{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:04:20Z","timestamp":1761491060438,"version":"3.44.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K08513","19K07295"],"award-info":[{"award-number":["16K08513","19K07295"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.ejphar.2020.173437","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T13:20:17Z","timestamp":1595942417000},"page":"173437","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["F-phenibut (\u03b2-(4-Fluorophenyl)-GABA), a potent GABAB receptor agonist, activates an outward-rectifying K+ current and suppresses the generation of action potentials in mouse cerebellar Purkinje cells"],"prefix":"10.1016","volume":"884","author":[{"given":"Tomohiko","family":"Irie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiju","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruri","family":"Kikura-Hanajiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173437_bib1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.00036.2003","article-title":"Molecular structure and physiological functions of GABA(B) receptors","volume":"84","author":"Bettler","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2020.173437_bib2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1476-5381.1983.tb09380.x","article-title":"Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes","volume":"78","author":"Bowery","year":"1983","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173437_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrn3886","article-title":"Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits","volume":"16","author":"Cerminara","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2020.173437_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1124\/pr.57.4.12","article-title":"International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels","volume":"57","author":"Goldstein","year":"2005","journal-title":"Pharmacol. Rev."},{"year":"2001","series-title":"Ion Channels of Excitable Membranes","author":"Hille","key":"10.1016\/j.ejphar.2020.173437_bib5"},{"key":"10.1016\/j.ejphar.2020.173437_bib6","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/nn764","article-title":"GABA(B) receptor activation enhances mGluR-mediated responses at cerebellar excitatory synapses","volume":"4","author":"Hirono","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2020.173437_bib7","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1152\/jn.00396.2006","article-title":"Activation of GIRK channels by muscarinic receptors and group II metabotropic glutamate receptors suppresses Golgi cell activity in the cochlear nucleus of mice","volume":"96","author":"Irie","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2020.173437_bib8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuropharm.2015.02.025","article-title":"MAM-2201, a synthetic cannabinoid drug of abuse, suppresses the synaptic input to cerebellar Purkinje cells via activation of presynaptic CB1 receptors","volume":"95","author":"Irie","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2020.173437_bib9","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.neuron.2017.10.014","article-title":"Double-nanodomain coupling of calcium channels, ryanodine receptors, and BK channels controls the generation of burst firing","volume":"96","author":"Irie","year":"2017","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.ejphar.2020.173437_bib10","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1460-9568.2010.07336.x","article-title":"Identification and characterization of Cs (+)-permeable K(+) channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation","volume":"32","author":"Ishii","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2020.173437_bib11","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1152\/physrev.2001.81.3.1143","article-title":"Cerebellar long-term depression: characterization, signal transduction, and functional roles","volume":"81","author":"Ito","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2020.173437_bib12","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/JCP.0000000000000731","article-title":"Dissociative intoxication and prolonged withdrawal associated with phenibut: a case report","volume":"37","author":"Joshi","year":"2017","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2020.173437_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11920-019-1009-0","article-title":"Phenibut (beta-Phenyl-gamma-Aminobutyric acid): an easily obtainable \"dietary supplement\" with propensities for physical dependence and addiction","volume":"21","author":"Jouney","year":"2019","journal-title":"Curr. Psychiatr. Rep."},{"key":"10.1016\/j.ejphar.2020.173437_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/386239a0","article-title":"Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors","volume":"386","author":"Kaupmann","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2020.173437_bib15","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s12311-019-01017-5","article-title":"Motor performances of spontaneous and genetically modified mutants with cerebellar atrophy","volume":"18","author":"Lalonde","year":"2019","journal-title":"Cerebellum"},{"key":"10.1016\/j.ejphar.2020.173437_bib16","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1527-3458.2001.tb00211.x","article-title":"Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug","volume":"7","author":"Lapin","year":"2001","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.ejphar.2020.173437_bib17","series-title":"The Synaptic Organization of the Brain","first-page":"271","article-title":"Cerebellum","author":"Llinas","year":"2004"},{"key":"10.1016\/j.ejphar.2020.173437_bib18","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/j.1460-9568.2006.04669.x","article-title":"Localization of metabotropic GABA receptor subunits GABAB1 and GABAB2 relative to synaptic sites in the rat developing cerebellum","volume":"23","author":"Lujan","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2020.173437_bib19","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.neuron.2012.04.026","article-title":"Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling","volume":"74","author":"Sandoz","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2020.173437_bib20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1113\/jphysiol.2004.081000","article-title":"GABAergic activation of an inwardly rectifying K+ current in mouse cerebellar Purkinje cells","volume":"563","author":"Tabata","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2020.173437_bib21","article-title":"Phenibut addiction in a patient with substance use disorder","volume":"11","author":"Zheng","year":"2019","journal-title":"Cureus"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992030529X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992030529X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:37:28Z","timestamp":1757975848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429992030529X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":21,"alternative-id":["S001429992030529X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173437","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"F-phenibut (\u03b2-(4-Fluorophenyl)-GABA), a potent GABAB receptor agonist, activates an outward-rectifying K+ current and suppresses the generation of action potentials in mouse cerebellar Purkinje cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173437","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173437"}}