{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T06:27:12Z","timestamp":1766557632747,"version":"build-2065373602"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007232","name":"Radiumhemmets Forskningsfonder","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003945","name":"Link\u00f6pings Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ejphar.2020.173709","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T12:48:33Z","timestamp":1604666913000},"page":"173709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Identification of proteasome inhibitors using analysis of gene expression profiles"],"prefix":"10.1016","volume":"889","author":[{"given":"Arjan","family":"Mofers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Selvaraju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Gubat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padraig","family":"D'Arcy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stig","family":"Linder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173709_bib1","doi-asserted-by":"crossref","first-page":"15115","DOI":"10.1073\/pnas.1212802109","article-title":"Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs","volume":"109","author":"Adams","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2020.173709_bib2","doi-asserted-by":"crossref","first-page":"9235","DOI":"10.1158\/0008-5472.CAN-06-0702","article-title":"Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis","volume":"66","author":"Aleo","year":"2006","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173709_bib3","doi-asserted-by":"crossref","first-page":"7874","DOI":"10.1021\/jm5006463","article-title":"Polypharmacology: challenges and opportunities in drug discovery","volume":"57","author":"Anighoro","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib4","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1021\/acs.jnatprod.5b00947","article-title":"Feeling nature's PAINS: natural products, natural product drugs, and Pan assay interference compounds (PAINS)","volume":"79","author":"Baell","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejphar.2020.173709_bib5","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/jm901137j","article-title":"New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays","volume":"53","author":"Baell","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib6","doi-asserted-by":"crossref","first-page":"8155","DOI":"10.1073\/pnas.1806797115","article-title":"Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2","volume":"115","author":"Banerjee","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2020.173709_bib7","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.chembiol.2019.03.016","article-title":"Parthenolide covalently targets and inhibits focal adhesion kinase in breast cancer cells","volume":"26","author":"Berdan","year":"2019","journal-title":"Cell chemical biology"},{"key":"10.1016\/j.ejphar.2020.173709_bib8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/sj.leu.2402415","article-title":"Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs","volume":"16","author":"Blagosklonny","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.ejphar.2020.173709_bib9","first-page":"1270","article-title":"Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase\/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice","volume":"63","author":"Blaskovich","year":"2003","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173709_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ddr.430340203","article-title":"Some practical considerations and applications of the national cancer Institute in vitro anticancer drug discovery screen","volume":"34","author":"Boyd","year":"1995","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ejphar.2020.173709_bib11","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1089\/ars.2013.5322","article-title":"Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress","volume":"21","author":"Brnjic","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2020.173709_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0009-2797(92)90071-R","article-title":"In vitro activation of heat shock transcription factor by 4-hydroxynonenal","volume":"84","author":"Cajone","year":"1992","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ejphar.2020.173709_bib13","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.yexcr.2014.12.009","article-title":"The natural tumorcide Manumycin-A targets protein phosphatase 1 alpha and reduces hydrogen peroxide to induce lymphoma apoptosis","volume":"332","author":"Carey","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2020.173709_bib14","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1021\/acs.jcim.7b00341","article-title":"Data resources for the computer-guided discovery of bioactive natural products","volume":"57","author":"Chen","year":"2017","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejphar.2020.173709_bib15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/leu.2017.329","article-title":"Management of relapsed and refractory multiple myeloma: novel agents, antibodies, immunotherapies and beyond","volume":"32","author":"Chim","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.ejphar.2020.173709_bib16","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1158\/1078-0432.CCR-13-2658","article-title":"Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses","volume":"20","author":"Coughlin","year":"2014","journal-title":"Clin. Canc. Res. : an official journal of the American Association for Cancer Research"},{"key":"10.1016\/j.ejphar.2020.173709_bib17","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/nm.2536","article-title":"Inhibition of proteasome deubiquitinating activity as a new cancer therapy","volume":"17","author":"D'Arcy","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2020.173709_bib18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.semcancer.2018.08.009","article-title":"Cancer cell plasticity: impact on tumor progression and therapy response","author":"da Silva-Diz","year":"2018","journal-title":"Semin. Canc. Biol."},{"key":"10.1016\/j.ejphar.2020.173709_bib19","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1021\/ci034243x","article-title":"ESOL: estimating aqueous solubility directly from molecular structure","volume":"44","author":"Delaney","year":"2004","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.ejphar.2020.173709_bib20","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.15252\/embj.201387076","article-title":"Survival of mycobacteria depends on proteasome-mediated amino acid recycling under nutrient limitation","volume":"33","author":"Elharar","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2020.173709_bib21","doi-asserted-by":"crossref","first-page":"170151","DOI":"10.1038\/sdata.2017.151","article-title":"Clustergrammer, a web-based heatmap visualization and analysis tool for high-dimensional biological data","volume":"4","author":"Fernandez","year":"2017","journal-title":"Sci Data"},{"key":"10.1016\/j.ejphar.2020.173709_bib22","doi-asserted-by":"crossref","first-page":"9695","DOI":"10.1128\/MCB.24.22.9695-9704.2004","article-title":"Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells","volume":"24","author":"Fribley","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2020.173709_bib23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bcp.2009.07.023","article-title":"Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase","volume":"79","author":"Gandin","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173709_bib24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1042\/BST0350012","article-title":"Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy","volume":"35","author":"Goldberg","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ejphar.2020.173709_bib25","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1039\/c1np00051a","article-title":"Multitargeting by curcumin as revealed by molecular interaction studies","volume":"28","author":"Gupta","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejphar.2020.173709_bib26","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/sj.bjc.6604003","article-title":"Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells","volume":"97","author":"Hamamura","year":"2007","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.ejphar.2020.173709_bib27","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1073\/pnas.90.6.2281","article-title":"Identification of Ras farnesyltransferase inhibitors by microbial screening","volume":"90","author":"Hara","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2020.173709_bib28","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.2174\/09298673113206660135","article-title":"Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment","volume":"21","author":"Hasima","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib29","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s00018-008-7452-4","article-title":"Curcumin: from ancient medicine to current clinical trials","volume":"65","author":"Hatcher","year":"2008","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"key":"10.1016\/j.ejphar.2020.173709_bib30","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fonc.2018.00614","article-title":"Bioactivities of EF24, a novel curcumin analog: a review","volume":"8","author":"He","year":"2018","journal-title":"Front Oncol"},{"key":"10.1016\/j.ejphar.2020.173709_bib31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","article-title":"The ubiquitin system","volume":"67","author":"Hershko","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejphar.2020.173709_bib32","doi-asserted-by":"crossref","first-page":"6915","DOI":"10.1038\/s41598-019-43399-w","article-title":"Identification of thiostrepton as a pharmacological approach to rescue misfolded alpha-sarcoglycan mutant proteins from degradation","volume":"9","author":"Hoch","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2020.173709_bib33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tibs.2006.11.005","article-title":"Cdc 48 (p97): a \"molecular gearbox\" in the ubiquitin pathway?","volume":"32","author":"Jentsch","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejphar.2020.173709_bib34","doi-asserted-by":"crossref","first-page":"13017","DOI":"10.1007\/s13277-016-5183-y","article-title":"Molecular targets of curcumin for cancer therapy: an updated review","volume":"37","author":"Kasi","year":"2016","journal-title":"Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine"},{"key":"10.1016\/j.ejphar.2020.173709_bib35","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrm2731","article-title":"Breaking the chains: structure and function of the deubiquitinases","volume":"10","author":"Komander","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2020.173709_bib36","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.febslet.2015.04.053","article-title":"Induction of heat shock protein HSPA6 (HSP70B') upon HSP90 inhibition in cancer cell lines","volume":"589","author":"Kuballa","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2020.173709_bib37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nrc2044","article-title":"The Connectivity Map: a new tool for biomedical research","volume":"7","author":"Lamb","year":"2007","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.ejphar.2020.173709_bib38","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2020.173709_bib39","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1074\/jbc.RA119.011396","article-title":"Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth","volume":"295","author":"Li","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib40","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/bph.14816","article-title":"Natural compounds as potential adjuvants to cancer therapy: preclinical evidence","volume":"177","author":"Lin","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173709_bib41","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1074\/jbc.271.9.4805","article-title":"Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols","volume":"271","author":"Liu","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib42","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.18632\/oncotarget.2113","article-title":"Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth","volume":"5","author":"Liu","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2020.173709_bib43","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/ijc.21534","article-title":"Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram","volume":"118","author":"Lovborg","year":"2006","journal-title":"International journal of cancer. Journal international du cancer"},{"key":"10.1016\/j.ejphar.2020.173709_bib44","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/cvr\/cvq046","article-title":"Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis","volume":"86","author":"Madrigal-Matute","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2020.173709_bib45","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1158\/0008-5472.CAN-06-2258","article-title":"Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition","volume":"67","author":"Meister","year":"2007","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173709_bib46","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.biopha.2018.03.102","article-title":"Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: overview and current state of the art","volume":"102","author":"Mellatyar","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.ejphar.2020.173709_bib47","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1093\/hmg\/ddi312","article-title":"Endoplasmic reticulum stress compromises the ubiquitin-proteasome system","volume":"14","author":"Menendez-Benito","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2020.173709_bib48","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1016\/j.ejmech.2011.07.057","article-title":"Natural products: an evolving role in future drug discovery","volume":"46","author":"Mishra","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib49","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/nchembio.190","article-title":"Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages","volume":"5","author":"Molina","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejphar.2020.173709_bib50","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The essential medicinal chemistry of curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib51","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.cell.2012.07.023","article-title":"Cancer vulnerabilities unveiled by genomic loss","volume":"150","author":"Nijhawan","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2020.173709_bib52","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1182\/blood-2005-08-3531","article-title":"Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells","volume":"107","author":"Obeng","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2020.173709_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058641","article-title":"Non-specific protein modifications by a phytochemical induce heat shock response for self-defense","volume":"8","author":"Ohnishi","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2020.173709_bib54","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.2174\/0929867322666151029104611","article-title":"Curcumin: a natural lead for potential new drug candidates","volume":"22","author":"Oliveira","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib55","doi-asserted-by":"crossref","first-page":"33542","DOI":"10.1074\/jbc.M113.511170","article-title":"Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells","volume":"288","author":"Pei","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib56","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.2174\/156802609789895719","article-title":"Ansamycin inhibitors of Hsp90: nature's prototype for anti-chaperone therapy","volume":"9","author":"Porter","year":"2009","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib57","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0014-2999(92)90167-3","article-title":"A highly selective delta 1-opioid receptor antagonist: 7-benzylidenenaltrexone","volume":"218","author":"Portoghese","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173709_bib58","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1158\/1078-0432.CCR-18-3224","article-title":"Targeted inhibition of the dual specificity phosphatases DUSP1 and DUSP6 suppress MPNST growth via JNK","volume":"25","author":"Ramkissoon","year":"2019","journal-title":"Clin. Canc. Res. : an official journal of the American Association for Cancer Research"},{"key":"10.1016\/j.ejphar.2020.173709_bib59","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4161\/cc.4.2.1414","article-title":"Proteasome inhibition in the treatment of cancer","volume":"4","author":"Richardson","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ejphar.2020.173709_bib60","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nchem.2479","article-title":"Counting on natural products for drug design","volume":"8","author":"Rodrigues","year":"2016","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib61","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1111\/jcmm.12602","article-title":"Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates","volume":"19","author":"Sandu","year":"2015","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2020.173709_bib62","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/cb200353m","article-title":"Using the heat-shock response to discover anticancer compounds that target protein homeostasis","volume":"7","author":"Santagata","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejphar.2020.173709_bib63","doi-asserted-by":"crossref","first-page":"9841","DOI":"10.1038\/s41598-019-46168-x","article-title":"Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system","volume":"9","author":"Selvaraju","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2020.173709_bib64","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1038\/sj.onc.1201790","article-title":"Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol","volume":"16","author":"Sharma","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2020.173709_bib65","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1021\/acsomega.7b00954","article-title":"Hsp72 is an intracellular target of the alpha,beta-unsaturated sesquiterpene lactone, parthenolide","volume":"2","author":"Shin","year":"2017","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejphar.2020.173709_bib66","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.critrevonc.2016.04.018","article-title":"Deubiquitinases and cancer: a snapshot","volume":"103","author":"Singh","year":"2016","journal-title":"Crit. Rev. Oncol.-Hematol."},{"key":"10.1016\/j.ejphar.2020.173709_bib67","doi-asserted-by":"crossref","first-page":"e457","DOI":"10.1038\/cddis.2012.192","article-title":"Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death","volume":"4","author":"Singha","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2020.173709_bib68","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1016\/j.bmcl.2015.07.014","article-title":"Cheminformatic comparison of approved drugs from natural product versus synthetic origins","volume":"25","author":"Stratton","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejphar.2020.173709_bib69","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A next generation connectivity map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2020.173709_bib70","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.molcel.2012.08.003","article-title":"Failure of amino acid homeostasis causes cell death following proteasome inhibition","volume":"48","author":"Suraweera","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejphar.2020.173709_bib71","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1021\/acschembio.5b00367","article-title":"Withaferin A analogs that target the AAA+ chaperone p97","volume":"10","author":"Tao","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejphar.2020.173709_bib72","doi-asserted-by":"crossref","first-page":"45429","DOI":"10.18632\/oncotarget.9742","article-title":"The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells","volume":"7","author":"Tomasella","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2020.173709_bib73","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1021\/acsmedchemlett.7b00489","article-title":"Manumycin A is a potent inhibitor of mammalian thioredoxin reductase-1 (TrxR-1)","volume":"9","author":"Tuladhar","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejphar.2020.173709_bib74","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/emboj\/cdg127","article-title":"Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome","volume":"22","author":"Uhle","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2020.173709_bib75","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.critrevonc.2016.01.024","article-title":"Resistance mechanisms after tyrosine kinase inhibitors afatinib and crizotinib in non-small cell lung cancer, a review of the literature","volume":"100","author":"van der Wekken","year":"2016","journal-title":"Crit. Rev. Oncol.-Hematol."},{"key":"10.1016\/j.ejphar.2020.173709_bib76","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1200\/JCO.2010.33.2312","article-title":"Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling","volume":"29","author":"Wagle","year":"2011","journal-title":"J. Clin. Oncol. : official journal of the American Society of Clinical Oncology"},{"key":"10.1016\/j.ejphar.2020.173709_bib77","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1093\/bioinformatics\/btg302","article-title":"Linking the growth inhibition response from the National Cancer Institute's anticancer screen to gene expression levels and other molecular target data","volume":"19","author":"Wallqvist","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ejphar.2020.173709_bib78","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1126\/science.aac7041","article-title":"Identification and characterization of essential genes in the human genome","volume":"350","author":"Wang","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2020.173709_bib79","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1021\/bi061994u","article-title":"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex","volume":"46","author":"Wang","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2020.173709_bib80","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1093\/bioinformatics\/bty060","article-title":"L1000FWD: fireworks visualization of drug-induced transcriptomic signatures","volume":"34","author":"Wang","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ejphar.2020.173709_bib81","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.canlet.2017.10.007","article-title":"Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance","volume":"412","author":"Wu","year":"2018","journal-title":"Canc. Lett."},{"key":"10.1016\/j.ejphar.2020.173709_bib82","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/sj.bjp.0704478","article-title":"Pharmacological profiles of a novel opioid receptor-like 1 (ORL(1)) receptor antagonist, JTC-801","volume":"135","author":"Yamada","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173709_bib83","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1158\/0008-5472.CAN-05-4529","article-title":"Celastrol, a triterpene extracted from the Chinese \"Thunder of God Vine,\" is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice","volume":"66","author":"Yang","year":"2006","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173709_bib84","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1124\/mol.106.030015","article-title":"The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from \"Indian winter cherry","volume":"71","author":"Yang","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173709_bib85","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13321-016-0137-3","article-title":"Badapple: promiscuity patterns from noisy evidence","volume":"8","author":"Yang","year":"2016","journal-title":"J. Cheminf."},{"key":"10.1016\/j.ejphar.2020.173709_bib86","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bmc.2003.11.013","article-title":"Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay","volume":"12","author":"Zhang","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173709_bib87","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biochi.2019.03.015","article-title":"Repurposing of auranofin: thioredoxin reductase remains a primary target of the drug","volume":"162","author":"Zhang","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.ejphar.2020.173709_bib88","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1158\/1535-7163.MCT-12-1057","article-title":"Deubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-kappaB inhibition and p53 reactivation in human lung cancer cells","volume":"12","author":"Zhou","year":"2013","journal-title":"Mol. Canc. Therapeut."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920308013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920308013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:09:48Z","timestamp":1762142988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920308013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":88,"alternative-id":["S0014299920308013"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173709","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of proteasome inhibitors using analysis of gene expression profiles","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173709","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"173709"}}