{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:14:28Z","timestamp":1762143268207,"version":"build-2065373602"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471314","81720108013"],"award-info":[{"award-number":["81471314","81720108013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20140243"],"award-info":[{"award-number":["BK20140243"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.ejphar.2021.173979","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T11:28:44Z","timestamp":1614166124000},"page":"173979","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The synergistic effects of opioid and neuropeptide B\/W in rat acute inflammatory and neuropathic pain models"],"prefix":"10.1016","volume":"898","author":[{"given":"Yanhong","family":"Xing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqiu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mannan","family":"Abdul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei-Fei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8036-698X","authenticated-orcid":false,"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.173979_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejphar.2018.07.056","article-title":"Synergistic action of ursolic acid and metformin in experimental model of insulin resistance and related behavioral alterations","volume":"835","author":"Ashish","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173979_bib2","doi-asserted-by":"crossref","first-page":"33847","DOI":"10.1074\/jbc.M101535200","article-title":"mu-Opioid receptor-mediated ERK activation involves calmodulindependent epidermal growth factor receptor transactivation","volume":"276","author":"Belcheva","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.173979_bib3","doi-asserted-by":"crossref","first-page":"27662","DOI":"10.1074\/jbc.M502593200","article-title":"Mu and kappa opioid receptors activate ERK\/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes","volume":"280","author":"Belcheva","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.173979_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2021.173979_bib5","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1097\/00001756-199510010-00007","article-title":"Characterization of the antiallodynic efficacy of morphine in amodel of neuropathic pain in rats","volume":"6","author":"Bian","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2021.173979_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ejphar.2021.173979_bib7","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.jhep.2018.07.004","article-title":"Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer","volume":"69","author":"Cun","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2021.173979_bib8","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0006-2952(00)00296-3","article-title":"Shifts in the affinity distribution of one class of seven-transmembrane receptors by activation of a separate class of seven-transmembrane receptors","volume":"59","author":"Djellas","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173979_bib9","doi-asserted-by":"crossref","first-page":"34010","DOI":"10.1074\/jbc.M205883200","article-title":"Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7","volume":"277","author":"Fujii","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.173979_bib10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ejp.1343","article-title":"Effects of glial glutamate transporter activator in formalin-induced pain behaviour in mice","volume":"23","author":"Ghallab","year":"2019","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ejphar.2021.173979_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuropharm.2016.12.008","article-title":"Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists","volume":"116","author":"Grenald","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2021.173979_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuropharm.2016.12.008","article-title":"Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists","volume":"116","author":"Grenald","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2021.173979_bib15","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/bja\/aes306","article-title":"Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain","volume":"109","author":"Hahm","year":"2012","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.ejphar.2021.173979_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0165-0270(85)90116-5","article-title":"Formalin test in mice, a useful technique for evaluating mild analgesics","volume":"14","author":"Hunskaar","year":"1985","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ejphar.2021.173979_bib17","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/00002508-200207001-00002","article-title":"Clinical pharmacology of opioids for pain","volume":"18","author":"Inturrisi","year":"2002","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.ejphar.2021.173979_bib18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/cne.20989","article-title":"A study of the rat neuropeptide B\/neuropeptide W system using in situ techniques","volume":"497","author":"Jackson","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ejphar.2021.173979_bib19","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0306-4530(02)00108-7","article-title":"Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change","volume":"28","author":"Jens","year":"2003","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ejphar.2021.173979_bib20","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1111\/bph.13534","article-title":"Opioid and cannabinoid synergy in a mouse neuropathic pain model","volume":"173","author":"Kazantzis","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173979_bib22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.brainres.2007.10.070","article-title":"Modulation of extracellular signal-regulated kinase (ERK) by opioid and cannabinoid receptors that are expressed in the same cell","volume":"1189","author":"Korzh","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2021.173979_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1124\/jpet.113.205245","article-title":"Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects","volume":"347","author":"Largent-Milnes","year":"2013","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2021.173979_bib24","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1111\/bph.13489","article-title":"BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice","volume":"173","author":"Li","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173979_bib25","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.pain.2010.05.002","article-title":"Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes","volume":"150","author":"Maier","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2021.173979_bib27","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/sj.bjp.0704599","article-title":"Neostigmine interactions with non steroidal anti-inflammatory drugs","volume":"135","author":"Miranda","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173979_bib28","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.pbb.2007.10.005","article-title":"Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain","volume":"88","author":"Miranda","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2021.173979_bib29","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1210\/en.2003-0536","article-title":"A role for neuropeptide W in the regulation of feeding behavior","volume":"144","author":"Mondal","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2021.173979_bib30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.bcp.2010.12.007","article-title":"The N-terminal domain of human hemokinin-1 influences functional selectivity property for tachykinin receptor neurokinin-1","volume":"81","author":"Mou","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173979_bib31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1023\/A:1010923820109","article-title":"Interaction between the antinociceptive effect of ketoprofen and adrenergic modulatory systems","volume":"25","author":"Pinardi","year":"2001","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2021.173979_bib32","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1200\/JCO.2013.52.5188","article-title":"Principles of opioid use in cancer pain","volume":"32","author":"Portenoy","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2021.173979_bib33","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1523\/JNEUROSCI.21-03-00823.2001","article-title":"Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat Caudate putamen nucleus","volume":"21","author":"Rodrigue","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.173979_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2013.00023","article-title":"NPBWR1 and NPBWR2: implications in energy homeostasis, pain, and emotion","volume":"4","author":"Sakurai","year":"2013","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejphar.2021.173979_bib35","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1097\/00001756-200112040-00017","article-title":"CB1-cannabinoid and mu-opioid receptor co-localization on postsynaptic target in the rat dorsal horn","volume":"12","author":"Salio","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2021.173979_bib36","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.lfs.2009.02.025","article-title":"Bi- or multifunctional opioid peptide drugs","volume":"86","author":"Schiller","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2021.173979_bib37","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.neuropharm.2006.05.019","article-title":"Interactions between CB1 cannabinoid and mu opioid receptors mediating inhibition of neurotransmitter release in rat nucleus accumbens","volume":"51","author":"Schoffelmeer","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2021.173979_bib38","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuropharm.2012.06.046","article-title":"AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid\/cannabinoid interaction studies","volume":"63","author":"Seely","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2021.173979_bib39","doi-asserted-by":"crossref","first-page":"35826","DOI":"10.1074\/jbc.M205337200","article-title":"Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8","volume":"277","author":"Shimomura","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.173979_bib40","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.regpep.2012.03.004","article-title":"Neuropeptide B and W regulate leptin and resistin secretion, and stimulate lipolysis in isolated rat adipocytes","volume":"176","author":"Skrzypski","year":"2012","journal-title":"Regul. Pept."},{"key":"10.1016\/j.ejphar.2021.173979_bib41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ejphar.2013.01.076","article-title":"Opioids, sensory systems and chronic pain","volume":"716","author":"Stein","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173979_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109903","article-title":"Morphine and clonidine combination therapy improves therapeutic window in mice: synergy in antinociceptive but not in sedative or cardiovascular effects","volume":"9","author":"Stone","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2021.173979_bib43","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1749-6632.2010.05642.x","article-title":"Neuropeptide W: a key player in the homeostatic regulation of feeding and energy metabolism?","volume":"1200","author":"Takenoya","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2021.173979_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.106.104117","article-title":"An overview of drug combination analysis with isobolograms","volume":"319","author":"Tallarida","year":"2006","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2021.173979_bib45","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pharmthera.2010.04.011","article-title":"The application of drug dose equivalence in the quantitative analysis of receptor occupation and drug combinations","volume":"127","author":"Tallarida","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2021.173979_bib46","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1073\/pnas.0837789100","article-title":"Characterization of a family of endogenous neuropeptide ligands for the G proteincoupled receptors GPR7 and GPR8","volume":"100","author":"Tanaka","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejphar.2021.173979_bib47","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/sj.bjp.0706045","article-title":"Synergistic and additive interactions of the cannabinoid agonist CP55,940 with l opioid receptor and a2-adrenoceptor agonists in acute pain models in mice","volume":"144","author":"Tham","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173979_bib49","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/ALN.0b013e3181c6316e","article-title":"Improving postoperative pain management: what are the unresolved issues?","volume":"112","author":"White","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2021.173979_bib50","doi-asserted-by":"crossref","first-page":"172909","DOI":"10.1016\/j.ejphar.2020.172909","article-title":"The intraperitoneal administration of MOTS-c produces antinociceptive and anti-inflammatory effects through the activation of AMPK pathway in the mouse formalin test","volume":"870","author":"Xinqiang","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173979_bib51","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainres.2005.03.027","article-title":"Anti-hyperalgesic effects of intrathecally administered neuropeptide W-23, and neuropeptide B, in tests of inflammatory pain in rats","volume":"1045","author":"Yamamoto","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2021.173979_bib52","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuroscience.2005.08.066","article-title":"Effect of intrathecal and I.C.V. administration of neuropeptide W-23 and neuropeptide B on the mechanical allodynia induced by partical sciatic nerve ligation in rats","volume":"137","author":"Yamamoto","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2021.173979_bib53","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/mp400749f","article-title":"Synergistic induction of apoptosis by methylseleninic acid and cisplatin, the role of ROS-ERK\/AKT-p53 pathway","volume":"11","author":"Yibo","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejphar.2021.173979_bib56","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-3-540-33823-9_2","volume":"177","author":"Z\u00f6llner","year":"2007","journal-title":"Opioids. Handb. Exp. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921001321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921001321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:12:20Z","timestamp":1762143140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921001321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":49,"alternative-id":["S0014299921001321"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.173979","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The synergistic effects of opioid and neuropeptide B\/W in rat acute inflammatory and neuropathic pain models","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.173979","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173979"}}