{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:22:09Z","timestamp":1776356529449,"version":"3.51.2"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST107-2320-B-016-010-MY3"],"award-info":[{"award-number":["MOST107-2320-B-016-010-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006578","name":"Chi Mei Medical Center","doi-asserted-by":"publisher","award":["CMNDMC 105\u201302"],"award-info":[{"award-number":["CMNDMC 105\u201302"]}],"id":[{"id":"10.13039\/501100006578","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006578","name":"Chi Mei Medical Center","doi-asserted-by":"publisher","award":["CMNDMC 106\u201303"],"award-info":[{"award-number":["CMNDMC 106\u201303"]}],"id":[{"id":"10.13039\/501100006578","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-C108-049"],"award-info":[{"award-number":["TSGH-C108-049"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ejphar.2020.173703","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T06:00:36Z","timestamp":1604556036000},"page":"173703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Targeting inhibition of CCR5 on improving obesity-associated insulin resistance and impairment of pancreatic insulin secretion in high fat-fed rodent models"],"prefix":"10.1016","volume":"891","author":[{"given":"Pei-Chi","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Tser","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieh-Hua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Feng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Shiuan","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173703_bib1","article-title":"Type 2 diabetes prevalence and its risk factors in HIV: a cross-sectional study","volume":"12","author":"Alastair","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2020.173703_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/obr.12242","article-title":"Macrophage recruitment in obese adipose tissue","volume":"16","author":"Bai","year":"2015","journal-title":"Obes. Rev."},{"key":"10.1016\/j.ejphar.2020.173703_bib3","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/eji.200324285","article-title":"Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non-obese diabetic mice","volume":"34","author":"Carla","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ejphar.2020.173703_bib4","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/eji.200324285","article-title":"Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non-obese diabetic mice","volume":"34","author":"Carvalho-Pinto","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ejphar.2020.173703_bib5","doi-asserted-by":"crossref","first-page":"29406","DOI":"10.1074\/jbc.M112.348946","article-title":"The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis","volume":"287","author":"Chan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173703_bib6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.freeradbiomed.2017.07.032","article-title":"Importance of NADPH oxidase-mediated redox signaling in the detrimental effect of CRP on pancreatic insulin secretion","volume":"112","author":"Chan","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2020.173703_bib7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4077\/CJP.2018.BAG584","article-title":"Importance of PLC-dependent PI3K\/AKT and AMPK signaling in RANTES\/CCR5 mediated macrophage chemotaxis","volume":"61","author":"Chien","year":"2018","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.ejphar.2020.173703_bib8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.4049\/jimmunol.160.1.426","article-title":"RANTES-induced T cell activation correlates with CD3 expression","volume":"160","author":"Dairaghi","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2020.173703_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrc2069","article-title":"G-protein-coupled receptors and cancer","volume":"7","author":"Dorsam","year":"2007","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.ejphar.2020.173703_bib10","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.2337\/db06-1650","article-title":"Increased number of islet-associated macrophages in type 2 diabetes","volume":"56","author":"Ehses","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2020.173703_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/2230-8210.146874","article-title":"Assessment of Insulin sensitivity\/resistance","volume":"19","author":"Gutch","year":"2015","journal-title":"Indian J Endocrinol Metab"},{"key":"10.1016\/j.ejphar.2020.173703_bib12","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1210\/jc.2014-1425","article-title":"\u03b2-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment","volume":"99","author":"Halban","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2020.173703_bib13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00210-018-1576-3","article-title":"CCR2 and CCR5 promote diclofenac-induced hepatotoxicity in mice","volume":"392","author":"He","year":"2019","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173703_bib14","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bcp.2008.11.014","article-title":"CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways","volume":"77","author":"Huang","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173703_bib15","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00125-009-1321-z","article-title":"The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality","volume":"52","author":"Kahn","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2020.173703_bib16","doi-asserted-by":"crossref","first-page":"E897","DOI":"10.1152\/ajpendo.00177.2013","article-title":"Loss of CCR5 results in glucose intolerance in diet-induced obese mice","volume":"305","author":"Kennedy","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2020.173703_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2015.51","article-title":"Silencing CCR2 in macrophages alleviates adipose tissue inflammation and the associated metabolic syndrome in dietary obese mice","volume":"5","author":"Kim","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.ejphar.2020.173703_bib18","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.2337\/db11-1506","article-title":"CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1\/M2 status","volume":"61","author":"Kitade","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2020.173703_bib19","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.2337\/db11-1506","article-title":"CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1\/M2 status","volume":"61","author":"Kitade","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2020.173703_bib20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/0962935031000096962","article-title":"Upregulation of expression of the chemokine receptor CCR5 by hydrogen peroxide in human monocytes","volume":"12","author":"Lehoux","year":"2003","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2020.173703_bib22","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/ars.2016.6755","article-title":"The role of oxidative stress and hypoxia in pancreatic beta-cell dysfunction in diabetes mellitus","volume":"26","author":"Gerber","year":"2017","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2020.173703_bib21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00125-006-0462-6","article-title":"Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line","volume":"50","author":"Morgan","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2020.173703_bib23","doi-asserted-by":"crossref","first-page":"28853","DOI":"10.1038\/srep28853","article-title":"Maraviroc reduces arterial stiffness in PI-treated HIV-infected patients","volume":"29","author":"Piconi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2020.173703_bib24","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1172\/JCI29103","article-title":"Islet beta cell failure in type 2 diabetes","volume":"116","author":"Prentki","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2020.173703_bib25","doi-asserted-by":"crossref","first-page":"e325","DOI":"10.1111\/j.1365-2567.2008.02966.x","article-title":"Induction of copper\/zinc-superoxide dismutase by CCL5\/CCR5 activation causes tumour necrosis factor-\u03b1 and reactive oxygen species production in macrophages","volume":"128","author":"Qiu","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.ejphar.2020.173703_bib26","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1126\/science.1104345","article-title":"Type 2 diabetes-a matter of beta-cell life and death?","volume":"307","author":"Rhodes","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2020.173703_bib27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3109\/08916930903246464","article-title":"CCR2 and CCR5 chemokine receptors differentially influence the development of autoimmune diabetes in the NOD mouse","volume":"43","author":"Solomon","year":"2010","journal-title":"Autoimmunity"},{"key":"10.1016\/j.ejphar.2020.173703_bib28","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/nm1303","article-title":"CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection","volume":"11","author":"Tyner","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2020.173703_bib29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1210\/er.2007-0023","article-title":"Glucolipotoxicity: fuel excess and \u03b2-cell dysfunction","volume":"29","author":"Vincent","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2020.173703_bib30","first-page":"5447","article-title":"Maraviroc: a review of its use in HIV infection and beyond","volume":"1","author":"Woollard","year":"2015","journal-title":"Drug Des. Dev. Ther."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920307950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920307950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:10:23Z","timestamp":1762143023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920307950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":30,"alternative-id":["S0014299920307950"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173703","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting inhibition of CCR5 on improving obesity-associated insulin resistance and impairment of pancreatic insulin secretion in high fat-fed rodent models","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173703","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173703"}}