{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:26:06Z","timestamp":1777573566476,"version":"3.51.4"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 106-2314-B-182A-040-MY3"],"award-info":[{"award-number":["MOST 106-2314-B-182A-040-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["104-2314-B-182A-100-MY2"],"award-info":[{"award-number":["104-2314-B-182A-100-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008798","name":"Ministry of Science Research and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3G30581\\u223C3"],"award-info":[{"award-number":["CMRPG3G30581\\u223C3"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3F0191\\u223C3"],"award-info":[{"award-number":["CMRPG3F0191\\u223C3"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ejphar.2021.174035","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T15:24:17Z","timestamp":1615649057000},"page":"174035","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["MicroRNA-126 inhibits pathological retinal neovascularization via suppressing vascular endothelial growth factor expression in a rat model of retinopathy of prematurity"],"prefix":"10.1016","volume":"900","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5161-3443","authenticated-orcid":false,"given":"Yuan-Yao","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Hsien","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-Lun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-7188","authenticated-orcid":false,"given":"Yi-Jen","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan-Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Chun","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.174035_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1006\/bbrc.1993.1671","article-title":"Synthesis and secretion of vascular permeability factor\/vascular endothelial growth factor by human retinal pigment epithelial cells","volume":"193","author":"Adamis","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2021.174035_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4331\/wjbc.v5.i1.1","article-title":"MicroRNA signature and function in retinal neovascularization","volume":"5","author":"Agrawal","year":"2014","journal-title":"World J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.174035_bib3","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/nm1095-1024","article-title":"Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity","volume":"1","author":"Alon","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2021.174035_bib4","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1242\/dev.02073","article-title":"MicroRNA functions in animal development and human disease","volume":"132","author":"Alvarez-Garcia","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ejphar.2021.174035_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000454716","article-title":"MicroRNA-126 reduces blood-retina barrier breakdown via the regulation of VCAM-1 and BCL2L11 in ischemic retinopathy","volume":"57","author":"Bai","year":"2017","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.ejphar.2021.174035_bib6","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.yexmp.2011.04.016","article-title":"MicroRNA-126 inhibits ischemia-induced retinal neovascularization via regulating angiogenic growth factors","volume":"91","author":"Bai","year":"2011","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.ejphar.2021.174035_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2021.174035_bib8","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1016\/j.ophtha.2017.05.007","article-title":"Re: good: Bevacizumab for retinopathy of prematurity: treatment when pathology is embedded in a normally developing vascular system (Ophthalmology. 2016;123:1843-1844","volume":"124","author":"Blair","year":"2017","journal-title":"Ophthalmology"},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2021.174035_bib9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/pr.2013.205","article-title":"Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010","volume":"74","author":"Blencowe","year":"2013","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejphar.2021.174035_bib10","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJMoa0911781","article-title":"Target ranges of oxygen saturation in extremely preterm infants","volume":"362","author":"Carlo","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2021.174035_bib11","article-title":"MicroRNA-410 reduces the expression of vascular endothelial growth factor and inhibits oxygen-induced retinal neovascularization","volume":"9","author":"Chen","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2021.174035_bib12","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/nprot.2009.187","article-title":"Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis","volume":"4","author":"Connor","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejphar.2021.174035_bib13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/archopht.1988.01060130517027","article-title":"Multicenter trial of cryotherapy for retinopathy of prematurity. Preliminary results. Cryotherapy for Retinopathy of Prematurity Cooperative Group","volume":"106","year":"1988","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.ejphar.2021.174035_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218282","article-title":"MicroRNA expression profile in retina and choroid in oxygen-induced retinopathy model","volume":"14","author":"Desjarlais","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2021.174035_bib15","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1097\/IAE.0b013e3181ca1457","article-title":"Treatment of type 1 retinopathy of prematurity with intravitreal bevacizumab (Avastin)","volume":"30","author":"Dorta","year":"2010","journal-title":"Retina"},{"key":"10.1016\/j.ejphar.2021.174035_bib16","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1001\/archopht.121.12.1684","article-title":"Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial","volume":"121","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.ejphar.2021.174035_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/BJ20060981","article-title":"Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity","volume":"401","author":"Ecroyd","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2021.174035_bib18","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.devcel.2008.07.008","article-title":"miR-126 regulates angiogenic signaling and vascular integrity","volume":"15","author":"Fish","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ejphar.2021.174035_bib19","first-page":"345","article-title":"Neutralizing antibody to VEGF reduces intravitreous neovascularization and may not interfere with ongoing intraretinal vascularization in a rat model of retinopathy of prematurity","volume":"14","author":"Geisen","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.ejphar.2021.174035_bib20","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1016\/S0021-9258(17)41787-X","article-title":"Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin","volume":"269","author":"Goldberg","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.174035_bib21","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.preteyeres.2010.05.003","article-title":"Animal models of choroidal and retinal neovascularization","volume":"29","author":"Grossniklaus","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.ejphar.2021.174035_bib22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1542\/peds.105.2.295","article-title":"Supplemental therapeutic oxygen for prethreshold retinopathy of prematurity (STOP-ROP), a randomized, controlled trial. I: primary outcomes","volume":"105","author":"Group","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.ejphar.2021.174035_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3928\/23258160-20170301-10","article-title":"Reactivation of retinopathy of prematurity three years after treatment with bevacizumab","volume":"48","author":"Hajrasouliha","year":"2017","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"10.1016\/j.ejphar.2021.174035_bib24","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1073\/pnas.0707493105","article-title":"MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1","volume":"105","author":"Harris","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2021.174035_bib25","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.vph.2011.07.005","article-title":"MicroRNAs and vascular (dys)function","volume":"55","author":"Hartmann","year":"2011","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174035_bib26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ophtha.2014.07.050","article-title":"Pathophysiology and mechanisms of severe retinopathy of prematurity","volume":"122","author":"Hartnett","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ejphar.2021.174035_bib27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jaapos.2012.12.155","article-title":"Effects of oxygen on the development and severity of retinopathy of prematurity","volume":"17","author":"Hartnett","year":"2013","journal-title":"Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus"},{"key":"10.1016\/j.ejphar.2021.174035_bib28","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1056\/NEJMra1208129","article-title":"Mechanisms and management of retinopathy of prematurity","volume":"367","author":"Hartnett","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2021.174035_bib29","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1001\/archophthalmol.2012.592","article-title":"Reactivation of retinopathy of prematurity after bevacizumab injection","volume":"130","author":"Hu","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.ejphar.2021.174035_bib30","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1371\/journal.pone.0000116","article-title":"MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia","volume":"1","author":"Hua","year":"2006","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2021.174035_bib31","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.exer.2006.05.007","article-title":"The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium","volume":"83","author":"Ikeda","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2021.174035_bib32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/EB.S94447","article-title":"Revisiting the mouse model of oxygen-induced retinopathy","volume":"8","author":"Kim","year":"2016","journal-title":"Eye Brain"},{"key":"10.1016\/j.ejphar.2021.174035_bib33","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1242\/dev.029736","article-title":"Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126","volume":"135","author":"Kuhnert","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ejphar.2021.174035_bib34","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3928\/23258160-20170630-06","article-title":"The epidemiology of retinopathy of prematurity in the United States","volume":"48","author":"Ludwig","year":"2017","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"10.1016\/j.ejphar.2021.174035_bib35","doi-asserted-by":"crossref","first-page":"d1030","DOI":"10.2741\/1056","article-title":"Animal models of oxygen-induced retinopathy","volume":"8","author":"Madan","year":"2003","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ejphar.2021.174035_bib36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/eye.2017.193","article-title":"Evaluation of the plasma microRNA levels in stage 3 premature retinopathy with plus disease: preliminary study","volume":"32","author":"Metin","year":"2018","journal-title":"Eye"},{"key":"10.1016\/j.ejphar.2021.174035_bib37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/(SICI)1099-0895(199703)13:1<37::AID-DMR174>3.0.CO;2-K","article-title":"Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy","volume":"13","author":"Miller","year":"1997","journal-title":"Diabetes Metab. Rev."},{"key":"10.1016\/j.ejphar.2021.174035_bib38","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1056\/NEJMoa1007374","article-title":"Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity","volume":"364","author":"Mintz-Hittner","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2021.174035_bib39","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1167\/iovs.05-1046","article-title":"Ontogeny of VEGF, IGF-I, and GH in neonatal rat serum, vitreous fluid, and retina from birth to weaning","volume":"47","author":"Modanlou","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2021.174035_bib40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1073\/pnas.012074399","article-title":"Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis","volume":"99","author":"Oh","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2021.174035_bib41","first-page":"94","article-title":"Current concepts of oxygen management in retinopathy of prematurity","volume":"9","author":"Owen","year":"2014","journal-title":"J. Ophthalmic Vis. Res."},{"key":"10.1016\/j.ejphar.2021.174035_bib42","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1203\/00006450-199412000-00007","article-title":"Exposure to alternating hypoxia and hyperoxia causes severe proliferative retinopathy in the newborn rat","volume":"36","author":"Penn","year":"1994","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejphar.2021.174035_bib43","first-page":"576","article-title":"Variable oxygen exposure causes preretinal neovascularization in the newborn rat","volume":"34","author":"Penn","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2021.174035_bib44","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/08977199709021522","article-title":"Detection of vascular endothelial growth factor (VEGF) protein in vascular and non-vascular cells of the normal and oxygen-injured rat retina","volume":"14","author":"Robbins","year":"1997","journal-title":"Growth Factors"},{"key":"10.1016\/j.ejphar.2021.174035_bib45","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.ophtha.2008.12.023","article-title":"Vitreous levels of erythropoietin and vascular endothelial growth factor in eyes with retinopathy of prematurity","volume":"116","author":"Sato","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ejphar.2021.174035_bib46","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5409\/wjcp.v5.i1.35","article-title":"Retinopathy of prematurity: past, present and future","volume":"5","author":"Shah","year":"2016","journal-title":"World J. Clin. Pediatr."},{"key":"10.1016\/j.ejphar.2021.174035_bib47","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/mt.2008.104","article-title":"MicroRNAs regulate ocular neovascularization","volume":"16","author":"Shen","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejphar.2021.174035_bib48","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2021.174035_bib49","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.ophtha.2007.08.050","article-title":"Vitreous levels of stromal cell-derived factor 1 and vascular endothelial growth factor in patients with retinopathy of prematurity","volume":"115","author":"Sonmez","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ejphar.2021.174035_bib50","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10456-009-9155-3","article-title":"Computer-aided quantification of retinal neovascularization","volume":"12","author":"Stahl","year":"2009","journal-title":"Angiogenesis"},{"key":"10.1016\/j.ejphar.2021.174035_bib51","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1523\/JNEUROSCI.15-07-04738.1995","article-title":"Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia","volume":"15","author":"Stone","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174035_bib52","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1167\/iovs.15-18542","article-title":"Characterization of fatty acid binding protein 7 (FABP7) in the murine retina","volume":"57","author":"Su","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2021.174035_bib53","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1167\/iovs.13-13397","article-title":"Effects of anti-VEGF treatment on the recovery of the developing retina following oxygen-induced retinopathy","volume":"55","author":"Tokunaga","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2021.174035_bib54","doi-asserted-by":"crossref","DOI":"10.3791\/50546-v","article-title":"Whole mount immunofluorescent staining of the neonatal mouse retina to investigate angiogenesis in vivo","author":"Tual-Chalot","year":"2013","journal-title":"JoVE"},{"key":"10.1016\/j.ejphar.2021.174035_bib55","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/cvr\/cvs003","article-title":"MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release","volume":"93","author":"van Mil","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2021.174035_bib56","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ophtha.2016.12.025","article-title":"Anti-vascular endothelial growth factor therapy for primary treatment of type 1 retinopathy of prematurity: a report by the American academy of Ophthalmology","volume":"124","author":"VanderVeen","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ejphar.2021.174035_bib57","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.ophtha.2018.05.001","article-title":"A dosing study of bevacizumab for retinopathy of prematurity: late recurrences and additional treatments","volume":"125","author":"Wallace","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ejphar.2021.174035_bib58","article-title":"miR-126 regulation of angiogenesis in age-related macular degeneration in CNV mouse model","volume":"17","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2021.174035_bib59","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.devcel.2008.07.002","article-title":"The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis","volume":"15","author":"Wang","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ejphar.2021.174035_bib60","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ajo.2012.06.010","article-title":"An updated study of the use of bevacizumab in the treatment of patients with prethreshold retinopathy of prematurity in taiwan","volume":"155","author":"Wu","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.ejphar.2021.174035_bib61","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/biot.200700169","article-title":"Statistical methods for efficiency adjusted real-time PCR quantification","volume":"3","author":"Yuan","year":"2008","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.ejphar.2021.174035_bib62","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1038\/mt.2016.108","article-title":"Strand and cell type-specific function of microRNA-126 in angiogenesis","volume":"24","author":"Zhou","year":"2016","journal-title":"Mol. Ther."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921001886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921001886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:20:01Z","timestamp":1777404001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921001886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":62,"alternative-id":["S0014299921001886"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174035","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-126 inhibits pathological retinal neovascularization via suppressing vascular endothelial growth factor expression in a rat model of retinopathy of prematurity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174035"}}