{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:25:07Z","timestamp":1790623507940,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["20199"],"award-info":[{"award-number":["20199"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.ejphar.2021.174133","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T01:38:48Z","timestamp":1620610728000},"page":"174133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Losartan protects endothelium-dependent relaxation in vivo in a murine model of rheumatoid arthritis"],"prefix":"10.1016","volume":"904","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3654-7302","authenticated-orcid":false,"given":"Moanna","family":"Villaluz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Dunning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl S.","family":"Goodyear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Ferrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Lockhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2006-2279","authenticated-orcid":false,"given":"Andrew","family":"MacKenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.174133_bib1","first-page":"1420","article-title":"Effect of losartan in complete freund's adjuvant -induced arthritis in rats","volume":"17","author":"Abdel El-Gaphar","year":"2018","journal-title":"Iran. J. Pharm. Res. (IJPR)"},{"key":"10.1016\/j.ejphar.2021.174133_bib2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2147\/JPR.S107385","article-title":"The effect of intra-articular vanilloid receptor agonists on pain behavior measures in a murine model of acute monoarthritis","volume":"9","author":"Abdullah","year":"2016","journal-title":"J. Pain Res."},{"key":"10.1016\/j.ejphar.2021.174133_bib3","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/eji.200939578","article-title":"Animal models of rheumatoid arthritis","volume":"39","author":"Asquith","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ejphar.2021.174133_bib4","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/art.24092","article-title":"Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies","volume":"59","author":"Avina-Zubieta","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ejphar.2021.174133_bib5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s13075-015-0829-5","article-title":"Effect of antiresorptive and anabolic bone therapy on development of osteoarthritis in a posttraumatic rat model of OA","volume":"17","author":"Bagi","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejphar.2021.174133_bib6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2174\/1874312901812010160","article-title":"Losartan, but not enalapril and valsartan, inhibits the expression of IFN-\u03b3, IL-6, IL-17F and IL-22 in PBMCs from rheumatoid arthritis patients","volume":"12","author":"Cardoso","year":"2018","journal-title":"Open Rheumatol. J."},{"key":"10.1016\/j.ejphar.2021.174133_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.peptides.2014.08.010","article-title":"Participation of AT1 and Mas receptors in the modulation of inflammatory pain","volume":"61","author":"Costa","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2021.174133_bib8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1113\/jphysiol.2004.062984","article-title":"Pathophysiology of vascular dysfunction in a rat model of chronic joint inflammation","volume":"557","author":"Egan","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2021.174133_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1113\/eph8602129","article-title":"Expression of constitutive but not inducible cyclooxygenase maintains articular perfusion in the rat knee","volume":"86","author":"Egan","year":"2001","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ejphar.2021.174133_bib10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/NNR.0000000000000082","article-title":"Evaluation of dynamic weight bearing for measuring nonevoked inflammatory hyperalgesia in mice","volume":"64","author":"Griffioen","year":"2015","journal-title":"Nurs. Res."},{"key":"10.1016\/j.ejphar.2021.174133_bib11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.vph.2017.11.001","article-title":"Endothelium-derived contraction in a model of rheumatoid arthritis is mediated via angiotensin II type 1 receptors","volume":"100","author":"Hamilton","year":"2018","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174133_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1475-097X.1989.tb00974.x","article-title":"Colloid osmotic and hydrostatic pressures and energy metabolism in high-protein joint swelling. A preliminary study of traumatic effusions of the knee","volume":"9","author":"Harilainen","year":"1989","journal-title":"Clin. Physiol."},{"key":"10.1016\/j.ejphar.2021.174133_bib13","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1161\/ATVBAHA.113.301490","article-title":"Endothelial dysfunction in rheumatoid arthritis: the role of monocyte chemotactic protein-1-induced protein","volume":"33","author":"He","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2021.174133_bib14","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/art.22423","article-title":"Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies using a novel proteinase-activated receptor 2 antagonist","volume":"56","author":"Kelso","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ejphar.2021.174133_bib15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.pharmthera.2010.11.001","article-title":"Endothelium-derived vasoactive agents, AT1 receptors and inflammation","volume":"131","author":"MacKenzie","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2021.174133_bib16","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.lfs.2013.04.011","article-title":"Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis","volume":"92","author":"Mackenzie","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2021.174133_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0165-1838(98)00087-3","article-title":"Cholinergic vasoregulation in normal and adjuvant monoarthritic rat knee joints","volume":"72","author":"McDougall","year":"1998","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.ejphar.2021.174133_bib18","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1111\/bph.12955","article-title":"Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP","volume":"172","author":"McGrath","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174133_bib19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.atherosclerosis.2016.01.004","article-title":"Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: a four week randomized placebo-controlled trial","volume":"246","author":"Mullan","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2021.174133_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","volume":"41","author":"Mulvany","year":"1977","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2021.174133_bib21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1113\/expphysiol.1995.sp003841","article-title":"Comparison of synovial PO2 and sympathetic vasoconstrictor responses in normal and acutely inflamed rabbit knee joints","volume":"80","author":"Najafipour","year":"1995","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ejphar.2021.174133_bib22","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1744-8069-9-38","article-title":"Angiotensin II produces nociceptive behavior through spinal AT1 receptor-mediated p38 mitogen-activated protein kinase activation in mice","volume":"9","author":"Nemoto","year":"2013","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2021.174133_bib23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1365-2125.2004.02344.x","article-title":"Laser Doppler imager (LDI) scanner and intradermal injection for in vivo pharmacology in human skin microcirculation: responses to acetylcholine, endothelin-1 and their repeatability","volume":"59","author":"Opazo Saez","year":"2005","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174133_bib24","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916656635","article-title":"EXPRESS: voluntary and evoked behavioral correlates in neuropathic pain states under different housing conditions","volume":"12","author":"Pitzer","year":"2016","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2021.174133_bib25","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1002\/art.30391","article-title":"Endothelial dysfunction in rat adjuvant-induced arthritis: up-regulation of the vascular arginase pathway","volume":"63","author":"Prati","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ejphar.2021.174133_bib26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/art.22335","article-title":"Angiotensin II type 1 receptor as a novel therapeutic target in rheumatoid arthritis: in vivo analyses in rodent models of arthritis and ex vivo analyses in human inflammatory synovitis","volume":"56","author":"Price","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ejphar.2021.174133_bib27","doi-asserted-by":"crossref","first-page":"14648","DOI":"10.1038\/srep14648","article-title":"Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice","volume":"5","author":"Quadros","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2021.174133_bib28","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1161\/01.CIR.0000099844.31524.05","article-title":"Explaining how \"high-grade\" systemic inflammation accelerates vascular risk in rheumatoid arthritis","volume":"108","author":"Sattar","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2021.174133_bib29","first-page":"599","article-title":"Repeatability of the evaluation of systemic microvascular endothelial function using laser Doppler perfusion monitoring: clinical and statistical implications","volume":"66","author":"Tibiri\u00e7\u00e1","year":"2011","journal-title":"Clinics"},{"key":"10.1016\/j.ejphar.2021.174133_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/ard.59.2.125","article-title":"Angiotensin converting enzyme in human synovium: increased stromal [(125)I]351A binding in rheumatoid arthritis","volume":"59","author":"Walsh","year":"2000","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2021.174133_bib31","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10787-018-0545-2","article-title":"Losartan suppresses the inflammatory response in collagen-induced arthritis by inhibiting the MAPK and NF-\u03baB pathways in B and T cells","volume":"27","author":"Wang","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ejphar.2021.174133_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180376","article-title":"Risk of cardiovascular disease in Chinese patients with rheumatoid arthritis: a cross-sectional study based on hospital medical records in 10 years","volume":"12","author":"Zou","year":"2017","journal-title":"PloS One"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921002867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921002867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:51:33Z","timestamp":1757976693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921002867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":32,"alternative-id":["S0014299921002867"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174133","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Losartan protects endothelium-dependent relaxation in vivo in a murine model of rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174133"}}