{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:54:20Z","timestamp":1782996860805,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Uniwersytet Medyczny w Lodzi","doi-asserted-by":"publisher","award":["503\/1-156-04\/503-11-001-19-00"],"award-info":[{"award-number":["503\/1-156-04\/503-11-001-19-00"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["-2013\/11-N\/NZ7\/00724"],"award-info":[{"award-number":["-2013\/11-N\/NZ7\/00724"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Ministerstwo Edukacji i Nauki","doi-asserted-by":"publisher","award":["1658\/MOB\/V\/2017\/0"],"award-info":[{"award-number":["1658\/MOB\/V\/2017\/0"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.ejphar.2020.173463","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T20:56:22Z","timestamp":1598043382000},"page":"173463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Cyclic derivative of morphiceptin Dmt-cyclo-(D-Lys-Phe-D-Pro-Asp)-NH2(P-317), a mixed agonist of MOP and KOP opioid receptors, exerts anti-inflammatory and anti-tumor activity in colitis and colitis-associated colorectal cancer in mice"],"prefix":"10.1016","volume":"885","author":[{"given":"Marta","family":"Zieli\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Szymaszkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Jacenik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Schodel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Sa\u0142aga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Zatorski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radzis\u0142aw","family":"Kordek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda M.","family":"Krajewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Fichna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173463_bib1","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/mi.2014.21","article-title":"Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis","volume":"7","author":"Ahmad","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.ejphar.2020.173463_bib2","first-page":"105","article-title":"Epidemiology of colorectal cancer","volume":"7","author":"Andrew R Marley","year":"2016","journal-title":"Int. J. Mol. Epidemiol. Genet."},{"key":"10.1016\/j.ejphar.2020.173463_bib3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/nmo.12521","article-title":"Activation of \u03bc opioid receptors modulates inflammation in acute experimental colitis","volume":"27","author":"Anselmi","year":"2015","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.ejphar.2020.173463_bib4","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3109\/0284186X.2012.737932","article-title":"Inhibitory effect of opiates on LPS mediated release of TNF and IL-8","volume":"52","author":"Bastami","year":"2013","journal-title":"Acta Oncol."},{"key":"10.1016\/j.ejphar.2020.173463_bib5","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S0022-3565(25)09680-6","article-title":"Inhibition of interleukin-1 and tumor necrosis factor-alpha synthesis following treatment of macrophages with the kappa opioid agonist U50, 488H","volume":"273","author":"Belkowski","year":"1995","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2020.173463_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/bmjspcare-2013-000573","article-title":"A preliminary evaluation of the effects of opioids on innate and adaptive human in vitro immune function","volume":"4","author":"Boland","year":"2014","journal-title":"BMJ Support. Palliat. Care"},{"key":"10.1016\/j.ejphar.2020.173463_bib7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/01.MIB.0000436277.13917.c4","article-title":"Initial disease course and treatment in an inflammatory bowel disease inception cohort in Europe: the ECCO-EpiCom cohort","volume":"20","author":"Burisch","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.ejphar.2020.173463_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/187152408783790604","article-title":"The effect of morphine on the expression of COX-2 and iNOS enzymes","volume":"8","author":"Capasso","year":"2008","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173463_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12032-014-0439-0","article-title":"Overexpression of cyclin D1 in meningioma is associated with malignancy grade and causes abnormalities in apoptosis, invasion and cell cycle progression","volume":"32","author":"Cheng","year":"2015","journal-title":"Med. Oncol."},{"key":"10.1016\/j.ejphar.2020.173463_bib11","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1038\/onc.2010.109","article-title":"Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer","volume":"29","author":"Danese","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2020.173463_bib13","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s10787-018-0538-1","article-title":"Involvement of central opioid receptors in protective effects of methadone on experimental colitis in rats","volume":"26","author":"Fakhraei","year":"2018","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ejphar.2020.173463_bib14","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/sj.bjc.6604057","article-title":"COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia","volume":"97","author":"Farooqui","year":"2007","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.ejphar.2020.173463_bib15","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2019.03.017","article-title":"Cytokine networks in the pathophysiology of inflammatory bowel disease","volume":"50","author":"Friedrich","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2020.173463_bib18","first-page":"4491","article-title":"Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth","volume":"62","author":"Gupta","year":"2002","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173463_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3835(02)00360-9","article-title":"Potential ability of morphine to inhibit the adhesion, invasion and metastasis of metastatic colon 26-L5 carcinoma cells","volume":"187","author":"Harimaya","year":"2002","journal-title":"Canc. Lett."},{"key":"10.1016\/j.ejphar.2020.173463_bib20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/phpp.12290","article-title":"Ultraviolet A eye irradiation ameliorates colon carcinoma induced by azoxymethane and dextran sodium sulfate through \u03b2-endorphin and methionine-enkephalin","volume":"33","author":"Hiramoto","year":"2017","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.ejphar.2020.173463_bib21","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1111\/j.1742-1241.2006.01105.x","article-title":"Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21waf1\/cip 1, p27kip1 in colorectal carcinoma: correlation with other cell cycle regulators (pRb, p53 and Ki-67 and PCNA) and clinicopathological features","volume":"62","author":"Ioachim","year":"2008","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.ejphar.2020.173463_bib22","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.3389\/fimmu.2017.01373","article-title":"TH17 cell and epithelial cell crosstalk during inflammatory bowel disease and carcinogenesis","volume":"8","author":"Kempski","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2020.173463_bib23","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in vivo experiments: the ARRIVE guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173463_bib25","doi-asserted-by":"crossref","first-page":"408","DOI":"10.4161\/15384101.2014.977103","article-title":"WWOX suppresses prostate cancer cell progression through cyclin D1-mediated cell cycle arrest in the G1 phase","volume":"14","author":"Lin","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ejphar.2020.173463_bib27","doi-asserted-by":"crossref","first-page":"6902","DOI":"10.1158\/0008-5472.CAN-17-1767","article-title":"miR-6883 family miRNAs target CDK4\/6 to induce G1 phase cell-cycle arrest in colon cancer cells","volume":"77","author":"Lulla","year":"2017","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173463_bib28","doi-asserted-by":"crossref","DOI":"10.1097\/MED.0000000000000219","article-title":"Expression and physiology of opioid receptors in the gastrointestinal tract","volume":"23","author":"Mosi\u0144ska","year":"2016","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.ejphar.2020.173463_bib29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10620-007-9897-y","article-title":"Functional expression of\u00a0?-opioid receptors in the human colon cancer cell line, HT-29, and their localization in human colon","volume":"53","author":"Nylund","year":"2008","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2020.173463_bib30","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.bbagen.2018.07.007","article-title":"Morphine, a potential inhibitor of myeloperoxidase activity","volume":"1862","author":"Nyssen","year":"2018","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.ejphar.2020.173463_bib31","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1248\/bpb.32.1571","article-title":"Effects of repeated morphine treatment on the antinociceptive effects, intestinal absorption, and efflux from intestinal epithelial cells of morphine","volume":"32","author":"Okura","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2020.173463_bib32","doi-asserted-by":"crossref","first-page":"144030","DOI":"10.1016\/j.gene.2019.144030","article-title":"The effects of tramadol on cancer stem cells and metabolic changes in colon carcinoma cells lines","volume":"718","author":"\u00d6zg\u00fcrb\u00fcz","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.ejphar.2020.173463_bib34","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1172\/JCI200316750","article-title":"Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation","volume":"111","author":"Philippe","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2020.173463_bib35","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/gut.2005.080887","article-title":"Mu opioid receptor expression is increased in inflammatory bowel diseases: implications for homeostatic intestinal inflammation","volume":"55","author":"Philippe","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2020.173463_bib36","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2019.04.016","article-title":"Environmental risk factors for inflammatory bowel diseases: an umbrella review of meta-analyses","volume":"157","author":"Piovani","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2020.173463_bib37","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/sj.bjp.0706227","article-title":"The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice","volume":"145","author":"Pol","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173463_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fimmu.2012.00107","article-title":"Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer","volume":"3","author":"Rubin","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2020.173463_bib43","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000500721","article-title":"Mechanism-based treatment strategies for IBD: cytokines, cell adhesion molecules, JAK inhibitors, gut flora, and more","volume":"4","author":"Schreiner","year":"2019","journal-title":"Inflamm. Intest. Dis."},{"key":"10.1016\/j.ejphar.2020.173463_bib44","doi-asserted-by":"crossref","unstructured":"Seyedian, S.S., Nokhostin, F., Malamir, M.D., 2019 n.d. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. J. Med. Life 12, 113\u2013122. doi:10.25122\/jml-2018-0075.","DOI":"10.25122\/jml-2018-0075"},{"key":"10.1016\/j.ejphar.2020.173463_bib45","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.pharep.2014.03.007","article-title":"Anti-inflammatory action of a novel orally available peptide 317 in mouse models of inflammatory bowel diseases","volume":"66","author":"Sobczak","year":"2014","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejphar.2020.173463_bib46","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3390\/medicina55090584","article-title":"Molecular basis of cancer pain management: an updated review","volume":"55","author":"Subramaniam","year":"2019","journal-title":"Medicina (B. Aires)."},{"key":"10.1016\/j.ejphar.2020.173463_bib47","doi-asserted-by":"crossref","first-page":"83207","DOI":"10.18632\/oncotarget.20544","article-title":"Inhibition of cell cycle progression by the hydroxytyrosol- cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells","volume":"8","author":"Terzuoli","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2020.173463_bib48","first-page":"2727","article-title":"Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies","volume":"29","author":"Triantafillidis","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejphar.2020.173463_bib49","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jgm.1625","article-title":"Pro-opiomelanocortin gene delivery suppresses the growth of established Lewis lung carcinoma through a melanocortin-1 receptor-independent pathway","volume":"14","author":"Tsai","year":"2012","journal-title":"J. Gene Med."},{"key":"10.1016\/j.ejphar.2020.173463_bib50","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection","volume":"131","author":"Van der Sluis","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2020.173463_bib51","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20200265","article-title":"Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways","volume":"40","author":"Wan","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ejphar.2020.173463_bib53","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/SPC.0000000000000208","article-title":"Opioids and cancer: friend or foe?","author":"Wigmore","year":"2016","journal-title":"Curr. Opin. Support. Palliat. Care PublishAh"},{"key":"10.1016\/j.ejphar.2020.173463_bib54","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2015.12.009","article-title":"Estrogen receptor beta as target for colorectal cancer prevention","volume":"372","author":"Williams","year":"2016","journal-title":"Canc. Lett."},{"key":"10.1016\/j.ejphar.2020.173463_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00510","article-title":"Fentanyl promotes breast cancer cell stemness and epithelial-mesenchymal transition by upregulating \u03b11, 6-fucosylation via Wnt\/\u03b2-catenin signaling pathway","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2020.173463_bib57","doi-asserted-by":"crossref","first-page":"734","DOI":"10.5009\/gnl14155","article-title":"Changes in the expression and distribution of claudins, increased epithelial apoptosis, and a mannan-binding lectin-associated immune response lead to barrier dysfunction in dextran sodium sulfate-induced rat colitis","volume":"9","author":"Yuan","year":"2015","journal-title":"Gut Liver"},{"key":"10.1016\/j.ejphar.2020.173463_bib59","first-page":"227","article-title":"Fentanyl inhibits proliferation and invasion of colorectal cancer via \u03b2-catenin","volume":"8","author":"Zhang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ejphar.2020.173463_bib60","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/jphp.12335","article-title":"Orally administered novel cyclic pentapeptide P-317 alleviates symptoms of diarrhoea-predominant irritable bowel syndrome","volume":"67","author":"Zieli\u0144ska","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173463_bib61","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/jphp.12335","article-title":"Orally administered novel cyclic pentapeptide P-317 alleviates symptoms of diarrhoea-predominant irritable bowel syndrome","volume":"67","author":"Zieli\u0144ska","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173463_bib62","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ejphar.2015.09.021","article-title":"Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice","volume":"765","author":"Zieli\u0144ska","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173463_bib63","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jff.2015.05.046","article-title":"Orally available extract from Brassica oleracea var. capitata rubra attenuates experimental colitis in mouse models of inflammatory bowel diseases","volume":"17","author":"Zieli\u0144ska","year":"2015","journal-title":"J. Funct. Foods"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920305550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920305550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:42:58Z","timestamp":1757976178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920305550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":49,"alternative-id":["S0014299920305550"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173463","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclic derivative of morphiceptin Dmt-cyclo-(D-Lys-Phe-D-Pro-Asp)-NH2(P-317), a mixed agonist of MOP and KOP opioid receptors, exerts anti-inflammatory and anti-tumor activity in colitis and colitis-associated colorectal cancer in mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173463","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173463"}}