{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T21:22:22Z","timestamp":1758057742196,"version":"3.44.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ejphar.2020.173767","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T01:59:14Z","timestamp":1606787954000},"page":"173767","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Cannabidiol selectively inhibits the contraction of rat small resistance arteries: Possible role for CGRP and voltage-gated calcium channels"],"prefix":"10.1016","volume":"891","author":[{"given":"Amna C.","family":"Mazeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Angus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine E.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2019","series-title":"Cannabinoid receptors (version 2019.4) in the IUPHAR\/BPS Guide to Pharmacology Database","author":"Abood","key":"10.1016\/j.ejphar.2020.173767_bib1"},{"key":"10.1016\/j.ejphar.2020.173767_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.374","article-title":"Distortion of KB estimates of endothelin-1 ETA and ETB receptor antagonists in pulmonary arteries: possible role of an endothelin-1 clearance mechanism","volume":"5","author":"Angus","year":"2017","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.ejphar.2020.173767_bib3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1056-8719(00)00121-0","article-title":"Techniques to study the pharmacodynamics of isolated large and small blood vessels","volume":"44","author":"Angus","year":"2000","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.ejphar.2020.173767_bib4","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/HJH.0000000000002333","article-title":"Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities","volume":"38","author":"Baranowska-Kuczko","year":"2020","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ejphar.2020.173767_bib5","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1111\/bph.12866","article-title":"Endothelial atypical cannabinoid receptor: do we have enough evidence?","volume":"171","author":"Bondarenko","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173767_bib6","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/sj.bjp.0703930","article-title":"Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens","volume":"132","author":"Christopoulos","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173767_bib7","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1056\/NEJMoa1611618","article-title":"Trial of cannabidiol for drug-resistant seizures in the Dravet syndrome","volume":"376","author":"Devinsky","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2020.173767_bib8","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJMoa1714631","article-title":"Effect of cannabidiol on drop seizures in the Lennox-Gastaut syndrome","volume":"378","author":"Devinsky","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2020.173767_bib9","doi-asserted-by":"crossref","first-page":"e1204","DOI":"10.1212\/WNL.0000000000005254","article-title":"Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome","volume":"90","author":"Devinsky","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2020.173767_bib10","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/epi.13060","article-title":"Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy","volume":"56","author":"Geffrey","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2020.173767_bib11","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/sj.bjp.0705160","article-title":"Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery","volume":"138","author":"Ho","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173767_bib12","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93760","article-title":"A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study","volume":"2","author":"Jadoon","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2020.173767_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejmech.2017.09.056","article-title":"Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities","volume":"141","author":"Kassab","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173767_bib14","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3389\/fphys.2019.00821","article-title":"Protective role of \u03b1-calcitonin gene-related peptide in cardiovascular diseases","volume":"10","author":"Kumar","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2020.173767_bib15","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1021\/bi0159581","article-title":"Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662","volume":"41","author":"Leesnitzer","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2020.173767_bib16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2202-11-44","article-title":"N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor","volume":"11","author":"McHugh","year":"2010","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.ejphar.2020.173767_bib17","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1111\/j.1476-5381.2012.02129.x","article-title":"Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries","volume":"167","author":"McNeish","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173767_bib18","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/bph.12944","article-title":"Are cannabidiol and Delta(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review","volume":"172","author":"McPartland","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173767_bib19","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1002\/j.1552-4604.2002.tb05998.x","article-title":"Cannabidiol: an overview of some pharmacological aspects","volume":"42","author":"Mechoulam","year":"2002","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173767_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejphar.2009.03.010","article-title":"Time-dependent vascular actions of cannabidiol in the rat aorta","volume":"612","author":"O'Sullivan","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173767_bib21","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1124\/mol.63.3.699","article-title":"Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor","volume":"63","author":"Offertaler","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173767_bib22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/sj.bjp.0705725","article-title":"The complexities of the cardiovascular actions of cannabinoids","volume":"142","author":"Randall","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173767_bib23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.vph.2017.02.001","article-title":"Binding and functional pharmacological characteristics of gepant-type antagonists in rat brain and mesenteric arteries","volume":"90","author":"Sheykhzade","year":"2017","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173767_bib24","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/cvr\/cvv179","article-title":"Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation","volume":"107","author":"Stanley","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2020.173767_bib25","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ejphar.2013.10.002","article-title":"Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes","volume":"720","author":"Stanley","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173767_bib26","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature02732","article-title":"The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels","volume":"430","author":"Voets","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2020.173767_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1124\/jpet.114.217125","article-title":"Cannabidiol improves vasorelaxation in Zucker diabetic fatty rats through cyclooxygenase activation","volume":"351","author":"Wheal","year":"2014","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2020.173767_bib28","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fphar.2017.00248","article-title":"In vivo cannabidiol treatment improves endothelium-dependent vasorelaxation in mesenteric arteries of Zucker diabetic fatty rats","volume":"8","author":"Wheal","year":"2017","journal-title":"Front. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920308591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920308591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:41:53Z","timestamp":1757976113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920308591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":28,"alternative-id":["S0014299920308591"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173767","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabidiol selectively inhibits the contraction of rat small resistance arteries: Possible role for CGRP and voltage-gated calcium channels","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173767","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173767"}}