{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:07:43Z","timestamp":1790885263551,"version":"4.1.0"},"reference-count":124,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.ejphar.2021.173989","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T09:46:20Z","timestamp":1614505580000},"page":"173989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Mechanisms of the antiangiogenic effects of aspirin in cancer"],"prefix":"10.1016","volume":"898","author":[{"given":"Shiyuan","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youqiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.173989_bib1","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1111\/j.1349-7006.2009.01322.x","article-title":"Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis","volume":"100","author":"Amano","year":"2009","journal-title":"Canc. Sci."},{"key":"10.1016\/j.ejphar.2021.173989_bib2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.matbio.2017.04.002","article-title":"The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis","volume":"64","author":"Andreuzzi","year":"2017","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ejphar.2021.173989_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fonc.2013.00211","article-title":"Vascular permeability and drug delivery in cancers","volume":"3","author":"Azzi","year":"2013","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejphar.2021.173989_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.gde.2004.12.005","article-title":"Cellular abnormalities of blood vessels as targets in cancer","volume":"15","author":"Baluk","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ejphar.2021.173989_bib5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1538-7836.2010.04131.x","article-title":"The platelet contribution to cancer progression","volume":"9","author":"Bambace","year":"2011","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.ejphar.2021.173989_bib6","doi-asserted-by":"crossref","first-page":"13030","DOI":"10.1073\/pnas.1709119114","article-title":"Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer","volume":"114","author":"Basudhar","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2021.173989_bib7","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1182\/blood-2011-02-334524","article-title":"Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis","volume":"118","author":"Battinelli","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2021.173989_bib8","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1161\/CIRCULATIONAHA.108.191087","article-title":"ACCF\/ACG\/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents","volume":"118","author":"Bhatt","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2021.173989_bib9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/PPO.0000000000000138","article-title":"The Contribution of angiogenesis to the process of metastasis","volume":"21","author":"Bielenberg","year":"2015","journal-title":"Canc. J. (Sudbury, Mass.)"},{"key":"10.1016\/j.ejphar.2021.173989_bib10","first-page":"1508","article-title":"Effects of selective COX-inhibitors and classical NSAIDs on endothelial cell proliferation and migration induced by human cholangiocarcinoma cell culture","volume":"92","author":"Boonmasawai","year":"2009","journal-title":"J. Med. Assoc. Thai."},{"key":"10.1016\/j.ejphar.2021.173989_bib11","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1096\/fj.06-5987com","article-title":"Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism","volume":"20","author":"Borthwick","year":"2006","journal-title":"Faseb. J."},{"key":"10.1016\/j.ejphar.2021.173989_bib12","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jamaoncol.2015.6396","article-title":"Population-wide impact of long-term use of aspirin and the risk for cancer","volume":"2","author":"Cao","year":"2016","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ejphar.2021.173989_bib13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrd3455","article-title":"Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases","volume":"10","author":"Carmeliet","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"issue":"10","key":"10.1016\/j.ejphar.2021.173989_bib14","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1517\/13543776.2015.1056736","article-title":"5-Fluorouracil derivatives: a patent review (2012 - 2014)","volume":"25","author":"Carrillo","year":"2015","journal-title":"Expert Opin. Ther. Pat."},{"issue":"2","key":"10.1016\/j.ejphar.2021.173989_bib15","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/vco.12206","article-title":"High COX-2 expression is associated with increased angiogenesis, proliferation and tumoural inflammatory infiltrate in canine malignant mammary tumours: a multivariate survival study","volume":"15","author":"Carvalho","year":"2017","journal-title":"Vet. Comp. Oncol."},{"key":"10.1016\/j.ejphar.2021.173989_bib16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/sj.onc.1209002","article-title":"Aspirin-triggered Lipoxin A4 inhibition of VEGF-induced endothelial cell migration involves actin polymerization and focal adhesion assembly","volume":"25","author":"Cezar-de-Mello","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2021.173989_bib17","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/sj.bjp.0707650","article-title":"ATL-1, an analogue of aspirin-triggered lipoxin A 4, is a potent inhibitor of several steps in angiogenesis induced by vascular endothelial growth factor","volume":"153","author":"Cezar-de-Mello","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173989_bib18","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/ATVBAHA.116.308587","article-title":"E-prostanoid 3 receptor mediates sprouting angiogenesis through suppression of the protein kinase A\/\u03b2-catenin\/notch pathway","volume":"37","author":"Chen","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2021.173989_bib19","first-page":"S1471","article-title":"Permeability of the endothelial barrier: identifying and reconciling controversies","volume":"10","author":"Claesson-Welsh","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejphar.2021.173989_bib20","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1073\/pnas.0900244106","article-title":"The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells","volume":"106","author":"Coffelt","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.ejphar.2021.173989_bib21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1538-7836.2011.04356.x","article-title":"Historical perspective and future directions in platelet research","volume":"9","author":"Coller","year":"2011","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.ejphar.2021.173989_bib22","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/ajg.2010.436","article-title":"Low-dose aspirin-induced ulceration is attenuated by aspirin-phosphatidylcholine: a randomized clinical trial","volume":"106","author":"Cryer","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2021.173989_bib23","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1158\/1078-0432.CCR-17-0242","article-title":"Aspirin inhibits cancer metastasis and angiogenesis via targeting heparanase","volume":"23","author":"Dai","year":"2017","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.ejphar.2021.173989_bib24","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/bjh.14520","article-title":"The aspirin story-from willow to wonder drug","volume":"177","author":"Desborough","year":"2017","journal-title":"Br. J. Haematol."},{"issue":"3","key":"10.1016\/j.ejphar.2021.173989_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11883-018-0717-y","article-title":"Weighing the anti-ischemic benefits and bleeding risks from aspirin therapy: a rational approach","volume":"20","author":"Dugani","year":"2018","journal-title":"Curr. Atherosclerosis Rep."},{"key":"10.1016\/j.ejphar.2021.173989_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12307-015-0173-y","article-title":"Thymidine phosphorylase in cancer; enemy or friend?","volume":"9","author":"Elamin","year":"2016","journal-title":"Canc. Microenviron."},{"issue":"86","key":"10.1016\/j.ejphar.2021.173989_bib27","first-page":"50417","article-title":"Imaging and 3D reconstruction of cerebrovascular structures in embryonic zebrafish","volume":"22","author":"Ethell","year":"2014","journal-title":"J Vis Exp"},{"key":"10.1016\/j.ejphar.2021.173989_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/bph.12250","article-title":"Platelet-mediated angiogenesis is independent of VEGF and fully inhibited by aspirin","volume":"170","author":"Etulain","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.ejphar.2021.173989_bib29","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1159\/000510582","volume":"6","author":"Fausto de Souza","year":"2020","journal-title":"Ocul. Oncol. Pathol."},{"key":"10.1016\/j.ejphar.2021.173989_bib30","doi-asserted-by":"crossref","first-page":"11714","DOI":"10.1074\/jbc.M109.064618","article-title":"Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors","volume":"285","author":"Fern\u00e1ndez","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.173989_bib31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1124\/jpet.300.2.385","article-title":"Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4)","volume":"300","author":"Fierro","year":"2002","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2021.173989_bib32","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1074\/jbc.M703090200","article-title":"Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1","volume":"283","author":"Finetti","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.173989_bib33","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2021.173989_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.febslet.2008.11.032","article-title":"Breaking the VE-cadherin bonds","volume":"583","author":"Gavard","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2021.173989_bib35","first-page":"697","article-title":"Salicylate inhibition of rat mammary carcinogenesis and angiogenesis in female rat compatible with misoprostol administration","volume":"26","author":"Ghezzo","year":"2005","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejphar.2021.173989_bib36","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1152\/physrev.00038.2010","article-title":"Normalization of the vasculature for treatment of cancer and other diseases","volume":"91","author":"Goel","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2021.173989_bib37","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2021.173989_bib38","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.15252\/emmm.201404156","article-title":"Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease","volume":"6","author":"Goveia","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ejphar.2021.173989_bib39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.lungcan.2007.07.014","article-title":"The host defence peptide LL-37\/hCAP-18 is a growth factor for lung cancer cells","volume":"59","author":"Haussen","year":"2008","journal-title":"Lung Canc."},{"key":"10.1016\/j.ejphar.2021.173989_bib40","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2174\/138161207780618858","article-title":"The Renin angiotensin system in the regulation of angiogenesis","volume":"13","author":"Heffelfinger","year":"2007","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.ejphar.2021.173989_bib41","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/cts.12070","article-title":"Initiation of aspirin therapy modulates angiogenic protein levels in women with breast cancer receiving tamoxifen therapy","volume":"6","author":"Holmes","year":"2013","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.ejphar.2021.173989_bib42","first-page":"6380643","article-title":"Aspirin disrupts the crosstalk of angiogenic and inflammatory cytokines between 4T1 breast cancer cells and macrophages","author":"Hsieh","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2021.173989_bib43","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1161\/HYPERTENSIONAHA.107.096446","article-title":"Angiotensin II induces capillary formation from endothelial cells via the LOX-1\u2013dependent redox-sensitive pathway","volume":"50","author":"Hu","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2021.173989_bib44","doi-asserted-by":"crossref","first-page":"10226","DOI":"10.1074\/jbc.M708820200","article-title":"Regulation of TGFbeta1-mediated collagen formation by LOX-1: studies based on forced overexpression of TGFbeta1 in wild-type and lox-1 knock-out mouse cardiac fibroblasts","volume":"283","author":"Hu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.173989_bib45","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1515\/med-2019-0062","article-title":"Aspirin, a potential GLUT1 inhibitor in a vascular endothelial cell line","volume":"14","author":"Hu","year":"2019","journal-title":"Open Med."},{"key":"10.1016\/j.ejphar.2021.173989_bib46","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/med.21514","article-title":"Complex roles of the old drug aspirin in cancer chemoprevention and therapy","volume":"39","author":"Hua","year":"2019","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejphar.2021.173989_bib47","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1158\/1535-7163.MCT-16-0074","article-title":"Antitumor and antiangiogenic effects of aspirin-PC in ovarian cancer","volume":"15","author":"Huang","year":"2016","journal-title":"Mol. Canc. Therapeut."},{"issue":"1","key":"10.1016\/j.ejphar.2021.173989_bib48","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s13046-020-01709-5","volume":"39","author":"Jiang","year":"2020","journal-title":"J. Exp. Clin. Canc. Res."},{"key":"10.1016\/j.ejphar.2021.173989_bib49","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/0973-1482.157337","article-title":"Seesaw of matrix metallo proteinases (MMPs)","volume":"12","author":"Kapoor","year":"2016","journal-title":"J. Canc. Res. Therapeut."},{"key":"10.1016\/j.ejphar.2021.173989_bib50","doi-asserted-by":"crossref","first-page":"106338","DOI":"10.1016\/j.prostaglandins.2019.106338","article-title":"Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer","volume":"144","author":"Karpisheh","year":"2019","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.ejphar.2021.173989_bib51","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2459\/JCM.0b013e32834eecdc","article-title":"Adherence junction proteins in angiogenesis: modulation by aspirin and salicylic acid","volume":"13","author":"Khaidakov","year":"2012","journal-title":"J. Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2021.173989_bib52","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/FJC.0b013e3181f801e4","article-title":"Antiangiogenic and antimitotic effects of aspirin in hypoxia\u2013reoxygenation modulation of the LOX-1-NADPH oxidase axis as a potential mechanism","volume":"56","author":"Khaidakov","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173989_bib53","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/1074248410378505","article-title":"Angiostatic effects of aspirin in hypoxia? Reoxygenation are linked to modulation of TGFb1 signaling","volume":"16","author":"Khaidakov","year":"2011","journal-title":"J. Cardiovasc. Pharmacol. Therapeut."},{"issue":"8","key":"10.1016\/j.ejphar.2021.173989_bib54","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1097\/PAS.0b013e31828b6ad3","article-title":"Prognostic significance of COX-2 expression and correlation with Bcl-2 and VEGF expression, microvessel density, and clinical variables in classical Hodgkin lymphoma","volume":"37","author":"Koh","year":"2013","journal-title":"Am. J. Surg. Pathol."},{"issue":"9","key":"10.1016\/j.ejphar.2021.173989_bib55","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.cgh.2011.05.020","article-title":"Low doses of acetylsalicylic acid increase risk of gastrointestinal bleeding in a meta-analysis","volume":"9","author":"Lanas","year":"2011","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2021.173989_bib56","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cpcardiol.2017.01.006","article-title":"Upper gastrointestinal toxicity associated with long-term aspirin therapy: consequences and prevention","volume":"42","author":"Lavie","year":"2017","journal-title":"Curr. Probl. Cardiol."},{"key":"10.1016\/j.ejphar.2021.173989_bib57","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/BC20110069","article-title":"Jumping the barrier: VE-cadherin, VEGF and other angiogenic modifiers in cancer","volume":"103","author":"Le Guelte","year":"2011","journal-title":"Biol. Cell."},{"issue":"6","key":"10.1016\/j.ejphar.2021.173989_bib58","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/cbf.3541","article-title":"Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma","volume":"38","author":"Li","year":"2020","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.ejphar.2021.173989_bib59","first-page":"879623","article-title":"Tumor angiogenesis as a target for dietary cancer prevention","author":"Li","year":"2012","journal-title":"J. Oncol."},{"key":"10.1016\/j.ejphar.2021.173989_bib60","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1242\/jcs.048942","article-title":"VEGF and inhibitors of TGFbeta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha5-integrin expression","volume":"122","author":"Liu","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2021.173989_bib61","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1158\/1535-7163.MCT-08-0715","article-title":"Combination of antiangiogenesis with chemotherapy for more effective cancer treatment","volume":"7","author":"Ma","year":"2008","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.ejphar.2021.173989_bib62","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s12079-018-00499-y","article-title":"Aspirin suppresses tumor cell-induced angiogenesis and their incongruity","volume":"13","author":"Maity","year":"2019","journal-title":"J. Cell Commun. Signal."},{"issue":"1","key":"10.1016\/j.ejphar.2021.173989_bib63","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1038\/s41598-020-62648-x","article-title":"Platelets disrupt vasculogenic mimicry by cancer cells","volume":"3","author":"Martini","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2021.173989_bib64","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11883-015-0555-0","article-title":"Aspirin for the primary prevention of cardiovascular disease: in need of clarity","volume":"18","author":"Miedema","year":"2016","journal-title":"Curr. Atherosclerosis Rep."},{"issue":"2","key":"10.1016\/j.ejphar.2021.173989_bib65","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/FJC.0b013e31825b61e2","article-title":"Aspirin downregulates angiotensin type 1 receptor transcription implications in capillary formation from endothelial cells","volume":"60","author":"Mitra","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173989_bib66","doi-asserted-by":"crossref","first-page":"112260","DOI":"10.1016\/j.ejmech.2020.112260","article-title":"Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: a minireview","volume":"194","author":"Mondal","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"8","key":"10.1016\/j.ejphar.2021.173989_bib67","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/jamainternmed.2016.2648","article-title":"Aspirin for primary prevention of atherosclerotic cardiovascular disease: advances in diagnosis and treatment","volume":"176","author":"Mora","year":"2016","journal-title":"JAMA Intern. Med."},{"issue":"6","key":"10.1016\/j.ejphar.2021.173989_bib68","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00418-018-1744-z","article-title":"Restriction of drug transport by the tumor environment","volume":"150","author":"Nandigama","year":"2018","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.ejphar.2021.173989_bib69","doi-asserted-by":"crossref","first-page":"e380","DOI":"10.1016\/j.wneu.2018.08.080","article-title":"Aspirin affects tumor angiogenesis and sensitizes human glioblastoma endothelial cells to temozolomide, bevacizumab, and sunitinib, impairing vascular endothelial growth factor-related signaling","volume":"120","author":"Navone","year":"2018","journal-title":"World Neurosurg."},{"key":"10.1016\/j.ejphar.2021.173989_bib70","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/j.gastro.2009.09.063","article-title":"Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions","volume":"138","author":"Ng","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2021.173989_bib71","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/anie.200803347","article-title":"Modulation of the biological properties of aspirin by formation of a bioorganometallic derivative","volume":"48","author":"Ott","year":"2009","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejphar.2021.173989_bib72","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1093\/carcin\/bgn127","article-title":"NO-donating aspirin inhibits angiogenesis by suppressing VEGF expression in HT-29human colon cancer mouse xenografts","volume":"29","author":"Ouyang","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejphar.2021.173989_bib73","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.biopha.2017.07.091","article-title":"Renin-angiotensin-aldosterone (RAAS): the ubiquitous system for homeostasis and pathologies","volume":"94","author":"Patel","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.ejphar.2021.173989_bib74","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/09537104.2018.1492105","article-title":"Aspirin, platelet inhibition and cancer prevention","volume":"29","author":"Patrignani","year":"2018","journal-title":"Platelets"},{"key":"10.1016\/j.ejphar.2021.173989_bib75","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jacc.2015.05.012","article-title":"The multifaceted clinical readouts of platelet inhibition by low-dose aspirin","volume":"66","author":"Patrono","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2021.173989_bib76","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jacc.2016.11.049","article-title":"Type 2 diabetes, obesity, and aspirin responsiveness","volume":"69","author":"Patrono","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2021.173989_bib77","doi-asserted-by":"crossref","first-page":"570","DOI":"10.2174\/157016112801784648","article-title":"Platelets in angiogenesis","volume":"10","author":"Patzelt","year":"2012","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173989_bib78","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/01902148.2017.1358776","article-title":"Physiopathology and genetics in aspirin-exacerbated respiratory disease","volume":"43","author":"Pav\u00f3n-Romero","year":"2017","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.ejphar.2021.173989_bib79","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1046\/j.1440-1746.2003.03152.x","article-title":"Effects of aspirin and indomethacin on endothelial cell proliferation in vitro","volume":"18","author":"Pearce","year":"2003","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2021.173989_bib80","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2019.08.002","article-title":"Multimerin-2 maintains vascular stability and permeability","volume":"87","author":"Pellicani","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ejphar.2021.173989_bib81","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1139\/y2012-036","article-title":"Platelet-associated angiogenesis regulating factors: a pharmacological perspective","volume":"90","author":"Radziwon-Balicka","year":"2012","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2021.173989_bib82","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/biomedicines5020034","article-title":"The role of angiogenesis in cancer treatment","volume":"5","author":"Rajabi","year":"2017","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2021.173989_bib83","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1096\/fj.201600530R","article-title":"Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1","volume":"30","author":"Rauzi","year":"2016","journal-title":"Faseb. J."},{"key":"10.1016\/j.ejphar.2021.173989_bib84","first-page":"868475","article-title":"Combined effects of pericytes in the tumor microenvironment","author":"Ribeiro","year":"2015","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.ejphar.2021.173989_bib85","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/MOG.0b013e32801145b0","article-title":"The use of nitric oxide-donating nonsteroidal anti-inflammatory drugs in the chemoprevention of colorectal neoplasia","volume":"23","author":"Rigas","year":"2007","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.ejphar.2021.173989_bib86","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.1257071","article-title":"Targeting vascular sprouts: manipulating metabolism could control angiogenesis","volume":"344","author":"Rivera","year":"2014","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.ejphar.2021.173989_bib87","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1002\/cam4.2881","volume":"9","author":"Rohwer","year":"2020","journal-title":"Canc. Med."},{"issue":"10145","key":"10.1016\/j.ejphar.2021.173989_bib88","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(18)31133-4","article-title":"Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials","volume":"392","author":"Rothwell","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2021.173989_bib89","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1182\/blood-2002-11-3400","article-title":"Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells","volume":"102","author":"Salcedo","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2021.173989_bib90","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1161\/ATVBAHA.113.301851","article-title":"Cathelicidin LL-37 induces angiogenesis via PGE2\u2013EP3 signaling in endothelial cells, in vivo inhibition by aspirin","volume":"33","author":"Salvado","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2021.173989_bib91","doi-asserted-by":"crossref","first-page":"18897","DOI":"10.1074\/jbc.M011147200","article-title":"Selective suppression of CCAAT\/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts","volume":"276","author":"Saunders","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.ejphar.2021.173989_bib92","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1136\/hrt.2010.217547","article-title":"Prevention of peptic ulcers with esomeprazole in patients at risk of ulcer development treated with low-dose acetylsalicylic acid: a randomised, controlled trial (OBERON)","volume":"97","author":"Scheiman","year":"2011","journal-title":"Heart (British Cardiac Society)"},{"issue":"3","key":"10.1016\/j.ejphar.2021.173989_bib93","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/FJC.0b013e31827cb626","article-title":"Esomeprazole for prevention and resolution of upper gastrointestinal symptoms in patients treated with low-dose acetylsalicylic acid for cardiovascular protection: the OBERON trial","volume":"61","author":"Scheiman","year":"2013","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173989_bib94","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00395-009-0072-9","article-title":"Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression","volume":"105","author":"Seeger","year":"2010","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2021.173989_bib95","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ygyno.2010.11.019","article-title":"Expression of GLUT-1 in epithelial ovarian carcinoma: correlation with tumor cell proliferation, angiogenesis, survival and ability to predict optimal cytoreduction","volume":"121","author":"Semaan","year":"2011","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.ejphar.2021.173989_bib96","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/14656566.2016.1269747","article-title":"Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease","volume":"18","author":"Sharma","year":"2017","journal-title":"Expet Opin. Pharmacother."},{"key":"10.1016\/j.ejphar.2021.173989_bib97","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1159\/000464434","article-title":"Aspirin inhibits IKK-\u03b2-mediated prostate cancer cell invasion by targeting matrix metalloproteinase-9 and urokinase-type plasminogen activator","volume":"41","author":"Shi","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2021.173989_bib98","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1046\/j.1538-7836.2003.00446.x","article-title":"Aspirin and salicylate inhibit colon cancer medium-and VEGF-induced endothelial tube formation: correlation with suppression of cyclooxygenase-2 expression","volume":"1","author":"Shtivelband","year":"2003","journal-title":"J. Thromb. Haemostasis"},{"issue":"4","key":"10.1016\/j.ejphar.2021.173989_bib99","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2174\/1570161115666170105124038","article-title":"Vascular endothelial growth factor (VEGF) signaling in tumour vascularization: potential and challenges","volume":"15","author":"Siveen","year":"2017","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.173989_bib100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2174\/157489007779606130","article-title":"The Role of angiotensin type 1 receptor in inflammation and endothelial dysfunction","volume":"2","author":"Skultetyova","year":"2007","journal-title":"Recent Pat. Cardiovasc. Drug Discov."},{"key":"10.1016\/j.ejphar.2021.173989_bib101","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1189\/jlb.0609385","article-title":"Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation","volume":"86","author":"Solinas","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejphar.2021.173989_bib102","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1016\/j.biomaterials.2014.02.012","article-title":"The role of macrophage phenotype in vascularization of tissue engineering scaffolds","volume":"35","author":"Spiller","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2021.173989_bib103","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biomaterials.2014.10.017","article-title":"Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds","volume":"37","author":"Spiller","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2021.173989_bib104","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.mehy.2014.05.007","article-title":"Aspirin may modify tumor microenvironment via antiplatelet effect","volume":"83","author":"Su","year":"2014","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.ejphar.2021.173989_bib105","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1158\/0008-5472.CAN-10-1040","article-title":"AACR centennial series: the biology of cancer metastasis: historical perspective","volume":"70","author":"Talmadge","year":"2010","journal-title":"Canc. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2021.173989_bib106","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3390\/jcm9010084","article-title":"Tumor angiogenesis and anti-angiogenic strategies for cancer treatment","volume":"9","author":"Teleanu","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ejphar.2021.173989_bib107","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(00)81433-6","article-title":"Cyclooxygenase regulates angiogenesis induced by colon cancer cells","volume":"93","author":"Tsujii","year":"1998","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.ejphar.2021.173989_bib108","first-page":"125","article-title":"Risk factors for gastrointestinal bleeding associated with low-dose aspirin","volume":"26","author":"Valkhoff","year":"2012","journal-title":"Best Pract. Clin."},{"key":"10.1016\/j.ejphar.2021.173989_bib109","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10456-014-9420-y","article-title":"Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions","volume":"17","author":"Vasudev","year":"2014","journal-title":"Angiogenesis"},{"issue":"1","key":"10.1016\/j.ejphar.2021.173989_bib110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/CRD.0000000000000174","article-title":"Yosprala\u00ae: a fixed dose combination of aspirin and omeprazole","volume":"26","author":"Veltri","year":"2018","journal-title":"Cardiol. Rev."},{"issue":"4","key":"10.1016\/j.ejphar.2021.173989_bib111","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10456-017-9562-9","article-title":"Tumor angiogenesis and vascular normalization: alternative therapeutic targets","volume":"20","author":"Viallard","year":"2017","journal-title":"Angiogenesis"},{"key":"10.1016\/j.ejphar.2021.173989_bib112","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tibs.2017.10.007","article-title":"Opposing functions of heparanase-1 and heparanase-2 in cancer progression","volume":"43","author":"Vlodavsky","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejphar.2021.173989_bib113","doi-asserted-by":"crossref","first-page":"R6","DOI":"10.1186\/bcr2221","article-title":"Human antimicrobial protein hCAP18\/LL-37 promotes a metastatic phenotype in breast cancer","volume":"11","author":"Weber","year":"2009","journal-title":"Breast Canc. Res."},{"key":"10.1016\/j.ejphar.2021.173989_bib114","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm.2537","article-title":"Tumor angiogenesis: molecular pathways and therapeutic targets","volume":"17","author":"Weis","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2021.173989_bib115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jtbi.2012.11.031","article-title":"The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems","volume":"320","author":"Wu","year":"2013","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.ejphar.2021.173989_bib116","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1073\/pnas.96.9.5292","article-title":"Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate","volume":"96","author":"Xu","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2021.173989_bib117","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.atherosclerosis.2004.01.024","article-title":"Aspirin inhibits monocyte chemoattractant protein-1 and interleukin-8 expression in TNF-\u03b1stimulated human umbilicaln vein endothelial cells","volume":"174","author":"Yang","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2021.173989_bib118","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1097\/01.LAB.0000090159.53224.B9","article-title":"COX-2\/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo","author":"Yoshida","year":"2003","journal-title":"Lab. Invest. J. Techn. Ethods Pathol."},{"key":"10.1016\/j.ejphar.2021.173989_bib119","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1074\/jbc.M113.526814","article-title":"Hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) protein diminishes sodium glucose transport 1 (SGLT1) and SGLT2 protein expression in renal epithelial tubular cells (LLC-PK1) under hypoxia","volume":"289","author":"Zapata-Morales","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.173989_bib120","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1182\/blood-2009-09-242065","article-title":"Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis","volume":"115","author":"Zaslavsky","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2021.173989_bib121","doi-asserted-by":"crossref","first-page":"7283","DOI":"10.1158\/0008-5472.CAN-05-0633","article-title":"15(S)-Hydroxyeicosatetraenoic acid induces angiogenesis via activation of PI3K-Akt-mTOR-S6K1 signaling","volume":"65","author":"Zhang","year":"2005","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejphar.2021.173989_bib122","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.3892\/or.2013.2339","article-title":"Impact of acetylsalicylic acid on tumor angiogenesis and lymphangiogenesis through inhibition of VEGF signaling in a murine sarcoma model","volume":"29","author":"Zhang","year":"2013","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.ejphar.2021.173989_bib123","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.3892\/ol.2016.5017","article-title":"Aspirin may inhibit angiogenesis and induce autophagy by inhibiting mTOR signaling pathway in murine hepatocarcinoma and sarcoma models","volume":"12","author":"Zhao","year":"2016","journal-title":"Oncol Lett. Oct"},{"key":"10.1016\/j.ejphar.2021.173989_bib124","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1124\/mol.64.5.1251","article-title":"Expression of the angiogenic factor thymidine phosphorylase in THP-1 monocytes: induction by autocrine tumor necrosis factor-alpha and inhibition by aspirin","volume":"64","author":"Zhu","year":"2003","journal-title":"Mol. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921001424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921001424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:48:24Z","timestamp":1757976504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921001424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":124,"alternative-id":["S0014299921001424"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.173989","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of the antiangiogenic effects of aspirin in cancer","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.173989","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173989"}}