{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:42:16Z","timestamp":1791506536707,"version":"4.3.4"},"reference-count":119,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.ejphar.2020.173749","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T20:44:50Z","timestamp":1606250690000},"page":"173749","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":89,"special_numbering":"C","title":["Crosstalk between endoplasmic reticulum stress and oxidative stress: Focus on protein disulfide isomerase and endoplasmic reticulum oxidase 1"],"prefix":"10.1016","volume":"892","author":[{"given":"Paul","family":"Victor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dronamraju","family":"Sarada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunka Mohanram","family":"Ramkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173749_bib1","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1007\/s00125-010-1699-7","article-title":"Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis","volume":"53","author":"Allagnat","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2020.173749_bib2","series-title":"Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress-Induced Endothelial Dysfunction, Oxidative Medicine and Cellular Longevity","first-page":"4946289","author":"Amodio","year":"2018"},{"key":"10.1016\/j.ejphar.2020.173749_bib3","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1089\/ars.2011.4004","article-title":"Ero1alpha regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM)","volume":"16","author":"Anelli","year":"2012","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2020.173749_bib4","first-page":"533","article-title":"Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma","volume":"14","author":"Aragon-Martin","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.ejphar.2020.173749_bib5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1083\/jcb.201303027","article-title":"Ero1-alpha and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases","volume":"202","author":"Araki","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejphar.2020.173749_bib6","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1021\/ja400427e","article-title":"1,3,5-Triazine as a modular scaffold for covalent inhibitors with streamlined target identification","volume":"135","author":"Banerjee","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejphar.2020.173749_bib7","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1038\/s41467-019-11646-3","article-title":"IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer","volume":"10","author":"Bartok","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2020.173749_bib8","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1074\/jbc.M113.507491","article-title":"The large Hsp70 Grp170 binds to unfolded protein substrates in vivo with a regulation distinct from conventional Hsp70s","volume":"289","author":"Behnke","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173749_bib9","doi-asserted-by":"crossref","first-page":"20993","DOI":"10.1074\/jbc.M110.126599","article-title":"A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity","volume":"285","author":"Blais","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173749_bib10","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1073\/pnas.1701757114","article-title":"ER stress and distinct outputs of the IRE1alpha RNase control proliferation and senescence in response to oncogenic Ras","volume":"114","author":"Blazanin","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2020.173749_bib11","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/ars.2014.5851","article-title":"Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease","volume":"21","author":"Cao","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2020.173749_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020649","article-title":"Genes of the unfolded protein response pathway harbor risk alleles for primary open angle glaucoma","volume":"6","author":"Carbone","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2020.173749_bib13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fnins.2017.00177","article-title":"GRP78 at the centre of the stage in cancer and neuroprotection","volume":"11","author":"Casas","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2020.173749_bib14","doi-asserted-by":"crossref","first-page":"25130","DOI":"10.1074\/jbc.M001914200","article-title":"Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing","volume":"275","author":"Chandel","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173749_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fncel.2014.00213","article-title":"A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress","volume":"8","author":"Chaudhari","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2020.173749_bib16","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1096\/fj.11-184622","article-title":"The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load","volume":"25","author":"Chin","year":"2011","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.ejphar.2020.173749_bib17","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3389\/fnins.2019.00560","article-title":"Linking the endoplasmic reticulum to Parkinson's disease and alpha-synucleinopathy","volume":"13","author":"Colla","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2020.173749_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/cdd.2011.92","article-title":"VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria","volume":"19","author":"De Stefani","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2020.173749_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.immuni.2008.10.018","article-title":"Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer","volume":"30","author":"Dong","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2020.173749_bib20","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1172\/JCI18127","article-title":"Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells","volume":"112","author":"Du","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2020.173749_bib21","first-page":"2965","article-title":"Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca(2)(+) and reactive oxygen species signaling","volume":"126","author":"Eisner","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2020.173749_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2012.08.017","article-title":"Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection","volume":"200","author":"Elanchezhian","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ejphar.2020.173749_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01744","article-title":"Endoplasmic reticulum unfolded protein response, aging and exercise: an update","volume":"9","author":"Est\u00e9banez","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2020.173749_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41420-017-0012-7","article-title":"Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells","volume":"4","author":"Fan","year":"2018","journal-title":"Cell death discovery"},{"key":"10.1016\/j.ejphar.2020.173749_bib25","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s12035-014-8740-7","article-title":"Amyloid-beta disrupts calcium and redox homeostasis in brain endothelial cells","volume":"51","author":"Fonseca","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2020.173749_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1042\/BJ20091954","article-title":"Human pancreas-specific protein disulfide-isomerase (PDIp) can function as a chaperone independently of its enzymatic activity by forming stable complexes with denatured substrate proteins","volume":"429","author":"Fu","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2020.173749_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4331\/wjbc.v9.i1.1","article-title":"Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease","volume":"9","author":"Fujii","year":"2018","journal-title":"World J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173749_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225601","article-title":"Cellular stress-modulating drugs can potentially Be identified by in silico screening with connectivity map (CMap)","volume":"20","author":"Gao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2020.173749_bib29","doi-asserted-by":"crossref","first-page":"a013169","DOI":"10.1101\/cshperspect.a013169","article-title":"Endoplasmic reticulum stress sensing in the unfolded protein response","volume":"5","author":"Gardner","year":"2013","journal-title":"Cold Spring Harbor perspectives in biology"},{"key":"10.1016\/j.ejphar.2020.173749_bib30","first-page":"1466","article-title":"calcium channel blockade ameliorates endoplasmic reticulum stress in the Hippocampus induced by amyloidopathy in the entorhinal cortex","volume":"18","author":"Ghanbari-Maman","year":"2019","journal-title":"Iran. J. Pharm. Res. (IJPR)"},{"key":"10.1016\/j.ejphar.2020.173749_bib31","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/ATVBAHA.118.311038","article-title":"Redox activation of Nox1 (NADPH oxidase 1) involves an intermolecular disulfide bond between protein disulfide isomerase and p47(phox) in vascular smooth muscle cells","volume":"39","author":"Gimenez","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2020.173749_bib32","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1089\/ars.2006.8.1391","article-title":"The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control","volume":"8","author":"Gorlach","year":"2006","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2020.173749_bib33","doi-asserted-by":"crossref","first-page":"107975","DOI":"10.1016\/j.exer.2020.107975","article-title":"Lysyl oxidase like 1: biological roles and regulation","volume":"193","author":"Greene","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2020.173749_bib34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2478\/ersc-2013-0001","article-title":"Protein disulfide isomerase superfamily in disease and the regulation of apoptosis","volume":"1","author":"Grek","year":"2014","journal-title":"Endoplasmic reticulum stress in diseases"},{"key":"10.1016\/j.ejphar.2020.173749_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2131\/jts.36.1","article-title":"Protein disulfide isomerase knockdown-induced cell death is cell-line-dependent and involves apoptosis in MCF-7 cells","volume":"36","author":"Hashida","year":"2011","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.ejphar.2020.173749_bib36","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1074\/jbc.M117.811315","article-title":"Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: overexpression paradigm versus knockin paradigm","volume":"293","author":"Hashimoto","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173749_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9040280","article-title":"The role of hydrogen peroxide and peroxiredoxins throughout the cell cycle","volume":"9","author":"Heo","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2020.173749_bib38","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbrc.2004.04.002","article-title":"Protein disulfide isomerase suppresses the transcriptional activity of NF-kappaB","volume":"318","author":"Higuchi","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2020.173749_bib39","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nchembio.467","article-title":"Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins","volume":"6","author":"Hoffstrom","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejphar.2020.173749_bib40","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.3389\/fimmu.2018.03083","article-title":"The C\/EBP homologous protein (CHOP) transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection","volume":"9","author":"Hu","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2020.173749_bib41","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1111\/febs.13598","article-title":"Cell death induced by endoplasmic reticulum stress","volume":"283","author":"Iurlaro","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2020.173749_bib42","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00281-013-0369-5","article-title":"The role of the unfolded protein response in diabetes mellitus","volume":"35","author":"Iwawaki","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.ejphar.2020.173749_bib43","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1172\/JCI61228","article-title":"Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents","volume":"122","author":"Jasuja","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2020.173749_bib44","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bbrc.2003.10.162","article-title":"Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells","volume":"312","author":"Joe","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2020.173749_bib45","doi-asserted-by":"crossref","first-page":"E2245","DOI":"10.1073\/pnas.1500439112","article-title":"Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective","volume":"112","author":"Kaplan","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2020.173749_bib46","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1021\/cb100387r","article-title":"Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120","volume":"6","author":"Khan","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejphar.2020.173749_bib47","first-page":"5753","article-title":"Combined expression of protein disulfide isomerase and endoplasmic reticulum oxidoreductin 1-alpha is a poor prognostic marker for non-small cell lung cancer","volume":"16","author":"Kim","year":"2018","journal-title":"Oncology letters"},{"key":"10.1016\/j.ejphar.2020.173749_bib48","article-title":"Hypoxia evokes increased PDI and PDIA6 expression in the infarcted myocardium of ex-germ-free and conventionally raised mice","volume":"8","author":"Kiouptsi","year":"2019","journal-title":"Biology open"},{"key":"10.1016\/j.ejphar.2020.173749_bib49","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1111\/j.1742-4658.2010.07793.x","article-title":"A structural overview of the PDI family of proteins","volume":"277","author":"Kozlov","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2020.173749_bib50","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.4049\/jimmunol.1303228","article-title":"Cancer-associated oxidase ERO1-alpha regulates the expression of MHC class I molecule via oxidative folding","volume":"194","author":"Kukita","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2020.173749_bib51","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.redox.2017.05.019","article-title":"HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases","volume":"13","author":"Kung","year":"2017","journal-title":"Redox biology"},{"key":"10.1016\/j.ejphar.2020.173749_bib52","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/cmdc.201700629","article-title":"Discovery and mechanistic elucidation of a class of protein disulfide isomerase inhibitors for the treatment of glioblastoma","volume":"13","author":"Kyani","year":"2018","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejphar.2020.173749_bib53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.stem.2018.10.023","article-title":"Single-cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes","volume":"24","author":"Lang","year":"2019","journal-title":"Cell stem cell"},{"key":"10.1016\/j.ejphar.2020.173749_bib54","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/ars.2015.6402","article-title":"Inhibition of excessive oxidative protein folding is protective in MPP(+) toxicity-induced Parkinson's disease models","volume":"25","author":"Lehtonen","year":"2016","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2020.173749_bib55","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1083\/jcb.200904060","article-title":"Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis","volume":"186","author":"Li","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejphar.2020.173749_bib56","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1161\/ATVBAHA.115.306964","article-title":"Mitochondrial reactive oxygen species mediate lysophosphatidylcholine-induced endothelial cell activation","volume":"36","author":"Li","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2020.173749_bib57","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/abbs\/gmu048","article-title":"New insights into the roles of CHOP-induced apoptosis in ER stress","volume":"46","author":"Li","year":"2014","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.ejphar.2020.173749_bib58","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00204-015-1520-y","article-title":"Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism","volume":"89","author":"Liemburg-Apers","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ejphar.2020.173749_bib59","doi-asserted-by":"crossref","first-page":"23543","DOI":"10.1074\/jbc.M115.666180","article-title":"Quercetin-3-rutinoside inhibits protein disulfide isomerase by binding to its b'x domain","volume":"290","author":"Lin","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173749_bib60","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3389\/fpls.2019.00749","article-title":"Communications between the endoplasmic reticulum and other organelles during abiotic stress response in plants","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.ejphar.2020.173749_bib61","series-title":"NF-kappaB Signaling in Inflammation. Signal Transduction and Targeted Therapy 2","author":"Liu","year":"2017"},{"key":"10.1016\/j.ejphar.2020.173749_bib62","first-page":"2746521","article-title":"Excessive oxidative stress contributes to increased acute ER stress kidney injury in aged mice","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxidative medicine and cellular longevity"},{"key":"10.1016\/j.ejphar.2020.173749_bib63","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0140-6736(17)30544-5","volume":"390","author":"Liu","year":"2017","journal-title":"Cataracts. Lancet"},{"key":"10.1016\/j.ejphar.2020.173749_bib64","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fphys.2019.00070","article-title":"Crosstalk between oxidative stress and endoplasmic reticulum (ER) stress in endothelial dysfunction and aberrant angiogenesis associated with diabetes: a focus on the protective roles of heme oxygenase (HO)-1","volume":"10","author":"Maamoun","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2020.173749_bib65","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1089\/ars.2016.6853","article-title":"Succination of protein disulfide isomerase links mitochondrial stress and endoplasmic reticulum stress in the adipocyte during diabetes","volume":"27","author":"Manuel","year":"2017","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2020.173749_bib66","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ni.1857","article-title":"TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages","volume":"11","author":"Martinon","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejphar.2020.173749_bib67","doi-asserted-by":"crossref","first-page":"40892","DOI":"10.1074\/jbc.M506623200","article-title":"The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria","volume":"280","author":"Mendes","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173749_bib68","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1159\/000447668","article-title":"Endoplasmic reticulum stress is a danger signal promoting innate inflammatory responses in bronchial epithelial cells","volume":"8","author":"Mijosek","year":"2016","journal-title":"Journal of innate immunity"},{"key":"10.1016\/j.ejphar.2020.173749_bib69","doi-asserted-by":"crossref","first-page":"8765","DOI":"10.1007\/s12035-018-1028-6","article-title":"The endoplasmic reticulum stress response in neuroprogressive diseases: emerging pathophysiological role and translational implications","volume":"55","author":"Morris","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2020.173749_bib70","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bcp.2014.02.022","article-title":"Adenanthin targets proteins involved in the regulation of disulphide bonds","volume":"89","author":"Muchowicz","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173749_bib71","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1210\/en.2012-2138","article-title":"Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice","volume":"154","author":"O'Neill","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2020.173749_bib72","doi-asserted-by":"crossref","first-page":"27004","DOI":"10.1074\/jbc.M114.564104","article-title":"Inhibition of the functional interplay between endoplasmic reticulum (ER) oxidoreduclin-1alpha (Ero1alpha) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A","volume":"289","author":"Okumura","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173749_bib73","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/j.bbadis.2014.06.028","article-title":"Selenite cataracts: activation of endoplasmic reticulum stress and loss of Nrf2\/Keap1-dependent stress protection","volume":"1842","author":"Palsamy","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2020.173749_bib74","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.exer.2014.01.021","article-title":"Valproic acid suppresses Nrf2\/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells","volume":"121","author":"Palsamy","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2020.173749_bib75","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cellsig.2019.03.008","article-title":"Activation of PERK-eIF2alpha-ATF4 pathway contributes to diabetic hepatotoxicity: attenuation of ER stress by Morin","volume":"59","author":"Pandey","year":"2019","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejphar.2020.173749_bib76","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fcell.2015.00030","article-title":"Novel roles for protein disulphide isomerase in disease states: a double edged sword?","volume":"3","author":"Parakh","year":"2015","journal-title":"Frontiers in cell and developmental biology"},{"key":"10.1016\/j.ejphar.2020.173749_bib77","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1136\/bjophthalmol-2011-300539","article-title":"Global estimates of visual impairment: 2010","volume":"96","author":"Pascolini","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.ejphar.2020.173749_bib78","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.3389\/fimmu.2019.02053","article-title":"Editorial: producing, sensing and responding to cellular stress in immunity","volume":"10","author":"Paula-Neto","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2020.173749_bib79","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1167\/iovs.14-16220","article-title":"Increased endoplasmic reticulum stress in human glaucomatous trabecular meshwork cells and tissues","volume":"56","author":"Peters","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2020.173749_bib80","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2337\/db06-1601","article-title":"Reactive oxygen species as a signal in glucose-stimulated insulin secretion","volume":"56","author":"Pi","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2020.173749_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.213","article-title":"Protein disulfide isomerase-mediated apoptosis and proliferation of vascular smooth muscle cells induced by mechanical stress and advanced glycosylation end products result in diabetic mouse vein graft atherosclerosis","volume":"8","author":"Ping","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2020.173749_bib82","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-981-10-7757-9_8","article-title":"The SarcoEndoplasmic reticulum calcium ATPase","volume":"87","author":"Primeau","year":"2018","journal-title":"Sub-cellular biochemistry"},{"key":"10.1016\/j.ejphar.2020.173749_bib83","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1038\/emboj.2013.183","article-title":"Toll-like receptor-mediated IRE1alpha activation as a therapeutic target for inflammatory arthritis","volume":"32","author":"Qiu","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2020.173749_bib84","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1042\/BJ20140412","article-title":"C\/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1alpha signalling in acute liver failure","volume":"466","author":"Rao","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2020.173749_bib85","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/dom.13379","article-title":"Effects of proinsulin misfolding on beta-cell dynamics, differentiation and function in diabetes","volume":"20","author":"Riahi","year":"2018","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.ejphar.2020.173749_bib86","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/1566524016666160523143937","article-title":"The role of the PERK\/eIF2alpha\/ATF4\/CHOP signaling pathway in tumor progression during endoplasmic reticulum stress","volume":"16","author":"Rozpedek","year":"2016","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.ejphar.2020.173749_bib87","doi-asserted-by":"crossref","first-page":"8477","DOI":"10.1074\/jbc.M705876200","article-title":"Significance of interactions of low molecular weight crystallin fragments in lens aging and cataract formation","volume":"283","author":"Santhoshkumar","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173749_bib88","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.bbabio.2010.01.005","article-title":"Calcium uptake mechanisms of mitochondria","volume":"1797","author":"Santo-Domingo","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2020.173749_bib89","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.bbamcr.2007.12.011","article-title":"Ero1 and redox homeostasis in the endoplasmic reticulum","volume":"1783","author":"Sevier","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2020.173749_bib90","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.4049\/jimmunol.1302549","article-title":"Cutting edge: endoplasmic reticulum stress licenses macrophages to produce mature IL-1beta in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway","volume":"192","author":"Shenderov","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2020.173749_bib91","doi-asserted-by":"crossref","first-page":"10263","DOI":"10.1021\/acs.jmedchem.0c00728","article-title":"Characterization of aminobenzylphenols as protein disulfide isomerase inhibitors in glioblastoma cell lines","volume":"63","author":"Shergalis","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173749_bib92","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejphar.2017.11.034","article-title":"Quercetin improves endothelial function in diabetic rats through inhibition of endoplasmic reticulum stress-mediated oxidative stress","volume":"819","author":"Suganya","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173749_bib93","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jnutbio.2017.12.012","article-title":"Establishment of pancreatic microenvironment model of ER stress: quercetin attenuates beta-cell apoptosis by invoking nitric oxide-cGMP signaling in endothelial cells","volume":"55","author":"Suganya","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ejphar.2020.173749_bib94","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2337\/diabetes.55.01.06.db05-0894","article-title":"Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy","volume":"55","author":"Susztak","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2020.173749_bib95","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/bjc.2016.105","article-title":"Cancer-associated oxidoreductase ERO1-alpha drives the production of VEGF via oxidative protein folding and regulating the mRNA level","volume":"114","author":"Tanaka","year":"2016","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.ejphar.2020.173749_bib96","doi-asserted-by":"crossref","first-page":"24706","DOI":"10.18632\/oncotarget.14960","article-title":"Cancer-associated oxidoreductase ERO1-alpha promotes immune escape through up-regulation of PD-L1 in human breast cancer","volume":"8","author":"Tanaka","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2020.173749_bib97","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/B978-0-12-385116-1.00003-0","article-title":"The role of PDI as a survival factor in cardiomyocyte ischemia","volume":"489","author":"Toldo","year":"2011","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ejphar.2020.173749_bib98","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature04782","article-title":"S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration","volume":"441","author":"Uehara","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2020.173749_bib99","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/152308603768295113","article-title":"Oxidation of ER resident proteins upon oxidative stress: effects of altering cellular redox\/antioxidant status and implications for protein maturation","volume":"5","author":"van der Vlies","year":"2003","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2020.173749_bib100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2017.02.026","article-title":"Morin activates the Nrf2-ARE pathway and reduces oxidative stress-induced DNA damage in pancreatic beta cells","volume":"801","author":"Vanitha","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173749_bib101","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1002\/jcp.24360","article-title":"Functional and morphological impact of ER stress on mitochondria","volume":"228","author":"Vannuvel","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2020.173749_bib102","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1158\/0008-5472.CAN-15-3099","article-title":"Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma","volume":"76","author":"Vatolin","year":"2016","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2020.173749_bib103","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.canlet.2010.07.016","article-title":"Targeting ER stress induced apoptosis and inflammation in cancer","volume":"332","author":"Verfaillie","year":"2013","journal-title":"Canc. Lett."},{"key":"10.1016\/j.ejphar.2020.173749_bib104","first-page":"671","article-title":"Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review)","volume":"43","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2020.173749_bib105","doi-asserted-by":"crossref","first-page":"78455","DOI":"10.18632\/oncotarget.12925","article-title":"Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2020.173749_bib106","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1046\/j.1523-1755.2001.00991.x","article-title":"Bacitracin inhibits fibronectin matrix assembly by mesangial cells in high glucose","volume":"60","author":"Weston","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2020.173749_bib107","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.redox.2018.09.021","article-title":"Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis","volume":"20","author":"Wu","year":"2019","journal-title":"Redox biology"},{"key":"10.1016\/j.ejphar.2020.173749_bib108","doi-asserted-by":"crossref","first-page":"16348","DOI":"10.1073\/pnas.1205226109","article-title":"Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment","volume":"109","author":"Xu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2020.173749_bib109","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.7150\/thno.30621","article-title":"Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes","volume":"9","author":"Xu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.ejphar.2020.173749_bib110","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.3389\/fimmu.2017.01612","article-title":"Transcription factor C\/EBP homologous protein in health and diseases","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2020.173749_bib111","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S1097-2765(00)00133-7","article-title":"ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs","volume":"6","author":"Ye","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejphar.2020.173749_bib112","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3390\/ijms17030327","article-title":"Endoplasmic reticulum stress and associated ROS","volume":"17","author":"Zeeshan","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2020.173749_bib113","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2020.173749_bib114","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2005.11.040","article-title":"Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response","volume":"124","author":"Zhang","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2020.173749_bib115","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1074\/jbc.M805477200","article-title":"GRP78, but not protein-disulfide isomerase, partially reverses hyperglycemia-induced inhibition of insulin synthesis and secretion in pancreatic {beta}-Cells","volume":"284","author":"Zhang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173749_bib116","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ebiom.2019.02.041","article-title":"Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1alpha and protein disulfide isomerase suppresses the progression of cervical cancer","volume":"41","author":"Zhang","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ejphar.2020.173749_bib117","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1093\/hmg\/ddy061","article-title":"Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease","volume":"27","author":"Zhou","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2020.173749_bib118","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1083\/jcb.200911086","article-title":"ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis","volume":"188","author":"Zito","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejphar.2020.173749_bib119","first-page":"501","article-title":"P4HB and PDIA3 are associated with tumor progression and therapeutic outcome of diffuse gliomas","volume":"39","author":"Zou","year":"2018","journal-title":"Oncol. Rep."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920308414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920308414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:43:22Z","timestamp":1757976202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920308414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":119,"alternative-id":["S0014299920308414"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173749","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crosstalk between endoplasmic reticulum stress and oxidative stress: Focus on protein disulfide isomerase and endoplasmic reticulum oxidase 1","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173749","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173749"}}