{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:53:51Z","timestamp":1791597231259,"version":"4.3.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.ejphar.2021.173999","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T16:59:35Z","timestamp":1614790775000},"page":"173999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis"],"prefix":"10.1016","volume":"898","author":[{"given":"Hua","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ming","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Sayed","family":"Ali Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-4813","authenticated-orcid":false,"given":"Jie-Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Ju","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1727-9047","authenticated-orcid":false,"given":"Chuang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.173999_bib1","doi-asserted-by":"crossref","first-page":"108258","DOI":"10.1016\/j.abb.2020.108258","article-title":"Phenylglyoxal inhibition of the mitochondrial F1FO-ATPase activated by Mg(2+) or by Ca(2+) provides clues on the mitochondrial permeability transition pore","volume":"681","author":"Algieri","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2021.173999_bib2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/CIRCRESAHA.119.316306","article-title":"Role of mitochondrial calcium and the permeability transition pore in regulating cell death","volume":"126","author":"Bauer","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2021.173999_bib3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1161\/CIRCINTERVENTIONS.111.966226","article-title":"Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction","volume":"5","author":"Chan","year":"2012","journal-title":"Circ. Cardiovasc. Interv."},{"key":"10.1016\/j.ejphar.2021.173999_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ahj.2019.05.010","article-title":"Clinical effects of cyclosporine in acute anterior myocardial infarction complicated by heart failure: a subgroup analysis of the CIRCUS Trial","volume":"216","author":"Claeys","year":"2019","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ejphar.2021.173999_bib5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1182\/blood-2016-09-739086","article-title":"Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial","volume":"132","author":"Cortes","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2021.173999_bib6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1105\/tpc.18.00535","article-title":"Iron- and reactive oxygen species-dependent ferroptotic cell death in rice-magnaporthe oryzae interactions","volume":"31","author":"Dangol","year":"2019","journal-title":"Plant Cell"},{"key":"10.1016\/j.ejphar.2021.173999_bib7","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1111\/jcmm.15127","article-title":"Mitochondrial and mitochondrial-independent pathways of myocardial cell death during ischaemia and reperfusion injury","volume":"24","author":"Davidson","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2021.173999_bib8","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2021.173999_bib9","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/ajh.24966","article-title":"Safety and efficacy of early start of iron chelation therapy with deferiprone in young children newly diagnosed with transfusion-dependent thalassemia: a randomized controlled trial","volume":"93","author":"Elalfy","year":"2018","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.ejphar.2021.173999_bib10","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2021.173999_bib11","doi-asserted-by":"crossref","first-page":"e1767","DOI":"10.1038\/cddis.2015.130","article-title":"A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis","volume":"6","author":"Fauster","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2021.173999_bib12","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.bbrc.2019.10.006","article-title":"Liproxstatin-1 protects the mouse myocardium against ischemia\/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels","volume":"520","author":"Feng","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2021.173999_bib13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/eci.12391","article-title":"Necrostatin-1 alleviates reperfusion injury following acute myocardial infarction in pigs","volume":"45","author":"Koudstaal","year":"2015","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2021.173999_bib14","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1038\/s41418-019-0299-4","article-title":"Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia\/reperfusion","volume":"26","author":"Li","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2021.173999_bib15","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s10557-007-6067-6","article-title":"The cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore","volume":"21","author":"Lim","year":"2007","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.ejphar.2021.173999_bib16","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.jacc.2009.10.052","article-title":"Effect of cyclosporine on left ventricular remodeling after reperfused myocardial infarction","volume":"55","author":"Mewton","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2021.173999_bib17","doi-asserted-by":"crossref","first-page":"12249","DOI":"10.1002\/jcp.27968","article-title":"Atrial fibrillation in beta-thalassemia patients with a focus on the role of iron-overload and oxidative stress: a review","volume":"234","author":"Nomani","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2021.173999_bib18","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ijcard.2012.03.055","article-title":"Targeting cell death in the reperfused heart: pharmacological approaches for cardioprotection","volume":"165","author":"Oerlemans","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2021.173999_bib19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s00395-012-0270-8","article-title":"Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo","volume":"107","author":"Oerlemans","year":"2012","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2021.173999_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/eurheartj\/ehi028","article-title":"Deferoxamine infusion during coronary artery bypass grafting ameliorates lipid peroxidation and protects the myocardium against reperfusion injury: immediate and long-term significance","volume":"26","author":"Paraskevaidis","year":"2005","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejphar.2021.173999_bib21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tibs.2018.11.002","article-title":"The structural basis of necroptotic cell death signaling","volume":"44","author":"Petrie","year":"2019","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejphar.2021.173999_bib22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1056\/NEJMoa071142","article-title":"Effect of cyclosporine on reperfusion injury in acute myocardial infarction","volume":"359","author":"Piot","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2021.173999_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10557-018-06848-8","article-title":"Inhibition of phosphoglycerate mutase 5 reduces necroptosis in rat hearts following ischemia\/reperfusion through suppression of dynamin-related protein 1","volume":"33","author":"She","year":"2019","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.ejphar.2021.173999_bib24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.ejphar.2021.173999_bib25","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s12975-017-0581-z","article-title":"Combination of emricasan with ponatinib synergistically reduces ischemia\/reperfusion injury in rat brain through simultaneous prevention of apoptosis and necroptosis","volume":"9","author":"Tian","year":"2018","journal-title":"Transl. Stroke Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921001527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921001527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:48:28Z","timestamp":1757976508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921001527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":25,"alternative-id":["S0014299921001527"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.173999","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.173999","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173999"}}