{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:23:07Z","timestamp":1777522987813,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002222","name":"The World Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["203\/PTEKIND\/6711820"],"award-info":[{"award-number":["203\/PTEKIND\/6711820"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2019\/SKK08\/USM\/02\/1"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK08\/USM\/02\/1"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ejphar.2020.173371","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T21:04:04Z","timestamp":1595538244000},"page":"173371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK\/SIRT1 signaling pathways"],"prefix":"10.1016","volume":"883","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-695X","authenticated-orcid":false,"given":"Mohamad Hafizi","family":"Abu Bakar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khairul Anuar","family":"Shariff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Shun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai Kuan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173371_bib1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12010-018-2920-2","article-title":"Withaferin A protects against high-fat diet\u2013induced obesity via attenuation of oxidative stress, inflammation, and insulin resistance","volume":"188","author":"Abu Bakar","year":"2019","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.ejphar.2020.173371_bib2","doi-asserted-by":"crossref","first-page":"8242","DOI":"10.3390\/molecules20058242","article-title":"Celastrol protects against antimycin A-induced insulin resistance in human skeletal muscle cells","volume":"20","author":"Abu Bakar","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2020.173371_bib3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s10238-018-0495-4","article-title":"Reduced mitochondrial DNA content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose","volume":"18","author":"Abu Bakar","year":"2018","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.ejphar.2020.173371_bib4","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1039\/C7MB00333A","article-title":"Association of cultured myotubes and fasting plasma metabolite profiles with mitochondrial dysfunction in type 2 diabetes subjects","volume":"13","author":"Abu Bakar","year":"2017","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.ejphar.2020.173371_bib5","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1039\/C5MB00158G","article-title":"Metabolomics - the complementary field in systems biology: A review on obesity and type 2 diabetes","volume":"11","author":"Abu Bakar","year":"2015","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.ejphar.2020.173371_bib6","doi-asserted-by":"crossref","first-page":"22227","DOI":"10.3390\/ijms151222227","article-title":"Amelioration of mitochondrial dysfunction-induced insulin resistance in differentiated 3T3-L1 adipocytes via inhibition of NF-\u03baB pathways","volume":"15","author":"Abu Bakar","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2020.173371_bib7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2017.01.043","article-title":"Celastrol attenuates mitochondrial dysfunction and inflammation in palmitate-mediated insulin resistance in C3A hepatocytes","volume":"799","author":"Abu Bakar","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173371_bib8","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.biopha.2017.07.021","article-title":"Improvement of mitochondrial function by celastrol in palmitate-treated C2C12 myotubes via activation of PI3K-Akt signaling pathway","volume":"93","author":"Abu Bakar","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2020.173371_bib9","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.bbabio.2016.07.008","article-title":"Mitochondrial involvement in skeletal muscle insulin resistance: A case of imbalanced bioenergetics","volume":"1857","author":"Affourtit","year":"2016","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.ejphar.2020.173371_bib10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/MOL.0b013e328328d0a4","article-title":"PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure","volume":"20","author":"Cant\u00f3","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.ejphar.2020.173371_bib11","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity","volume":"458","author":"Cant\u00f3","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2020.173371_bib12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jdiacomp.2015.08.022","article-title":"SIRT1 and insulin resistance","volume":"30","author":"Cao","year":"2016","journal-title":"J. Diabet. Complicat."},{"key":"10.1016\/j.ejphar.2020.173371_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fmed.2017.00069","article-title":"Celastrol: A spectrum of treatment opportunities in chronic diseases","volume":"4","author":"Casc\u00e3o","year":"2017","journal-title":"Front. Med."},{"key":"10.1016\/j.ejphar.2020.173371_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.hgmx.2016.06.011","article-title":"Low-grade inflammation and its relation to obesity and chronic degenerative diseases","volume":"80","author":"Castro","year":"2017","journal-title":"Rev. M\u00e9dica del Hosp. Gen. M\u00e9xico"},{"key":"10.1016\/j.ejphar.2020.173371_bib15","first-page":"1","article-title":"Mechanisms linking inflammation to insulin resistance","volume":"2015","author":"Chen","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.ejphar.2020.173371_bib16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.molmed.2013.05.001","article-title":"Chronic adipose tissue inflammation: All immune cells on the stage","volume":"19","author":"Cildir","year":"2013","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejphar.2020.173371_bib17","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nm.4350","article-title":"Insulin action and resistance in obesity and type 2 diabetes","volume":"23","author":"Czech","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2020.173371_bib18","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/JOE-16-0598","article-title":"Skeletal muscle insulin resistance: Role of mitochondria and other ROS sources","volume":"233","author":"Di Meo","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ejphar.2020.173371_bib19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","article-title":"Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes","volume":"105","author":"Esser","year":"2014","journal-title":"Diabet. Res. Clin. Pract."},{"key":"10.1016\/j.ejphar.2020.173371_bib20","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.bbadis.2019.02.002","article-title":"Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of pgc-1\u03b1\/glut4 axis-mediated glucose consumption","volume":"1865","author":"Fang","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"10.1016\/j.ejphar.2020.173371_bib21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/edrv.19.4.0336","article-title":"Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects","volume":"19","author":"Ferrannini","year":"1998","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2020.173371_bib22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nprot.2006.478","article-title":"Organelle isolation: Functional mitochondria from mouse liver, muscle and cultured filroblasts","volume":"2","author":"Frezza","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejphar.2020.173371_bib23","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: Mechanisms of cellular energy sensing and restoration of metabolic balance","volume":"66","author":"Garcia","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejphar.2020.173371_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbadis.2011.10.008","article-title":"Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis","volume":"1822","author":"Gomes","year":"2012","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"10.1016\/j.ejphar.2020.173371_bib25","series-title":"Mitochondrial Dynamics in Cardiovascular Medicine","first-page":"465","article-title":"Insulin resistance and mitochondrial dysfunction","author":"Gonzalez-Franquesa","year":"2017"},{"key":"10.1016\/j.ejphar.2020.173371_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ab.2011.07.017","article-title":"Isolation of functional mitochondria from rat kidney and skeletal muscle without manual homogenization","volume":"418","author":"Gross","year":"2011","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2020.173371_bib27","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.3892\/ijmm.2016.2549","article-title":"Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1\u03b1-SIRT3 signaling pathway","volume":"37","author":"Guan","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2020.173371_bib28","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.2337\/diacare.20.7.1087","article-title":"The homeostasis model in the San Antonio heart study","volume":"20","author":"Haffner","year":"1997","journal-title":"Diabet. Care"},{"key":"10.1016\/j.ejphar.2020.173371_bib29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/dmrr.2601","article-title":"Mitochondrial dysfunction as a central event for mechanisms underlying insulin resistance: The roles of long chain fatty acids","volume":"31","author":"Hafizi Abu Bakar","year":"2015","journal-title":"Diabet. Metab. Res. Rev."},{"key":"10.1016\/j.ejphar.2020.173371_bib30","first-page":"2641248","article-title":"Protective effects of celastrol on diabetic liver injury via TLR4\/MyD88\/NF-\u03baB signaling pathway in type 2 diabetic rats","author":"Han","year":"2016","journal-title":"J. Diabet. Res."},{"key":"10.1016\/j.ejphar.2020.173371_bib31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bse0470069","article-title":"Regulation of mitochondrial biogenesis","volume":"47","author":"Jornayvaz","year":"2010","journal-title":"Essays Biochem."},{"key":"10.1016\/j.ejphar.2020.173371_bib32","doi-asserted-by":"crossref","first-page":"642038","DOI":"10.1155\/2012\/642038","article-title":"Mitochondrial dysregulation in the pathogenesis of diabetes: Potential for mitochondrial biogenesis-mediated interventions","volume":"2012","author":"Joseph","year":"2012","journal-title":"Exp. Diabet. Res."},{"key":"10.1016\/j.ejphar.2020.173371_bib33","article-title":"Celastrol, an NF-\u03baB inhibitor, improves insulin resistance and attenuates renal injury in db\/db mice","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2020.173371_bib34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4093\/dmj.2013.37.5.315","article-title":"SIRT1 in type 2 diabetes: Mechanisms and therapeutic potential","volume":"37","author":"Kitada","year":"2013","journal-title":"Diabet. Metab. J."},{"key":"10.1016\/j.ejphar.2020.173371_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/abbs\/gms108","article-title":"SIRT1 and energy metabolism","volume":"45","author":"Li","year":"2013","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.ejphar.2020.173371_bib36","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.05.011","article-title":"Treatment of obesity with celastrol","volume":"161","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2020.173371_bib37","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.18632\/aging.101302","article-title":"Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2\/HO-1, MAP kinase and NF-\u03baB pathways","volume":"9","author":"Luo","year":"2017","journal-title":"Aging Albany NY"},{"key":"10.1016\/j.ejphar.2020.173371_bib38","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.cmet.2015.08.005","article-title":"Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1\u03b1 transcriptional Axis","volume":"22","author":"Ma","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejphar.2020.173371_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/21623945.2015.1061723","article-title":"High-fat diet-induced obesity rat model: A comparison between Wistar and Sprague-Dawley rat","volume":"5","author":"Marques","year":"2016","journal-title":"Adipocyte"},{"key":"10.1016\/j.ejphar.2020.173371_bib40","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1042\/cs0840407","article-title":"A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates","volume":"84","author":"Miller","year":"1993","journal-title":"Clin. Sci."},{"key":"10.1016\/j.ejphar.2020.173371_bib41","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.biopha.2018.11.051","article-title":"Molecular modulators of celastrol as the keystones for its diverse pharmacological activities","volume":"109","author":"Ng","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2020.173371_bib42","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of insulin action and insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2020.173371_bib43","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3389\/fphys.2016.00546","article-title":"Maternal high fat diet alters skeletal muscle mitochondrial catalytic activity in adult male rat offspring","volume":"7","author":"Pileggi","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2020.173371_bib44","first-page":"BR346","article-title":"A 6-week training program increased muscle antioxidant system in elderly diabetic fatty rats","volume":"18","author":"Rosety-Rodr\u00edguez","year":"2012","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.ejphar.2020.173371_bib45","article-title":"Adipose tissue inflammation and ectopic lipid accumulation","volume":"EJ12\u20130271","author":"Suganami","year":"2012","journal-title":"Endocr. J."},{"key":"10.1016\/j.ejphar.2020.173371_bib46","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.jnutbio.2011.12.003","article-title":"Caveolin-3 is involved in the protection of resveratrol against high-fat-diet-induced insulin resistance by promoting GLUT4 translocation to the plasma membrane in skeletal muscle of ovariectomized rats","volume":"23","author":"Tan","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ejphar.2020.173371_bib47","series-title":"Pathophysiology of Obesity-Induced Health Complications","first-page":"3","article-title":"Prevalence, consequences, causes and management of obesity","author":"Tappia","year":"2020"},{"key":"10.1016\/j.ejphar.2020.173371_bib48","first-page":"93","article-title":"Recent advances in obesity-induced inflammation and insulin resistance","volume":"4","author":"Tateya","year":"2013","journal-title":"Front. Endocrinol. Lausanne"},{"key":"10.1016\/j.ejphar.2020.173371_bib49","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.coph.2012.02.010","article-title":"SIRT1 signaling as potential modulator of skeletal muscle diseases","volume":"12","author":"Tonkin","year":"2012","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173371_bib50","doi-asserted-by":"crossref","first-page":"636","DOI":"10.2337\/db17-0316","article-title":"Disruption of mitochondria-associated endoplasmic reticulum membrane (MAM) integrity contributes to muscle insulin resistance in mice and humans","volume":"67","author":"Tubbs","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2020.173371_bib51","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.taap.2008.08.005","article-title":"Indirubin-3\u2032-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction","volume":"233","author":"Varela","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173371_bib52","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2014.09.043","article-title":"Celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism","volume":"744","author":"Wang","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173371_bib53","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cca.2012.12.007","article-title":"Role of leptin and adiponectin in insulin resistance","volume":"417","author":"Yadav","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ejphar.2020.173371_bib54","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11684-013-0262-6","article-title":"Mechanisms of insulin resistance in obesity","volume":"7","author":"Ye","year":"2013","journal-title":"Front. Med."},{"key":"10.1016\/j.ejphar.2020.173371_bib55","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/ajh.2010.75","article-title":"Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1","volume":"23","author":"Yu","year":"2010","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ejphar.2020.173371_bib56","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.molmet.2016.11.002","article-title":"Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1","volume":"6","author":"Zhang","year":"2017","journal-title":"Mol. Metab."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920304635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920304635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:19:14Z","timestamp":1777393154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920304635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":56,"alternative-id":["S0014299920304635"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173371","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK\/SIRT1 signaling pathways","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173371","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173371"}}