{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:47:37Z","timestamp":1772308057973,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ejphar.2021.174095","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T20:11:02Z","timestamp":1618949462000},"page":"174095","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Cardioprotective effect of anisodamine against ischemia\/reperfusion injury through the mitochondrial ATP-sensitive potassium channel"],"prefix":"10.1016","volume":"901","author":[{"given":"Shiru","family":"Bai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuechao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianlei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Er","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongpin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.174095_bib1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.lfs.2016.03.021","article-title":"Preconditioning at a distance: involvement of endothelial vasoactive substances in cardioprotection against ischemia-reperfusion injury","volume":"151","author":"Aggarwal","year":"2016","journal-title":"Life. Sci."},{"key":"10.1016\/j.ejphar.2021.174095_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.carrev.2010.01.004","article-title":"Visualization of excessive intracellular calcium ion overload caused by the occurrence of reperfusion injury","volume":"11","author":"Akutsu","year":"2010","journal-title":"Cardiovasc. Revascularization Med. : Mol. Interv."},{"key":"10.1016\/j.ejphar.2021.174095_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijcard.2019.07.067","article-title":"Clinical and procedural predictors and short-term survival of the patients with no reflow phenomenon after primary percutaneous coronary intervention","volume":"294","author":"Ashraf","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2021.174095_bib3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4149\/gpb_2015009","article-title":"Mitochondrial ATP-sensitive K+ channels mediate the antioxidative influence of diosgenin on myocardial reperfusion injury in rat hearts","volume":"34","author":"Badalzadeh","year":"2015","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.ejphar.2021.174095_bib4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/MCA.0000000000000366","article-title":"Intracoronary administration of different doses of anisodamine in primary percutaneous coronary intervention: protective effect in patients with ST-segment elevation myocardial infarction","volume":"27","author":"Bai","year":"2016","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.ejphar.2021.174095_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1152\/ajplegacy.1968.214.1.197","article-title":"QRS-T variations in the rat electrocardiogram","volume":"214","author":"Beinfield","year":"1968","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2021.174095_bib6","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/physrev.1999.79.2.609","article-title":"Molecular and cellular mechanisms of myocardial stunning","volume":"79","author":"Bolli","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2021.174095_bib8","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000461","article-title":"Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction","volume":"2","author":"Disatnik","year":"2013","journal-title":"J. Am. Heart. Assoc."},{"key":"10.1016\/j.ejphar.2021.174095_bib9","doi-asserted-by":"crossref","first-page":"144448","DOI":"10.1016\/j.gene.2020.144448","article-title":"hsa-miR-766-5p as a new regulator of mitochondrial apoptosis pathway for discriminating of cell death from cardiac differentiation","volume":"736","author":"Dokanehiifard","year":"2020","journal-title":"Gene."},{"key":"10.1016\/j.ejphar.2021.174095_bib10","doi-asserted-by":"crossref","first-page":"H284","DOI":"10.1152\/ajpheart.00034.2002","article-title":"Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart","volume":"283","author":"Dos Santos","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2021.174095_bib11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.mito.2020.01.005","article-title":"Calcium overload decreases net free radical emission in cardiac mitochondria","volume":"51","author":"Duong","year":"2020","journal-title":"Mitochondrion."},{"key":"10.1016\/j.ejphar.2021.174095_bib12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1385\/CT:4:4:375","article-title":"The oxygen radical generator pyrogallol impairs cardiomyocyte contractile function via a superoxide and p38 MAP kinase-dependent pathway: protection by anisodamine and tetramethylpyrazine","volume":"4","author":"Esberg","year":"2004","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.ejphar.2021.174095_bib13","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/eurheartj\/eht090","article-title":"Myocardial reperfusion injury: looking beyond primary PCI","volume":"34","author":"Frohlich","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejphar.2021.174095_bib14","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.bpj.2013.07.006","article-title":"A computational model of reactive oxygen species and redox balance in cardiac mitochondria","volume":"105","author":"Gauthier","year":"2013","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejphar.2021.174095_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.nutres.2017.07.003","article-title":"Xyloglucan intake attenuates myocardial injury by inhibiting apoptosis and improving energy metabolism in a rat model of myocardial infarction","volume":"45","author":"Lim","year":"2017","journal-title":"Nutr. Res. (N.Y.)"},{"key":"10.1016\/j.ejphar.2021.174095_bib16","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.yjmcc.2011.06.012","article-title":"Methods in cardiomyocyte isolation, culture, and gene transfer","volume":"51","author":"Louch","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2021.174095_bib17","first-page":"647","article-title":"[Problem of end effector of ischemic postconditioning of the heart]","volume":"101","author":"Maslov","year":"2015","journal-title":"Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova."},{"key":"10.1016\/j.ejphar.2021.174095_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-2999(02)01374-2","article-title":"Anisodamine inhibits cardiac contraction and intracellular Ca(2+) transients in isolated adult rat ventricular myocytes","volume":"439","author":"Norby","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174095_bib19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41586-019-1498-3","article-title":"Identification of an ATP-sensitive potassium channel in mitochondria","volume":"572","author":"Paggio","year":"2019","journal-title":"Nature."},{"key":"10.1016\/j.ejphar.2021.174095_bib20","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/MCA.0000000000000167","article-title":"Effect of intracoronary anisodamine and diltiazem administration during primary percutaneous coronary intervention in acute myocardial infarction","volume":"25","author":"Peng","year":"2014","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.ejphar.2021.174095_bib21","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00424-013-1217-0","article-title":"Catestatin reduces myocardial ischaemia\/reperfusion injury: involvement of PI3K\/Akt, PKCs, mitochondrial KATP channels and ROS signalling","volume":"465","author":"Perrelli","year":"2013","journal-title":"Pflueg. Arch. Eur. J. Physiol."},{"key":"10.1016\/j.ejphar.2021.174095_bib22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jat.1154","article-title":"The pharmacological properties of anisodamine","volume":"27","author":"Poupko","year":"2007","journal-title":"J. Appl. Toxicol. : J. Anal. Toxicol."},{"key":"10.1016\/j.ejphar.2021.174095_bib23","doi-asserted-by":"crossref","first-page":"635","DOI":"10.2459\/JCM.0b013e32832997f3","article-title":"Ischemia and reperfusion-induced arrhythmias: role of hyperoxic preconditioning","volume":"10","author":"Pourkhalili","year":"2009","journal-title":"J. Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2021.174095_bib24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00395-012-0281-5","article-title":"The mechanism of beta-adrenergic preconditioning: roles for adenosine and ROS during triggering and mediation","volume":"107","author":"Salie","year":"2012","journal-title":"Basic. Res. Cardiol."},{"key":"10.1016\/j.ejphar.2021.174095_bib25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1161\/01.RES.8.1.129","article-title":"The electrocardiogram of the normal and hypertensive rat","volume":"8","author":"Sambhi","year":"1960","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2021.174095_bib26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cardiores.2003.10.011","article-title":"Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury","volume":"61","author":"Vinten-Johansen","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2021.174095_bib27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3389\/fphys.2014.00264","article-title":"Functional crosstalk between the mitochondrial PTP and KATP channels determine arrhythmic vulnerability to oxidative stress","volume":"5","author":"Xie","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2021.174095_bib28","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1001\/jama.1982.03320350062033","article-title":"Anisodamine inhibits thromboxane synthesis, granulocyte aggregation, and platelet aggregation. A possible mechanism for its efficacy in bacteremic shock","volume":"247","author":"Xiu","year":"1982","journal-title":"JAMA."},{"key":"10.1016\/j.ejphar.2021.174095_bib33","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2021.174095_bib29","first-page":"4205","article-title":"Protective effects of pinacidil hyperpolarizing cardioplegia on myocardial ischemia reperfusion injury by mitochondrial KATP channels","volume":"124","author":"Yu","year":"2011","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.ejphar.2021.174095_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12542","article-title":"Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion\/mitophagy and activating the AMPK-OPA1 signaling pathways","volume":"66","author":"Zhang","year":"2019","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ejphar.2021.174095_bib31","doi-asserted-by":"crossref","first-page":"864946","DOI":"10.1155\/2015\/864946","article-title":"Molecular characterization of reactive oxygen species in myocardial ischemia-reperfusion injury","volume":"2015","author":"Zhou","year":"2015","journal-title":"BioMed. Res. Int."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992100248X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992100248X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:49:38Z","timestamp":1757976578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429992100248X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":32,"alternative-id":["S001429992100248X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174095","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardioprotective effect of anisodamine against ischemia\/reperfusion injury through the mitochondrial ATP-sensitive potassium channel","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174095","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174095"}}