{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:18:24Z","timestamp":1785280704506,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ejphar.2020.173377","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T21:26:17Z","timestamp":1595021177000},"page":"173377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity"],"prefix":"10.1016","volume":"883","author":[{"given":"Nisha","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Serres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilah","family":"Toker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeala","family":"Sade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verity","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita Sati","family":"Batra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Saiardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galila","family":"Agam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Belmaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar R.","family":"Vasudevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant C.","family":"Churchill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173377_bib1","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1111\/bph.14179","article-title":"Ebselen has lithium-like effects on central 5-HT2A receptor function","volume":"175","author":"Antoniadou","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173377_bib2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1471-4159.1993.tb03197.x","article-title":"In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330","volume":"60","author":"Atack","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2020.173377_bib3","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1476-5381.1993.tb13884.x","article-title":"Characterization of the effects of lithium on phosphatidylinositol (PI) cycle activity in human muscarinic m1 receptor-transfected CHO cells","volume":"110","author":"Atack","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173377_bib4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0022-3565(25)22382-5","article-title":"Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers","volume":"270","author":"Atack","year":"1994","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2020.173377_bib5","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/nprot.2006.337","article-title":"Extraction and analysis of soluble inositol polyphosphates from yeast","volume":"1","author":"Azevedo","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejphar.2020.173377_bib6","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1177\/0269881118784876","article-title":"The putative lithium-mimetic ebselen reduces impulsivity in rodent models","volume":"32","author":"Barkus","year":"2018","journal-title":"J. Psychopharmacol. Oxf. Engl."},{"key":"10.1016\/j.ejphar.2020.173377_bib7","first-page":"1","article-title":"Expression of c-fos protein in the experimental epilepsy induced by pilocarpine","volume":"14","author":"Barone","year":"1993","journal-title":"Synap. N. Y. N"},{"key":"10.1016\/j.ejphar.2020.173377_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/sj.mp.4002012","article-title":"A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder","volume":"13","author":"Baum","year":"2008","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ejphar.2020.173377_bib9","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.neubiorev.2007.05.001","article-title":"Lithium-pilocarpine seizures as a model for lithium action in mania","volume":"31","author":"Belmaker","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2020.173377_bib10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0893-133X(98)00017-7","volume":"19","author":"Belmaker","year":"1998","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2020.173377_bib11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1042\/bj2060587","article-title":"Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands","volume":"206","author":"Berridge","year":"1982","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2020.173377_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0092-8674(89)90026-3","article-title":"Neural and developmental actions of lithium: a unifying hypothesis","volume":"59","author":"Berridge","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2020.173377_bib13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0006-2952(89)90211-6","article-title":"Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?","volume":"38","author":"Cotgreave","year":"1989","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173377_bib14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/1752-1947-5-449","article-title":"Changes in physiological tremor associated with an epileptic seizure: a case report","volume":"5","author":"Daneault","year":"2011","journal-title":"J. Med. Case Rep."},{"key":"10.1016\/j.ejphar.2020.173377_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/14756369909036548","article-title":"Inhibitors of inositol monophosphatase","volume":"14","author":"Fauroux","year":"1999","journal-title":"J. Enzym. Inhib."},{"key":"10.1016\/j.ejphar.2020.173377_bib16","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"2008"},{"key":"10.1016\/j.ejphar.2020.173377_bib17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0140-6736(09)61828-6","article-title":"Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial","volume":"375","author":"Geddes","year":"2010","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.ejphar.2020.173377_bib18","doi-asserted-by":"crossref","first-page":"421S","DOI":"10.1042\/bst023421s","article-title":"Effect of lithium on muscarinic cholinoceptor-stimulated phosphoinositide-specific phospholipase C substrate selectivity in CHO-m1 cells","volume":"23","author":"Godwin","year":"1995","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ejphar.2020.173377_bib19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1126\/science.6301005","article-title":"Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats","volume":"220","author":"Honchar","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2020.173377_bib20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/35073015","article-title":"Back in the water: the return of the inositol phosphates","volume":"2","author":"Irvine","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2020.173377_bib21","doi-asserted-by":"crossref","first-page":"22253","DOI":"10.1074\/jbc.M116.752634","article-title":"Valproate induces the unfolded protein response by increasing ceramide levels","volume":"291","author":"Jadhav","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173377_bib22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1471-4159.1979.tb05179.x","article-title":"Effects of lithium treatment in vitro and in vivo on acetylcholine metabolism in rat brain","volume":"33","author":"Jope","year":"1979","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2020.173377_bib23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0014-4886(86)90045-2","article-title":"Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats","volume":"91","author":"Jope","year":"1986","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2020.173377_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0006-8993(90)91523-J","article-title":"Lithium augments fos protoonocogene expression in PC12 pheochromocytoma cells: implications for therapeutic action of lithium","volume":"521","author":"Kalasapudi","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2020.173377_bib25","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0140-6736(17)31791-9","article-title":"Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial","volume":"390","author":"Kil","year":"2017","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.ejphar.2020.173377_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ejphar.2020.173377_bib27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jad.2016.03.041","article-title":"DGKH genetic risk variant influences gene expression in bipolar affective disorder","volume":"198","author":"Kittel-Schneider","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ejphar.2020.173377_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0006-8993(90)90155-5","article-title":"Intracerebroventricular myo-inositol antagonizes lithium-induced suppression of rearing behaviour in rats","volume":"534","author":"Kofman","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2020.173377_bib29","first-page":"185","article-title":"Myo-inositol attenuates two specific behavioral effects of acute lithium in rats","volume":"27","author":"Kofman","year":"1991","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.ejphar.2020.173377_bib30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF02246978","article-title":"Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures","volume":"110","author":"Kofman","year":"1993","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2020.173377_bib31","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0006-8993(92)90598-4","article-title":"Chronic lithium administration alters a prominent PKC substrate in rat hippocampus","volume":"570","author":"Lenox","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2020.173377_bib32","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/S0006-3223(99)00235-8","article-title":"Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness","volume":"46","author":"Manji","year":"1999","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.ejphar.2020.173377_bib33","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1007\/s00213-016-4319-5","article-title":"Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing","volume":"233","author":"Masaki","year":"2016","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2020.173377_bib34","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00213-015-4189-2","article-title":"Effects of the potential lithium-mimetic, ebselen, on brain neurochemistry: a magnetic resonance spectroscopy study at 7 tesla","volume":"233","author":"Masaki","year":"2016","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2020.173377_bib35","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1039\/b312808c","article-title":"Removal of the phosphate group in mechanism-based inhibitors of inositol monophosphatase leads to unusual inhibitory activity","volume":"2","author":"Miller","year":"2004","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejphar.2020.173377_bib36","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0028-3908(98)00024-0","article-title":"Paradoxical effects of lithium on serotonergic receptor function: an immunocytochemical, behavioural and autoradiographic study","volume":"37","author":"Moorman","year":"1998","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2020.173377_bib37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0165-6147(91)90581-C","article-title":"Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences","volume":"12","author":"Nahorski","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2020.173377_bib38","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.bcp.2013.08.028","article-title":"The early research and development of ebselen","volume":"86","author":"Parnham","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173377_bib39","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0166-4328(88)90019-8","article-title":"Susceptibility to pilocarpine-induced seizures in rats increases with age","volume":"31","author":"Patel","year":"1988","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2020.173377_bib40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0924-977X(95)00054-S","article-title":"Phorbol ester intracerebroventricularly induces a behavioral hypoactivity that is not affected by chronic or acute lithium","volume":"6","author":"Patishi","year":"1996","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.ejphar.2020.173377_bib41","doi-asserted-by":"crossref","first-page":"e968","DOI":"10.1038\/tp.2016.217","article-title":"IP3 accumulation and\/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes","volume":"6","author":"Sade","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.ejphar.2020.173377_bib42","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1177\/0269881105059327","article-title":"Stereoselective and region-specific induction of immediate early gene expression in rat parietal cortex by blockade of neurokinin 1 receptors","volume":"20","author":"Serres","year":"2006","journal-title":"J. Psychopharmacol. Oxf. Engl."},{"key":"10.1016\/j.ejphar.2020.173377_bib43","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.neuropharm.2012.06.068","article-title":"Blockade of \u03b12-adrenoceptors induces Arc gene expression in rat brain in a glutamate receptor-dependent manner: a combined qPCR, in situ hybridisation and immunocytochemistry study","volume":"63","author":"Serres","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2020.173377_bib44","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1471-4159.1985.tb12886.x","article-title":"Effects of systemically administered lithium on phosphoinositide metabolism in rat brain, kidney, and testis","volume":"44","author":"Sherman","year":"1985","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2020.173377_bib45","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00213-013-2969-0","article-title":"The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test","volume":"227","author":"Shtein","year":"2013","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2020.173377_bib46","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/ncomms2320","article-title":"A safe lithium mimetic for bipolar disorder","volume":"4","author":"Singh","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2020.173377_bib47","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1038\/npp.2015.343","article-title":"Effect of the putative lithium mimetic ebselen on brain myo-inositol, sleep, and emotional processing in humans","volume":"41","author":"Singh","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2020.173377_bib48","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0014-2999(92)90242-V","article-title":"The protein kinase C activators, phorbol 12-myristate,13-acetate and phorbol 12,13-dibutyrate, are convulsant in the pico-nanomolar range in mice","volume":"213","author":"Smith","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173377_bib49","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.nbd.2009.07.010","article-title":"Beneficial effects of anti-inflammatory therapy in a mouse model of Niemann-Pick disease type C1","volume":"36","author":"Smith","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2020.173377_bib50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0006-8993(84)90177-X","article-title":"Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis","volume":"321","author":"Turski","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2020.173377_bib51","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0006-8993(91)90238-Q","article-title":"Lithium augments pilocarpine-induced fos gene expression in rat brain","volume":"553","author":"Weiner","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2020.173377_bib52","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1399-5618.2007.00530.x","article-title":"Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study","volume":"9","author":"Zarate","year":"2007","journal-title":"Bipolar Disord."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920304696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920304696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:42:32Z","timestamp":1757976152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920304696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":52,"alternative-id":["S0014299920304696"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173377","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173377","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173377"}}