{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:55:40Z","timestamp":1780322140239,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100017128","name":"Natural Science Foundation for Distinguished Young Scholars of Anhui Province","doi-asserted-by":"publisher","award":["1908085J30"],"award-info":[{"award-number":["1908085J30"]}],"id":[{"id":"10.13039\/100017128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["0601037104"],"award-info":[{"award-number":["0601037104"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["0601037206"],"award-info":[{"award-number":["0601037206"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2019xkjT015"],"award-info":[{"award-number":["2019xkjT015"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["20810366050"],"award-info":[{"award-number":["20810366050"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014215","name":"Huxiang Youth Talent Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014215","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.ejphar.2020.173816","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T03:53:42Z","timestamp":1608263622000},"page":"173816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The interaction of ASIC1a and ERS mediates nerve cell apoptosis induced by insulin deficiency"],"prefix":"10.1016","volume":"893","author":[{"given":"Xuesheng","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2020.173816_bib1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1073\/pnas.69.1.258","article-title":"Neurotransmitter synthesis by neuroblastoma clones (neuroblast differentiation-cell culture-choline acetyltransferase-acetylcholinesterase-tyrosine hydroxylase-axons-dendrites)","volume":"69","author":"Amano","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2020.173816_bib2","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3389\/fphar.2019.00977","article-title":"Endoplasmic reticulum stress activates unfolded protein response signaling and mediates inflammation, obesity, and cardiac dysfunction: therapeutic and molecular approach","volume":"10","author":"Amen","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173816_bib3","first-page":"7869318","article-title":"Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in diabetes mellitus by inhibiting endoplasmic reticulum stress","author":"J","year":"2019","journal-title":"Journal of diabetes research"},{"key":"10.1016\/j.ejphar.2020.173816_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bbi.2016.05.010","article-title":"The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise","volume":"57","author":"Cai","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2020.173816_bib5","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.exphem.2004.08.014","article-title":"Protein partners of C\/EBPepsilon","volume":"32","author":"Chih","year":"2004","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.ejphar.2020.173816_bib6","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1159\/000443071","article-title":"Pterostilbene inhibits the growth of human esophageal cancer cells by regulating endoplasmic reticulum stress","volume":"38","author":"Feng","year":"2016","journal-title":"Cell. Physiol. Biochem. : international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"key":"10.1016\/j.ejphar.2020.173816_bib7","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/emboj.2008.67","article-title":"Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis","volume":"27","author":"Fritzius","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2020.173816_bib8","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1182\/blood-2003-10-3688","article-title":"Retinoic acid regulates C\/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes","volume":"104","author":"Gery","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2020.173816_bib9","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s41419-018-0593-y","article-title":"Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N-acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress","volume":"9","author":"He","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2020.173816_bib10","doi-asserted-by":"crossref","first-page":"14393","DOI":"10.1074\/jbc.RA117.001032","article-title":"TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis","volume":"293","author":"Huang","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173816_bib11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.chemosphere.2019.04.026","article-title":"Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: activation of ROS-mediated ERS, apoptosis and the Nrf 2 pathway","volume":"227","author":"Jia","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ejphar.2020.173816_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fcell.2020.00177","article-title":"Adipose-derived stem cells protect ischemia-reperfusion and partial hepatectomy by attenuating endoplasmic reticulum stress","volume":"8","author":"Jiao","year":"2020","journal-title":"Frontiers in cell and developmental biology"},{"key":"10.1016\/j.ejphar.2020.173816_bib13","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2337\/db14-1052","article-title":"Absence of glucagon and insulin action reveals a role for the GLP-1 receptor in endogenous glucose production","volume":"64","author":"Jun","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2020.173816_bib14","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00401-017-1733-7","article-title":"Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits","volume":"134","author":"Lacampagne","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejphar.2020.173816_bib15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1172\/JCI29528","article-title":"Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2","volume":"117","author":"Le Bacquer","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2020.173816_bib16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","article-title":"IRE1\u03b1 induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress","volume":"16","author":"Lerner","year":"2012","journal-title":"Cell Metabol."},{"key":"10.1016\/j.ejphar.2020.173816_bib17","doi-asserted-by":"crossref","first-page":"12357","DOI":"10.1021\/acsnano.8b06322","article-title":"Mitochondria-targeted DNA nanoprobe for real-time imaging and simultaneous quantification of Ca and pH in neurons","volume":"12","author":"Liu","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejphar.2020.173816_bib18","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1053\/j.gastro.2017.08.036","article-title":"The combination of alcohol and cigarette smoke induces endoplasmic reticulum stress and cell death in pancreatic acinar cells","volume":"153","author":"Lugea","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2020.173816_bib19","doi-asserted-by":"crossref","first-page":"8192","DOI":"10.1021\/acs.jmedchem.7b01072","article-title":"Molecular basis for allosteric inhibition of acid-sensing ion channel 1a by ibuprofen","volume":"60","author":"Lynagh","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2020.173816_bib20","doi-asserted-by":"crossref","first-page":"43748","DOI":"10.1074\/jbc.M108594200","article-title":"Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons","volume":"276","author":"Nakamura","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2020.173816_bib21","doi-asserted-by":"crossref","first-page":"E7469","DOI":"10.1073\/pnas.1807233115","article-title":"Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death","volume":"115","author":"Qiang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2020.173816_bib22","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1038\/s41467-019-11498-x","article-title":"S100A9 extends lifespan in insulin deficiency","volume":"10","author":"Ramadori","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2020.173816_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21062103","article-title":"Immunotherapy strategies for the prevention and treatment of distinct stages of type 1 diabetes: an overview","volume":"21","author":"Rapini","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2020.173816_bib24","doi-asserted-by":"crossref","first-page":"e766","DOI":"10.1038\/cddis.2013.295","article-title":"Insulin concentration is critical in culturing human neural stem cells and neurons","volume":"4","author":"Rhee","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2020.173816_bib25","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1101\/gad.6.3.439","article-title":"CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C\/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription","volume":"6","author":"Ron","year":"1992","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejphar.2020.173816_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51111","article-title":"\u03b211-12 linker isomerization governs acid-sensing ion channel desensitization and recovery","volume":"9","author":"Rook","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.ejphar.2020.173816_bib27","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1172\/JCI120843","article-title":"Altered mitochondrial function in insulin-deficient and insulin-resistant states","volume":"128","author":"Ruegsegger","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2020.173816_bib28","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1096\/fj.201802043R","article-title":"Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes","volume":"33","author":"Ruegsegger","year":"2019","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.ejphar.2020.173816_bib29","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-019-1551-2","article-title":"DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome","volume":"573","author":"Samir","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2020.173816_bib30","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1016\/j.drudis.2019.08.003","article-title":"ER stress response mediates diabetic microvascular complications","volume":"24","author":"Sankrityayan","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejphar.2020.173816_bib31","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1124\/mol.117.110064","article-title":"Diminazene is a slow pore blocker of acid-sensing ion channel 1a (ASIC1a)","volume":"92","author":"Schmidt","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2020.173816_bib32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1161\/CIRCRESAHA.119.315925","article-title":"Neuronal ASIC1A as a cerebral pH sensor: bringing the flow","volume":"125","author":"Stark","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2020.173816_bib33","doi-asserted-by":"crossref","first-page":"104728","DOI":"10.1016\/j.neuint.2020.104728","article-title":"Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose via regulating endoplasmic reticulum","volume":"136","author":"Tang","year":"2020","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2020.173816_bib34","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12974-015-0465-7","article-title":"Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons","volume":"12","author":"Wang","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2020.173816_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau3075","article-title":"Fear extinction requires ASIC1a-dependent regulation of hippocampal-prefrontal correlates","volume":"4","author":"Wang","year":"2018","journal-title":"Science advances"},{"key":"10.1016\/j.ejphar.2020.173816_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2018.10.003","article-title":"ASIC1a promotes high glucose and PDGF-induced hepatic stellate cell activation by inducing autophagy through CaMKK\u03b2\/ERK signaling pathway","volume":"300","author":"Wang","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejphar.2020.173816_bib37","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s10495-019-01566-4","article-title":"Rotenone protects against \u03b2-cell apoptosis and attenuates type 1 diabetes mellitus","volume":"24","author":"Wu","year":"2019","journal-title":"Apoptosis : an international journal on programmed cell death"},{"key":"10.1016\/j.ejphar.2020.173816_bib38","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2004.08.026","article-title":"Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels","volume":"118","author":"Xiong","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2020.173816_bib39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/cns.12979","article-title":"Subtype-selective inhibition of acid-sensing ion channel 3 by a natural flavonoid","volume":"25","author":"Yan","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ejphar.2020.173816_bib40","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1161\/STROKEAHA.119.025940","article-title":"\u03b2-Estradiol protects against acidosis-mediated and ischemic neuronal injury by promoting ASIC1a (Acid-Sensing ion channel 1a) protein degradation","volume":"50","author":"Zhou","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2020.173816_bib41","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1177\/0022034516640206","article-title":"Ca2+-Dependent endoplasmic reticulum stress regulates mechanical stress-mediated cartilage thinning","volume":"95","author":"Zhu","year":"2016","journal-title":"JDR (J. Dent. Res.)"},{"key":"10.1016\/j.ejphar.2020.173816_bib42","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202001337R","article-title":"ASIC1a regulates miR-350\/SPRY2 by N -methyladenosine to promote liver fibrosis","author":"Zhu","year":"2020","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.ejphar.2020.173816_bib43","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1111\/jcmm.14275","article-title":"PI3-kinase\/Akt pathway-regulated membrane transportation of acid-sensing ion channel 1a\/Calcium ion influx\/endoplasmic reticulum stress activation on PDGF-induced HSC Activation","volume":"23","author":"Zuo","year":"2019","journal-title":"J. Cell Mol. Med."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920309213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299920309213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:12:13Z","timestamp":1762143133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299920309213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":43,"alternative-id":["S0014299920309213"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173816","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interaction of ASIC1a and ERS mediates nerve cell apoptosis induced by insulin deficiency","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173816","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173816"}}