{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:24:21Z","timestamp":1779121461081,"version":"3.51.4"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T00:00:00Z","timestamp":1598140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004252","name":"Qatar University","doi-asserted-by":"publisher","award":["QUUG-CPH-CPH-15\/16-9"],"award-info":[{"award-number":["QUUG-CPH-CPH-15\/16-9"]}],"id":[{"id":"10.13039\/501100004252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ejphar.2020.173420","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T19:18:07Z","timestamp":1596914287000},"page":"173420","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Anti-hypertrophic effect of Na+\/H+ exchanger-1 inhibition is mediated by reduced cathepsin B"],"prefix":"10.1016","volume":"888","author":[{"given":"Sadaf","family":"Riaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabeel","family":"Abdulrahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahab","family":"Uddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha","family":"Jabeen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain P.","family":"Gadeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Fliegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Mraiche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173420_bib1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1152\/physiolgenomics.00133.2017","article-title":"Na(+)\/H(+) exchanger isoform 1-induced osteopontin expression facilitates cardiac hypertrophy through p90 ribosomal S6 kinase","volume":"50","author":"Abdulrahman","year":"2018","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.ejphar.2020.173420_bib2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.18632\/oncoscience.147","article-title":"Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt\/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells","volume":"2","author":"Amantini","year":"2015","journal-title":"Oncoscience"},{"key":"10.1016\/j.ejphar.2020.173420_bib3","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1124\/mol.65.5.1092","article-title":"Nuclear factor-\u03baB mediates up-regulation of cathepsin B by doxorubicin in tumor cells","volume":"65","author":"Bien","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173420_bib4","doi-asserted-by":"crossref","first-page":"26991","DOI":"10.1074\/jbc.M311838200","article-title":"CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion","volume":"279","author":"Bourguignon","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173420_bib5","series-title":"Role of Cysteine Cathepsins in Extracellular Proteolysis","first-page":"23","author":"Br\u00f6mme","year":"2011"},{"key":"10.1016\/j.ejphar.2020.173420_bib6","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1161\/01.HYP.0000242331.99369.2f","article-title":"Elastolytic cathepsin induction\/activation system exists in myocardium and is upregulated in hypertensive heart failure","volume":"48","author":"Cheng","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2020.173420_bib7","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/CIRCULATIONAHA.111.066712","article-title":"Role for cysteine protease cathepsins in heart disease: focus on biology and mechanisms with clinical implication","volume":"125","author":"Cheng","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2020.173420_bib8","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nrcardio.2010.51","article-title":"Early detection of myocardial dysfunction and heart failure","volume":"7","author":"de Couto","year":"2010","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejphar.2020.173420_bib9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/cvr\/cvn281","article-title":"Subcellular remodelling may induce cardiac dysfunction in congestive heart failure","volume":"81","author":"Dhalla","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2020.173420_bib10","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/HCO.0b013e32833cd550","article-title":"Primary prevention of heart failure: an update","volume":"25","author":"Dupree","year":"2010","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.ejphar.2020.173420_bib11","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1096\/fj.03-0966fje","article-title":"Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases","volume":"18","author":"Fedarko","year":"2004","journal-title":"Faseb. J. : Off. Publ. Feder. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.ejphar.2020.173420_bib12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1517\/14728220802600707","article-title":"Regulation of the Na(+)\/H(+) exchanger in the healthy and diseased myocardium","volume":"13","author":"Fliegel","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejphar.2020.173420_bib13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.matbio.2009.08.001","article-title":"The alpha 2 chain of collagen type VI sequesters latent proforms of matrix-metalloproteinases and modulates their activation and activity","volume":"28","author":"Freise","year":"2009","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ejphar.2020.173420_bib14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly","volume":"65","author":"Frey","year":"2003","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2020.173420_bib15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ejheart.2005.09.004","article-title":"Enhanced myocardial cathepsin B expression in patients with dilated cardiomyopathy","volume":"8","author":"Ge","year":"2006","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ejphar.2020.173420_bib16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1593\/neo.08178","article-title":"Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles","volume":"10","author":"Giusti","year":"2008","journal-title":"Neoplasia"},{"key":"10.1016\/j.ejphar.2020.173420_bib17","doi-asserted-by":"crossref","first-page":"940","DOI":"10.3892\/or.2013.2923","article-title":"Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe","volume":"31","author":"Greco","year":"2014","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejphar.2020.173420_bib18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2020.173420_bib19","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1161\/01.RES.69.6.1476","article-title":"Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart","volume":"69","author":"Hescheler","year":"1991","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2020.173420_bib20","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1006\/bbrc.1995.2820","article-title":"Procathepsin L degrades extracellular matrix proteins in the presence of glycosaminoglycans in vitro","volume":"217","author":"Ishidoh","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2020.173420_bib21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/cvr\/cvm039","article-title":"NHE-1 inhibition-induced cardioprotection against ischaemia\/reperfusion is associated with attenuation of the mitochondrial permeability transition","volume":"77","author":"Javadov","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2020.173420_bib22","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.yjmcc.2008.12.023","article-title":"Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction","volume":"46","author":"Javadov","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2020.173420_bib23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1471-4914(03)00025-X","article-title":"Apoptosis in heart: basic mechanisms and implications in cardiovascular diseases","volume":"9","author":"Kang","year":"2003","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejphar.2020.173420_bib24","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1161\/CIRCULATIONAHA.110.942268","article-title":"Molecular pathways underlying cardiac remodeling during pathophysiological stimulation","volume":"122","author":"Kehat","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2020.173420_bib25","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0014-5793(99)00897-2","article-title":"Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases","volume":"455","author":"Kostoulas","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2020.173420_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2020.173420_bib27","article-title":"LFG-500 inhibits the invasion of cancer cells via down-regulation of PI3K\/AKT\/NF-kappaB signaling pathway","volume":"9","author":"Li","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2020.173420_bib28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3892\/mmr.2013.1507","article-title":"Cathepsin B inhibition attenuates cardiac dysfunction and remodeling following myocardial infarction by inhibiting the NLRP3 pathway","volume":"8","author":"Liu","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2020.173420_bib29","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1139\/y06-065","article-title":"Physiological role and regulation of the Na+\/H+ exchanger","volume":"84","author":"Malo","year":"2006","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173420_bib30","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/sj.bjp.0705631","article-title":"Na+\/H+ exchange inhibition attenuates left ventricular remodeling and preserves systolic function in pressure-overloaded hearts","volume":"141","author":"Marano","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173420_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projections of global mortality and burden of disease from 2002 to 2030","volume":"3","author":"Mathers CD","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.ejphar.2020.173420_bib32","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1124\/jpet.106.108845","article-title":"Calcineurin activation is not necessary for Doxorubicin-induced hypertrophy in H9c2 embryonic rat cardiac cells: involvement of the phosphoinositide 3-kinase-Akt pathway","volume":"319","author":"Merten","year":"2006","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2020.173420_bib33","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4161\/auto.4600","article-title":"How to interpret LC3 immunoblotting","volume":"3","author":"Mizushima","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.ejphar.2020.173420_bib34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11010-015-2380-8","article-title":"Na(+)\/H (+) exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3\/Gata4","volume":"404","author":"Mlih","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2020.173420_bib35","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/jcp.24958","article-title":"Targeting osteopontin, the silent partner of Na+\/H+ exchanger isoform 1 in cardiac remodeling","volume":"230","author":"Mohamed","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2020.173420_bib36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11010-011-0933-z","article-title":"Elevated expression of activated Na(+)\/H(+) exchanger protein induces hypertrophy in isolated rat neonatal ventricular cardiomyocytes","volume":"358","author":"Mraiche","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2020.173420_bib37","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10741-011-9269-8","article-title":"Role of various proteases in cardiac remodeling and progression of heart failure","volume":"17","author":"M\u00fcller","year":"2012","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ejphar.2020.173420_bib38","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/ki.2009.424","article-title":"Proteinuria: an enzymatic disease of the podocyte?","volume":"77","author":"Mundel","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2020.173420_bib39","article-title":"Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation","volume":"7","author":"Pan","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2020.173420_bib40","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1742-4658.2008.06815.x","article-title":"Autocatalytic processing of procathepsin B is triggered by proenzyme activity","volume":"276","author":"Pungercar","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2020.173420_bib41","series-title":"Cathepsin B Induced Cardiomyocyte Hypertrophy Requires Activation of the Na+\/H+ Exchanger Isoform-1, Master's Thesis, College of Pharmacy","author":"Riaz","year":"2016"},{"key":"10.1016\/j.ejphar.2020.173420_bib42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbamcr.2009.09.015","article-title":"Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics","volume":"1803","author":"Rodriguez","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2020.173420_bib43","first-page":"6517","article-title":"Pericellular pH affects distribution and secretion of cathepsin B in malignant cells","volume":"54","author":"Rozhin","year":"1994","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173420_bib44","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.biocel.2013.04.023","article-title":"Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome( )( )","volume":"45","author":"Sandri","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejphar.2020.173420_bib45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1023\/B:MCBI.0000041865.63445.40","article-title":"Role of proteases in the pathophysiology of cardiac disease","volume":"263","author":"Singh","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2020.173420_bib46","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1369\/0022155413484765","article-title":"Tissue- and cell-specific co-localization of intracellular gelatinolytic activity and matrix metalloproteinase 2","volume":"61","author":"Solli","year":"2013","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.ejphar.2020.173420_bib47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/pca.1086","article-title":"Application of Scion image software to the simultaneous determination of curcuminoids in turmeric (Curcuma longa)","volume":"20","author":"Sotanaphun","year":"2009","journal-title":"Phytochem. Anal. : PCA (Phytochem. Anal.)"},{"key":"10.1016\/j.ejphar.2020.173420_bib48","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1600-0854.2009.00904.x","article-title":"Na+\/H+ exchangers and RhoA regulate acidic extracellular pH-induced lysosome trafficking in prostate cancer cells","volume":"10","author":"Steffan","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.ejphar.2020.173420_bib49","doi-asserted-by":"crossref","first-page":"15345","DOI":"10.1074\/jbc.M512818200","article-title":"Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator","volume":"281","author":"Stempien-Otero","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173420_bib50","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/cvr\/cvq328","article-title":"Cathepsin-L contributes to cardiac repair and remodelling post-infarction","volume":"89","author":"Sun","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2020.173420_bib51","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000191","article-title":"Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways","volume":"2","author":"Sun","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ejphar.2020.173420_bib52","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and autophagy","volume":"445","author":"Tanida","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2020.173420_bib53","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.abb.2008.05.007","article-title":"Sodium hydrogen exchanger and phospholipase D are required for alpha1-adrenergic receptor stimulation of metalloproteinase-9 and cellular invasion in CCL39 fibroblasts","volume":"477","author":"Taves","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2020.173420_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081313","article-title":"Na+\/H+ exchangers induce autophagy in neurons and inhibit polyglutamine-induced aggregate formation","volume":"8","author":"Togashi","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2020.173420_bib55","first-page":"125","article-title":"The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro. In vitro cellular & developmental biology","volume":"47","author":"Watkins","year":"2011","journal-title":"Animal"},{"key":"10.1016\/j.ejphar.2020.173420_bib56","doi-asserted-by":"crossref","first-page":"38894","DOI":"10.1038\/srep38894","article-title":"Pleiotropic effects of myocardial MMP-9 inhibition to prevent ventricular arrhythmia","volume":"6","author":"Weng","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2020.173420_bib57","series-title":"Global Status Report on Noncommunicable Disaeses 2010","author":"WHO","year":"2011"},{"key":"10.1016\/j.ejphar.2020.173420_bib58","series-title":"Cardiovascular Diseases Key Facts","author":"WHO","year":"2013"},{"key":"10.1016\/j.ejphar.2020.173420_bib59","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3109\/07853890109002108","article-title":"Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium","volume":"33","author":"Wilson","year":"2001","journal-title":"Ann. Med."},{"issue":"9","key":"10.1016\/j.ejphar.2020.173420_bib60","doi-asserted-by":"crossref","first-page":"H1143","DOI":"10.1152\/ajpheart.00601.2014","article-title":"Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNFalpha\/ASK1\/JNK pathway","volume":"308","author":"Wu","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2020.173420_bib61","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1152\/physiolgenomics.00064.2010","article-title":"Elevated myocardial Na+\/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy","volume":"42","author":"Xue","year":"2010","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.ejphar.2020.173420_bib62","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2007.11.004","article-title":"FoxO3 coordinately activates protein degradation by the autophagic\/lysosomal and proteasomal pathways in atrophying muscle cells","volume":"6","author":"Zhao","year":"2007","journal-title":"Cell Metabol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920305124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920305124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:13:09Z","timestamp":1777410789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920305124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":62,"alternative-id":["S0014299920305124"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173420","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-hypertrophic effect of Na+\/H+ exchanger-1 inhibition is mediated by reduced cathepsin B","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173420","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"173420"}}