{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:42:42Z","timestamp":1788903762005,"version":"build-2803163510"},"reference-count":124,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.ejphar.2021.174156","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:10:54Z","timestamp":1620432654000},"page":"174156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Ecstasy (3,4-methylenedioxymethamphetamine): Cardiovascular effects and mechanisms"],"prefix":"10.1016","volume":"903","author":[{"given":"Diogo A.","family":"Fonseca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Tapadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Dulce","family":"Cotrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.174156_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0014-2999(01)01070-6","article-title":"Effects of methylenedioxymethamphetamine on noradrenaline-evoked contractions of rat right ventricle and small mesenteric artery","volume":"422","author":"Al-Sahli","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ejphar.2015.03.079","article-title":"Direct and indirect cardiovascular actions of cathinone and MDMA in the anaesthetized rat","volume":"758","author":"Alsufyani","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib3","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/0269881116642542","article-title":"Treating posttraumatic stress disorder with MDMA-assisted psychotherapy: A preliminary meta-analysis and comparison to prolonged exposure therapy","volume":"30","author":"Amoroso","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s100720200062","article-title":"Subarachnoid haemorrhage with \u2018Ecstasy\u2019 abuse in a young adult","volume":"23","author":"Auer","year":"2002","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.ejphar.2021.174156_bib5","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1124\/jpet.302.3.898","article-title":"Changes in cardiovascular responsiveness and cardiotoxicity elicited during binge administration of ecstasy","volume":"302","author":"Badon","year":"2002","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2021.174156_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.vph.2007.03.001","article-title":"Vasoconstriction of porcine left anterior descending coronary artery by ecstasy and cathinone is not an indirect sympathomimetic effect","volume":"47","author":"Baker","year":"2007","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib7","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1007\/s00213-017-4621-x","article-title":"MDMA does not alter responses to the Trier Social Stress Test in humans","volume":"234","author":"Bershad","year":"2017","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2021.174156_bib8","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/sj.bjp.0706688","article-title":"Effects of MDMA, MDA and MDEA on blood pressure, heart rate, locomotor activity and body temperature in the rat involve \u03b1-adrenoceptors","volume":"147","author":"Bexis","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s12012-019-09526-9","article-title":"MDMA induced cardio-toxicity and pathological myocardial effects: a systematic review of experimental data and autopsy findings","volume":"19","author":"Bonsignore","year":"2019","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.ejphar.2021.174156_bib10","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1038\/sj.bjp.0704402","article-title":"In vitro neuronal and vascular responses to 5-HT in rats chronically exposed to MDMA","volume":"134","author":"Cannon","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s12035-009-8064-1","article-title":"Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: An overview","volume":"39","author":"Capela","year":"2009","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2021.174156_bib12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00414-008-0262-2","article-title":"Cardiac oxidative stress determination and myocardial morphology after a single ecstasy (MDMA) administration in a rat model","volume":"122","author":"Cerretani","year":"2008","journal-title":"Int. J. Leg. Med."},{"key":"10.1016\/j.ejphar.2021.174156_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00213-004-1788-8","article-title":"Acute and long-term of MDMA on cerebral dopamine biochemistry and function","volume":"173","author":"Colado","year":"2004","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2021.174156_bib14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1365-2125.2000.00121.x","article-title":"Non-linear pharmacokinetics of MDMA ('ecstasy\u2019) in humans","volume":"49","author":"De La Torre","year":"2000","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1749-6632.2000.tb05199.x","article-title":"Pharmacology of MDMA in humans","volume":"914","author":"De La Torre","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2021.174156_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00007691-200404000-00009","article-title":"Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition","volume":"26","author":"De La Torre","year":"2004","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.ejphar.2021.174156_bib17","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1001\/jama.1987.03390120077027","article-title":"Eve\u2019 and \u2019Ecstasy\u2019: A report of five deaths associated with the use of MDEA and MDMA","volume":"257","author":"Dowling","year":"1987","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"10.1016\/j.ejphar.2021.174156_bib18","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.amjcard.2007.06.045","article-title":"Possible association between 3,4-methylenedioxymethamphetamine abuse and valvular heart disease","volume":"100","author":"Droogmans","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2021.174156_bib19","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1093\/brain\/awm256","article-title":"The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients","volume":"130","author":"Ducros","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.ejphar.2021.174156_bib20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00000433-200009000-00016","article-title":"Aortic dissection after ingestion of \u2018ecstasy\u2019 (MDMA)","volume":"21","author":"Duflou","year":"2000","journal-title":"Am. J. Forensic Med. Pathol"},{"key":"10.1016\/j.ejphar.2021.174156_bib21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/clpt.2009.62","article-title":"Cannabis coadministration potentiates the effects of ecstasy on heart rate and temperature in humans","volume":"86","author":"Dumont","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2021.174156_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/0269881108100020","article-title":"Ethanol co-administration moderates 3,4-methylenedioxymethamphetamine effects on human physiology","volume":"24","author":"Dumont","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib23","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s00431-007-0609-6","article-title":"Severe Ecstasy poisoning in an 8-month-old infant","volume":"167","author":"Eifinger","year":"2008","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ejphar.2021.174156_bib24","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1177\/1925362118797751","article-title":"3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) intoxication in a young adult with giant coronary aneurysms from Kawasaki disease","volume":"8","author":"Eigsti","year":"2018","journal-title":"Acad. Forensic Pathol"},{"key":"10.1016\/j.ejphar.2021.174156_bib25","first-page":"459","article-title":"Case report of ecstasy-induced renal venous thrombosis","volume":"3","author":"Eldehni","year":"2010","journal-title":"NDT Plus"},{"key":"10.1016\/j.ejphar.2021.174156_bib26","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1124\/jpet.107.129056","article-title":"Pharmacological interaction between 3,4-methylenedioxymethamphetamine (ecstasy) and paroxetine: pharmacological effects and pharmacokinetics","volume":"323","author":"Farr\u00e9","year":"2007","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2021.174156_bib27","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s00213-004-1789-7","article-title":"Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics","volume":"173","author":"Farr\u00e9","year":"2004","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2021.174156_bib28","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s00204-018-2226-8","article-title":"Aged rats are more vulnerable than adolescents to \u201cecstasy\u201d-induced toxicity","volume":"92","author":"Feio-Azevedo","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ejphar.2021.174156_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s12012-017-9398-y","article-title":"Hyperthermia severely affects the vascular effects of MDMA and metabolites in the human internal mammary artery in vitro","volume":"17","author":"Fonseca","year":"2017","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.ejphar.2021.174156_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tiv.2018.11.006","article-title":"MDMA modulates 5-HT1-mediated contractile response of the human internal thoracic artery in vitro","volume":"55","author":"Fonseca","year":"2019","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.ejphar.2021.174156_bib31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00213-005-0149-6","article-title":"Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans","volume":"183","author":"Freedman","year":"2005","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2021.174156_bib32","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1056\/NEJM199010183231617","article-title":"Myocardial infarction after inhalation of methamphetamine","volume":"323","author":"Furst","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2021.174156_bib33","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/eurheartj\/ehp598","article-title":"Amphetamines induce tissue factor and impair tissue factor pathway inhibitor: Role of dopamine receptor type 4","volume":"31","author":"Gebhard","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejphar.2021.174156_bib34","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1136\/jnnp.56.9.1036","article-title":"Subarachnoid haemorrhage associated with MDMA abuse","volume":"56","author":"Gledhill","year":"1993","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ejphar.2021.174156_bib35","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1124\/pr.55.3.3","article-title":"The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, \u2018ecstasy\u2019)","volume":"55","author":"Green","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2021.174156_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/ajem.2003.50028","article-title":"Multiple toxicity from 3,4-methylenedioxymethamphetamine (\u2018ecstasy\u2019)","volume":"21","author":"Greene","year":"2003","journal-title":"Am. J. Emerg. Med."},{"key":"10.1016\/j.ejphar.2021.174156_bib37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0166-4328(96)00078-2","article-title":"Psychobiologic effects of 3,4-methylenedioxymethamphetamine in humans: methodological considerations and preliminary observations","volume":"73","author":"Grob","year":"1996","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2021.174156_bib38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/0960327110370984","article-title":"Morbidity associated with MDMA (ecstasy) abuse: A survey of emergency department admissions","volume":"30","author":"Halpern","year":"2011","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ejphar.2021.174156_bib39","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1177\/003693309203700508","article-title":"\u2018Ecstacy\u2019 and intracerebral haemorrage","volume":"37","author":"Harries","year":"1992","journal-title":"Scot. Med. J."},{"key":"10.1016\/j.ejphar.2021.174156_bib40","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00213-002-1131-1","article-title":"Subjective and hormonal effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans","volume":"162","author":"Harris","year":"2002","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2021.174156_bib41","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0140-6736(92)91469-O","article-title":"Toxicity and deaths from 3,4-methylenedioxymethamphetamine (\u2018ecstasy\u2019)","volume":"340","author":"Henry","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2021.174156_bib42","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/PAF.0b013e318187e756","article-title":"Contraction band necrosis in two ecstasy abusers: A latent lethal lesion associated with ecstasy","volume":"30","author":"Hua","year":"2009","journal-title":"Am. J. Forensic Med. Pathol"},{"key":"10.1016\/j.ejphar.2021.174156_bib43","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1124\/jpet.111.188425","article-title":"Effects of the \u03b12-adrenergic agonist clonidine on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine in healthy volunteers","volume":"340","author":"Hysek","year":"2012","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2021.174156_bib44","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/JCP.0b013e3182979d32","article-title":"\u03b11-Adrenergic receptors contribute to the acute effects of 3,4-methylenedioxymethamphetamine in humans","volume":"33","author":"Hysek","year":"2013","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib45","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1111\/j.1476-5381.2012.01936.x","article-title":"Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans","volume":"166","author":"Hysek","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib46","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/clpt.2011.78","article-title":"The norepinephrine transporter inhibitor reboxetine reduces stimulant effects of MDMA (ecstasy) in humans","volume":"90","author":"Hysek","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2021.174156_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036476","article-title":"Duloxetine inhibits effects of MDMA (\u2018ecstasy\u2019) in vitro and in humans in a randomized placebo-controlled laboratory study","volume":"7","author":"Hysek","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2021.174156_bib48","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1017\/S1461145713001132","article-title":"Pharmacokinetic and pharmacodynamic effects of methylphenidate and MDMA administered alone or in combination","volume":"17","author":"Hysek","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib49","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1136\/emj.2009.079905","article-title":"Effects of a \u03b2-blocker on the cardiovascular response to MDMA (Ecstasy)","volume":"27","author":"Hysek","year":"2010","journal-title":"Emerg. Med. J."},{"key":"10.1016\/j.ejphar.2021.174156_bib50","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/sj.npp.1300896","article-title":"Plasma drug concentrations and physiological measures in \u2018dance party\u2019 participants","volume":"31","author":"Irvine","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2021.174156_bib51","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5847\/wjem.j.issn.1920-8642.2012.04.012","article-title":"ST elevation myocardial infarction in a young patient after ingestion of caffeinated energy drink and ecstasy","volume":"3","author":"Israelit","year":"2012","journal-title":"World J. Emerg. Med."},{"key":"10.1016\/j.ejphar.2021.174156_bib52","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1136\/bjo.82.7.841b","article-title":"Retinal haemorrhage caused by \u2018ecstasy\u2019","volume":"82","author":"Jacks","year":"1998","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.ejphar.2021.174156_bib53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00213-008-1258-9","article-title":"The effect of long-term repeated exposure to 3,4- methylenedioxymethamphetamine on cardiovascular and thermoregulatory changes","volume":"201","author":"Jaehne","year":"2008","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2021.174156_bib54","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/20009666.2019.1650593","article-title":"Ecstasy induced acute systolic heart failure and non-ischemic cardiomyopathy in a young female: a rare case report and literature review","volume":"9","author":"Kafle","year":"2019","journal-title":"J. Community Hosp. Intern. Med. Perspect."},{"key":"10.1016\/j.ejphar.2021.174156_bib55","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.hjc.2016.11.026","article-title":"Acute ascending aortic dissection after MDMA\/ecstasy use: A case report","volume":"57","author":"Kanahara","year":"2016","journal-title":"Hellenic J. Cardiol."},{"key":"10.1016\/j.ejphar.2021.174156_bib56","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1080\/00952990802308254","article-title":"Signal-averaged electrocardiogram in physically healthy, chronic 3,4-methylenedioxymethamphetamine (MDMA) users","volume":"34","author":"Kanneganti","year":"2008","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"10.1016\/j.ejphar.2021.174156_bib57","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00213-014-3752-6","article-title":"MDMA: A social drug in a social context","volume":"232","author":"Kirkpatrick","year":"2015","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2021.174156_bib58","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.psyneuen.2014.04.006","article-title":"Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans","volume":"46","author":"Kirkpatrick","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ejphar.2021.174156_bib59","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1038\/npp.2014.12","article-title":"Effects of MDMA and intranasal oxytocin on social and emotional processing","volume":"39","author":"Kirkpatrick","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2021.174156_bib60","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/FTD.0b013e3181684fa0","article-title":"Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adults","volume":"30","author":"Kolbrich","year":"2008","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.ejphar.2021.174156_bib61","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/JCP.0b013e31817ef470","article-title":"Physiological and subjective responses to controlled oral 3,4-methylenedioxymethamphetamine administration","volume":"28","author":"Kolbrich","year":"2008","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib62","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fphar.2012.00121","article-title":"The effects of psychostimulant drugs on blood brain barrier function and neuroinflammation","volume":"3","author":"Kousik","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib63","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0196-0644(03)00511-0","article-title":"Methylene 3, 4 dioxymethamphetamine-induced acute myocardial infarction","volume":"42","author":"Lai","year":"2003","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.ejphar.2021.174156_bib64","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/sj.bjp.0702875","article-title":"Investigation of the prejunctional \u03b12-adrenoceptor mediated actions of MDMA in rat atrium and vas deferens","volume":"128","author":"Lavelle","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib65","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0967-5868(03)00151-6","article-title":"Ecstasy\u2019-induced subarachnoid haemorrhage: An under-reported neurological complication?","volume":"10","author":"Lee","year":"2003","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174156_bib66","doi-asserted-by":"crossref","first-page":"969","DOI":"10.7326\/0003-4819-133-12-200012190-00012","article-title":"Cardiovascular effects of 3,4-methylenedioxymethamphetamine: A double-blind, placebo-controlled trial","volume":"133","author":"Lester","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejphar.2021.174156_bib67","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s002130000648","article-title":"Gender differences in the subjective effects of MDMA","volume":"154","author":"Liechti","year":"2001","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2021.174156_bib68","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0893-133X(00)00126-3","article-title":"Psychological and physiological effects of MDMA ('Ecstasy\u2019) after pretreatment with the 5-HT2 antagonist ketanserin in healthy humans","volume":"23","author":"Liechti","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2021.174156_bib69","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0924-977X(00)00086-9","article-title":"Acute psychological and physiological effects of MDMA ('Ecstasy\u2019) after haloperidol pretreatment in healthy humans","volume":"10","author":"Liechti","year":"2000","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.ejphar.2021.174156_bib70","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/026988110001400313","article-title":"The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3,4-methylenedioxymethamphetamine ('Ecstasy\u2019) in healthy volunteers","volume":"14","author":"Liechti","year":"2000","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib71","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/01.pec.0000092582.40174.38","article-title":"Atrial fibrillation in an adolescent - the agony of ecstasy","volume":"19","author":"Madhok","year":"2003","journal-title":"Pediatr. Emerg. Care"},{"key":"10.1016\/j.ejphar.2021.174156_bib72","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0022-3565(24)34877-3","article-title":"Cardiovascular and neuroendocrine effects and pharmacokinetics of 3,4-methylenedioxymethamphetamine in humans","volume":"290","author":"Mas","year":"1999","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2021.174156_bib73","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/sj.bjp.0704094","article-title":"Vascular actions of MDMA involve \u03b11 and \u03b12-adrenoceptors in the anaesthetized rat","volume":"133","author":"McDaid","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib74","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/01.pec.0000136072.37575.19","article-title":"Accidental Ecstasy poisoning in a toddler","volume":"20","author":"Melian","year":"2004","journal-title":"Pediatr. Emerg. Care"},{"key":"10.1016\/j.ejphar.2021.174156_bib75","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/jcp.49.2.149","article-title":"Pathology of deaths associated with \u2018ecstasy\u2019 and \u2018eve\u2019 misuse","volume":"49","author":"Milroy","year":"1996","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.ejphar.2021.174156_bib76","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1365-2559.2010.03728.x","article-title":"The histopathology of drugs of abuse","volume":"59","author":"Milroy","year":"2011","journal-title":"Histopathology"},{"key":"10.1016\/j.ejphar.2021.174156_bib77","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S2215-0366(18)30135-4","article-title":"3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a randomised, double-blind, dose-response, phase 2 clinical trial","volume":"5","author":"Mithoefer","year":"2018","journal-title":"Lancet Psychiat"},{"key":"10.1016\/j.ejphar.2021.174156_bib78","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00392-010-0205-z","article-title":"Ecstasy-induced myocardial infarction in a teenager: Rare complication of a widely used illicit drug","volume":"99","author":"M\u00f6ller","year":"2010","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.ejphar.2021.174156_bib79","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0014-2999(02)01586-8","article-title":"In vitro neuronal and vascular responses to 5-hydroxytryptamine: Modulation by 4-methylthioamphetamine, 4-methylthiomethamphetamine and 3,4-methylenedioxymethamphetamine","volume":"444","author":"Murphy","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib80","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.lfs.2019.01.050","article-title":"Binge ethanol and MDMA combination exacerbates HSP27 and Trx-1 (biomarkers of toxic cardiac effects) expression in right ventricle","volume":"220","author":"Navarro-Zaragoza","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2021.174156_bib81","article-title":"Binge ethanol and MDMA combination exacerbates toxic cardiac effects by inducing cellular stress","volume":"10","author":"Navarro-Zaragoza","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2021.174156_bib82","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0031-9384(00)00235-3","article-title":"Cardiovascular and sympathetic responses and reflex changes elicited by MDMA","volume":"70","author":"O'Cain","year":"2000","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2021.174156_bib83","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuropharm.2014.02.015","article-title":"Current preclinical studies on neuroinflammation and changes in blood-brain barrier integrity by MDMA and methamphetamine","volume":"87","author":"O'Shea","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2021.174156_bib84","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1176\/appi.psy.45.1.84","article-title":"Ecstasy: pharmacodynamic and pharmacokinetic interactions","volume":"45","author":"Oesterheld","year":"2004","journal-title":"Psychosomatics"},{"key":"10.1016\/j.ejphar.2021.174156_bib85","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1177\/0036933013496918","article-title":"Acute myocardial infarction in pregnancy following unlicensed use of methylenedioxymethamphetamine ('ecstasy\u2019)","volume":"58","author":"Okunoye","year":"2013","journal-title":"Scot. Med. J."},{"key":"10.1016\/j.ejphar.2021.174156_bib86","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1093\/ehjci\/jew123","article-title":"Aortic thrombus causing myocardial infarction after recreational MDMA Use","volume":"17","author":"Papachristidis","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ejphar.2021.174156_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047599","article-title":"Clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, \u2018Ecstasy\u2019): the influence of gender and genetics (CYP2D6, COMT, 5-HTT)","volume":"7","author":"Pardo-Lozano","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2021.174156_bib88","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0091-3057(01)00711-0","article-title":"Recreational Ecstasy\/MDMA, the serotonin syndrome, and serotonergic neurotoxicity","volume":"71","author":"Parrott","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2021.174156_bib89","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00213-012-2894-7","article-title":"Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 2 h apart","volume":"225","author":"Peir\u00f3","year":"2013","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2021.174156_bib90","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuropharm.2017.03.019","article-title":"3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) produces edema due to BBB disruption induced by MMP-9 activation in rat hippocampus","volume":"118","author":"P\u00e9rez-Hern\u00e1ndez","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2021.174156_bib91","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/nbm.1352","article-title":"Cardiac effects of MDMA on the metabolic profile determined with 1H-magnetic resonance spectroscopy in the rat","volume":"22","author":"Perrine","year":"2009","journal-title":"NMR Biomed."},{"key":"10.1016\/j.ejphar.2021.174156_bib92","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00213-017-4812-5","article-title":"(\u00b1)-MDMA and its enantiomers: potential therapeutic advantages of R(\u2212)-MDMA","volume":"235","author":"Pitts","year":"2018","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2021.174156_bib93","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fphar.2017.00455","article-title":"MDMA-induced dissociative state not mediated by the 5-HT2A receptor","volume":"8","author":"Puxty","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib94","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1136\/heart.85.6.e10","article-title":"Ecstasy induced acute myocardial infarction","volume":"85","author":"Qasim","year":"2001","journal-title":"Heart"},{"key":"10.1016\/j.ejphar.2021.174156_bib95","first-page":"590","article-title":"Case 6\/2016 - heart failure in a 23-year-old male with a history of illicit drug use","volume":"107","author":"Ribas","year":"2016","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.ejphar.2021.174156_bib96","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3109\/10408444.2012.725029","article-title":"Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): Interindividual differences due to polymorphisms and drugdrug interactions","volume":"42","author":"Rietjens","year":"2012","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ejphar.2021.174156_bib97","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/jnnp.56.9.1035","article-title":"Cerebral venous sinus thrombosis induced by \u2018ecstasy\u2019","volume":"56","author":"Rothwell","year":"1993","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ejphar.2021.174156_bib98","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1017\/S1461145714000145","article-title":"3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) disrupts blood-brain barrier integrity through a mechanism involving P2X7 receptors","volume":"17","author":"Rubio-Araiz","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib99","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1124\/jpet.107.126169","article-title":"3,4-Methylenedioxymethamphetamine- and 8-hydroxy-2-di-n-propylamino- tetralin-induced hypothermia: Role and location of 5-hydroxytryptamine 1A receptors","volume":"323","author":"Rusyniak","year":"2007","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2021.174156_bib100","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.legalmed.2009.09.003","article-title":"A fatal case of myocardial damage due to misuse of the \u2018designer drug\u2019 MDMA","volume":"11","author":"Sano","year":"2009","journal-title":"Leg. Med."},{"key":"10.1016\/j.ejphar.2021.174156_bib101","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/JCP.0000000000000962","article-title":"Methylenedioxymethamphetamine (MDMA) in psychiatry: pros, cons, and suggestions","volume":"38","author":"Schenk","year":"2018","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib102","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/bph.12423","article-title":"Effects of 3,4-methylenedioxymethamphetamine (MDMA) and its main metabolites on cardiovascular function in conscious rats","volume":"171","author":"Schindler","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib103","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1124\/jpet.114.222356","article-title":"Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy subjects","volume":"353","author":"Schmid","year":"2015","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2021.174156_bib104","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/FPC.0000000000000231","article-title":"CYP2D6 function moderates the pharmacokinetics and pharmacodynamics of 3,4-methylene-dioxymethamphetamine in a controlled study in healthy individuals","volume":"26","author":"Schmid","year":"2016","journal-title":"Pharmacogenetics Genom."},{"key":"10.1016\/j.ejphar.2021.174156_bib105","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1124\/mol.63.6.1223","article-title":"3,4-Methylenedioxymethamphetamine (MDMA, \u2018Ecstasy\u2019) induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro","volume":"63","author":"Setola","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib106","series-title":"Annals of the New York Academy of Sciences","first-page":"242","article-title":"Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury: An experimental study in rats and mice using biochemical and morphologic approaches","author":"Sharma","year":"2008"},{"key":"10.1016\/j.ejphar.2021.174156_bib107","doi-asserted-by":"crossref","first-page":"470","DOI":"10.2174\/138920110791591526","article-title":"The cardiovascular and cardiac actions of ecstasy and its metabolites","volume":"11","author":"Shenouda","year":"2010","journal-title":"Curr. Pharmaceut. Biotechnol."},{"key":"10.1016\/j.ejphar.2021.174156_bib108","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/cvr\/cvn129","article-title":"Ecstasy produces left ventricular dysfunction and oxidative stress in rats","volume":"79","author":"Shenouda","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2021.174156_bib109","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s12012-009-9034-6","article-title":"Metabolites of MDMA induce oxidative stress and contractile dysfunction in adult rat left ventricular myocytes","volume":"9","author":"Shenouda","year":"2009","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.ejphar.2021.174156_bib110","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.bbadis.2014.01.013","article-title":"MDMA induces cardiac contractile dysfunction through autophagy upregulation and lysosome destabilization in rats","author":"Shintani-Ishida","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.ejphar.2021.174156_bib111","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.tiv.2016.04.002","article-title":"Contractile effects of 3,4-methylenedioxymethamphetamine on the human internal mammary artery","volume":"34","author":"Silva","year":"2016","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.ejphar.2021.174156_bib112","series-title":"Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture","first-page":"159","article-title":"Drug-induced aortic aneurysms, ruptures and dissections","author":"Spigset","year":"2011"},{"key":"10.1016\/j.ejphar.2021.174156_bib113","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00000433-198812000-00015","article-title":"\u2018Ecstasy\u2019 and sudden cardiac death","volume":"9","author":"Suarez","year":"1988","journal-title":"Am. J. Forensic Med. Pathol"},{"key":"10.1016\/j.ejphar.2021.174156_bib114","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00213-006-0576-z","article-title":"The effects of fluoxetine on the subjective and physiological effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans","volume":"189","author":"Tancer","year":"2007","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejphar.2021.174156_bib115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0014-2999(02)02661-4","article-title":"Vascular actions of 3,4-methylenedioxymethamphetamine in \u03b12A\/D-adrenoceptor knockout mice","volume":"457","author":"Vandeputte","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib116","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3389\/fpsyt.2019.00755","article-title":"No influence of dopamine system gene variations on acute effects of MDMA","volume":"10","author":"Vizeli","year":"2019","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.ejphar.2021.174156_bib117","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/0269881117691569","article-title":"Safety pharmacology of acute MDMA administration in healthy subjects","volume":"31","author":"Vizeli","year":"2017","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib118","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00228-017-2392-2","article-title":"No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA","volume":"74","author":"Vizeli","year":"2018","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174156_bib119","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1021\/acschemneuro.8b00590","article-title":"Role of serotonin transporter and receptor gene variations in the acute effects of MDMA in healthy subjects","volume":"10","author":"Vizeli","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174156_bib120","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.euroneuro.2017.01.008","article-title":"Pharmacogenetics of ecstasy: CYP1A2, CYP2C19, and CYP2B6 polymorphisms moderate pharmacokinetics of MDMA in healthy subjects","volume":"27","author":"Vizeli","year":"2017","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.ejphar.2021.174156_bib121","first-page":"1","article-title":"Case of cardiac arrest treated with extra-corporeal life support after MDMA intoxication","author":"Voizeux","year":"2019","journal-title":"Case Reports Crit. Care 2019"},{"key":"10.1016\/j.ejphar.2021.174156_bib122","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/sj.npp.1395197","article-title":"Psychological and cardiovascular effects and short-term sequelae of MDMA ('Ecstasy\u2019) in MDMA-naive healthy volunteers","volume":"19","author":"Vollenweider","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2021.174156_bib123","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.tox.2013.05.013","article-title":"Roles of 3,4-methylenedioxymethamphetamine (MDMA)-induced alteration of connexin 43 and intracellular Ca2+ oscillation in its cardiotoxicity","volume":"310","author":"Zhuo","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2021.174156_bib124","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.yjmcc.2019.09.007","article-title":"Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings","volume":"136","author":"Zwartsen","year":"2019","journal-title":"J. Mol. Cell. Cardiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921003095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921003095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:51:23Z","timestamp":1757976683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921003095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":124,"alternative-id":["S0014299921003095"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174156","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ecstasy (3,4-methylenedioxymethamphetamine): Cardiovascular effects and mechanisms","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174156"}}