cragg","year":"2016","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.ejphar.2020.173299_bib14","first-page":"538","article-title":"Anti-HBV efficacy of bifendate in treatment of chronic hepatitis B, a primary study","volume":"82","author":"Cui","year":"2002","journal-title":"Zhonghua Yixue Zazhi"},{"key":"10.1016\/j.ejphar.2020.173299_bib15","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1038\/sj.onc.1210421","article-title":"MAP kinase signalling pathways in cancer","volume":"26","author":"Dhillon","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2020.173299_bib16","article-title":"Mortality assessment of patients with hepatocellular carcinoma according to underlying disease and treatment modalities","volume":"96","author":"Golabi","year":"2017","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.ejphar.2020.173299_bib17","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1101\/gad.13.15.1899","article-title":"BCL-2 family members and the mitochondria in apoptosis","volume":"13","author":"Gross","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejphar.2020.173299_bib18","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ejmech.2018.01.019","article-title":"Synthesis and biological evaluation of bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potential P-glycoprotein and tumor metastasis inhibitors","volume":"145","author":"Gu","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173299_bib19","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/aps.2016.141","article-title":"LYRM03, an ubenimex derivative, attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway","volume":"38","author":"He","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2020.173299_bib20","first-page":"6311","article-title":"The intrinsic mitochondrial membrane potential (Deltapsim) is associated with steady-state mitochondrial activity and the extent to which colonic epithelial cells undergo butyrate-mediated growth arrest and apoptosis","volume":"63","author":"Heerdt","year":"2003","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173299_bib21","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bcp.2018.02.023","article-title":"Lanatoside C inhibits cell proliferation and induces apoptosis through attenuating Wnt\/beta-catenin\/c-Myc signaling pathway in human gastric cancer cell","volume":"150","author":"Hu","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173299_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13046-016-0349-4","article-title":"Enhancement of anti-tumor effects of 5-fluorouracil on hepatocellular carcinoma by low-intensity ultrasound","volume":"35","author":"Hu","year":"2016","journal-title":"J. Exp. Clin. Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173299_bib23","doi-asserted-by":"crossref","first-page":"31199","DOI":"10.1074\/jbc.C000405200","article-title":"Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1","volume":"275","author":"Jiang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173299_bib24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10637-006-9001-z","article-title":"The anti-hepatitis drug DDB chemosensitizes multidrug resistant cancer cells in vitro and in vivo by inhibiting P-gp and enhancing apoptosis","volume":"25","author":"Jin","year":"2007","journal-title":"Invest. N. Drugs"},{"key":"10.1016\/j.ejphar.2020.173299_bib25","first-page":"573","article-title":"Why target apoptosis in cancer treatment?","volume":"2","author":"Kasibhatla","year":"2003","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.ejphar.2020.173299_bib26","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","article-title":"Pathological roles of MAPK signaling pathways in human diseases","volume":"1802","author":"Kim","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2020.173299_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrc3038","article-title":"Otto Warburg's contributions to current concepts of cancer metabolism","volume":"11","author":"Koppenol","year":"2011","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.ejphar.2020.173299_bib28","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1139\/o2012-030","article-title":"Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells","volume":"90","author":"Li","year":"2012","journal-title":"Biochem. Cell. Biol."},{"key":"10.1016\/j.ejphar.2020.173299_bib29","first-page":"1769","article-title":"Salidroside protects PC-12 cells against amyloid beta-induced apoptosis by activation of the ERK1\/2 and AKT signaling pathways","volume":"43","author":"Liao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2020.173299_bib30","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.2217\/nnm-2018-0059","article-title":"Radiosensitizing effects of different size bovine serum albumin-templated gold nanoparticles on H22 hepatoma-bearing mice","volume":"13","author":"Liu","year":"2018","journal-title":"Nanomedicine (Lond)."},{"key":"10.1016\/j.ejphar.2020.173299_bib31","first-page":"214","article-title":"Inducing effect of dimethy-4, 4'-dimethoxy-5, 6,5',6-dimethylenedioxybipheny-2, 2'-dicarboxylate (DDB) on differentiation of leukemia HL-60 cells","volume":"76","author":"Liu","year":"1996","journal-title":"Zhonghua Yixue Zazhi"},{"key":"10.1016\/j.ejphar.2020.173299_bib32","doi-asserted-by":"crossref","first-page":"16018","DOI":"10.1038\/nrdp.2016.18","article-title":"Hepatocellular carcinoma","volume":"2","author":"Llovet","year":"2016","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.ejphar.2020.173299_bib33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1023\/A:1022945107762","article-title":"The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update","volume":"8","author":"Ly","year":"2003","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejphar.2020.173299_bib34","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41467-017-02787-4","article-title":"Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression","volume":"9","author":"Marquez-Jurado","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2020.173299_bib35","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.devcel.2011.06.017","article-title":"Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics","volume":"21","author":"Martinou","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ejphar.2020.173299_bib36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cld.2015.01.001","article-title":"Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability","volume":"19","author":"McGlynn","year":"2015","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.ejphar.2020.173299_bib37","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1182\/blood-2004-07-2938","article-title":"Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AEF release","volume":"105","author":"Park","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2020.173299_bib38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1042\/bse0470099","article-title":"Mitochondria in cell death","volume":"47","author":"Parsons","year":"2010","journal-title":"Essays Biochem."},{"key":"10.1016\/j.ejphar.2020.173299_bib39","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.molcel.2015.02.021","article-title":"Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis","volume":"58","author":"Pyakurel","year":"2015","journal-title":"Mol. Cell."},{"key":"10.1016\/j.ejphar.2020.173299_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbamcr.2003.10.016","article-title":"Control of mitochondrial permeability by Bcl-2 family members","volume":"1644","author":"Sharpe","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2020.173299_bib41","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.bbamcr.2006.10.005","article-title":"The MEK\/ERK cascade: from signaling specificity to diverse functions","volume":"1773","author":"Shaul","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2020.173299_bib42","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1073\/pnas.95.4.1455","article-title":"Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux","volume":"95","author":"Shimizu","year":"1998","journal-title":"P. Nat. Acad. Sci. USA."},{"key":"10.1016\/j.ejphar.2020.173299_bib43","first-page":"144","article-title":"Evaluation of effectiveness of herbal medication in cancer care: a review study","volume":"5","author":"Tavakoli","year":"2012","journal-title":"J. Canc. Prev."},{"key":"10.1016\/j.ejphar.2020.173299_bib44","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.7878464","article-title":"Apoptosis in the pathogenesis and treatment of disease","volume":"267","author":"Thompson","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2020.173299_bib45","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2020.173299_bib46","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/sj.onc.1207556","article-title":"Mitogen-activated protein kinases in apoptosis regulation","volume":"23","author":"Wada","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2020.173299_bib47","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10495-006-0623-6","article-title":"Roles of mitogen-activated protein kinase pathways during Escherichia coli-induced apoptosis in U937 cells","volume":"12","author":"Wang","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejphar.2020.173299_bib48","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12032-019-1323-8","article-title":"Caffeine enhances the anti-tumor effect of 5-fluorouracil via increasing the production of reactive oxygen species in hepatocellular carcinoma","volume":"36","author":"Wang","year":"2019","journal-title":"Med. Oncol."},{"key":"10.1016\/j.ejphar.2020.173299_bib49","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1053\/j.gastro.2019.10.025","article-title":"Disruption of SIRT7 increases the efficacy of checkpoint inhibitor via MEF2D regulation of programmed cell death 1 ligand 1 in hepatocellular carcinoma cells","volume":"158","author":"Xiang","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2020.173299_bib50","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13020-015-0033-1","article-title":"Bufothionine induced the mitochondria-mediated apoptosis in H22 liver tumor and acute liver injury","volume":"10","author":"Xie","year":"2015","journal-title":"Chin. Med."},{"key":"10.1016\/j.ejphar.2020.173299_bib51","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s13238-014-0089-1","article-title":"Mitochondria-mediated apoptosis in mammals","volume":"5","author":"Xiong","year":"2014","journal-title":"Protein Cell."},{"key":"10.1016\/j.ejphar.2020.173299_bib52","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/ptr.6029","article-title":"Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt\/MAPK pathway and inhibition of P-glycoprotein in K562\/ADR cells","volume":"32","author":"Yan","year":"2018","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejphar.2020.173299_bib53","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.3892\/etm.2017.4343","article-title":"LFG-500, a newly synthesized flavonoid, induces apoptosis in human ovarian carcinoma SKOV3 cells with involvement of the reactive oxygen species-mitochondria pathway","volume":"13","author":"Yin","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejphar.2020.173299_bib54","first-page":"2118","article-title":"Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr\/Abl+ human myeloid leukemia cells","volume":"63","author":"Yu","year":"2003","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173299_bib55","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.fct.2012.11.048","article-title":"MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells","volume":"53","author":"Yuan","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2020.173299_bib56","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2147\/IJN.S231144","article-title":"Enhancing antitumor efficacy of nucleoside analog 5-fluorodeoxyuridine on HER2-overexpressing breast cancer by affibody-engineered DNA nanoparticle","volume":"15","author":"Zhang","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejphar.2020.173299_bib57","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s10495-015-1145-x","article-title":"LYG-202 exerts antitumor effect on PI3K\/Akt signaling pathway in human breast cancer cells","volume":"20","author":"Zhao","year":"2015","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejphar.2020.173299_bib58","doi-asserted-by":"crossref","first-page":"101965","DOI":"10.18632\/oncotarget.21949","article-title":"Tomentodione M sensitizes multidrug resistant cancer cells by decreasing P-glycoprotein via inhibition of p38 MAPK signaling","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920303915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920303915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:09:34Z","timestamp":1762142974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920303915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":58,"alternative-id":["S0014299920303915"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173299","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"6H2L, a novel synthetic derivative of bifendate, induces apoptosis in hepatoma cells via mitochondrial and MAPK pathway","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173299"}}