{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:08:48Z","timestamp":1783728528558,"version":"3.55.0"},"reference-count":161,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ejphar.2020.173727","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T09:43:15Z","timestamp":1604569395000},"page":"173727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Tumour suppression through modulation of neprilysin signaling: A comprehensive review"],"prefix":"10.1016","volume":"891","author":[{"given":"Runali","family":"Sankhe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreedhara Ranganath K.","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Kishore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173727_bib1","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/nn.2433","article-title":"Amyloid-\u03b2 as a positive endogenous regulator of release probability at hippocampal synapses","volume":"12","author":"Abramov","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2020.173727_bib2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0302-2838(03)00322-1","article-title":"Expression and immunolocalisation of neutral endopeptidase in prostate cancer","volume":"44","author":"Albrecht","year":"2003","journal-title":"Eur. Urol."},{"key":"10.1016\/j.ejphar.2020.173727_bib3","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/(SICI)1097-0215(19970729)72:3<498::AID-IJC19>3.0.CO;2-8","article-title":"Bombesin stimulates the motility of human prostate\u2010carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin\u2010associated proteins","volume":"72","author":"Aprikian","year":"1997","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.ejphar.2020.173727_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/138920207782446160","article-title":"The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications","volume":"8","author":"Arcaro","year":"2007","journal-title":"Curr. Genom."},{"key":"10.1016\/j.ejphar.2020.173727_bib5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/1559827617700600","article-title":"Cancer epidemiology: a survey of modifiable risk factors for prevention and survivorship","volume":"12","author":"Arem","year":"2018","journal-title":"Am. J. Lifestyle Med."},{"key":"10.1016\/j.ejphar.2020.173727_bib6","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.3892\/mmr.2016.5463","article-title":"Endostatin and irradiation modifies the activity of ADAM10 and neprilysin in breast cancer cells","volume":"14","author":"Aydemir","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2020.173727_bib7","doi-asserted-by":"crossref","DOI":"10.1177\/1934578X0600100807","article-title":"Induction effects of apigenin, luteolin and vinpocetin on neutral endopeptidase (NEP) and angiotensin-converting enzyme activity (ACE) of SK-N-SH cells","volume":"1","author":"Ayoub","year":"2006","journal-title":"Natural Product Communications"},{"key":"10.1016\/j.ejphar.2020.173727_bib8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1211\/jpp.58.4.0009","article-title":"Induction of neutral endopeptidase (NEP) activity of SK\u2010N\u2010SH cells by natural compounds from green tea","volume":"58","author":"Ayoub","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173727_bib9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/13880200802055891","article-title":"Influence of selected natural products on neutral endopeptidase activity and \u03b2-amyloid production in SK-N-SH cells","volume":"46","author":"Ayoub","year":"2008","journal-title":"Pharmaceut. Biol."},{"key":"10.1016\/j.ejphar.2020.173727_bib10","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/stem.435","article-title":"The CD10 enzyme is a key player to identify and regulate human mammary stem cells","volume":"28","author":"Bachelard-Cascales","year":"2010","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2020.173727_bib11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1139\/Y08-058","article-title":"The endothelin axis in cancer: the promise and the challenges of molecularly targeted therapy","volume":"86","author":"Bagnato","year":"2008","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173727_bib12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1746-1596-4-38","article-title":"CD10 expression in urothelial carcinoma of the bladder","volume":"4","author":"Bahadir","year":"2009","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.ejphar.2020.173727_bib13","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3233\/JAD-2011-110746","article-title":"\u03b3-Secretase-mediated regulation of neprilysin: influence of cell density and aging and modulation by imatinib","volume":"27","author":"Bauer","year":"2011","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.ejphar.2020.173727_bib14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jacc.2016.04.060","article-title":"A test in context: neprilysin: function, inhibition, and biomarker","volume":"68","author":"Bayes-Genis","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2020.173727_bib15","series-title":"Advances in Cancer Research","first-page":"141","article-title":"Alterations in DNA methylation: a fundamental aspect of neoplasia","author":"Baylln","year":"1997"},{"key":"10.1016\/j.ejphar.2020.173727_bib16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/embor.2008.222","article-title":"Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease","volume":"10","author":"Belyaev","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ejphar.2020.173727_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2004.10.008","article-title":"Immunophenotyping of acute leukaemias","volume":"98","author":"B\u00e9n\u00e9","year":"2005","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ejphar.2020.173727_bib18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-pharmtox-010716-105106","article-title":"Targeting epigenetics in cancer","volume":"58","author":"Bennett","year":"2018","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2020.173727_bib19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000093901","article-title":"CD10 expression in urothelial bladder carcinomas: a pilot study","volume":"77","author":"Bircan","year":"2006","journal-title":"Urol. Int."},{"key":"10.1016\/j.ejphar.2020.173727_bib20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2148-8-16","article-title":"Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships","volume":"8","author":"Bland","year":"2008","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.ejphar.2020.173727_bib21","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1196\/annals.1392.000","article-title":"Novel markers for the prospective isolation of human MSC","volume":"1106","author":"B\u00fchring","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2020.173727_bib22","first-page":"2849","article-title":"Effects of recombinant neutral endopeptidase (EC 3.4. 24.11) on the growth of lung cancer cell lines in vitro and in vivo","volume":"4","author":"Bunn","year":"1998","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.lfs.2008.11.019","article-title":"Minocycline prevents A\u03b2 (25\u201335)-induced reduction of somatostatin and neprilysin content in rat temporal cortex","volume":"84","author":"Burgos-Ramos","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2020.173727_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrcardio.2016.200","article-title":"Long-term neprilysin inhibition\u2014implications for ARNIs","volume":"14","author":"Campbell","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejphar.2020.173727_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2018.00257","article-title":"Neprilysin inhibitors and bradykinin","volume":"5","author":"Campbell","year":"2018","journal-title":"Front. Med."},{"key":"10.1016\/j.ejphar.2020.173727_bib26","series-title":"Ectopeptidases in Tumour Biology: a Review. Histology and Histopathology","author":"Carl-McGrath","year":"2006"},{"key":"10.1016\/j.ejphar.2020.173727_bib27","first-page":"1223","article-title":"The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer","volume":"25","author":"Carl-McGrath","year":"2004","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejphar.2020.173727_bib28","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/carcin\/bgt493","article-title":"The activation of P2Y2 receptors increases MCF-7 breast cancer cells migration through the MEK-ERK1\/2 signalling pathway","volume":"35","author":"Chadet","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejphar.2020.173727_bib29","article-title":"The difficulties in cancer treatment","volume":"6","author":"Chakraborty","year":"2012","journal-title":"ecancermedicalscience"},{"key":"10.1016\/j.ejphar.2020.173727_bib30","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1423-0127-19-94","article-title":"Functional role of post-translational modifications of Sp1 in tumorigenesis","volume":"19","author":"Chang","year":"2012","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejphar.2020.173727_bib31","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.yexcr.2015.04.004","article-title":"(\u2212)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer\u05f3 s disease model mice by upregulating neprilysin expression","volume":"334","author":"Chang","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib32","doi-asserted-by":"crossref","first-page":"29760","DOI":"10.1038\/srep29760","article-title":"Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer\u2019s disease","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2020.173727_bib33","doi-asserted-by":"crossref","first-page":"14160","DOI":"10.1074\/jbc.M116.728980","article-title":"Molecular features of phosphatase and tensin homolog (PTEN) regulation by C-terminal phosphorylation","volume":"291","author":"Chen","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173727_bib34","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1039\/b9pp00168a","article-title":"Oestrogen receptor-\u03b2 signalling protects against transplanted skin tumour growth in the mouse","volume":"9","author":"Cho","year":"2010","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.ejphar.2020.173727_bib35","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2119\/molmed.2014.00105","article-title":"The role of estrogen receptor \u03b2 in prostate cancer","volume":"20","author":"Christoforou","year":"2014","journal-title":"Mol. Med."},{"key":"10.1016\/j.ejphar.2020.173727_bib36","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1164\/ajrccm.159.3.9806062","article-title":"Low neutral endopeptidase levels in bronchoalveolar lavage fluid of lung cancer patients","volume":"159","author":"Cohen","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2020.173727_bib37","first-page":"1370","article-title":"Tumor-suppressive effects of neutral endopeptidase in androgen-independent prostate cancer cells","volume":"7","author":"Dai","year":"2001","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrc.2017.51","article-title":"Microenvironmental regulation of tumour angiogenesis","volume":"17","author":"De Palma","year":"2017","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.ejphar.2020.173727_bib39","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1208\/s12248-014-9605-8","article-title":"Curcumin inhibits the AKT\/NF-\u03baB signaling via CpG demethylation of the promoter and restoration of NEP in the N2a cell line","volume":"16","author":"Deng","year":"2014","journal-title":"AAPS J."},{"key":"10.1016\/j.ejphar.2020.173727_bib40","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tem.2005.07.009","article-title":"Angiotensin receptors: a new role in cancer?","volume":"16","author":"Deshayes","year":"2005","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.ejphar.2020.173727_bib41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40360-019-0304-z","article-title":"Effects of neprilysin-renin inhibition in comparison with neprilysin-angiotensin inhibition on the neurohumoral changes in rats with heart failure","volume":"20","author":"Dizaye","year":"2019","journal-title":"BMC Pharmacology and Toxicology"},{"key":"10.1016\/j.ejphar.2020.173727_bib42","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1172\/JCI114251","article-title":"Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the Guinea pig. Possible role of free radicals","volume":"84","author":"Dusser","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2020.173727_bib43","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2174\/156800911795538048","article-title":"Angiotensin peptides and lung cancer","volume":"11","author":"E Gallagher","year":"2011","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.ejphar.2020.173727_bib44","series-title":"Possible Role of Resveratrol Targeting Estradiol and Neprilysin Pathways in Lipopolysaccharide Model of Alzheimer Disease","first-page":"107","author":"El-Sayed","year":"2015"},{"key":"10.1016\/j.ejphar.2020.173727_bib45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12307-016-0189-y","article-title":"Neuropeptide levels as well as neprilysin activity decrease in renal cell carcinoma","volume":"9","author":"Erin","year":"2016","journal-title":"Cancer Microenvironment"},{"key":"10.1016\/j.ejphar.2020.173727_bib46","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.gendis.2018.06.003","article-title":"Epigenetic mechanisms as a new approach in cancer treatment: an updated review","volume":"5","author":"Fardi","year":"2018","journal-title":"Genes & diseases"},{"key":"10.1016\/j.ejphar.2020.173727_bib47","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1139\/cjpp-2013-0440","article-title":"Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells","volume":"92","author":"Fujiwara","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173727_bib48","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1093\/carcin\/bgh236","article-title":"Inhibition of human lung cancer cell growth by angiotensin-(1-7)","volume":"25","author":"Gallagher","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejphar.2020.173727_bib49","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00002371-199803000-00007","article-title":"Hematopoietic progenitor cells of lymphocytes and dendritic cells","volume":"21","author":"Galy","year":"1998","journal-title":"J. Immunother."},{"key":"10.1016\/j.ejphar.2020.173727_bib50","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1172\/JCI117526","article-title":"CD10\/NEP in non-small cell lung carcinomas. Relationship to cellular proliferation","volume":"94","author":"Ganju","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2020.173727_bib51","first-page":"409","article-title":"Endopeptidase 24.11\/CD10 is down-regulated in renal cell cancer","volume":"2","author":"G\u00f6hring","year":"1998","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2020.173727_bib52","doi-asserted-by":"crossref","first-page":"33597","DOI":"10.1074\/jbc.M602490200","article-title":"Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2","volume":"281","author":"Goodman","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173727_bib53","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000355462","article-title":"Impact of vitamin D on amyloid precursor protein processing and amyloid-\u03b2 peptide degradation in Alzheimer's disease","volume":"13","author":"Grimm","year":"2014","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.ejphar.2020.173727_bib54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11060-018-2786-8","article-title":"Do statins, ACE inhibitors or sartans improve outcome in primary glioblastoma?","volume":"138","author":"Happold","year":"2018","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.ejphar.2020.173727_bib55","doi-asserted-by":"crossref","first-page":"L278","DOI":"10.1152\/ajplung.1995.268.2.L278","article-title":"Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis","volume":"268","author":"Harrison","year":"1995","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ejphar.2020.173727_bib56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/15216540211470","article-title":"The focal adhesion kinase\u2010\u2010a regulator of cell migration and invasion","volume":"53","author":"Hauck","year":"2002","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ejphar.2020.173727_bib57","series-title":"Chronic kidney disease, heart failure and neprilysin inhibition","author":"Haynes","year":"2019"},{"key":"10.1016\/j.ejphar.2020.173727_bib58","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2174\/156720508783954703","article-title":"Neprilysin and amyloid beta peptide degradation","volume":"5","author":"Hersh","year":"2008","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib59","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/jlb.63.3.312","article-title":"CD10 inhibitors increase f\u2010Met\u2010Leu\u2010Phe\u2010induced neutrophil transmigration","volume":"63","author":"Hofman","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejphar.2020.173727_bib60","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/ijc.26028","article-title":"The impact of amyloid precursor protein signalling and histone deacetylase inhibition on neprilysin expression in human prostate cells","volume":"130","author":"Hong","year":"2012","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.ejphar.2020.173727_bib61","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.pcan.4500984","article-title":"Neutral endopeptidase inhibits prostate cancer tumorigenesis by reducing FGF-2-mediated angiogenesis","volume":"11","author":"Horiguchi","year":"2008","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.ejphar.2020.173727_bib62","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/jjco\/hyi076","article-title":"CD10-positive stromal cells in gastric carcinoma: correlation with invasion and metastasis","volume":"35","author":"Huang","year":"2005","journal-title":"Jpn. J. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.ejphar.2020.173727_bib63","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1536\/ihj.19-065","article-title":"Effects of angiotensin receptor neprilysin inhibitors on Inducibility of Ventricular Arrhythmias in rats with ischemic Cardiomyopathy","volume":"60","author":"Huo","year":"2019","journal-title":"Int. Heart J."},{"key":"10.1016\/j.ejphar.2020.173727_bib64","first-page":"1192","article-title":"Adenoviral neutral endopeptidase gene delivery in combination with paclitaxel for the treatment of prostate cancer","volume":"41","author":"Iida","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejphar.2020.173727_bib65","doi-asserted-by":"crossref","first-page":"11898","DOI":"10.1074\/jbc.M212737200","article-title":"Direct binding of neutral endopeptidase 24.11 to ezrin\/radixin\/moesin (ERM) proteins competes with the interaction of CD44 with ERM proteins","volume":"279","author":"Iwase","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173727_bib66","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nrurol.2018.9","article-title":"Clinical implications of PTEN loss in prostate cancer","volume":"15","author":"Jamaspishvili","year":"2018","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.ejphar.2020.173727_bib67","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/ndt\/gfu269","article-title":"Neprilysin inhibition in chronic kidney disease","volume":"30","author":"Judge","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.ejphar.2020.173727_bib68","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.lungcan.2015.06.003","article-title":"Tumoral CD10 expression correlates with high-grade histology and increases risk of recurrence in patients with stage I lung adenocarcinoma","volume":"89","author":"Kadota","year":"2015","journal-title":"Lung Canc."},{"key":"10.1016\/j.ejphar.2020.173727_bib69","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1158\/1078-0432.CCR-04-2395","article-title":"Neutral endopeptidase 24.11\/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo","volume":"11","author":"Kajiyama","year":"2005","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib70","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2174\/156720509789207949","article-title":"A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease","volume":"6","author":"Kalinin","year":"2009","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib71","doi-asserted-by":"crossref","first-page":"15795","DOI":"10.1038\/ncomms15795","article-title":"Corrigendum: Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival","volume":"8","author":"Kang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2020.173727_bib72","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00008390-200206000-00007","article-title":"Differential expression of the CD10 antigen (neutral endopeptidase) in primary versus metastatic malignant melanomas of the skin","volume":"12","author":"Kanitakis","year":"2002","journal-title":"Melanoma Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib73","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00004347-200304000-00010","article-title":"Neutral endopeptidase\/CD10 expression in the stroma of epithelial ovarian carcinoma","volume":"22","author":"Khin","year":"2003","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.ejphar.2020.173727_bib74","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neuropharm.2013.02.006","article-title":"The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction","volume":"70","author":"Klein","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2020.173727_bib75","doi-asserted-by":"crossref","first-page":"102197","DOI":"10.1016\/j.nano.2020.102197","article-title":"Biologicals to direct nanotherapeutics towards HER2-positive breast cancers","author":"Kumar","year":"2020","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.ejphar.2020.173727_bib76","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/gut.2009.178376","article-title":"CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liver","volume":"59","author":"Kuniyasu","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2020.173727_bib77","doi-asserted-by":"crossref","first-page":"81686","DOI":"10.18632\/oncotarget.20970","article-title":"Update on the therapeutic significance of estrogen receptor beta in malignant gliomas","volume":"8","author":"Lan","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2020.173727_bib78","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1016\/j.ddstr.2013.11.002","article-title":"Angiotensin receptor-neprilysin inhibition with LCZ696: a novel approach for the treatment of heart failure","volume":"9","author":"Langenickel","year":"2012","journal-title":"Drug Discov. Today Ther. Strat."},{"key":"10.1016\/j.ejphar.2020.173727_bib79","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/aje\/kwp030","article-title":"Reproductive factors and risk of renal cell cancer: the Nurses' Health Study","volume":"169","author":"Lee","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ejphar.2020.173727_bib80","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2407-14-40","article-title":"Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model\u2013role of tumor stroma cells","volume":"14","author":"Leithner","year":"2014","journal-title":"BMC Canc."},{"key":"10.1016\/j.ejphar.2020.173727_bib81","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1158\/1541-7786.MCR-12-0609","article-title":"Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells","volume":"11","author":"Li","year":"2013","journal-title":"Mol. Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib82","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1074\/jbc.M109.051664","article-title":"Estrogen stimulates degradation of \u03b2-amyloid peptide by up-regulating neprilysin","volume":"285","author":"Liang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173727_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007630","article-title":"The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten","volume":"14","author":"Liang","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ejphar.2020.173727_bib84","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cgh.2012.11.012","article-title":"Association between sex hormones and colorectal cancer risk in men and women","volume":"11","author":"Lin","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2020.173727_bib85","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1158\/1055-9965.2203.13.12","article-title":"Estrogen and risk of gastric cancer: a protective effect in a nationwide cohort study of patients with prostate cancer in Sweden","volume":"13","author":"Lindblad","year":"2004","journal-title":"Cancer Epidemiology and Prevention Biomarkers"},{"key":"10.1016\/j.ejphar.2020.173727_bib86","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.3892\/mmr.2014.2811","article-title":"Estrogen receptor \u03b2 agonist enhances temozolomide sensitivity of glioma cells by inhibiting PI3K\/AKT\/mTOR pathway","volume":"11","author":"Liu","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2020.173727_bib87","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/nrc2228","article-title":"Emerging roles of proteases in tumour suppression","volume":"7","author":"L\u00f3pez-Ot\u00edn","year":"2007","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.ejphar.2020.173727_bib88","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2476842","article-title":"PTEN inhibits cell proliferation, promotes cell apoptosis, and induces cell cycle arrest via downregulating the PI3K\/AKT\/hTERT pathway in lung adenocarcinoma A549 cells","volume":"2016","author":"Lu","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejphar.2020.173727_bib89","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1535-6108(03)00248-4","article-title":"Targeting the PI3K-Akt pathway in human cancer: rationale and promise","volume":"4","author":"Luo","year":"2003","journal-title":"Canc. Cell"},{"key":"10.1016\/j.ejphar.2020.173727_bib90","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1389450114666140106100909","article-title":"Therapeutic targeting of cancers with loss of PTEN function","volume":"15","author":"M Dillon","year":"2014","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejphar.2020.173727_bib91","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/stem.592","article-title":"Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer","volume":"29","author":"Maguer-Satta","year":"2011","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2020.173727_bib92","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.biopha.2017.04.024","article-title":"Neprilysin inhibitors: a new hope to halt the diabetic cardiovascular and renal complications?","volume":"90","author":"Malek","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2020.173727_bib93","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.lfs.2019.02.027","article-title":"Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy","volume":"221","author":"Malek","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2020.173727_bib94","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4251\/wjgo.v6.i3.67","article-title":"Xenoestrogens challenge 17\u03b2-estradiol protective effects in colon cancer","volume":"6","author":"Marino","year":"2014","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.ejphar.2020.173727_bib95","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1040-8428(02)00172-5","article-title":"The role of the CD44\/ezrin complex in cancer metastasis","volume":"46","author":"Martin","year":"2003","journal-title":"Crit. Rev. Oncol.-Hematol."},{"key":"10.1016\/j.ejphar.2020.173727_bib96","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/jcp.22848","article-title":"Targeting of substance P induces cancer cell death and decreases the steady state of EGFR and Her2","volume":"227","author":"Mayordomo","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2020.173727_bib97","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fonc.2015.00024","article-title":"PTEN: multiple functions in human malignant tumors","volume":"5","author":"Milella","year":"2015","journal-title":"Front.Oncol"},{"key":"10.1016\/j.ejphar.2020.173727_bib98","series-title":"Genetic Susceptibility to Lung Cancer, Seminars in Respiratory and Critical Care Medicine","first-page":"197","volume":"vol. 333","author":"Miller","year":"2003"},{"key":"10.1016\/j.ejphar.2020.173727_bib99","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00005-014-0311-0","article-title":"Opioids, neutral endopeptidase, its inhibitors and cancer: is there a relationship among them?","volume":"63","author":"Mizerska-Dudka","year":"2015","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.ejphar.2020.173727_bib100","doi-asserted-by":"crossref","first-page":"13355","DOI":"10.1007\/s13277-016-5248-y","article-title":"Neutral endopeptidase (NEP) is differentially involved in biological activities and cell signaling of colon cancer cell lines derived from various stages of tumor development","volume":"37","author":"Mizerska-Kowalska","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.ejphar.2020.173727_bib101","doi-asserted-by":"crossref","first-page":"39819","DOI":"10.1074\/jbc.M110.161547","article-title":"Neprilysin is Identical to skin fibroblast Elastase its role in skin aging and uv responses","volume":"285","author":"Morisaki","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173727_bib102","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0002-9440(10)64656-1","article-title":"Pten, a protean tumor suppressor","volume":"158","author":"Mutter","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2020.173727_bib103","article-title":"The Alzheimer's amyloid-degrading peptidase, neprilysin: can we control it?","volume":"2012","author":"Nalivaeva","year":"2012","journal-title":"Int. J. Alzheimer's Dis."},{"key":"10.1016\/j.ejphar.2020.173727_bib104","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/PGP.0b013e318064511c","article-title":"CD10 expression in pure stromal and sex cord-stromal tumors of the ovary: an immunohistochemical analysis of 101 cases","volume":"26","author":"Oliva","year":"2007","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.ejphar.2020.173727_bib105","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1158\/1078-0432.CCR-04-0120","article-title":"Neutral endopeptidase protein expression and prognosis in localized prostate cancer","volume":"10","author":"Osman","year":"2004","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib106","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jmb.2009.08.025","article-title":"Structural substrate conditions required for neutral endopeptidase-mediated natriuretic peptide degradation","volume":"393","author":"Pankow","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejphar.2020.173727_bib107","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/MPH.0b013e3181c74aca","article-title":"Is methylation the key to CD10 loss?","volume":"32","author":"Papandreou","year":"2010","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.ejphar.2020.173727_bib108","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1038\/s41598-019-38867-2","article-title":"The circulating form of neprilysin is not a general biomarker for overall survival in treatment-na\u00efve cancer patients","volume":"9","author":"Pavo","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2020.173727_bib109","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1158\/1535-7163.MCT-14-0981","article-title":"Angiotensin-(1-7) decreases cell growth and angiogenesis of human nasopharyngeal carcinoma xenografts","volume":"15","author":"Pei","year":"2016","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.ejphar.2020.173727_bib110","doi-asserted-by":"crossref","first-page":"15004","DOI":"10.1038\/sigtrans.2015.4","article-title":"The role of MicroRNAs in human cancer","volume":"1","author":"Peng","year":"2016","journal-title":"Signal transduction and targeted therapy"},{"key":"10.1016\/j.ejphar.2020.173727_bib111","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0022-3565(25)38250-9","article-title":"Effects of converting enzyme inhibitor and neutral endopeptidase inhibitor on blood pressure and renal function in experimental hypertension","volume":"265","author":"Pham","year":"1993","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2020.173727_bib112","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan5616","article-title":"Targeting the renin-angiotensin system to improve cancer treatment: implications for immunotherapy","volume":"9","author":"Pinter","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejphar.2020.173727_bib113","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41389-018-0027-9","article-title":"Targeting estrogen receptor beta (ER\u03b2) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ER\u03b2 expression and functionality","volume":"7","author":"Pinton","year":"2018","journal-title":"Oncogenesis"},{"key":"10.1016\/j.ejphar.2020.173727_bib114","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1111\/j.1742-4658.2011.08082.x","article-title":"Natriuretic peptide metabolism, clearance and degradation","volume":"278","author":"Potter","year":"2011","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.ejphar.2020.173727_bib115","article-title":"Abstract LB-A33: mitogen activated protein kinase (MAPK) signaling in neprilysin-hypermethylated breast cancer","volume":"17","author":"Reagor","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ejphar.2020.173727_bib116","doi-asserted-by":"crossref","first-page":"12361","DOI":"10.1074\/jbc.274.18.12361","article-title":"Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration","volume":"274","author":"Reiske","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173727_bib117","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nrm1437","article-title":"The co-workers of actin filaments: from cell structures to signals","volume":"5","author":"Revenu","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2020.173727_bib118","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s11897-017-0327-y","article-title":"Potential expanded indications for neprilysin inhibitors","volume":"14","author":"Riddell","year":"2017","journal-title":"Curr. Heart Fail. Rep."},{"key":"10.1016\/j.ejphar.2020.173727_bib119","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1136\/jcp.2005.026328","article-title":"Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma","volume":"58","author":"R\u00f6cken","year":"2005","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.ejphar.2020.173727_bib120","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nm1206","article-title":"Somatostatin regulates brain amyloid \u03b2 peptide A\u03b2 42 through modulation of proteolytic degradation","volume":"11","author":"Saito","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2020.173727_bib121","first-page":"1","article-title":"Neprilysin, the kidney brush border neutral proteinase: a possible potential target for ischemic renal injury","author":"Sankhe","year":"2019","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.ejphar.2020.173727_bib122","doi-asserted-by":"crossref","first-page":"129073","DOI":"10.1016\/j.molstruc.2020.129073","article-title":"Repurposing of existing FDA approved drugs for Neprilysin inhibition: an in-silico study","volume":"1224","author":"Sankhe","year":"2020","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ejphar.2020.173727_bib123","series-title":"Ovarian Cancer G Protein-Coupled Receptor 1 Inhibits A549 Cells Migration through Casein Kinase 2\u03b1 Intronless Gene and Neutral Endopeptidase","first-page":"556720","author":"Sharma","year":"2019"},{"key":"10.1016\/j.ejphar.2020.173727_bib124","doi-asserted-by":"crossref","first-page":"10662","DOI":"10.1073\/pnas.88.23.10662","article-title":"CD10\/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung","volume":"88","author":"Shipp","year":"1991","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.ejphar.2020.173727_bib125","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10549-007-9516-9","article-title":"On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancer","volume":"106","author":"Smollich","year":"2007","journal-title":"Breast Canc. Res. Treat."},{"key":"10.1016\/j.ejphar.2020.173727_bib126","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s13046-019-1359-9","article-title":"Estrogen receptor \u03b2 inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy","volume":"38","author":"Song","year":"2019","journal-title":"J. Exp. Clin. Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib127","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2016.16","article-title":"Epigenetic suppression of neprilysin regulates breast cancer invasion","volume":"5","author":"Stephen","year":"2016","journal-title":"Oncogenesis"},{"key":"10.1016\/j.ejphar.2020.173727_bib128","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nrc3792","article-title":"FAK in cancer: mechanistic findings and clinical applications","volume":"14","author":"Sulzmaier","year":"2014","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.ejphar.2020.173727_bib129","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1535-6108(03)00331-3","article-title":"Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN","volume":"5","author":"Sumitomo","year":"2004","journal-title":"Canc. Cell"},{"key":"10.1016\/j.ejphar.2020.173727_bib130","first-page":"3294","article-title":"Neutral endopeptidase inhibits neuropeptide-mediated transactivation of the insulin-like growth factor receptor-Akt cell survival pathway","volume":"61","author":"Sumitomo","year":"2001","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib131","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bbapap.2004.11.001","article-title":"Involvement of neutral endopeptidase in neoplastic progression","volume":"1751","author":"Sumitomo","year":"2005","journal-title":"Biochim. Biophys. Acta Protein Proteonomics"},{"key":"10.1016\/j.ejphar.2020.173727_bib132","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1172\/JCI10536","article-title":"Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling","volume":"106","author":"Sumitomo","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2020.173727_bib133","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1172\/JCI116145","article-title":"CD10\/neutral endopeptidase 24.11 in developing human fetal lung. Patterns of expression and modulation of peptide-mediated proliferation","volume":"90","author":"Sunday","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2020.173727_bib134","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/2279-042X.132704","article-title":"A comparative study of pre-and post-menopausal breast cancer: risk factors, presentation, characteristics and management","volume":"3","author":"Surakasula","year":"2014","journal-title":"J. Res. Pharm. Pract."},{"key":"10.1016\/j.ejphar.2020.173727_bib135","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fonc.2018.00092","article-title":"Combination therapy with histone deacetylase inhibitors (HDACi) for the treatment of cancer: achieving the full therapeutic potential of HDACi","volume":"8","author":"Suraweera","year":"2018","journal-title":"Front.Oncol"},{"key":"10.1016\/j.ejphar.2020.173727_bib136","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1038\/ncomms3902","article-title":"Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis","volume":"4","author":"Suzuki","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2020.173727_bib137","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/690690","article-title":"Emerging roles of focal adhesion kinase in cancer","volume":"2015","author":"Tai","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejphar.2020.173727_bib138","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000087476","article-title":"Anti-progressive effect of neutral endopeptidase 24.11 (NEP\/CD10) on cervical carcinoma in vitro and in vivo","volume":"69","author":"Terauchi","year":"2005","journal-title":"Oncology"},{"key":"10.1016\/j.ejphar.2020.173727_bib139","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jdermsci.2012.11.003","article-title":"CD10 expression by melanoma cells is associated with aggressive behavior in vitro and predicts rapid metastatic progression in humans","volume":"69","author":"Thomas-Pfaab","year":"2013","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.ejphar.2020.173727_bib140","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10571-014-0138-6","article-title":"Activation of 5-HT 2C receptor promotes the expression of neprilysin in U251 human glioma cells","volume":"35","author":"Tian","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2020.173727_bib141","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/1521-1878(200103)23:3<261::AID-BIES1036>3.0.CO;2-K","article-title":"The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function","volume":"23","author":"Turner","year":"2001","journal-title":"Bioessays"},{"key":"10.1016\/j.ejphar.2020.173727_bib142","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1349-7006.2006.00227.x","article-title":"Methylation of neutral endopeptidase 24.11 promoter in rat hepatocellular carcinoma","volume":"97","author":"Uematsu","year":"2006","journal-title":"Canc. Sci."},{"key":"10.1016\/j.ejphar.2020.173727_bib143","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s13770-016-9089-y","article-title":"Substance P and thiorphan synergically enhance angiogenesis in wound healing","volume":"13","author":"Um","year":"2016","journal-title":"Tissue Eng. Regen. Med."},{"key":"10.1016\/j.ejphar.2020.173727_bib144","first-page":"307","article-title":"Glioblastoma multiforme\u2013an overview","volume":"18","author":"Urba\u0144ska","year":"2014","journal-title":"Contemp. Oncol."},{"key":"10.1016\/j.ejphar.2020.173727_bib145","series-title":"Differential Expression of Neutral endopeptidase-24.11 (Neprilysin) and Endothelin-Converting Enzyme in Human Prostate Cancer Cell Lines","author":"Usmani","year":"2002"},{"key":"10.1016\/j.ejphar.2020.173727_bib146","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/ejhf.232","article-title":"Renal effects of the angiotensin receptor neprilysin inhibitor LCZ696 in patients with heart failure and preserved ejection fraction","volume":"17","author":"Voors","year":"2015","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ejphar.2020.173727_bib147","article-title":"Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons","volume":"6","author":"Wang","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2020.173727_bib148","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pharmthera.2015.03.001","article-title":"PIM kinase (and Akt) biology and signaling in tumors","volume":"151","author":"Warfel","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2020.173727_bib149","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1164\/rccm.201002-0154OC","article-title":"Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease","volume":"183","author":"Wick","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2020.173727_bib150","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuroscience.2017.08.030","article-title":"Epigallocatechin gallate induces extracellular degradation of amyloid \u03b2-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways","volume":"362","author":"Yamamoto","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2020.173727_bib151","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12943-019-0954-x","article-title":"Targeting PI3K in cancer: mechanisms and advances in clinical trials","volume":"18","author":"Yang","year":"2019","journal-title":"Mol. Canc."},{"key":"10.1016\/j.ejphar.2020.173727_bib152","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4103\/0973-1482.183182","article-title":"Cigarette smoke condensate could promote human bronchial epithelial BEAS-2B cell migration through shifting neprilysin trafficking","volume":"14","author":"Yang","year":"2018","journal-title":"J. Canc. Res. Therapeut."},{"key":"10.1016\/j.ejphar.2020.173727_bib153","first-page":"924","article-title":"Enhancement of neutral endopeptidase activity in SK-N-SH cells by ginsenoside Rb1","volume":"29","author":"Yang","year":"2008","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.ejphar.2020.173727_bib154","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40035-017-0089-1","article-title":"The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer\u2019s disease","volume":"6","author":"Yang","year":"2017","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.ejphar.2020.173727_bib155","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2016.9","article-title":"Death receptor 6 (DR6) is required for mouse B16 tumor angiogenesis via the NF-\u03baB, P38 MAPK and STAT3 pathways","volume":"5","author":"Yang","year":"2016","journal-title":"Oncogenesis"},{"key":"10.1016\/j.ejphar.2020.173727_bib156","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/ptr.6305","article-title":"Naringenin promotes microglial M2 polarization and A\u03b2 degradation enzyme expression","volume":"33","author":"Yang","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejphar.2020.173727_bib157","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4062\/biomolther.2012.20.3.245","article-title":"Mechanisms of amyloid-\u03b2 peptide clearance: potential therapeutic targets for Alzheimer\u2019s disease","volume":"20","author":"Yoon","year":"2012","journal-title":"Biomolecules & therapeutics"},{"key":"10.1016\/j.ejphar.2020.173727_bib158","article-title":"Estrogen inhibits renal cell carcinoma cell progression through estrogen receptor-\u03b2 activation","volume":"8","author":"Yu","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2020.173727_bib159","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.intimp.2016.02.015","article-title":"Methionine enkephalin, its role in immunoregulation and cancer therapy","volume":"37","author":"Zhao","year":"2016","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejphar.2020.173727_bib160","doi-asserted-by":"crossref","first-page":"44940","DOI":"10.1038\/srep44940","article-title":"12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT","volume":"7","author":"Zhu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2020.173727_bib161","series-title":"Epigenetic and Pharmacological Regulation of the Amyloid-Degrading Enzyme Neprilysin Results in Modulation of Cognitive Functions in Mammals, Doklady Biological Sciences","first-page":"145","author":"Zhuravin","year":"2011"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920308190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920308190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:11:43Z","timestamp":1762143103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920308190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":161,"alternative-id":["S0014299920308190"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173727","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumour suppression through modulation of neprilysin signaling: A comprehensive review","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173727","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173727"}}